Роль различных типов антиген-презентирующих клеток в регуляции апоптоза лимфоцитов и репликации ВИЧ-1 при ВИЧ-инфекции

1. Аббасова С. Г., Липкин В. М., Трапезников H.H., Кушлинский Н. Е. Система Fas FasL в норме и патологии //Вопр. биол. мед. фарм. химии. — 1999. — № 3. — С. 3−17.

2. Белецкий И. П. Взаимосвязь молекулярных механизмов клеточной гибели, опосредованной рецепторами семейства TNF-Rs: Автореф.дис.д-ра биол.наук. Пущино, 2001. — С. 7−35.

3. Духанин A.C., Патрашев Д. В., Огурцов С. И. Изменение трансмембранного потенциала тимоцитов при дексаметазони Са2±индуцированном апоптозе //Экспер. и клин, фармакология. — 1999. № З.-С. 40−43.

4. Ковальчук Л. В., Чередеев А. Н. Новые иммунопатогенетические вгляды: апоптотические иммунодефициты //Иммунология. — 1998. № 6. — С.17−18.

5. Никонова М. Ф., Буланова Е. Г., и др. Различная готовность к развитию апоптоза активированных Т-лимфоцитов в норме и при СКВ //Иммунология 1997. — N 4. — С. 21−24.

6. Никонова М. Ф., Литвина М. М., Варфоломеева М. И., Ярилина A.A., Ярилин A.A. Апоптоз и пролиферация как альтернативные формы ответа Т-лимфоцитов на стимуляцию //Иммунология 1999. № 2. С. 20−23.

7. Новиков В. С. Программированная клеточная гибель — Наука, Санкт-Петербург. 1996.

8. Норкин М. Н., Леплина О. Ю. и др. Роль апоптоза и анергии Т-клеток в патогенезе гнойно-септических заболеваний //Медицинская иммунология. 2000. — Т. 2 (№ 1). — С. 35−42.

9. Огурцов С. И., Духанин A.C. Митохондриальная и ядерная глюкокортикоид-чувствительные щелочные протеазы тимоцитов. //Бюллетень эксп. биологии и медицины. 2001. — Том. 132. — С 23−25.

10. Талаев В. Ю., Лебедева И. Е. и др. Пролиферация Т-клеток и апоптоз мононуклеарных клеток пуповинной крови: связь с состоянием новорожденных, влияние интерлейкинов 2,4,7 и дексаметазона на эти параметры //Иммунология. 2001. — № 3 — С.29−35.

11. Тотолян A.A., Фрейдлин И. С. Клетки иммунной системы. — СПб.: Наука, 2000. С. 169−172.

12. Ярилин А. А, Никонова М. Ф., и др. Апоптоз, роль в патологии и значимость его оценки при клинико-иммунологическом обследовании больных. //Медицинская иммунология. 2000. — Т. 2 (№ 1). — С. 7−16.

13. Ярилин A.A. Апоптоз и его место в иммунных реакциях. //Иммунология. 1996.-№ 6. С. 10−22.

14. Ярилин A.A. Апоптоз. Природа феномена и его место в целостном организме. //Патологическая физиология и экспериментальная терапия.- 1998. № 2. С. 38−48.

15. Ярилин A.A. Апоптоз и патология //Аллергия и иммунопатология (под ред. Порядина Г. В.) Москва, 1999. — С. 167−185.

16. Abbate I., F. Dianzani, F. Bianchi, G. Mosiello, F. Carletti, D. Fiumara, M.R. Capobianchi. RANTES stimulates cell-mediated transmission of HIV-1 infection // J Interfer. Cytokine Res. 1999. — Vol. 19. — P. 345−350.

17. Bussolino F., Mitola S., Serini G., Barillari G., Ensoli B. Interactions between endothelial cells and HIV-1. // J. Biochem. Cell Biol. 2001, — Vol. 33.-P. 371−390.

18. Cohen, O. J., A. Kinter, A. S. Fauci Host factors in the pathogenesis of HIV disease // Immunol Rev. 1997. Vol. 159. P.31−48.

19. Accornero P., Radrizzani M., Delia D. et al. Differential susceptibility to HIV-GP120-sensitized apoptosis in CD4+ T-cell clones with different T-helper phenotypes: role of CD95/CD95L interactions //Blood. 1997. -Vol.89.-P.558−569.

20. Adachi S., Cross A., Babior B. M" Gottlieb R, A, Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fasmediated apoptosis //J. Biol. Chem. 1997. — Vol.272. -P.21 878−21 885.

21. Aiello A., Delia D. et al. Flow cytometric detection of mitochondrial BcL-2 protein in normal and neoplastic human lymphoid cells //Cytometry. — 1992. -Vol.13. -P.502−509.

22. Aiken C., Konner J., Landau N.R., Lenburg M.E., Trono D. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic do-main //Cell. 1994. — Vol.76. -P.853−864.

23. Alam A., Cohen L. et al. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells //J. Exp. Med. 1999. — Vol.190 (12). -P.1879−1890.

24. Alnemri E.S., Fernandes T.F. et al. Involvement of BcL-2 in glucocorticoid induced apoptosis in human pre-B-leukemias //Cancer Res. — 1992. — Vol.52. -P.491−495.

25. Alnemri E.S., Livingston D.J. et al. Human ICE/CED-3 protease nomenclature. //Cell. 1996. Vol.87. — P.171−189.

26. Ameisen J. Programmed cell death (apoptosis) and AIDS pathogenesis. — // AIDS Research and Human Retr. 1994. — Vol. 10. — P. S3-S5.

27. Andersen J.L., Planelles V. The role of Vpr in HIV-1 pathogenesis //Curr. HIV Res.-2005. Vol.3 (1).-P.43−51.

28. Andreola G., Rivoltini L., Castelli C. et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles //J. Exp. Med. 2002. — Vol.195. — P.1303−1316.

29. Ankarcrona M., Depbaukt J.M. et al. Interleukin-1-beta-induced nitric oxide production inactivates apoptosis in pancreatic RIN 4m 05 °F cells //Exp. Cell Res. 1994.-Vol.213.-P.172−177.

30. Antoni B., Sabbatini P., Rabson A., White E. Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection //J. Virol. 1995. — Vol.69. — P.2384−2392.

31. Arai T., Hiromatsu M. et al. Endogeneous interleikin-10 prevents apoptosis oin macrophages during Salmonella infection. //Biochem. Biophys. Res. Communs. 1995. — Vol.213. — P.600−607.

32. Askew D.S., Ashmun R.A. et al. Constitutive c-myc expression in an IL-3-dependent myeloid cell line supresses cycle arrest and accelerates apopotsis. //Oncogen. 1991. — Vol.6. — P. 1915;1922.

