Индукция проницаемости внутренней мембраны митохондрий дрожжей Yarrowia lipolytica
Диссертация
С помощью стандартных тестов (измерение величины мембранного потенциала, скорости дыхания, набухания), была изучена возможность индукции поры в дрожжевых митохондриях в условиях окислительного стресса и ее регуляция. Нам удалось эмпирически подобрать комбинацию прооксидантов (менадиона, фениларсиноксида и оксалоацетата), которые снижали мембранный потенциал, действуя в относительно низких… Читать ещё >
Содержание
- СОКРАЩЕНИЯ И ОБОЗНАЧЕНИЯ, ПРИНЯТЫЕ В ТЕКСТЕ ОБЗОР ЛИТЕРАТУРЫ
- Глава 1. Апоптоз
- Глава 2. Неспецифическая Са2±зависимая проницаемость митохондрий 12 животных
- Глава 2. 1. Са2±зависимая, циклоспорин А-чувствптельная пора
- Глава 2. 2. Са2±зависнмая циклоспорин А-нечувствительная пора, 14 индуцируемая жирными кислотами
- Глава.
- 2. 3. Неспецифическая проницаемость митохондрий дрожжей
- Глава.
- 2. 4. Влияние жирных кислот на дрожжевые митохондрии
- Глава 3. Окислительный стресс. Прооксиданты. Антиоксиданты
- Глава.
- 3. 1. Окислительный стресс
- Глава.
- 3. 2. Активные формы кислорода
- Глава.
- 3. 3. Источники АФК в митохондриях
- Глава.
- 3. 4. Митохондрпальпые системы удаления АФК
- Глава.
- 3. 5. Проницаемость митохондрий животных в условиях 30 окислительного стресса
- Глава.
- 3. 6. Окислительный стресс в клетках дрожжей
- Глава 4. Митохондриальный АТР-чувствительный калиевый капал
- Глава.
- 4. 1. Системы транспорта калия в митохондриях животных
- Глава.
- 4. 2. Системы транспорта калия в митохондриях растений
- Глава.
- 4. 3. Системы транспорта калия в митохондриях дрожжей
- ЭКСПЕРИМЕНТАЛЬНАЯ ЧАСТ
- Глава 1. Материалы и методы исследования
- Глава.
- 1. 1. Реагенты
- Глава.
- 1. 2. Организм
- Глава.
- 1. 3. Условия выращивания
- Глава.
- 1. 4. Выделение митохондрий из дрожжей У. lipolytica
- Глава.
- 1. 5. Выделение митохондрий печени крысы
- Глава.
- 1. 6. Аналитические методы
- РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЯ И ИХ ОБСУЖДЕНИЕ
- Глава 1. В митохондриях дрожжей К lipolytics не индуцируется 47 «классическая» Са2±зависимая, циклоспорин А-чувствительная пора
- Глава 2. В митохондриях дрожжей Y. lipolytica не индуцируется 57 Са2+/пальмитат-зависимая пора
- Глава 3. Изучение влияния прооксидантов на митохондрии дрожжей 62 Y. lipolytica
- Глава 4. Митохондриальный АТР-зависимый калиевый канал в 78 митохондриях дрожжей Y. lipolytica
Список литературы
- Akerman К.Е., Wikstrom М.К. (1976) Safranine as a probe of the mitochondrial membrane potential. FEBS Lett. 68, 191−197.
- Almeida В., Buttner S., Ohlmeier S., Silva A., Mesquita A., Sampaio-Marques В., Osorio N.S., Kollau A., Mayer В., Leao C., Laranjinha J., Rodrigues F., Madeo F., Ludovico, P. (2007) NO-mediated apoptosis in yeasts. J. Cell Sci., 120, 3279−3288.
- Balcavage W.X., Lyoyd J.L., Mattoon J.R., Ohnishi T. and Scarpa A. (1973) Cation movements and respiratory response in yeast mitochondria treated with high Ca2' concentrations. Biochim. Biophys. Acta 305, 41—51.
- Bazhenova E.N., Deryabina Y.I., Eriksson O., Zvyagilskaya R.A., Saris N.E. (1998a) Characterization of a high capacity calcium transport system in mitochondria of the yeast Endomyces magnusii. J. Biol. Chem, 20, 273, 4372−4377.
- Bazhenova E.N., Saris N-E., Pentilla Т., Zvyagilskaya R.A. (1998). Stimulation of the mitochondrial calcium uniporter by hypotonicity and ruthenium red. Biochim. Biophys. Acta, 1371, 96−100.
