Изучение механизмов антиоксидантного действия пептидов и их композиций
Диссертация
Для разработки обоснованной стратегии поиска перспективных пептидных антиоксидантов необходимо исследование механизмов их взаимодействия с АФК и модельными свободными радикалами. Несмотря на различия в химической структуре антиоксидантов, ключевыми механизмами их взаимодействия с АФК являются донирование атома водорода (ДАВ) или донирование электрона (ДЭ). Тем не менее, антиоксидантные эффекты… Читать ещё >
Содержание
- Список сокращений
- 1. Введение
- 2. Литературный обзор
- 2. 1. Методы анализа антиоксидантных свойств пептидов
- 2. 2. Получение антиоксидантных пептидов и их композиций
- 2. 3. Антиоксидантные свойства пептидов
- 2. 4. Применение антиоксидантных пептидов
- 3. Материалы и методы
- 3. 1. Материалы
- 3. 1. 1. Экспериментальные животные
- 3. 1. 2. Реагенты
- 3. 1. 3. Пептидные композиции
- 3. 2. Методы
- 3. 2. 1. Определение антиоксидантной емкости (АОЕ)
- 3. 2. 2. Расчет геометрии молекул и электронных дескрипторов 49 исследуемых антиоксидантов полуэмпирическими квантово-химическими методами
- 3. 2. 3. Характеристика пептидных композиций
- 3. 2. 3. 1. Определение содержания свободных аминокислот в составе 52 пептидных композиций
- 3. 2. 3. 2. Определение общего содержания аминокислот в составе 53 пептидных композиций
- 3. 2. 3. 3. Анализ молекулярно-массового распределения пептидных 54 композиций
- 3. 2. 3. 4. Фракционирование и идентификация низкомолекулярных 54 компонентов пептидных композиций
- 3. 2. 3. 5. Фракционирование и идентификация олигопептидных 56 компонентов пептидных композиций
- 3. 2. 4. Верификация антиоксидантных свойств пептидных композиций in 58 vivo
- 3. 2. 5. Определение содержания ТБК-реактивных продуктов в сыворотке 59 крови лабораторных животных
- 3. 2. 6. Определение содержания ТБК-реактивных продуктов в 60 гомогенатах тканей лабораторных животных
- 3. 2. 7. Определение АОЕ сыворотки крови лабораторных животных по 60 отношению к пероксильному радикалу и катион-радикалу АБТС
- 3. 2. 8. Определение АОЕ тканевых экстрактов по отношению к катион- 60 радикалу АБТС
- 3. 2. 9. Определение АОЕ тканевых экстрактов по отношению к 62 пероксильному радикалу
- 3. 1. Материалы
- 4. 1. Антиоксидантные свойства аминокислот, тирозин- и метионин- 64 содержащих дипептидов
- 4. 1. 1. Антиоксидантные свойства аминокислот и их производных
- 4. 1. 2. Антиоксидантные свойства тирозиновых дипептидов
- 4. 1. 3. Антиоксидантные свойства метиониновых дипептидов
- 4. 2. Расчеты молекулярных и электронных дескрипторов 72 антиоксидантных свойств аминокислот, метиониновых и тирозиновых дипептидов
- 4. 2. 1. Расчеты молекулярных и электронных дескрипторов редокс 73 активных аминокислот
- 4. 2. 2. Расчеты молекулярных и электронных дескрипторов дипептидов
- 4. 2. 2. 1. Расчеты молекулярных и электронных дескрипторов метионин- 82 содержащих дипептидов
- 4. 2. 2. 2. Расчеты молекулярных и электронных дескрипторов тирозин-содержащих дипептидов
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