33. Bachmann M.F., Oxenius A., Mak T.W., Zinkernagel R.M. //J.Immunol. — 1995. Vol.155. — P. 3727−3733.

34. Badley A.D., Dockreil D., Simpson M. et al. Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor //J. Exp. Med. 1997. — Vol.185. -P.55−64.

35. Badley A.D., Dockrell D., Simpson M. et al. Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor //J. Exp. Med. 1997. -Vol.185.-P.55−64.

36. Badley A.D., McElhinny J.A., Leibson PJ. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes //J. Virol. 1996. -Vol.70. -P.199−206.

37. Badley A.D., Pilon A.A., Landay A., Lynch D.H. Mechanisms of HIV-associated lymphocyte apoptosis //Blood. 2000. — Vol.96. — P.2951−2964.

38. Balasubramanian K., Chandra J., Schroit A.J. Immune clearance of phosphatidylserine expressing cells by phagocytes. The role of beta (2)-glycoprotein I in macrophage recognition //J. biol. Chem. 1997. -Vol.272. — P.31 113−31 117.

39. Balasubramanian K., Schroit A.J. Characterization of phosphatydylserine-dependet p2-glycoprotein I macrophage interaction: Implications for apoptic cell clearance by phagocytes //J. Biol. Chem. 1998 — Vol.273 — P.29 272−29 277.

40. Banchereau J., Steinman R. Dendritic cells and control of immunity //Nature. 1998. — Vol.392 — P.245−252.

41. Banda N.K., Bernier J., Kurahara D.K. et al. Crosslinking CD4 by human immunodeficiency virus gpl20 primes T cells for activation-induced apoptosis//J. Exp. Med. 1992. — Vol.76. -P.1099−1106.

42. Bartz S. R, Emerman M. Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8. //J. Virol. -1999. Vol.73 (3). -P.1956;1963.

43. Bartz S.R., Emerman M. Human immunodeficiency vims type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/Caspase-8 //J. Virol. 1999. — Vol.73. -P.956−1963.

44. Baughman G., Harrigan M. et al. Genes newly identified as regulated by glucocorticoids inmuribe thymocytes //Mol. Endocrinol. — 1991. — Vol.5. -P.637−644.

45. Beauvais F., Michel L. et al. The nitric oxide donors, acide and hidroxylamine, inhibit the programmed cell death of cytokine-deprived human eosinophils. //FEBS Lett. 1995. Vol. 361. — P.229−232.

46. Bess J.W., Gorelick Jr.R.J., Bosche W.J., Henderson L.E. and Arthur L.O. Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations //Virology. 1997. — Vol.230. — P. 134−144.

47. Bettuzzi S., Troiano L. et al. //Biochem. Biophys. Res. Communs. 1991. -Vol.175.-P.810−815.

48. Bilello J.A., Stellrecht K., Drusano G.L., Stein D.S. Soluble tumor necrosis factorreceptor type II (sTNFRII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients //J. Infect. Dis. -1996. Vol.173. -P.464−467.

49. Blanchard N., Lankar D., Faure F., Regnault A., Dumont C., Raposo G., Hivroz C. TCR activation of human Tcells induces the production of exosomes bearing the TCR/CD3/zeta complex //J. Immunol. -2002. — Vol. 168(7). -P.3235−3241.

50. Blanco J., Barretina J., Henson G. et al. The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis //Antimicrob. Agents Chemother. — 2000. Vol.44. -P.51−56.

51. Bogdanov V.Y., Balasubramanian V., Hathcock J. et al. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein //Nat. Med. 2003. — Vol.9. — P.458−462.

52. Boldin M.P., Goncharov Y.V. et al. Involvement of MACH, a novel MORTl/FADD-interacting protease, in Fas/APOand TNF receptor — induced cell death. //Cell. 1996. — Vol.85. — P.803−815.

53. Bolton L., Beom-Ik Hahn, Park E.A. et al. Death of CD4+ T-cell leines caused by immunodefficiency wirus type 1 does not depend on caspases or apoprosis //J. Virology 2002. — Vol.76. — P.5094−5107.

54. Bonderman D., Teml A. Jakowitsch J. et al. Coronary no-reflow is caused by shedding of active tissue factor from dissected atherosclerotic plaque //Blood. -2002. Vol.99 (8). — P.2794−2800.

55. Bossy-Wetzel E., Green D. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors //J. Biol. Chem. 1999. — Vol.274. — P. 17 484−17 490.

56. Bredesen D.E. Neural apoptosis //Ann. Neurol. 1995. — Vol.38. — P.839−851.

57. Brunner T., Mogil R.J., LaFace D. et al. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas //Nature. 1995. — Vol.373. -P.441−444.

58. Bussolino F., Mitola S., Serini G., Barillari G., Ensoli B. Interactions between endothelial cells and HIV-1. //J. Biochem. Cell Biol. 2001. — Vol. 33.-P. 371−390.

59. Butcher E. C. and L. J. Picker. Lymphocyte homing and homeostasis //Science -1996. Vol.272 — P.60.

60. Buttner J., Dornmair K., Schramm H.J. Screening of inhibitors of HIV-1 protease using an Escherichia coli cell assay //Biochem. Biophy. Res. Comm. 1997. — Vol.233. — P.36−38.

61. Cai J., Yang J., Jones D.P. Mitochondrial control of apoptosis: the role of cytochrome c. //Biochim. Biophys. Acta. 1998. — Vol.1366. -P.139−149.

62. Carbonari M., Cibati M. Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometry method. //Blood.- 1994. Vol.83. — P.1268−1277.

63. Castedo M., Hirsh T., Susin S.A. et al. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. //J. Immunol. 1996. — Vol.157. — P.512−521.

64. Cheng J., Zhou T. et al. Protection from Fas-mediated apoptosis by soluble form of the GAS molecule //Science 1994. — Vol.263. — P. 1759−1762.

65. Chinnaiyan A.M., Woffendin C., Dixit V.M., Nabel G.J. The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication //Nat. Med. -1997.-Vol.3.-P.333−337.

66. Chiu L., Cherwinski H., Ransom J., Dunne J.F. Flow cytometric ratio analysis of the Hoeshst 33 342 emission spectrum: multiparametric characterization of apoptosis lymphocytes. //J. Immunol. Methods. 1996. -Vol.189.-P.157−171.

67. Choi, J., D. R. Enis, K. P. Koh, S. L. Shiao, and J. S. Pober. T lymphocyte-endothelial cell interactions annual review of immunology //Annu. Rev. Immunol. -2004. Vol.22 — P.683−709.

68. Chollet-Martin S., Simon F., Matheron S. et al. Comparison of plasma cytokine levels in African patients with HIV-1 and HIV-2 infection //AIDS. 1994. -Vol.8. -P.879−884.