- Bednarczyk P., Dolovy K., Szewczyk A. (2005). Matrix Mg2+ regulates mitochondrial ATP-dependent potassium channel from heart. FEBS. 579: 1625−1632.
- Belizario J.E., Alves J., Occhiucci J.M., Garay-Malpartida M., Sesso A. (2007) A mechanistic view of mitochondrial death decision pores. Braz .J. Med. Biol. Res. 40, 101 124.
- Bernardi P., Rrauskopf A., Basso E., Petronilli V., Blachly-Dyson E., Di Lisa F., Forte M.A. (2006) The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 273,2077−2099.
- Berrisford J.M., Sazanov L.A. (2009) Structural basis for the mechanism of respiratory complex I. J. Biol. Chem. 284, 29 773−29 783.
- Bienert G.P., Moller A.L., Kristiansen K.A., Schulz A., Moller I.M., Schjoerring J.K., Jahn T.P. (2007) Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J. Biol. Chem., 282, 1183−1192.
- Blagovi В., Rupci J., Mesari M., Man V. (2005) Lipid analysis of the plasma membrane and mitochondria of brewer’s yeast. Folia Microbiol (Praha), 50, 24−30.
- Bradford M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248−254.
- Bradshaw P.C., Jung D.W., Pfeiffer D.R. (2001) Free Fatty Acids Activate a Vigorous Ca2+:2H+ Antiport Activity inYeast Mitochondria. J. Biol. Chem., 276, 40 502−40 509.
- Branco M.R., Marinho H.S., Cyrne L., Antunes F. (2004) Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J. Biol. Chem., 279, 6501−6506.
- Biittner S., Eisenberg Т., Carmona-Gutierrez D., Ruli D., Knauer H., Ruckenstuhl C., Sigrist C., Wissing S., ICollroser M., Frohlich K.U., Sigrist S., Madeo F. (2007) Endonuclease G regulates budding yeast life and death. Mol. Cell. 26, 233−246.
- Carafoli E. (1987) Intracellular calcium homeostasis. Ann. Rev. Biochem., 56, 395−433
- Castrejon V., Pena A., Uribe S. (2002). Closure of the yeast mitochondria unspecific channel (YMUC) unmasks a Mg2+ and quinine sensitive K+ uptake pathway in Saccharomyces cerevisiae. J.Bioener.g Biomembr., 34, 299−306.
- Chinta S.J., Rane A., Yadava N., Andersen J.K., Nicholls D.G., Polster B.M. (2009) Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic. Biol. Med., 46, 939−947.
- Circu M.L., and Aw T.Y. Gluthatione and apoptosis. (2008) Free Radic. Res., 1, 1−18.
- Colin J., Garibal J., Mignotte В., Guenal, I. (2009) The mitochondrial TOM complex modulates bax-induced apoptosis in Drosophila. Biochem. Biophys. Res. Commun., 379, 931−943.
- Costa A.D., Quinlan C.L., Andrukhiv A. (2006). The direct physiological effects of mitoK (ATP) opening on heart mitochondria. Am. J. Physiol. Heart Circ. Physiol., 290: 406−415.
- Cymerman I.A., Chung I., Beckmann B.M., Bujnicki J.M., Meiss G. (2008) EXOG, a novel paralog of Endonuclease G in higher eukaryotes. Nucleic Acids Res. 36, 1369−79.
- Dahlem YA, Wolf G, Siemen D, Horn TF. (2006). Combined modulation of the mitochondrial ATP-dependent potassium channel and the permeability transition pore causes prolongation of the biphasic calcium dynamics. Cell Calcium., 39, 387−400.
- DePablo M., Susin S., Jacotot E., Larocette, Costantini P., Ravagnan L., Zamzani N., and Kroemer G. (1999) Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis, 4, 81−87.
- Deryabina Y.I., Bazhenova E.N., Saris N.E., Zvyagilskaya R.A., (2001) Ca(2+) efflux in mitochondria from the yeast Endomyces magnusii. J. Bio. l Chem., 276, 47 801−47 806.
- Eisenberg, Т., Buttner, S., and Kroemer, G. (2007) The mitochondrial pathway in yeast apoptosis. Apoptosis, 12, 1011−1023.
- Fabrizio P., Longo V.D. 2008 Chronological aging-induced apoptosis in yeast., 1783,1280−1285.
