Липоксигеназный путь в нефотосинтезирующих тканях некоторых высших растений
Обнаружены два новых дивиниловых эфира: (9Z, 11-Е, 1' Е)-12-(1'-гексенилокси)-9,11-додекадиеновая кислота (этеролевая кислота) и {9Z, 11Е, 1' Е, 3'Z)-12-(1', 3' -гексадиенилокси)-9,11-додекадиеновая кислота (этероленовая кислота). б. Предложен механизм синтеза дивиниловых оксилипинов, который заключается в образовании, а затем депротонировании эпоксиаллильного карбокатиона. 7. Этеролевая кислота… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗОВАННЫХ СОКРАЩЕНИЙ
- ГЛАВА I. ОБЗОР ЛИТЕРАТУРЫ
- 1. Липоксигеназы
- 1. 1. Распространение и свойства растительных липоксигеназ
- 1. 2. Свойства соевой липоксигеназы
- 1. 3. Природа фермента. Механизм автоактивации
- 1. 4. Специфичность действия липоксигеназ
- 1. 5. Метаболические превращения гидроперекисей полиеновых жирных кислот, контролируемые липоксигеназой
- 1. -6. Пути метаболизма гидроперекисных продуктов
- 1. 6. 1. Алленоксидсинтазный (гидропероксиддегидразный) путь
- 1. 6. 2. Гидропероксидлиазный путь
- 1. 6. 3. Редкие пути метаболизма гидропероксидов жирных кислот
- 1. Липоксигеназы
- 2. 1. Реактивы и материалы
- 2. 1. 1. Меченые соединения промышленного производства
- 2. 1. 2. Получение меченых соединений в лабораторных условиях
- 2. 1. 3. Химические реактивы
- 2. 1. 4. Хроматографические материалы
- 2. 2. Методы исследования
- 2. 2. 1. Анализ оксигенированных жирных кислот методом высокоэффективной жидкостной хроматографии (ВЭЖХ)
- 2. 2. 2. Метаболизм [1−14CJ-меченых линолеата, линолената и 9-гидроперекисей липоксигеназой из гомогената клубней картофеля
- 2. 2. 3. Метаболическое окисление [1−14С]линолевой и [1−14С] линоленовой кислот и их 9- и 13- (S)~ гидроперекисей в фильтрате гомогената луковиц тюльпана Tulipa gesneriana L
- 2. 2. 4. Условия инкубации [1−14С] линолевой и [ 1−14С] линоленовой кислот и их 9- и 13- (S)~ гидроперекисей с соком луковиц чеснока
- 2. 2. 5. Кислотный гидролиз метаболитов VIII и IX
- 2. 2. 6. Исследование антиагрегационного действия метаболита VIII (этеролевой кислоты) на тромбоциты человека in vitro
- 3. 1. Липоксигеназный путь в клубнях картофеля
- 3. 2. Липоксигеназный путь в луковицах тюльпана
СПИСОК ИСПОЛЬЗОВАННЫХ СОКРАЩЕНИЙ ЛО — липоксигеназа АОС — алленоксидсинтаза АОЦ — алленоксидциклаза ГПЛ — гидропероксидлиаза ГП — гидроперекись ВЭЖХ — высокоэффективная жидкостная хроматография Трис — трис (гидроксиметил)аминометан МЭС — морфолиноэтансульфоновая кислота АДФ — аденозин-5'-дифосфат АК — арахидоновая кислота Адр — адреналин
АСК — ацетилсалициловая кислота)-ГПОД — 9 (2)-гидроперокси-10(Е), 12октадекадиеновая кислота)-ГПОТ — 9 (5) -гидроперокси-10(Е), 12(И)октадекатриеновая кислота ]-ГПОД — 13(5)-гидроперокси-9(2), 11 (Е) октадекадиеновая кислота)-ГПОТ — 13 (5) -гидроперокси-9(2), 11(Е), октадекатриеновая кислота -кетол — 9-гидрокси-10-оксо-12(2), 15(Л)октадекадиеновая кислота -кетол — 11-гидрокси-12-оксо-9(2), 15(Л)-октадекадиеновая кислота
12,13-а-кетол — 12-оксо-13-гидрокси-9(2), 15(2)октадекадиеновая кислота 9,12-у-кетол — 9-гидрокси-12-оксо-10(Е), 15(2) октадекадиеновая кислота 10,13-у-кетол — 10-оксо-13-гидрокси-11(?), 15(2)октадекадиеновая кислота 12-оксо-ФДК — (95,135)-12-оксо-10,15(2)-фитодиеновая кислота
15-ГПЭТЕ — 15-гидроперокси-5(2), 8(2), 11(2), 13(Е)-эйкозатетраеновая кислота 5,15-диГПЭТЕ — 5,15-дигидроперокси-б (?), 8(2), 11(2), 13(?) эйкозатетраеновая кислота 15(5) -ГЭТЕ — 15 (5) -гидрокси-5 (2), 8 (2), 11 (2), 13 [Е) -эйкозатетраеновая кислота
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