69. Chui V.K., Walsh C.M. et al. BcL-2 blocks degranulation but not Fas-based cell-mediated cytotoxicity //J. Immunol. 1995. — Vol.154. -P.2023;2029.

70. SO. Cicala C., Arthos J., Rubbert A. et al. HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4 (+) T cells /Proc. Nat. Acad. Sci. USA. 2000. — Vol.97. — P. 1178−1183.

71. Clapham D.E. Calcium signalling //Cell. 1995. — Vol.80. — P.259−268.

72. Cohen J.J. Glucocrticoid-induced apoptosis in the thymus //Sem. Immunol. -1992.-Vol.4.-P.363−369.

73. Cohen O. J., A. Kinter, A. S. Fauci Host factors in the pathogenesis of HIV disease // Immunol Rev. 1997. Vol. 159. — P.31−48.

74. Collins, K. L., B. K. Chen, S. A. Kalams, B. D. Walker, D. Baltimore 1998. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes Nature. 391:397−401.

75. Connor R.I., Chen B.K., Choe S., Landau N.R. Vpr is required for efficient replication of human immunodeficiency virus type 1 in mononuclear phagocytes //Virology. 1995. — Vol.206. — P.936−944.

76. Conti L., Rainaldi G., Matarrese P. et al. The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS //J. Exp. Med. 1998. — Vol.187.-P.403−413.

77. Cossarizza A., Kalashnikova G. et al. Mithochondrial modifications during rat thymocyte apoptosis: a study at the single cell level //Exp. Cell Research. 1994. — Vol.214. — P.323−330.

78. Cossarizza A., Troiano L., Mussini C. Mitochondria and HIV infection: The first decade //J. Biol. Regul. and Homeostat.Agents. — 2002. Vol. 16, N1. -P. 18−24.

79. Curnow S.J., Barad M., Brun-Roubereau N., Schmitt-Verhulst AM. Flow-cytometric analysis of apoptotic and nonapoptotic T-cell receptor-transgenic thymocytes following in vitro presentation of antigen //Cytometry. 1994. -Vol.16.-P.41−48.

80. Dao T., Huleatt J., e.a. Specific resistance of T cells to CD95-induced apoptosis during S phase of cell cycle. //J. Immunol. — 1997. Vol.159. -P.4261−4267.

81. Darzynkiewicz Z., Staiano-Caco L., Melamed M.R. Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation //Proc. Nat. Acad. Sci. USA. 1981. — Vol.76. — P.2383−2387.

82. De Maeyer E., De Maeyer-Guignard J. Interferony //Current opinion in Immunol. 1992. Vol.4. — P.321−326.

83. Deacon, N. J., A. Tsykin, A. Solomon, K. Smith, M. Ludford-Menting, D. J. Hooker, D. A. McPhee, A. L. Greenway.1995. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients, cience. 270:988−91.

84. Dezube B.J., Pardee A.B., Chapman B. Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS //J. Acquir. Immune. Defic. Syndr. -1993. -Vol.6. -P.787−794.

85. Dias O., Dumont C. et al. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. //J. Immunol. 1998. — Vol.161. — P.3375−3383.

86. Dransfield I., Buckle A.M. et al. Neutrophil apoptosis is associated with a reduction in CD 16 (FcyRIII) expression //J. Immunol. 1994. — Vol.153. -P.1254−1263.

87. Dransfield I., Stocks S.C., Haslett C. Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis. //Blood. -1995. Vol.85. — P.3264−3273.

88. Du C., Fang M., Li Y., Li L., Wang X. Smack a mitochondrial protein that promotes cytochrome c dependent caspase activation by elimination IAP proteins //Cell. 2000. — Vol.102. — P.33−42.

89. Duke R.S., Cohen J.J. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells //Limphokine Res. 1986. -Vol.5. -P.289−299.

90. Dunn A.I. Nitric oxide synthase inhibitors prevent the cerebral tryptophan an seotonergic responses to endotoxin and interluekin 1 //Neurosci. Res. Communs. 1993. -Vol.13, N.3.-P.149−156.

91. Enari M., Talanian W.W. et al. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis //Nature. 1996. — Vol.380.-P.723−726.

92. Enari M., Talanian W.W. et al. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis //Nature. — 1996. — Vol. 80.-P.723−726.

93. English H.F., Kuprianov N. et al. Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration //Prostate. 1989. — Vol.15. -P.233−250.

94. Epperson D. E., J.S. Pober. Antigen-presenting function of human endothelial cells: direct activation of resting CD8+ T cells. // J.Immunol. -1994.-Vol. 153.-P. 5402−5410.

95. Fadok V.A., Savill J.S., Haslett C. et al. Different populations of macrophages receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells //J. Immunol. 1992. — Vol.149. -P.4029.

96. Fadok V.A., Voelker D.R. et al. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages //J. Immunol. 1992. — Vol.148. — P.2207−2216.

97. Fauci A. S. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis //Science 1988. — Vol.239. P.617−622.

98. Fauci, A. S. Host factors and the pathogenesis of HIV-induced disease // Nature. 1996. Vol. 384. — P. 529−534.

99. Finzi D., Blankson J., Siliciano J.D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy //Nat. Med. 1999. — Vol.5. — P.512−517.

100. Fleischer B. CD26: A surface protease involved in T-cell activation //Immunol. Today. 1994. — Vol.4. -P.180−184.

101. Frassantino M.A., Silvestris F. et.al. Fas/FasL-deregulated apoptosis and IL-6 insensitivity in highly malignant myeloma cells //Clin. Exp. Immunol. 1998.-Vol.114.-P.179−188.

102. Frey T. Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems //Cytometry. 1997. — Vol.28. — P.253−263.

103. Froelich C.J., Dixit V.M. et al. Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases //Immunology Today. 1998. -Vol.19. -P.30−36.

104. Gallo R.C. Tat as one key to HIV-induced immune pathogenesis and Pat toxoid as an important component of a vaccine //Proc. Nat. Acad. Sci. USA. 1999. — Vol.96. — P.8324−8326.

105. Gandhi R., Chen B., Straus S. et al. HIV-directly kills CD4+ T cells by Fas-independent mechanism //J. Exp. Med. 1998. — Vol.187. — P.1113−1122.

106. Garcia, J. V., and A. D. Miller 1991. Serine phosphorylation-independent downregulation of cell-surface CD4 by Nef. Nature. 350: 508−511.

107. Garsia-Ruiz G, Cotell A. et.al. //J. Biol. Chem. 1997. — Vol.272. -P.11 369−11 273.

108. Gavrieli Y., Sherman Y. et al. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation //J. Cell. Biol. — 1992. -Vol.119.-P.493−501.

109. Gervaix A., D. West, L.M. Leoni, DD. Richman F. Wong-Staal, J. Corbeil 1997. A new reporter cell line to monitor HIV infection and drug susceptibility in vitro. Proc Natl Acad Sci USA, 94: 4653−4658.