- Facundo HT, de Paula JG, Kowaltowski A J. (2007). Mitochondrial ATP-sensitive K+ channels are redox-sensitive pathways that control reactive oxygen species production. Free Radic Biol Med., Apr 1- 42(7): 1039−1048.
- Fahrenkrog В., Sauder U., Aebi U. (2004) The S. cerevisiae HtrA-like protein Nmal 1 lp is a nuclear serine protease that mediates yeast apoptosis. J. Cell. Sci 117, 115−126.
- Fannjiang Y., Cheng W.C., Lee S.J., Qi В., Pevsner J., McCaffery J.M., Hill R.B., Basanez G., Hardwick J. M. (2004) Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev. 18, 2785−2797.
- Folmer V., Pedroso N., Matias A.C., Lopes S.C., Antunes F., Cyrne L., Marinho H.S. (2008) H2O2 induces rapid biophysical and permeability changes in the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta. 1778, 1141−1147.
- Fujii J., Ikeda, Y. (2002) Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox. Rep., 1, 123−130-
- Galkin A., Brandt U. (2005) Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica. J. Biol. Chem., 280, 30 129−30 135.
- Gao, W., Pu, Y., Luo, K.Q., and Chang, D.C. (2001) Temporal relationship between cytochrome с release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. J. Cell Sci., 114, 2855−2862.
- Gardner P.R. (2002) Aconitase: sensitive target and measure of superoxide. Methods Enzymol., 349, 9−23.
- Garlid K.D., Paucek P. (2001). The mitochondrial potassium cycle. IUBMB Life, 52: 153 158.
- Garlid K.D., Paucek P. (2003b). Mitochondrial potassium transport: the K+ cycle. Biochim. Biophys. Acta, 1606: 23−41.
- Garrido E.O., Grant C.M. (2002) Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides. Mol. Microbio. l, 43, 993−1003.
- Gateau-Roesch O., Pavlov E., Lazareva A.V., Limarenko E.A., Levrat C., Saris N.E., Louisot P., Mironova G.D. (2000) Calcium-binding properties of the mitochondrial channel-forming hydrophobic component. J. Bioenerg. Biomembr., 32, 105−110.
- Gogvadze V., Robertson J.D., Enoksson M., Zhivotovsky В., Orrenius S. (2004) Mitochondrial cytochrome с release may occur by volume-dependent mechanisms not involving permeability transition. Biochem. J., 378, 213−217.
- Grigoriev S., Skarga Y.Y., Mironova G.D., Marinov B.S. (1999). Regulation of mitochondrial Кдтр channel by redox agents. Biochim. Biophys. Acta., 1410(1): 91−96.
- Grover G., Garlid K. (2000). ATP-sensitive potassium channels: a review of their cardioprotective pharmacology. J.Mol.Cell Cardiol., 32: 677−695.
- Grover GJ, Sleph PG, Dzwonczyk S. (1992). Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine Al-receptors. Circulation, Oct- 86(4): 1310−6.
- Guerin В., Bunoust O., Rouqueys V., Rigoulet M. (1994) ATP-induced Unspecific Channel in Yeast Mitochondria . J. Biol. Chem., 269, 25 406−25 410.
- Guo J., Lemire B.D. (2004) The ubiquinone-binding site of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase is a source of superoxide. J. Biol. Chem. 278, 4 762 947 635.
- Gutierrez-Aguilar M, Perez-Vazquez V, Bunoust O, Manon S, Rigoulet M, Uribe S. 2007. In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition. Biochim. Biophys. Acta.
- Halestrap A.P. (2009a) What is the mitochondrial permeability transition pore? J. Mol. Cell. Cardiol. 46, 821−831.
- Halestrap A.P. (2009b) Mitochondrial calcium in health and disease. Biochim. Biophy. s Acta. 1787, 1289−1290.
- Halestrap AP, Pasdois P. (2009) The role of the mitochondrial permeability transition pore in heart disease. Biochim. Biophys. Acta. 1787, 1402−1411.
- Han D., Canali R., Rettori D., Kaplowitz, N. (2003) Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol. Pharmacol., 64, 1136−1144.
- Hanada M., Aime-Sempe C., Sato Т., Reed, J.C. (1995) Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J. Biol. Chem., 270, 11 962−11 969.
- Herker E., Jungwirth H., Lehmann K.A., Maldener C., Frohlich K.U., Wissing S., Buttner S., Fehr M., Sigrist S., Madeo F. (2004) Chronological aging leads yto apoptosis in yeasts. J. Cell Biol.,. 164, 501−507.
