ΠŸΠΎΠΌΠΎΡ‰ΡŒ Π² ΡƒΡ‡Ρ‘Π±Π΅, ΠΎΡ‡Π΅Π½ΡŒ быстро...
Π Π°Π±ΠΎΡ‚Π°Π΅ΠΌ вмСстС Π΄ΠΎ ΠΏΠΎΠ±Π΅Π΄Ρ‹

Бвязь ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ²-супрСссоров ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ с Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ спорадичСской Ρ„ΠΎΡ€ΠΌΡ‹ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½

Π”ΠΈΡΡΠ΅Ρ€Ρ‚Π°Ρ†ΠΈΡΠŸΠΎΠΌΠΎΡ‰ΡŒ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈΠ£Π·Π½Π°Ρ‚ΡŒ ΡΡ‚ΠΎΠΈΠΌΠΎΡΡ‚ΡŒΠΌΠΎΠ΅ΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹

Π Π°ΠΊ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ относится ΠΊ Ρ‡ΠΈΡΠ»Ρƒ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ часто Π²ΡΡ‚Ρ€Π΅Ρ‡Π°ΡŽΡ‰ΠΈΡ…ΡΡ Ρ„ΠΎΡ€ΠΌ злокачСствСнных Π½ΠΎΠ²ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π² Π±ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²Π΅ Ρ€Π°Π·Π²ΠΈΡ‚Ρ‹Ρ… стран, Π° Π² ΡΡ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Π΅ заболСваСмости ΠΈ ΡΠΌΠ΅Ρ€Ρ‚ности Π² Π ΠΎΡΡΠΈΠΈ Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ‚ 1-Π΅ мСсто. Π’ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ дСсятилСтия Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡ‚ΡŒ насСлСния России злокачСствСнными новообразованиями ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ»Π°ΡΡŒ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° ΠΈ ΠΈΠΌΠ΅Π΅Ρ‚ Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΡŽ ΠΊ Π΄Π°Π»ΡŒΠ½Π΅ΠΉΡˆΠ΅ΠΌΡƒ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΡŽ. Π•ΠΆΠ΅Π³ΠΎΠ΄Π½ΠΎ… Π§ΠΈΡ‚Π°Ρ‚ΡŒ Π΅Ρ‰Ρ‘ >

Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅

  • 1. ΠžΠ±Π·ΠΎΡ€ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹
    • 1. 1. ΠžΠ±Ρ‰ΠΈΠ΅ характСристики процСсса развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
      • 1. 1. 1. Бвойства злокачСствСнных ΠΊΠ»Π΅Ρ‚ΠΎΠΊ
      • 1. 1. 2. Π­Ρ‚Π°ΠΏΠ½ΠΎΡΡ‚ΡŒ процСсса возникновСния злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 1. 2. ΠžΠ½ΠΊΠΎΠ³Π΅Π½Ρ‹ ΠΈ Π³Π΅Π½Ρ‹-супрСссоры ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
      • 1. 2. 1. ΠžΠ½ΠΊΠΎΠ³Π΅Π½Ρ‹
      • 1. 2. 2. Π“Π΅Π½Ρ‹-супрСссоры ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 1. 3. БпорадичСскиС ΠΈ Π½Π°ΡΠ»Π΅Π΄ΡƒΠ΅ΠΌΡ‹Π΅ Ρ„ΠΎΡ€ΠΌΡ‹ Ρ€Π°ΠΊΠ°
    • 1. 4. Π Π°ΠΊ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹
      • 1. 4. 1. ΠžΠ±Ρ‰Π°Ρ характСристика
      • 1. 4. 2. Π“Π΅Π½Ρ‹, ΡƒΡ‡Π°ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ Π² ΠΏΡ€ΠΎΡ†Π΅ΡΡΠ΅ развития Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹
        • 1. 4. 2. 1. Π“Π΅Π½Ρ‹ BRCA1 ΠΈ BRCA2 ΠΈ ΠΈΡ… Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹Π΅ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΈ
    • 1. 5. Бвязь гСнСтичСского ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° с Ρ€ΠΈΡΠΊΠΎΠΌ развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
  • 2. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹
    • 2. 1. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹
    • 2. 2. ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹
      • 2. 2. 1. ΠšΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ·
      • 2. 2. 2. Π’Ρ‹Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π”ΠΠš
      • 2. 2. 3. ΠŸΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°Π·Π½Π°Ρ цСпная рСакция
      • 2. 2. 4. РСстрикция
      • 2. 2. 5. Π­Π»Π΅ΠΊΡ‚Ρ€ΠΎΡ„ΠΎΡ€Π΅Π· Π² Π°Π³Π°Ρ€ΠΎΠ·Π½ΠΎΠΌ Π³Π΅Π»Π΅
      • 2. 2. 6. БтатистичСский Π°Π½Π°Π»ΠΈΠ· Π΄Π°Π½Π½Ρ‹Ρ…
  • 3. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ собствСнных исслСдований
    • 3. 1. Бвязь аллСльного состояния исслСдованных Π³Π΅Π½ΠΎΠ² с Ρ€ΠΈΡΠΊΠΎΠΌ развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
      • 3. 1. 1. ΠŸΡ€ΠΈΠ½Ρ†ΠΈΠΏΡ‹ ΠΎΡ‚Π±ΠΎΡ€Π° исслСдованных Π³Π΅Π½ΠΎΠ². Π₯арактСристики исслСдованных Π³Π΅Π½ΠΎΠ²
      • 3. 1. 2. Π₯арактСристики исслСдованных ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… сайтов
      • 3. 1. 3. Π₯Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ распрСдСлСния Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ² ΠΏΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹ΠΌ сайтам Π² ΠΏΠΎΠΏΡƒΠ»ΡΡ†ΠΈΠΈ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°
      • 3. 1. 4. Π˜Π΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡ Π³Π°ΠΏΠ»ΠΎΡ‚ΠΈΠΏΠΎΠ² Π² Π³Π΅Π½Π°Ρ… BRCA1 ΠΈ BRCA
        • 3. 1. 4. 1. ΠšΠΎΡ€Ρ€Π΅Π»ΡΡ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ·
        • 3. 1. 4. 2. ΠšΠ°Ρ‡Π΅ΡΡ‚Π²Π΅Π½Π½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ· Π³Π°ΠΏΠ»ΠΎΡ‚ΠΈΠΏΠΎΠ²
      • 3. 1. 5. ИсслСдованиС связи сайтов ΠΈ Π³Π°ΠΏΠ»ΠΎΡ‚ΠΈΠΏΠΎΠ² с Ρ€ΠΈΡΠΊΠΎΠΌ развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
      • 3. 1. 6. Π˜Π΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡ Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ² BRCA1 ΠΈ BRCA2 с ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½Ρ‹ΠΌ риском развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 3. 2. ВыявлСниС Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ², ассоциированных с Ρ€ΠΈΡΠΊΠΎΠΌ развития Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹, ΠΏΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€ΡΠ½Ρ‹ΠΌ сайтам ΠΏΡ€ΠΈ ΠΏΠ°Ρ€Π½ΠΎΠΌ сочСтании исслСдуСмых Π³Π΅Π½ΠΎΠ²
      • 3. 2. 1. Анализ гСнСтичСской структуры популяции
      • 3. 2. 2. Π“Π΅Π½ΠΎΡ‚ΠΈΠΏΡ‹, Π·Π½Π°Ρ‡ΠΈΠΌΠΎ Π²Π»ΠΈΡΡŽΡ‰ΠΈΠ΅ Π½Π° Ρ€ΠΈΡΠΊ развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 3. 3. Π“Ρ€ΡƒΠΏΠΏΡ‹ ассоциаций ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… сайтов исслСдованных Π³Π΅Π½ΠΎΠ² с Π²Ρ‹ΡΠΎΠΊΠΈΠΌ ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΌ риском развития злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
      • 3. 3. 1. ΠžΡ‚Π±ΠΎΡ€ ассоциаций ΠΏΠΎ Ρ‚Ρ€Π΅ΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹ΠΌ сайтам с Π²Ρ‹ΡΠΎΠΊΠΈΠΌ ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΌ риском развития ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ
        • 3. 3. 1. 1. Ассоциации с Π½ΠΈΠ·ΠΊΠΈΠΌ риском развития ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ
        • 3. 3. 1. 2. Ассоциации с Π²Ρ‹ΡΠΎΠΊΠΈΠΌ риском развития ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ

Бвязь ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ²-супрСссоров ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ с Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ спорадичСской Ρ„ΠΎΡ€ΠΌΡ‹ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ (Ρ€Π΅Ρ„Π΅Ρ€Π°Ρ‚, курсовая, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½Π°Ρ)

ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Ρ‚Π΅ΠΌΡ‹

Π Π°ΠΊ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ относится ΠΊ Ρ‡ΠΈΡΠ»Ρƒ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ часто Π²ΡΡ‚Ρ€Π΅Ρ‡Π°ΡŽΡ‰ΠΈΡ…ΡΡ Ρ„ΠΎΡ€ΠΌ злокачСствСнных Π½ΠΎΠ²ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π² Π±ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²Π΅ Ρ€Π°Π·Π²ΠΈΡ‚Ρ‹Ρ… стран, Π° Π² ΡΡ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Π΅ заболСваСмости ΠΈ ΡΠΌΠ΅Ρ€Ρ‚ности Π² Π ΠΎΡΡΠΈΠΈ Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ‚ 1-Π΅ мСсто. Π’ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ дСсятилСтия Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡ‚ΡŒ насСлСния России злокачСствСнными новообразованиями ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ»Π°ΡΡŒ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° ΠΈ ΠΈΠΌΠ΅Π΅Ρ‚ Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΡŽ ΠΊ Π΄Π°Π»ΡŒΠ½Π΅ΠΉΡˆΠ΅ΠΌΡƒ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΡŽ. Π•ΠΆΠ΅Π³ΠΎΠ΄Π½ΠΎ частота случаСв Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ увСличиваСтся Π½Π° 1,2%. Π’ ΡΠ²ΡΠ·ΠΈ с ΡΡ‚ΠΈΠΌ исслСдованиС ΠΏΡ€ΠΈΡ‡ΠΈΠ½ возникновСния Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ становится всС Π±ΠΎΠ»Π΅Π΅ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌ.

Π Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ являСтся многоэтапным гСнСтичСски ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΠΈΡ€ΡƒΠ΅ΠΌΡ‹ΠΌ процСссом, ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΡŽΡ‰ΠΈΠΌ собой ΠΌΠΈΠΊΡ€ΠΎΡΠ²ΠΎΠ»ΡŽΡ†ΠΈΡŽ ΠΎΡ‚Π΄Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… ΠΊΠ»ΠΎΠ½ΠΎΠ² Π² ΠΏΡ€Π΅Π΄Π΅Π»Π°Ρ… ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ. ΠŸΡ€ΠΎΠ³Ρ€Π΅ΡΡΠΈΡ ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ обуславливаСтся Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ΠΌ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ Π² ΠΎΠ΄Π½ΠΎΠΌ ΠΈΠ»ΠΈ Π½Π΅ΡΠΊΠΎΠ»ΡŒΠΊΠΈΡ… Π³Π΅Π½Π°Ρ…, Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… ΠΊΠΎΠΎΠΏΠ΅Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎ, ΠΈ ΠΎΡ‚Π±ΠΎΡ€ΠΎΠΌ ΠΌΡƒΡ‚Π°Π½Ρ‚Π½Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… ΠΊΠ»ΠΎΠ½ΠΎΠ².