110. Gougeon M.-L., Montagnier L. Apoptosis in AIDS //Science. 1993. -Vol.260.-P.1269−1270.

111. Griffith T.S., Ferguson T.A. The role of FasL-induced apoptosis in immune privilege //Immunol. Today. 1997. Vol.18. — P.240−244.

112. Groux H., Torpier G. et al. Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals. //J. Exp. Med. 1992. — Vol.175. — P.331−340.

113. Hadida F., Vieillard V., Mollet L., Clark-Lewis I., Baggiolini M., Debre P. Cutting edge: RANTES regulates Fas ligand expression and killing by HIV-specific CD8 cytotoxic T cells //J. Immunol. 1999. — Vol.163. — P. 11 051 109.

114. Hartnell A., Robinson D.S., Kay A.B., Wardlaw A.J. CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines //Immunology 1993.-Vol.281.-P. 281−286.

115. Hayry P., E. von Willebrand and L. C. Andersson. Expression of HLAABC andDR locus antigens on human kidney endothelial, tubular and glomerular cells //Scand. J. Immunol. 1980. — Vol.11 -P.303.

116. He J. Human immunodeficiency virus type 1 protein R (vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity //J. Virol. -1995. Vol.69. — P.6705−6711.

117. Herbein G., Mahlknecht U., Batliwalla F. et al. Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HTV gpl20 with chemokine receptor CXCR4. Nature. 1998;395:189−194.

118. Herbein G., van Lint., Lovett J., Verdin E. Distinct mechanisms trigger apoptosis in guman immunodefeciency virus type 1-infected and uninfected bystander T lymphocytes //J. Virology. 1998. -.Vol.72. — P.660−670.

119. Higashimoto I., Chihara J. et al. Regulation of eosinophil cell death by adhesion to fibronectin //Int. Arch. Allergy Immunol. 1996. — Vol. 111. -P.66−69.

120. Hockenbery D.M., Oltavai Z.N. et al. BcL-2 functions in an antioxidant pathway to prevent apoptosis //Cell. 1993. — Vol.75. — P.241−251.

121. Holme P.A., Muller F., Solum N.O. et al. Enchanced activation of platellets with abnormal release of RANTES in human immunodificiency virus type 1 infection//The FASEB J. 1998. -Vol.12. — P.79−90.

122. Houenou L.J., Turner P.L. et.al. A serine protease inhibitor, protease neoxin 1. Rescues motoneurons from naturally eccuring and axotomy-induced cell death //Proc. Nat. Acad. Sci. USA. 1995. — Vol.92. — P.895−899.

123. Hrimech M., Yao X-J., Bachand F., Rougeau N., Cohen E.A. Human immunodeficiency virus type 1 (HIV-1) vpr functions as an immediate-early protein during HIV-1 infection //J. Virol. 1999. — Vol.73. — P.4101−4109.

124. Huang M.B., Jin L.L., James C.O., Khan M., Powell M.D., Bond V.C. Characterization of Nef-CXCR4 interactions important for apoptosis induction //J. Virol. 2004. — Vol.78. — P. 11 084−11 096.

125. Huang Y., Zhang L., Ho D.D. Characterization of nef sequences in a long-term survivors of human immunodeficiency virus type 1 infection //J. Virol. 1995.-Vol.69.-P.93−100.

126. Huang Y., Zhang L., Ho DD 1995. Characterization of nef sequences in a long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 69: 93−100.

127. Itoh K., Hirohata S. The role of IL-10 in human B cell activation, proliferation, and differentiation //J. Immunol. 1995. — Vol.154. — P.4341−4350.

128. Jacobson M.D., Weil M., Raff M.C. Programmed cell death in animal development //Cell. 1997. — Vol.88. — P.347−354.

129. Jacobson M.D., Raff M.C. Programmed cell death and Bcl-2 protection in very low oxygen //Nature 1995. — Vol.374. — P.814−821.

130. Jacotot E., Ravagnan L., Loeffler M. et al. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore //J. Exp. Med. 2000. -Vol.191. — P.33−45.

131. James C. O., Huang M.-B., Khan M. et al. Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors //J. Virol. 2004. — Vol.78. — P.3099−3109.

132. James C.O., M-B. Huang., M. Khan., M. Garcia-Barrio, M.D. Powell, V.C. Bond. 2004. Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors. J. Virol. 78: 3099−3109.

133. Jamieson, B. D., G. M. Aldrovandi, V. Planelles, J. B. Jowett, L. Gao, L. M. Bloch, I. S. Chen, J. A. Zack 1994. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity J Virol. 68:3478−3485.

134. Janeway C.A. Thymic selection: two pathways to life and two to death //Immunity 1994. — Vol. 1. — P.3−6.

135. Jeremias I., Herr I., Boehler T., Debatin K.M. TRAIL/Apo-2-ligand-induced apoptosis in human T cells //Eur. J. Immunol. -1998. — Vol.28. — P.143−152.

136. Johnson N., Parkin J.M. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis //Clin. Exp. Immunol. — 1998. -Vol.113.-P.229−234.

137. Johnson V.A., Byington R.E. Quantitative assays for virus infectivity //In Techniques in HIV research, Stockton Press, London, UK, 1990. -P.71.

138. Kameoka M., Suzuki S., Kimura T. et al. Exposure of resting peripheral blood T cells to HTV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells //Int. Immunol. — 1997. -Vol.9. —P.1453−1462.

139. Kaneko H., Saito K. et al. Preferential elimination of CD28+ T cells in CLE and the relation with activation-induced apoptosis //Clin. Exp. Immunol. 1996. — Vol. 106. — P.218−229.

140. Katsikis P.D., Wunderlich E.S., Smith C.A., Herzenberg L.A., Herzenberg L.A. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals //J. Exp. Med. — 1995. -Vol.181.-P.2029;2036.

141. Kennedy N., Kataoka T., Tschopp J., Budd R.C. Caspase activation is required for T cell proliferation //J. Exp. Med. 1999. — Vol.190. — P. 18 911 895.

142. Kerr J.F.R., Wyllie A.H. et all. Apoptosis: a basic biological phenomenon with wide-ranging implication in tissue kinetics. // Br. J. Cancer. 1972. — Vol.26.-P.239−257.

143. Kestler H.W., Ringler D.J., Mori K. et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS //1991. — Vol.65. -P.651−662.

144. Kestler, H. W., D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, R. C. Desrosiers 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. 65:651−662.

145. Kim J., Schimming A.W. et al. Ligation of FcyRII (CD32) pivotally regulates survival of human eosinophils //J. Immunol. 1999. — Vol.162. -P.4253−4259.