- Imai, H., and Nakagawa, Y. (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med., 34, 145−169.
- Inoue I., Nagase H., Kishi K. & Higuti T. (1991). ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature, 352: 244−247.
- Johansson C., Lillig, C.H., Holmgren, A. (2004) Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. J. Biol. Chem., 279, 7537−7543.
- Jung D.W., Bradshaw P.C., Pfeiffer D.R. (1997). Properties of a cyclosporin-insensitive permeability transition pore in yeast mitochondria. J Biol Chem. 272, 21 104−21 112.
- Kerscher S, Drose S, Zwicker K, Zickermann V, Brandt U (2002) Yarrowia lipolytica, a yeast genetic system to study mitochondrial complex I. Biochim Biophys Acta. 1555, 8391.
- Kerscher S, Kashani-Poor N, Zwicker K, Zickermann V, Brandt U (2001) Exploring the catalytic core of complex I by Yarrowia lipolytica yeast genetics. J. Bioenerg. Biomembr., 33, 187−196.
- Kirsch M., De Groot, H. (2001) NAD (P)H, a directly operating antioxidant? FASEB. J., 15, 1569−1574.
- Kong J., and Rablcin S. (2000) Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A. Biochim. Biophys. Acta, 1485,45−55.
- Korshunov, S.S., Krasnikov, B.F., Pereverzev, M.O., and Skulachev, V.P. (1999) The antioxidant functions of cytochrome c. FEBSLettt., 462, 192−198.
- Kowaltowski A.J., Castilho R.F., Vercesi A.E. (2001). Mitochondrial permeability transition and oxidative stress. FEBS Letters, 495, 12−15.
- Kowaltowski A.J., Vercesi A.E., Rhee S.G., Netto L.E. (2000). Catalases and thioredoxin peroxidase protect Saccharomyces cerevisiae against Ca2±induced mitochondrial membrane permeabilization and cell death. FEBS Lett. 473, 177−82.
- Kushnareva YE and Sokolove PM (2000). Prooxidants open both the mitochondrial permeability transition pore and a low-conductance channel in the inner mitochondrial membrane. Arch. Biochem. Biophys, 376, 377−388.
- Lambert A.J., Brand M.D. (2004) Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem. J., 382, 511−517.
- Laun P., Heeren G., Rinnerthaler M., Rid R., Kossler S., Koller L., Breitenbach M.(2008) Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: a short review.Biochim. Biophys. Acta. 1783, 1328−1334.
- Laun P., Rinnerthaler M., Bogengruber E., Heeren G., Breitenbach M. (2006) Yeast as a model for chronological and reproductive aging a comparison. Exp. Gerontol. 41, 12 081 212.
- Leung A.W., Varanyuwatana P., Halestrap A.P. (2008b) The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition. J. Biol. Chem. 283, 26 312−23.
- Leung, A.W., and Halestrap, A.P. (2008a) Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim. Biophys. Acta, 1777, 946−952.
- Linnane A.W., Kios M., Vitetta L. (2007) Coenzyme Q(10)~its role as a prooxidant in the formation of superoxide anion/hydrogen peroxide and the regulation of the metabolome. Mitochondrion, 1, Supp 1: S51−61.
- Listenberger L., Ory D., and Schaffer J. (2001) Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J. Biol. Chem., 276, 14 890−14 895.
- Lohret T.A., Kinnally K.W. (1995). Multiple Conductance Channel Activity of Wild-Type and Voltage-Dependent Anion-Selective Channel (VDAC)-Less Yeast Mitochondria. Biophys. Jl, 68, 2299−2309.
- Low С. P., Shui G" Liew L.P., Buttner S., Madeo, F" Dawes I.W., Wenk, M.R., Yang, H. (2008) Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast. J. Cell Sci., 121,2671−2684.
- Lucken-Ardjomande, S., Montessuit, S., and Martinou, J.C. (2008) Contributions to Baxinsertion and oligomerization of lipids of the mitochondrial outer membrane. Cell Death Differ., 15, 923−937.
- Ludovico P., Rodrigues F., Almeida A., Silva M. Т., Barrientos A., Corte-Real M. (2002) Cytochrome с release and mitochondria involvement in programmed cell death induccd by acetic acid in Saccharomyces cerevisiae. Mol. Biol. Cell. 13, 2598−2606.
- Lushchak O.V., Lushchak V.I.(2008) Catalasc modifies yeast Saccharomyces cerevisiae response towards S-nitrosoglutathione-induced stress. Redox Rep. 13, 283−291.