Π Π°ΡΡˆΠΈΡ„Ρ€ΠΎΠ²ΠΊΠ° Π³Π΅Π½ΠΎΠΌΠ° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΠΎΠ»ΠΎΠΆΠΈΠ»Π° Π½Π°Ρ‡Π°Π»ΠΎ Π½ΠΎΠ²ΠΎΠΌΡƒ Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΡŽ молСкулярной ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹ — ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Π΅, ΠΈΠΌΠ΅ΡŽΡ‰Π΅ΠΉ Π΄Π²Π΅ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹Π΅ особСнности — ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΉ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΊ Π±ΠΎΠ»ΡŒΠ½ΠΎΠΌΡƒ ΠΈ ΠΏΡ€Π΅Π΄ΡƒΠΏΡ€Π΅Π΄ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€. ΠžΡΠ½ΠΎΠ²Ρƒ ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹ ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‚ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π³Π΅Π½Π½ΠΎΠΉ сСти заболСвания, идСнтификация Π² Π½Π΅ΠΉ Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΡŒΠ½Ρ‹Ρ… Π³Π΅Π½ΠΎΠ² ΠΈ Π³Π΅Π½ΠΎΠ²-ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ‚ΠΎΡ€ΠΎΠ², Π°Π½Π°Π»ΠΈΠ· ассоциации ΠΈΡ… ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠΎΠ² с ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½Ρ‹ΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ, Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Π½Π° ΡΡ‚ΠΎΠΉ основС комплСкса профилактичСских мСроприятий для ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½ΠΎΠ³ΠΎ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°. Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ² прСдрасполоТСнности ΠΊ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈΠΌ заболСваниям, Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Π»Π΅ΠΆΠΈΡ‚ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌ Π”ΠΠš, являСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡ‚ΡŒΡŽ исслСдований, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰Π΅ΠΉ сущСствСнно Ρ€Π°ΡΡˆΠΈΡ€ΠΈΡ‚ΡŒ число ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… Π”ΠΠš-ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ², ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΡ… диагностичСскоС Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅.

Π’ Π½Π°ΡΡ‚оящСС врСмя ΠΈΠΌΠ΅ΡŽΡ‚ΡΡ многочислСнныС Π΄ΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒΡΡ‚Π²Π° Ρ‚ΠΎΠ³ΠΎ, Ρ‡Ρ‚ΠΎ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ΅ состояниС Π³Π΅Π½ΠΎΠ² BRCA1 ΠΈ BRCA2 ΠΈΠΌΠ΅Π΅Ρ‚ ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΡŽΡ‰Π΅Π΅ Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ Π² Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½. Показано, Ρ‡Ρ‚ΠΎ высоко-ΠΏΠ΅Π½Π΅Ρ‚Ρ€Π°Π½Ρ‚Π½Ρ‹Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ Π² ΡΡ‚ΠΈΡ… Π³Π΅Π½Π°Ρ… Π² Π³Π΅Ρ‚Π΅Ρ€ΠΎΠ·ΠΈΠ³ΠΎΡ‚Π½ΠΎΠΌ состоянии Π»Π΅ΠΆΠ°Ρ‚ Π² ΠΎΡΠ½ΠΎΠ²Π΅ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π΄ΠΎΠ»ΠΈ сСмСйных Ρ„ΠΎΡ€ΠΌ Ρ€Π°ΠΊΠ°. Π‘Π΅ΠΌΠ΅ΠΉΠ½Ρ‹Π΅ Ρ„ΠΎΡ€ΠΌΡ‹ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‚, ΠΊΠ°ΠΊ ΠΏΡ€Π°Π²ΠΈΠ»ΠΎ, с ΠΌΠ΅Π½ΡŒΡˆΠ΅ΠΉ частотой, Ρ‡Π΅ΠΌ спорадичСскиС, ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½Ρ‹ достаточно Ρ…ΠΎΡ€ΠΎΡˆΠΎ. БпорадичСскиС Ρ„ΠΎΡ€ΠΌΡ‹ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Π²ΡΡ‚Ρ€Π΅Ρ‡Π°ΡŽΡ‚ΡΡ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ Π² 90% случаСв ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½Ρ‹ явно нСдостаточно. Π’ ΡΡ‚ΠΎΠΉ связи основная ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ значимая ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ° связана с ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ гСнСтичСской ΠΏΡ€ΠΈΡ€ΠΎΠ΄Ρ‹ спорадичСских Ρ„ΠΎΡ€ΠΌ злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ, Π² Ρ‡Π°ΡΡ‚ности Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹.