146. Kirchhoff, F., T. C. Greenough, D. B. Brettler, J. L. Sullivan, R. C. Desrosiers 1995. Brief report: absence of intact nef sequences in a long-term survivor with non-progressive HIV-1 infection N Engl J Med. 332:228−232.

147. Kitajima J., Kawahara K. et al. Nitric oxide-mediate apoptosis in murine mastocytoma //Biochem. Biophys. Res. Comm. 1994. — Vol.204. — P.244−251.

148. Knijff-Dutmer E.A., Koerts J., Nieuwland R. et al. Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis //Arthritis Rheum. 2002. — Vol.46 (6). — P. 1498−503.

149. Kojima H., Eshima K., Takayama H., Sitkovsky MV. Leukocyte function-associated antigen-1 dependent lysis of Fas+ (CD95+/Apo-l+) innocent bystanders by antigen-specific CD8+ CTL //J. Immunol. 1997. — Vol.158. P.2728−2734.

150. Koopman G., Reutelingsperger C.P.M. et al. Annexin V for flow cytometric detection of phosphatidylserine expression on B cellc undergoing apoptosis //Blood. 1994. — Vol.84. — P.1415−1420.

151. Krammer P. CD95's deadly mission in the immune system //Nature. — 2000. Vol.407. — P.789−795.

152. Kroemer G., Zamzani N., Susin S.A. Mitochondrial control of apoptosis //Immunology Today. 1997.-Vol.18 (1). -P.44−51.

153. Kuerbitz S.J., Plunkett B.S. et.al. Wild-type p53 is a cell cycle check point determinant following irradiation //Proc. Nat. Acad. Sci. USA. — 1992. — Vol.89.-P.7491−7495.

154. Kuida K., Lippke J.A., Ku G. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme // Science. — 1995. Vol.267.-P.2000;2003.

155. La Ferla F.M., Tinkle B.T., Bieberich C.J., Haudenschild C.C., Jay G. The Alzheimer’s A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice //Nat Genet. 1995 Jan. — Vol. 9(1). — P.21−30.

156. Lam M., Dubyak G., Chen L. et al. Evidence that BcL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca fluxes //Proc. Nat. Acad. Sci. USA. 1994. — Vol. 91. -P.6569−6573.

157. Lama, J., A. Mangasarian, D. Trono 1999. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nefand Vpu-inhibitable manner Curr Biol. 9:622−631.

158. Laurent-Crawford A.G., Coccia E., Krust B., Hovanessian A.G. Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+target cells //Res. Virol. 1995. -Vol.146.-P.5−17.

159. Laurent-Crawford A.G., Krust B., Riviere Y. et al. Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells //AIDS Res. Hum. Retroviruses. 1993. -Vol.9. — P.761 -773.

160. Le Rouzic E, Benichou S. The Vpr protein from HIV-1: distinct roles along the viral life cycle //Retrovirology. 2005. — Vol.22. — P. 11.

161. Levin A.J., Perry M.E. The role of the p-53 tumour-suppressor gene in tumorgenesis //Br. J. Cancer. 1994. — Vol.69. -P.409−416.

162. Levy J.A. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 1993. — Vol.57. — P. 183−289.

163. Lewis D.E., Ng Tang D.S., Adu-Oppong A., Schober W., Rodgers J.R. Anergy and apoptosis in CD8+ T cells from HIV-infected persons //J. Immunol. 1994.-Vol. 153 — P. 412.

164. Lewis D.E., Ng Tang D.S., Wang X., Kozinetz C. Costimulatory pathways mediate monocyte-dependent lymphocyte apoptosis in HIV //Clin. Immunol. 1999. — Vol.90. — P.302−312.

165. Li C.J., Friedman D.J., Wang C., Metelev V., Pardee A.B. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein //Science. -1995. Vol.268. — P.429−431.

166. Li J., Eastman A. Apoptosis in interleukin-2-dependent cytotoxic T-lymphocyte cell line is associated with intracellular acidification //J.Biol. Chem. 1995. — Vol.270. — P.3203−3211.

167. Li P., Nijhawan D., Budihardjo I. et al. Cytochrome c and dATP-dependent formation of Apaf-l/caspase-9 complex initiates an apoptotic protease cascade //Cell. 1997. — Vol.91. — P.479−489.

168. Liegler T.J., Yonemoto W., Elbeik T., Vittinghoff E., Buchbinder S.P., Greene W.C. Diminished spontaneous apoptosis in lymphocytes from human immunodeficiency virus-infected long-term nonprogressors //J. InfectDis. -1998. Vol.178.-P.669−679.

169. Liepe B.A., Stone C., Koistinaho J., Copenhagen D.R. Nitric oxide synthase in Muller cells and neurons of salamander and fish retina //J. Neurosci. 1994. — Vol.14. -P.7641−7654.

170. Linsley P. S., J.A. Ledbetter. The role of CD28 receptor during T cell responses to antigen //Annu. Rev. Immunol. 1993. — Vol.11 — P.191−198.

171. Liu Z., Hultin L.E., Cumberland W.G. et al. Elavated relative fluorescence intensity of CD38 antigen expression on CD8+T Cells is a marker of prognosis in HIV infection: Results of 6 years of follow-up //Cytometry -1996.-Vol.26.-C.l-7.

172. Loetsher H., Pan J.C. et al. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor//Cell. 1990. — Vol. 61. -P.351−359.

173. Los M., Van de Craen Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis //Nature. 1995. — Vol.375. — P.81−83.

174. Lu Q.L., Hanby A.M. et al. BcL-2 protein localizes to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines//J. Cell. Sci. 1994. — Vol.107. — P.363−371.

175. Lui Y., Cousin J.M. et al. Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes //J. Immunol. 1999. — Vol.162. -P.3639−3646.

176. Macho A., Castedo M. et al. Mitochondrial disfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers //Blood. -1996. Vol.86. — P.2481−2487.

177. Macho A., Decaudin D., Castedo M., Hirsch T., Susin S.A., Zamzami N., Kroemer G. Chloromethyl-X-Rosamine is an aldehyde-fixable potentialsensitive fluorochrome for the detection of early apoptosis //Cytometry. -1996.-Vol.25.-P.333−340.

178. Mack M., Kleinschmidt A., Bruhl H., Klier C. et al. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection //Nat. Med. 2000. — Vol.6. — P.769−775.

179. Mackay C. R. Dual personality of memory T cells //Nature 1999. -Vol.401 -P.659.

180. Mackey C., Imhof B. Cell adhesion in the immune system // Immunol. Today. 1993. — Vol.14. — P.99−104.

181. Maftah A., Peti J.M., Ratinaud M.H., Julien R. 10-N nonyl-acridine orange: a fluorescent probe which stains mitochondria independently of their energetic state. //Biochem. Biophys. Res. Communs. 1989. — Vol.164. -P.185−190.