- Madeo F., Frolich E., Frohlich, K.U. (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J. Cell Biol., 139, 729−734.
- Madeo F., Hcrker E., Maldener C., Wissing S., Liichelt S., Herlan M., Fehr M., Lauber K., Sigrist S.J., Wesselborg S., Frohlich K.U. (2002) A caspase-rclated protease regulates apoptosis in yeast.Mol Cell., 9, 911−917.
- Madzak C., Gaillardin C., Beclcerich J.M. (2004) Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review. J. Biotechnol., 109, 63−81.
- Manon S., Chaudhuri В., Guerin M. (1997). Release of cytochrome с and decrease of cytochrome с oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL. FEBS Lett. 415, 29−32.
- Manon S" Guerin M. (1997). The ATP-induced K+ -transport pathway of yeast mitochondria may function as an uncoupling pathway. Biochim. Biophy. s Acta., 1318, 31 721.
- Manon S., Guerin M. (1998) Investigation of the yeast mitochondrial unselective channel in intact and permeabilized spheroplasts. Biochem. Mol. Biol. Int., 44, 565−575.
- Manon S., Roucou X., Guerin M., Rigoulet M., Guerin В (1998) Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore? J. Bioener. g Biomembr., 30, 419−29.
- Manon S., Roucou X., Rigoulet M., Guerin M. (1995). Stimulation of oxidative phosphorylation by electrophoretic K+ entry associated to electroneutral K+/H+ exchange in yeast mitochondria. Biochim Biophys Acta, 1231, 282−8.
- Miranda-Vizuete A., Damdimopoulos A.E., Spyrou G., (2000) The mitochondrial thioredoxin system. Antioxid Redox Signal. 2, 801−810.
- Mironova G.D., Belosludtsev K.N., Belosludtseva N.V., Gritsenko E.N., Khodorov B.I., Saris N.E. (2007b) Mitochondrial Ca2+ cycle mediated by the palmitate-activated cyclosporine A-insensitive pore. J. Bioenerg. Biomembr., 39, 167−174.
- Mironova G.D., Skarga Yu.Yu., Grigoriev S.M., Negoda A.E., Kolomytkin O.V., Marinov B.S. (1999). Reconstitution of the mitochondrial ATP-dependent potassium channel into bilayer lipid membrane. J. Bioenerg. Biomembr., 31, 157−161.
- Mirzaei H., Regnier F. (2007) Identification of yeast oxidized proteins: chromatographic top-down approach for identification of carbonylated, fragmented and cross-linked proteins in yeast. J. Chromatogr. A. 1141, 22−31.
- Miwa S., Brand M.D. (2003) Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling. Biochem Soc Trans. 31, 1300−1301.
- Monteiro G., Kowaltowski A.J., Barros M.H., Nettoa L.E.S. 2004. Glutathione and thioredoxin peroxidases mediate susceptibility of yeast mitochondria to Ca2±induced damage. Arch. Biochem. Biophys., 425: 14—24.
- Moye-Rowley W.S. (2000) Transcription factors regulating the response to oxidative stress in yeast. Antioxid Redox Signal. 4, 123−40.
- Nakae Y., Kwok W.M., Bosnjak Z.J., Jiang M.T. (2003). Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers. J. Physiol. Heart Circ. Physiol., 284: 1865−1871.
- Nazarko T.Y., Farre J.C., Subramani S. (2009) Peroxisome size provides insights into the function of autophagy-related proteins. Mol. Biol Cell. 20, 3828−39.
- Ohnishi S.T., Ohnishi Т., Muranaka S. (2005). A possible site of superoxide generation in the complex I segment of rat heart mitochondria. J. Bioenerg. Biomembr., 37, 1−15.
- Owsianowski E., Walter D., Fahrenkrog B. (2008) Negative regulation of apoptosis in yeast. Biochim, Biophy. s Acta. 1783, 1303−1310.
- Palkova Z., Vachova L., Gaskova D., Kucerova H. Synchronous plasma membrane electrochemical potential oscillations during yeast colony development and aging. Mol. Membr. Biol. 2009 26, 228−235.
- Parihar A., Vaccaro P., Ghafourifar P. (2008) Nitric oxide irreversibly inhibits cytochrome oxidase at low oxygen concentrations: evidence for inverse oxygen concentration-dependent peroxynitrite formation. IUBMB Life. 60, 64−67.
- Parrella E., Longo V.D. (2008) The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods, 46, 256−62.
