Стереоселективный синтез C-11 — С-13 фрагментов 14-членных макролидных антибиотиков пикромицина и нарбомицина
Диссертация
Высокое сходство структур 14-членных макролидных антибиотиков позволяет разработать единую стратегию синтеза, заключающуюся в разбиении структуры агликонов на C-I — С-6, С-9 — С-13 фрагменты, синтезируемых из Сахаров, последующем их соединении, построении стереохимии С-6, С-8 центров, макролактонизации и гликозилировании сахарными компонентами. Одно из главных требований при синтезе фрагментов… Читать ещё >
Содержание
- ГЛАВА I. ОБЗОР ЛИТЕРАТУРЫ Структура 12- и 14-членных макролидных антибиотиков
- 1. 1. Строение Сахаров — компонентов 12- и 14-членных макролидных антибиотиков
- 1. Дезозамин
- 2. Халкоза
- 3. Мегозамин
- 4-Кладиноза. б. Микароза б.Арканоза
- 7. 0. леандроза
- 8. 0. ливоза
- 1−2. Строение агликонов 12- и 14-членных макролидных антибиотиков
- 1−2.1 12-Членные макролидные антибиотики
- 1. Метимицин
- 2. Неометимицин
- 3. Антибиотик КЧ*
- 1−2.2 14-Членные макролидные антибиотики
- 1. Пикромицин и нарбомицин
- 2. Эритромицины
- 3. Мегаломицины (A, B, Cj и С2)
- 4. Олеандомицин
- 5. Ланкомицин (Шот-шцин)
- 1. 3. Конформация ма1фолидных антибиотиков
- ГЛАВА 2. ОБСУЙЩЕНИЕ РЕЗУЛЬТАТОВ Стереоселективный синтез C-II — C-I3 фрагментов 14-членных макролидных антибиотиков пикромицина и нарбомицина
- 2−1 Синтез C-II — С-13 фрагмента пикромицина
- 2. 1. 1. Синтез C-II — C-I3 фрагмента пикромицина из левоглюкозана (1,6-ангидро- -глюкопиранозы)
- 2. 1. 2. Синтез C-II — С-13 фрагмента пикромицина из диацетонглюкозы (1,2−5,6-ди-0-изопропилиден
- — Я-глюкофуранозы)
- 2−2 Синтез C-II — С-13 фрагмента нарбомицина
- ГЛАВА 3. ЭКСПЕРИМЕНТАЛЬНАЯ ЧАСТ
- ВЫВОДЫ
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