182. Marchetti P., Castedo M. et al. Mithochondrial permeability pore transition is a central coordinating event of apoptosis //J. Exp. Med. 1996. — Vol.184. — P.1155−1160.

183. Marchetti P., Hirch T. et al. Mitochondrial permeability transition triggers lymphocyte apoptosis //J. Immunol. 1999. — Vol.157. — P.4830−4836.

184. Martin S., Tesse A., Hugel B. et al. Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression //Circulation. 2004. — Vol.109. — P. 1653−1659.

185. Martin S J., Newmeyer D.D. Cell-free reconstitution of Fas-, UV radiation-and ceramide induced apoptosis //EMBO J. 1995. — Vol.14. — P.5191−5200.

186. Martin S.J., Reutelingsperger C.P., McGahon A.J. et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

187. Maury C.P.J., Lahdevirta J. Correlation of serum cytokine levels with haematological abnormalities in human immunodeficiency virus infection //J. Intern. Med. 1990. — Vol.227. — P.253−257.

188. McCloskey T.W., Oyaizu N., Bakshi S., Kowalski R., Kohn N., Pahwa S. CD95 expression and apoptosis during pediatric HIV infection: early upregulation of CD95 expression //Clin. Immunol. Immunopathol. — 1998. Vol.87.-P.33−41.

189. McCloskey T.W., Oyaizu N., Kaplan M., Pahwa S. Expression of the Fas antigen in patients infected with human immunodeficiency virus //Cytometry. 1995. — Vol.22. — P. 111−114.

190. McConkey D.J., Nicoreta P. et al. Glucocorticoids activate a suicide process in thymocytes throught an elevation of cytosolic Ca concentration //Arch. Biochem. Boiphys. 1989. — Vol.269. — P.365−370.

191. Meagher L.C., Cousin J.M., et al. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes //J. Immunol. 1996. Vol.156. — P.4422−4428.

192. Mellors J.W., Munoz A., Giorgia J.V. Plasma viral load and CD4 lymphocytes as prognostic markers of HIV-1 infection //Ann. Intern. Med. -1997. Vol.126. — P.946−954.

193. Mellors J.W., Rinaldo C.RJr., Gupta P., White R.M., Todd J.A., Kingsley L.A. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma //Science. 1996. — Vol.272. — P. 1167−1170.

194. Memon S.A., Moreno М.В. et al. BcL-2 blocks glucocorticoidbut not Fasor activation-induced apoptosis in a T-cell hybridoma //J. Immunol. 1995.-Vol. 155.-P.4644−4652.

195. Memon S.A., Moreno M.B. et al. BcL-2 blocks glucocorticoidbut not Fasor activation-induced apoptosis in a T cell hybridoma //J. Immunol. 1995. Vol. 155. — P.4644−4652.

196. Meyaard L., Otto S., Jonker R.R., Mijnster MJ., Keet R.P., Miedema F. Programmed death of T cells in HIV-l infection //Science. 1992. -Vol.257.-P.217−231.

197. Migliorati G., Pagliacci M. et al. Glucocorticoid-induced apoptosis in mouse natural killer cells and cytotoxic T-lymphocytes //Immunology. — 1994. Vol.81.-P.21−26.

198. Mignon-Godefroy K., Rott O. et al. Curative and protective effects of IL-10 in experimental autoimmune thyroiditis (EAT). Evidence for IL-10-enchanced cell death in EAT //J. Immunol. 1995. — Vol.154. — P.6634−6643.

199. Moreira A.L., Sampaio E.P., Zmuidzinas A. Thalodomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.//J. Exp. Med. 1993.-Vol.177.-P.1675−1680.

200. Moutouh L., Estaquier J., Richman D.D., Corbeil J. Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis in lymphoblastoid T-cell-line-expressing wild-type and mutated CD4 receptors //J.Virol. 1998. — Vol.72. -P.8061−8072.

201. Mower D.A., Peckham D.W. et al. Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse В cell apoptosis //J. Immunol. 1994. — Vol.152. — P.4832−4842.

202. Murray A.G., Libby P., Pober J.S. Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro//J Immunol.- 1995;Vol. 154-P. 151−161.

203. Muthumani K., Choo A.Y., Premkumar A. et al. Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism //Cell Death Differ. 2005. Vol.12. — P.962−970.

204. Muzio M., Chinnaiyan F.C. et al. FLICE, a novel FADD-homologous ICE/CED3-like protease is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex //Cell. 1996. — Vol.85. — P.817−827.

205. Nagahara Y., Ikekita M. et al. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria //J. Immunol. — 2000. Vol.165. — P.3250−3259.

206. Neefjes J., Momburg F. Cell biology of antigen presentation // Curr. Opion Immunol. 1993. — Vol.5 -P.27−39.

207. Newton K., Harris A. et al. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes //EMBO J. 1998. — Vol. 17. -P.706−718.

208. Nicholson D.W., Thornberry N.A. et al Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis //Nature. — 1995. -Vol. 376. -P.37−43.

209. Nicoletti I., Migliorati G. et al. A rapid simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry //J. Immunol. Methods. 1991. — Vol.139. — P.271−279.

210. Nicotera P., Zhivotovsky B. et al. Nuclear calcium transport and the role of calcium in apoptosis //Cell. Calcium. 1994. — Vol.16. — P.279−288.

211. Nishikava K., Morii T. et al. //J. Allergy Clin. Immunol. 1992. — Vol.90. -P.379−387.

212. Noraz N., Gozlan J., Corbeil J., Brunner T., Spector S. HTV-induced apoptosis of activated primary CD4+ T lymphocytes is not mediated by Fas-Fas ligand //AIDS. 1997. — Vol.11. — P. 1671−1680.

213. Nossal G.J.V. Negative selection of lymphocytes //Cell. 1994. — Vol.76. -P.229−239.

214. O’Brien W.A., Hartigan P.M., Martin D. et al. Changes in plasma HIV-1 RNA and CD4 lymphocyte counts and the risk of progression to AIDS //N. Engl. J.Med. 1996. —Vol.334. -P.426−431.

215. Ormerod MG. Flow cytometric studies of apoptosis //CMB. 1994. -Vol.1.-P.35−43.253.0rrenius S., Nicotera P. The calcium ion and cell death //J. Neural.

216. Pardi R., Inverardi L., Bender J. Regulatory mechanisms in leucocyte adhesion //Immunol. Today. 1992. — Vol. 13. — P.224−230.

217. Perrin-Wolff M., Bertoglio J. et al. Structure-activity relationships in glucocorticoid-induced apoptosis in T lymphocytes //Biochem. Pharmacol. -1995. -Vol.50. -P.103−110.

218. Petit P.X., Le Cocuer H. et al. Alterations of mitochondrial structure and function are early events in dexamethasone-induced thymocyte apoptosis //J. Cell. Biol. 1995. — Vol.130. — P.157−167.