- Pastore, D., Stoppelli, M.C., Di Fonzo, N. and Passarella, S. (1999) The existence of the K+channel in plant mitochondria. J. Biol. Chem., 274, 26 683−26 690.
- Penzo D, Tagliapietra C, Colonna R, Petronilli V, Bernardi P. 2002. Effects of fatty acids on mitochondria: implications for cell death. Biochim. Biophys. Acta, 1555, 160— 165.
- Pereira C., Camougrand N., Manon .S, Sousa M.J., Corte-Real M. (2007) ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome с release in yeast apoptosis. Molecul. Microbiol., 66, 571−582.
- Perrone, G.G., Tan, S.X., and Dawes, I.W. (2008) Reactive oxygen species and yeasy apoptosis. Biochim. Biophys. Acta, 1783, 1354−1368.
- Petrussa, E., Casolo, V., Braidot, E., Chiandussi, E., Macri, F. and Vianello., A. (2001) Cyclosporin A induces the opening of a potassium-selective channel in higher plant mitochondria. J. Bioenerg. Biomembr., 33, 107−117.
- Polcic P, Sabova' L and Kolarov J, (1997) Fatty acids induced uncoupling of Saccharomyces cerevisiae mitochondria requires an intact ADP/ATP carrier. FEBS Lett. 412,207−210.
- Priault M., Camougrand N., Kinnally K.W., Vallette F.M., Manon S. (2003) Yeast as a tool to study Bax/mitochondrial interactions in cell death. FEMS Yeast Res. 4, 15−27.
- Prieto S" Bouillaud F. and Rial E. (1995) The mechanism for the ATP-induced uncoupling of respiration in mitochondria of the yeast Saccharomyces cerevisiae. Biochem. J., 307, 657−661.
- Rebrin I., Sohal R.S. (2008) Pro-oxidant shift in glutathione redox state during aging. Adv. Drug Deliv. Rev. 60, 1545−1552.
- Rebrin, I., Kamzalov, S., Sohal, R.S. (2003) Effects of age and caloric restriction on glutathione redox state in mice. Free Radic. Biol. Med., 35, 626−635.
- Roucou X., Manon S., Guerin M. (1995). ATP opens an electrophoretic potassium transport pathway in respiring yeast mitochondria. FEBS Lett., 364, 61−64.
- Roucou X., Manon S., Guerin M. (1997). Modulation of the electrophoretic ATP-induced K±transport in yeast mitochondria by delta pH. Biochem. Mo. I Bio.I Int., 43, 5361.
- Ruy F., Vercesi A.E., Andrade P.B.M., Bianconi M.L., Chaimovich H., Kowaltowski A.J. (2004) A Highly Active ATP-Insensitive K+ Import Pathway in Plant Mitochondria. J. Bioenerg. Biomembr., 36,195−202.
- Schmitt M.J. and Reiter, J. (2008) Viral induced yeast apoptosis. Biochim. Biophys. Acta, 1783, 1413−1417.
- Severin F.F., Meer M.V., Smirnova E.A., Knorre D.A., Skulachev, V.P. (2008) Natural causes of programmed death of yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta, 1783, 1350−1353.
- Sheridan C., Delivani P., Cullen S.P., Martin S.J. (2008) Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome С release. Mol. Cell. 31, 570−85.
- Silva R.D., Sotoca R., Johansson В., Ludovico P., Sansonetty F., Silva M.T., Peinado J.M., Corte- Real M. (2005) Hyperosmotic stress induces metacaspase- and mitochondria-dependent apoptosis in Saccharomyces cerevisiae. Mol. Microbiol. 58, 824−834.
- Singh K., ICang P.J., Park H.O. (2008) The Rho5 GTPase is necessary for oxidant-induced cell death in budding yeast. Proc, Natl, Acad, Sci U S A. 105, 1522−1527.
- Skulachev V.P. (2001) NAD(P)+ decomposition and antioxidant defense of the cell. FEBS Lett., 492, 1−3.
- Sparagna G., Hickson-Bick D., Buja L., and McMillin J. (2000) A metabolic role for mitochondria in palmitate-iinduced cardiac myocyte apoptosis. Am. J. Physiol. Heart Circ. Physiol., 279, 2124−2132.
- Srivastava S, Chan C, (2007) Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition. Free Radio Res, 41, 8−49.
- Starkov A. A, Fiskum G., Chinopoulos C., Lorenzo B.J., Browne S.E., Patel M.S., Beal M.F.(2004) Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J. Neurosci. 24, 779−788.
