Роль различных типов антиген-презентирующих клеток в регуляции апоптоза лимфоцитов и репликации ВИЧ-1 при ВИЧ-инфекции
![Диссертация: Роль различных типов антиген-презентирующих клеток в регуляции апоптоза лимфоцитов и репликации ВИЧ-1 при ВИЧ-инфекции](https://westud.ru/work/5127281/cover.png)
Srivastava R.K., Sasaki C.Y., Hardwick J.M., Longo D.L. Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription //J. Exp. Med. 1999. — Vol.190. -P.253−265. Moutouh L., Estaquier J., Richman D.D., Corbeil J. Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis… Читать ещё >
Содержание
- выводы
- 1. Репликация ВИЧ-1 в С04-лимфоцитах является результатом их межклеточных взаимодействий как с профессиональными, так и полупрофессиональными антиген-презентирующими клетками
- 2. Ведущим фактором репликации ВИЧ-1 в лимфоцитах взаимодействующих с различными типами антиген-презентирующих клеток, являются лиганд-рецепторные взаимодействия
- 3. Репликация ВИЧ-1 в лимфоцитах, взаимодействующих с эндотелиальными клетками, не сопровождается появлением классических признаков их активации и пролиферации
4. Эндотелиальные клетки индуцируют устойчивость к апоптозу продуктивно инфицированных лимфоцитов, в то время как профессиональные антиген-презентирующие клетки (дендритные клетки и макрофаги) не обладают данной способностью.
5. Устойчивость продуктивно инфицированных лимфоцитов к апоптозу обусловлена их лиганд-рецепторными межклеточными взаимодействиями с эндотелиальными клетками.
6. Способность эндотелиальных клеток инициировать репликацию ВИЧ-1 в лимфоцитах является результатом экспрессии в инфицированных клетках вирусного белка Nef. Дендритные клетки и макрофаги инициируют репликацию ВИЧ-1 в лимфоцитах Nef-независимым путем.
7. Устойчивость к апоптозу у продуктивно инфицировнных лимфоцитов, взаимодействующих с эндотелиальными клетками, обусловлена вирусным белком Nef.
Роль различных типов антиген-презентирующих клеток в регуляции апоптоза лимфоцитов и репликации ВИЧ-1 при ВИЧ-инфекции (реферат, курсовая, диплом, контрольная)
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