219. Phenix B.N., Angel J.B., Mandy F. et al. Decreased HIV-associated T cell apoptosis by HIV protease inhibitors //AIDS Res. Hum. Retroviruses. — 2000. -Vol.16. -P.559−567.

220. Phenix B.N., Beckett B., Alam A. et al. HIV protease induces apoptosis of HIV infected T cells through activation of caspase 8 //Eighth. Annual. Canadian Conference of HIV/AIDS Research. Victoria, British Columbia, 1999. Abstract 409.

221. Phenix B.N., Cooper C., Owen C., Badley A. D. Modulation of apoptosis by HIV protease inhibitors //Apoptosis. 2002. — Vol.7. — P.295−312.

222. Pober J. S. Immunobiology of human vascular endothelium // Immunol Res. 1999. — Vol. 19- P. 225−232.

223. Pober J. S., Collins M. A., Gimbrone Jr., P. Libby and C. S. Reiss. Inducible expression of class II major histocompatibility complex antigens and the immunogenicity of vascular endothelium //Transplantation 1986. -Vol.41 -P.141.

224. Pober J.S., Ma W., Biedermann B., Libby P. Vascular cells have limited capacities to activate and differentiate T-cells: implications fro transplant vascular sclerosis // Transplant Immunology 1997; Vol. 5. — P. 251−254.

225. Poli G., Kinter A., Justement J.S. Tumour necrosis factor functions in an autocrine manner in the induction of human immunodeficiency virus expression //Proc Natl. Acad. Sci. USA. 1990. — Vol.87. — P.782−785.

226. Poon B., Grovit-Ferbas K., Stewart S.A., Chen ISY. Cell cycle arrest by vpr in HTV-l virions and insensitivity to antiretroviral agents //Science. — 1998. Vol.281. — P.266−269.

227. Radvany L.G., Shi Y. et al. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response //J. Immunol. — 1996. Vol.156. -P.1788−1798.

228. Rapaport E., Casella C., Ikle D., Mustafa F., Isaak D., Finkel T. Mapping of HIV-1 determinants of apoptosis in infected T cells //Virology. — 1998. -Vol.252. P.407−417.

229. Rebollo A., Pitton C. et al. A role for the intermediate affinity IL-2R in the protection against glucocorticoid-induced apoptosis //Immunology. -1995. -Vol.84. N.3. — P.388−395.

230. Reid S., Penna G., Adorini L. The control of T-cell responses by dendrtic cells subsets // Curr. Opion Immunol. 2000. — Vol.12 — P. 114−121.

231. Rittmaster R.S., Manning A.P. et al. Evidence for atrophy and apoptosis in the ventral prostate of rats given the a-reductase inhibitor finasteride //Endocrinology. 1995. — Vol.136. -P.741−748.

232. Rogers H., Tripp C., Unanue E. Different stages in the natural and acquired resistance to an intracellular pathogen //The Immunologist. -1995. — Vol.3. -P.152−155.

233. Ross, T. M., A. E. Oran, B. R. Cullen 1999. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein Curr Biol. 9:613−621.

234. Rothbard J., Gefter M. Interaction between immunogenic peptides and MHC proteins //Annu. Rev. Immunol. 1991. — Vol.9 — P.527- 535.

235. Rozmyslowicz T., Majka M., Kijowski J. et al. Plateletand megakaryocytederived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV //AIDS. -2003. Vol.17. — P.33—42.

236. Russel J.H., White C.L. et al. //Proc. Nat. Acad. Sci. USA. 1991. -Vol.88.-P.2151−2155.

237. Saikumar P., Dong Z., Weinberg J.M., Venkatachalam M.A. Mechanisms of cell death in hypoxia/reoxygenation injury //Oncogene. 1998. — Vol.17 (25). -P.3341−9.

238. Sallusto F., D. Lenig, R. Forster, M. Lipp and A. Lanzavecchia. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions //Nature 1999. Vol.401 -P.708.

239. Savil J., Fadok V. Phagocyte recognition of cells ubdergiong apoptosis //Immunol. Today. 1993. — Vol.14. — P. 131−137.

240. Scales D., Ni H., Sahheen F., Capodici J., Cannon G., Weissman D. Nonproliferating bystander CD4+ T cells lacking activation markers support HIV replication during immune activation //J. Immunol. 2001. — Vol.166. -P.6437−6433.

241. Scheglovitova O., M.R. Capobianchi, G. Antonelli, D. Guanmu, F. Dianzani. CD4-positive lymphoid cells rescue HIV-1 replication from abortively infected human primary endothelial cells. // Arch. Virol. 1993. -Vol. 132. — P. 267−280.

242. Schlossmann S., Boumsell L., Gilks W. et al. Leucocyte typing IV: White cell differentiation antigens //Oxford University Press, New York, 1995.

243. Schmidt I., Uittenbogaart C. et al. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry //Cytometry. 1994. — Vol.15. — P. 12−20.

244. Schuler M., Bossy-Wetzel E. et al. P-53 induced apoptosis by caspases activation through mitochondrial cytochrome c release //J. Biol. Chem. -2000. Vol.275 (10). -P.7337−7342.

245. Schwartz, O., V. Marechal, S. Le Gall, F. Lemonnier, J. M. Heard 1996. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein Nat Med. 2:338−342.

246. Shimizu S., Eguchi Y., Kosaka H. et al. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL //Nature. 1995. — Vol.374. — P.811−813.

247. Silvetris F., Camarda G., Cafforio P., Dammacco F. Upregulation of Fas ligand secretion in non-lymphopenic stages of HIV-1 infection //AIDS. — 1998. -Vol.12.-P.1103−1118.

248. Simmons, A., V. Aluvihare, A. McMichael 2001. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators Immunity. 14: 763−77.

249. Sperber K., Beuria P., Singha N., Gelman I., Cortes P., Chen H., Kraus T. Induction of apoptosis by HIV-1-infected monocytic cells //J. Immunol. — 2003. Vol.170 -P.1566−1578.

250. Spinozzi F., Agea E. et al. Tlymphocytes bearing the gamma delta T cell receptor are susceptible to steroid-induced programmed cell death //Scand. J. Immunol. 1995. — Vol.41 (5). -P.504−508.

251. Srivastava R.K., Sasaki C.Y., Hardwick J.M., Longo D.L. Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription //J. Exp. Med. 1999. — Vol.190. -P.253−265.

252. Stoeckler J.D., Stoeckler H.A., Kouttab N. et al. 1,2,5-Dihydroxyvitamin D3 Modulates CD38 Expression on human lymphocytes //J. Immunol. — 1996. Vol.157. — P.4908−4917.

253. Strack P.R., West Frey M., Rizzo C.J. et al. Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2 //Proc. Natl. Acad. Sci. USA. -1996. Vol.93. — P.9571−9576.

