Π₯ΠΈΡΠ°Π»ΡΠ½ΡΠ΅ Π±Π»ΠΎΠΊΠΈ ΠΈΠ· R-(-) β ΠΊΠ°ΡΠ²ΠΎΠ½Π° ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΈΡ ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π² Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΌ ΡΠΈΠ½ΡΠ΅Π·Π΅
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
Π Ρ ΠΎΠ΄Π΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΠΉ 6-ΠΌΠ΅ΡΠΈΠ»ΠΊΠ°ΡΠ²ΠΎΠ½Π° ΠΈ ΠΊΠ°ΡΠ²ΠΎΠ½Π° Π²ΡΠ΄Π΅Π»Π΅Π½Ρ ΠΈ ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ Π°Π½ΠΎΠΌΠ°Π»ΡΠ½ΡΠΉ ΠΏΡΠΎΠ΄ΡΠΊΡ ΡΠ΅Π³ΠΈΠΎΠΈ ΡΡΠ΅ΡΠ΅ΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΠΊΡΡΡΠΈΡ ΡΠΏΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ»ΡΡΠ° Π² ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΎΠ·ΠΎΠ½ΠΎΠ»ΠΈΠ·Π° (lR, 2R, 4R, 6R)-4-H3onponeHmi-1-ΠΌΠ΅ΡΠΈΠ»-7-ΠΎΠΊΡΠ°Π±ΠΈΡΠΈΠΊΠ»ΠΎΠ³Π΅ΠΏΡ-2-ΠΈΠ»ΠΌΠ΅ΡΠ°Π½ΡΡΠ»ΡΡΠΎΠ½Π°ΡΠ° ΠΌΠ΅ΡΠ°Π½ΠΎΠ»ΠΎΠΌ ΠΈ Π½ΠΎΠ²ΠΎΠ΅ ΠΎΡΡΠΎΠ³ΠΎΠ½Π°Π»ΡΠ½ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ Ρ ΠΈΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ΅ ΡΠΈΠΊΠ»ΠΎΠ³Π΅ΠΊΡΠ΅Π½Π° —Π±ΠΈΡ (ΡΡΠΈΡΡΠΈΠ»ΡΠΈΠ»Π°Π½), ΠΎΠ±ΡΠ°Π·ΡΡΡΠ΅Π΅ΡΡ ΠΏΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΠΠ‘ΠΠ Π‘ΠΠΠ ΠΠ©ΠΠΠΠ
- ΠΠΠΠΠ 1. ΠΠΠ’ΠΠ ΠΠ’Π£Π ΠΠ«Π ΠΠΠΠΠ ΠΠΠ ΠΠΠ ΠΠΠ Π₯ΠΠ ΠΠΠ¬ΠΠΠ― ΠΠΠ’Π ΠΠ¦Π Π Π‘ΠΠΠ’ΠΠΠ ΠΠ ΠΠ ΠΠΠΠ«Π₯ Π‘ΠΠΠΠΠΠΠΠΠ
- 1. 1. ΠΠΎΠ½ΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π±Π»ΠΎΠΊΠΈ
- 1. 2. Π‘Π΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠΈΠ΄Ρ
- 1. 2. 1. ΠΠΎΠ½ΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠΈΠ΄Ρ
- 1. 2. 2. ΠΠΈΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠΈΠ΄Ρ
- 1. 2. 3. Π’ΡΠΈΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠΈΠ΄Ρ
- 1. 3. ΠΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠΈΠ΄Ρ
- 1. 4. ΠΠ»ΠΊΠ°Π»ΠΎΠΈΠ΄Ρ, ΡΡΠ΅ΡΠΎΠΈΠ΄Ρ ΠΈ Π΄ΡΡΠ³ΠΈΠ΅ Π±ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ
- ΠΠΠΠΠ 2. ΠΠΠ‘Π£ΠΠΠΠΠΠ Π ΠΠΠ£ΠΠ¬Π’ΠΠ’ΠΠ
- 2. 1. ΠΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΈΠ· Π-(-)-ΠΊΠ°ΡΠ²ΠΎΠ½Π°
- 2. 1. 1. ΠΡΠ°ΠΊΡΠΈΡΠ½ΡΠΉ ΡΠΈΠ½ΡΠ΅Π· (lR, 4S, 6R)-4-H3onponeHmi-l, 3,3-ΡΡΠΈΠΌΠ΅ΡΠΈΠ»-7-ΠΎΠΊΡΠ°Π±ΠΈΡΠΈΠΊΠ»ΠΎ[4.1.0]Π³Π΅ΠΏΡΠ°Π½-2-ΠΎΠ½Π°
- 2. 1. 2. ΠΠ»ΠΎΠΊΠΈ ΠΈΠ· 6-ΠΌΠ΅ΡΠΈΠ»ΠΊΠ°ΡΠ²ΠΎΠ½Π° ΠΈ ΡΠΏΠΎΠΊΡΠΈΠΊΠ°ΡΠ²ΠΎΠ½Π°
- 2. 1. 3. ΠΠΈΠ΄ΡΠΎΡ Π»ΠΎΡΠΈΠ΄ ΠΊΠ°ΡΠ²ΠΎΠ½Π° Π² ΡΠΈΠ½ΡΠ΅Π·Π΅ ΡΠΈΠ°Π·ΠΎΠ»ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π³ΠΎ Π‘ -Π‘ -Π±Π»ΠΎΠΊΠ° Π³Π΅ΡΠΈ-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠΈΠΊΠ»ΠΎΠΏΡΠΎΠΏΠ°Π½ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΡΠΏΠΎΡΠΈΠ»ΠΎΠ½ΠΎΠ²
- 2. 2. ΠΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΈΠ· (-)-ΠΊΠ°ΡΠ²Π΅ΠΎΠ»Π°
- 2. 2. 1. Π‘ΠΈΠ½ΡΠ΅Π· ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ (-)-ΠΊΠ°ΡΠ²Π΅ΠΎΠ»Π°
- 2. 2. 2. ΠΠΎΠ²ΡΠ΅ ΠΎΡΡΠΎΠ³ΠΎΠ½Π°Π»ΡΠ½ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π±Π»ΠΎΠΊΠΈ ΠΈΠ· (-)-ΠΊΠ°ΡΠ²Π΅ΠΎΠ»Π°
- 2. 2. 3. ΠΠΎΠ²Π°Ρ NBS-ΠΈΠ½ΠΈΡΠΈΠΈΡΡΠ΅ΠΌΠ°Ρ ΡΠΊΠ΅Π»Π΅ΡΠ½Π°Ρ ΠΏΠ΅ΡΠ΅Π³ΡΡΠΏΠΏΠΈΡΠΎΠ²ΠΊΠ° (-)-ΠΊΠ°ΡΠ²Π΅ΠΎΠ»Π°
- 2. 1. ΠΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΈΠ· Π-(-)-ΠΊΠ°ΡΠ²ΠΎΠ½Π°
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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