- Starkov A.A., Fiskum G. (2003) Regulation of brain mitochondrial H202 production by membrane potential and NAD(P)H redox state. J. Neurochem., 86, 1101−1107.
- Stasyk O.V., Nazarko T.Y., Sibirny A.A. (2008) Methods of plate pexophagy monitoring and positive selection for ATG gene cloning in yeasts. Methods Enzymol. 45, 229−39.
- Sultan A., and Sokolove P. (2001a) Palmitic acid opens a novel cyclosporin A-insensitive pore in the inner mitochondrial membrane. Arch. Biochem. Biophys., 386, 3151.
- Sultan A., and Sokolove P. (2001b) Free fatty acid effects on mitochondrial permeability: an overview. Arch. Biochem. Biophys., 386, 52−61.
- Szeto S.S., Reinke S.N., Sykes B.D., Lemire B.D.(2007) Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate. J. Biol. Chem., 282, 27 518−27 526.
- Szewczyk A. (1996) The. ATP-regulated K+ channel in mitochondria: Five years after its discovery. Acta Bioch. Polonica, 43, 713−719.
- Titorenko V.I., Rachubinski R.A. (2009) Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system. Int. Rev. Cell. Mol. Biol. 27, 191−244.
- Toninello A., Salvi M., Schweizer M., Richter C. (2004) Menadione induces a low conductance state of the mitochondrial inner membrane sensitive to bongkrekic acid. Free Radic Biol Med., 37, 1073−1080.
- Tretter L.A., Adam-Vizi V. (2004) Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. J. Neurosci., 24, 7771−7778.
- Turrens, J.F. (2003) Mitochondrial formation of reactive oxygen species. J. Physiol., 552, 335−344.
- Vachova L., Kucerova H., Devaux F., Ulehlova M., Palkova Z. (2009) Metabolic diversification of cells during the development of yeast colonies. Environ Microbiol. 11, 494−504.
- Votyakova T.V., Bazhenova E.N., Zvyagil’skaya R.A. (1990). Polyamines improve Ca2+ transport system of the yeast mitochondria. FEBS Lett. 261, 139−141.
- Votyakova T.V., Bazhenova E.N., Zvyagil’skaya R.A. (1993). Regulation of the yeast mitochondrial Ca2+ uptake by polyamines and Mg2+. J. Bioenerg. Biomembr. 25, 569−574.
- Wang E., Erdahl W.L., Hamidinia S.A., Chapman C.J., Taylor R.W., feiffer D.R. (2001) Transport Properties of the Calcium Ionophore ETH-129. Biophy. J., 81, 32 753 284.
- Webb J.S., Givskov M., Kjelleberg, S. (2003) Bacterial biofilms: prokaryotic adventures in multicellularity. Curr. Opin. Microbiol., 6, 578−585.
- Wieckowski M., Brdiczka D., and Wojtczak L. (2000) Long-chain fatty acids opening of the reconstituted mitochondrial permeability transition pore. FEBS Lett., 484, 61−64.
- Wood, Z.A., Schroder, E., Robin Harris, J., and Poole, L.B. (2003) Structure, mechanism and regulation of peroxiredoxins. Trends Biochem. Sci., 28, 32−40.
- Zorov D.B., Juhaszova M., Yaniv Y., Nuss H.B., Wang S., Sollott S.J. (2009) Regulation and pharmacology of the mitochondrial permeability transition pore. Cardiovasc Res. 83, 213−25.
- Zvyagilskaya R. A., Parkhomenko O.A., Gordeeva A.V., Deryabina Y.I., Persson B.L. (2004). Bioenergetics of Yarrowia lipolytica cells grown at alkaline conditions. Biosci Reports, 24, 117−125.
- Zvyagilskaya R. A., Parkhomenko O.A., Gordeeva A.V., Deryabina Y.I., Persson B.L. 2004. Bioenergetics of Yarrowia lipolytica cells grown at alkaline conditions. Biosci Reports, 24, 117−125.
- Zvyagilskaya R. Persson B. L. (2003) Dual regulation of proton- and sodium- coupled phosphate transport systems in the yeast Yarrowia lipolytica by phosphate and extracellular pH. IUBMB Life 55 (3): 151−154.
- Zvyagilskaya R., Andreishcheva E., Soares I.M.I., Khozin I., Berhe A., Persson B.L. (2001a). Isolation and characterization of a novel leaf-inhabiting osmo-, salt, and alkali-tolerant Yarrowia lipolytica strain. J. Basic Microbiol. 41, 283−303.