254. Strasser A., Harris A.W. et al. BcL-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis //EMBO J. 1995. — Vol.14. — P.6136−6147.

255. Suda T., Hashimoto H., Tanaka M., Ochi T., Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing //J. Exp. Med. 1997. — Vol.186. — P.2045;2050. •.

256. Susin S.A., Zamzani N. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95 and ceramide-induced apoptosis //J. Exp. Med. — 1997. — Vol.186. — P.25−37.

257. Susin S.A., Zamzani N. BcL-2 inhibits the mithochondrial release of an apoptogenic protease//J. Exp. Med. 1996.-Vol.184.-P.1331−1341.

258. Sutterwala F., Mosser D. The taming of IL-12: suppressing the production of proinflamatory cytokines //J.Leukoc. Biol. 1999. — Vol.284. — P.543−551.

259. Sutterwala F., Mosser D. The taming of IL-12: suppressing the production of proinflammatory cytokines //J. Leukoc. Biol. — 1999. Vol.65 — P.543−551.

260. Swat W., Ignatowicz K. et al. Detection of apoptosis in immature CD4+8+ thymocytes by flow cytometry //J. Immunol. Methods. 1991. Vol.137. -P.79−87.

261. Tanaka Y., Schroit A.J. Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages//J. Biol. Chem. 1983. — Vol.258. -P.l 1335−11 343.

262. Tenniswood M.P., Guenette R.S. Active cell death in hormone-dependent tissue//Cancer Metastasis. Rev. 1992. — Vol.11. -P.197−220.

263. Terenzi F., Diaz-Guerra M.S. et al. Bacterial lipopeptides induced nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages //J. Biol. Chem. 1995. — Vol.270. — P.6017−6021.

264. Tilly J.L., Tilly K.J. Inhibitors of oxidative stress mimic the ability of follicle stimulating hormone to supress apoptosis in cultured rat ovarian follicles //Endocrinology. 1995. — Vol.136. -P.242−252.

265. Trauth B.C., Klass C. et al. Monoclonal antibody-mediated tumor regresion by induction of apoptosis //Science. 1989. — Vol.245. — P. 301 305.

266. Trimble J.J., Salkowitz J.R., Kestler H.W. Animal models for AIDS pathogenesis //Adv. Pharmacol. 2000. — Vol.49. — P.479−514.

267. Vercammen D., Brouckaert G. et al. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways //J. Exp. Med. 1998.-Vol.188. (5). -P.919−930.

268. Verhagen A. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins //Cell. -2000.-Vol.102.-P.43−53.

269. Vocero-Akbani A.M., Heyden N.V., Lissy N.A., Ratner L., Dowdy S.F. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein //Nat. Med. 1999. — Vol.5. — P.29−33.

270. Von Boehmer H. Thymic selection: a matter of life and death //Cell. -1994.-Vol.76.-P.219−228.

271. Walker R.E., Spooner K.M., Kelly G. et al. Inhibition of immunoreactive tumor necrosis factorby a chimeric antibody in patients infected with human immunodeficiency virus type 1 //J. Infect. Dis. — 1996. — Vol.174. — P.63−68.

272. Walsh G., Wen B. et al. A role for FADD in T cell activation and development //Immunity. 1998. — Vol.8. — P.439−449.

273. Walsh G.M., Williamson M.L. et al. Ligation of CD69 induces apoptosis and cell death in human eosinophils cultured with granulocyte-macrophage colony-stimulating factor //Blood. 1996. — Vol. 87(7) — P.2815−2821.

274. Watson S. R. and L. M. Bradley. The recirculation of naive and memory lymphocytes //Cell Adhesion Commun. 1998. — Vol.6 — P. 105.

275. Wei X., Ghosh S.K., Taylor M.E. et al. Viral dynamics in human immunodeficiency virus type 1 infection //Nature. 1995. -Vol.373. — P. 117−122.

276. Wesch D., Marx S., Kabelitz D. Monocyt-dependet death of freshly isolated T-lymphocytes: induction of phorbolester and mitogens and differential effects of catalase //J. Immunology 1998. — Vol.161 — P.1248−1256.

277. Wesselborg S., Janssen O., Kabelitz D. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells //J. Immunol. 1993 — Vol.150. -P.4338−4345.

278. Wright S.C., Zhong J. et al. Inhibition of apoptosis mechanisms of tumor promotion //FASEB J. 1994. — Vol. 8. — P.654−660.

279. Yagi T., Sugimoto A., Tanaka M. et al. Fas/FasL interaction is not involved in apoptosis of activated CD4+ cells upon HIV-1 infection in vitro //AIDS Res. Hum. Retroviruses. 1998. -Vol.18. -P.307−315.

280. Yang L.P., Riley J.L., Carroll R.G. et al. Productive infection of neonatal CD8+ T lymphocytes by HIV-1 //J. Exp. Med. 1998. Vol.187. — P.1139−1144.

281. Yang Y., Mercep M., Ware C.F., Ashwell J.D. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids //J. Exp. Med. — 1995. — Vol.181.-P.1673−1682.

282. Yao X-J., Mouland A.J., Subbramanian R.A. et al. Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells //J. Virol. 1998. — Vol.72. — P.4686−4693.

283. Yeh W., Pompa J. et al. FADD essential for embryo development and signalling from some, but not all, inducers of apoptosis //Science. 1998. —1. Vol.279. -P.1954;1958.

284. Yoon, K., J. G. Jeong, S. Kim 2001. Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis AIDS Res Hum Retroviruses. 17:99−104.

285. Zamzani N., Marchetti P. et al. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis //FEBS. 1996. — Vol.3. — P.53−57.

286. Zamzani N., Marchetti P. et al. Reduction of mithochondrial potential constitutes an early irreversible step of programmed lymphocyte cell death in vivo //J. Exp. Med. 1995. — Vol.181. — P. 1661−1672.

287. Zamzani N., Marchetti P. et al. Sequential reduction of mithochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death //J. Exp. Med. 1995. — Vol.182. — P.367−377.

288. Zamzani N., Susin S. et al. Mitochondrial control of nuclear apoptosis //J. Exp. Med. 1996. — Vol. 183. — P. 1533 -1544.

289. Zauli G., D. Gibellini, P. Secchiero. 1999. Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cell to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood.93:1000−1010.

290. Zhang J., Cado D. et al. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mortl //Nature. — 1998. Vol.392. — P.296−300.

291. Zhang L., Ramratnam B., Tenner-Racz K. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy //N. Engl. J.Med. -1999.-Vol.340.-P.1605−1613.

292. Zubiaga M., Munoz E. et al/ IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid induced apoptosis//J. Immunol. —1992. -Vol.149. -P.107−112.* *.