- Zvyagilskaya R.A., Parchomenko O.A., Persson B.L. (2000) Two systems for phosphate uptake in Yarrowia lipolytica cells grown under alkaline conditions. IUBMB Life, 50, 151−155.
- Андреев А. Ю., Кушнарева Ю. E., Старков A. A. (2005) Метаболизм активных форм кислорода в митохондооиях. Биохимия, 70, 246−264.
- Андреищева Е.Н., Соарес М.И.М., Звягильская Р. А. 1997. Энергетический обмен дрожжей Candida (Yarrowia) lipolytica в норме и при солевом стрессе. Физиол. раст. 44, 657 664.
- Баженова Е.Н., Дерябина Ю. И., Звягильская Р. А. (1997) Стимулирующее действие АДФ на систему транспорта ионов кальция митохондрий дрожжей. ДАН СССР, 353, 1−3.
- Белослудцев К.Н., Белослудцева Н. В., Миронова Г. Д. (2005) Возможный механизм образования и регуляции пальмитат-индуцированной циклоспорин А-нечувствительной поры. Биохимия, 70, 815−821.
- Белослудцев К.Н., Белослудцева Н. В., Миронова Г. Д. (2008) Роль митохондриальной пальмитат/Са2±активируемой поры в пальмитат-индуцированном апоптозе. Биофизика, 53, 967−971.
- Гесслер Н.Н., Аверьянов А. А., Белозерская Т. А. (2007) Активные формы кислорода в регуляции отногенеза грибов. Биохимия, 72, 1342−1365.
- Грабельных О.И. (2005) Энергетические функции митохондрий растений в стрессовых условиях. J. Stress Physio & Biochemistry, 1, 37−54.
- Дерябина Ю.И., Исакова Е. П., Шурубор Е. И., Звягильская Р. А. (2004) Кальций-зависимая неспецифическая проницаемость внутренней митохондриальной мембраны не индуцируется в митохондриях дрожжей Endomyces magnusii. Биохимияб, 69, 1261- 1270.
- Дерябина Ю.И., Звягильская Р. А. (2000) Са2±транспортирующая система митохондрий дрожжей Endomyces magnusii-. независимые пути для поглощения и выхода иона. Биохимия, 65, 607−1611.
- Звягильская Р.А. и Котельникова А.В. (1991) Структура и функциональная активность дрожжевых митохондрий (монография). М.:ВИНИТИ, сер. Биол. Хим. 36, 172 сс.
- Звягильская Р.А., Лейкин Ю. Н., Кожокару Н. Л., Котельникова А. В. (1983) Транспорт ионов кальция дрожжевыми митохондриями. ДАН СССР, 269, 12 381 240.
- Звягильская Р.А., Перссон Б. Л. (2004). Новый алкалотолерантный штамм дрожжей Yarrowia lipolytica -перспективная модель для изучения свойств и регуляции Na зависимых переносчиков фосфата у дрожжей (обзор). Биохимия, 69, 1613−1621.
- Зоров Д.Б., Исаев Н.К.,. Плотников Е. Ю, Зорова Л. Д., Стельмашук Е. В., Васильева А. К., Архангельская А. А.,. Хряпенкова Т. Г. (2007) Митохондрия как многоликий Янусю Биохимия, 72, 1115−1126.
- Кулинский В.И., Колесниченко Л. С. (2007) Митохондриальный глутатион, Биохимия, 72, 856−866.
- Кушнарева Ю. Е., Старков А. А. (2005) Метаболизм активных форм кислорода в митохондриях. Биохимия, 70, 246−264.
- Лейкин Ю.Н., Вотякова Т. В., Баженова Е. Н., Звягильская Р. А., Котельникова А. В. (1987) Взаимодействие ионов кальция с митохондриями дрожжей Endomyces magnusii. Биохимия, 52, 676−682.
- Лущак В.И. (2010) Окислительный стресс в дрожжах. Биохимия, 74 (в печати)
- Миронова Г. Д., Качаева Е. В., Копылов А. Т. (2007). Митохондриальный АТФ-чувствительный калиевый канал. I. Структура канала, механизм его функционирования и регуляция. Вестник РАМН, 2, 44−50.
- Мохова Е.Н., Хайлова JI.C. (2005) Участие анионных переносчиков внутренней мембраны митохондрий в разобщающем действии жирных кислот. Биохимия, 70,