Π˜Π·Π²Π΅ΡΡ‚Π½ΠΎ Ρ‚Π°ΠΊΠΆΠ΅, Ρ‡Ρ‚ΠΎ Π±Π΅Π»ΠΊΠΈ BRCA1 ΠΈ BRCA2 ΡΠ²Π»ΡΡŽΡ‚ΡΡ элСмСнтами ΠΏΠΎΠ»ΠΈΠ±Π΅Π»ΠΊΠΎΠ²Ρ‹Ρ… комплСксов. Π€ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Π°Ρ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ этих ΠΏΠΎΠ»ΠΈΠ±Π΅Π»ΠΊΠΎΠ²Ρ‹Ρ… комплСксов зависит Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ ΠΎΡ‚ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ‚Π½Ρ‹Ρ… ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ Π±Π΅Π»ΠΊΠΎΠ² BRCA1 ΠΈ BRCA2, Π½ΠΎ ΠΈ ΠΎΡ‚ аминокислотных ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚Π΅ΠΉ Π΄Ρ€ΡƒΠ³ΠΈΡ… Π±Π΅Π»ΠΊΠΎΠ² этих комплСксов. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅, основными ΠΊΠ°Π½Π΄ΠΈΠ΄Π°Ρ‚Π°ΠΌΠΈ ΠΏΡ€ΠΈ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ Π½Π°Π±ΠΎΡ€Π° исслСдуСмых Π³Π΅Π½ΠΎΠ² ΡΠ²Π»ΡΡŽΡ‚ΡΡ Ρ‚Π΅ Π³Π΅Π½Ρ‹, ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ‹ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Ρ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΡŽΡ‚ совмСстно с Π±Π΅Π»ΠΊΠ°ΠΌΠΈ BRCA1 ΠΈ BRCA2 ΠΏΠΎΠ»ΠΈΠ±Π΅Π»ΠΊΠΎΠ²Ρ‹Π΅ комплСксы.

Π¦Π΅Π»ΠΈ ΠΈ Π·Π°Π΄Π°Ρ‡ΠΈ исслСдования. ЦСлью Π΄Π°Π½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹ являлся популяционно-гСнСтичСский Π°Π½Π°Π»ΠΈΠ· связи ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ² BRCA1, BRCA2, Π 53, Π 21, RAD51, NBS1, BARD1, MSH6, XRCC1 с Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ спорадичСских Ρ„ΠΎΡ€ΠΌ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½. Для этого Ρ€Π΅ΡˆΠ°Π»ΠΈΡΡŒ ΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΠ΅ Π·Π°Π΄Π°Ρ‡ΠΈ:

1. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ частот Π°Π»Π»Π΅Π»Π΅ΠΉ ΠΈ Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ² ΠΏΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹ΠΌ сайтам Π³Π΅Π½ΠΎΠ² BRCA1, BRCA2, Π 53, Π 21, RAD51, NBS1, BARD1, MSH6, XRCC1 Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ€Π°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΠΈ Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅.

2. Анализ гСнСтичСской структуры ΠΏΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹ΠΌ сайтам Ρƒ Π³Ρ€ΡƒΠΏΠΏΡ‹ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ€Π°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΠΈ Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅.

3. Π˜Π΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡ ассоциаций ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… сайтов, статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎ Π²Π»ΠΈΡΡŽΡ‰ΠΈΡ… Π½Π° Ρ€ΠΈΡΠΊ развития спорадичСских Ρ„ΠΎΡ€ΠΌ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½.

Научная Π½ΠΎΠ²ΠΈΠ·Π½Π°. Π’ΠΏΠ΅Ρ€Π²Ρ‹Π΅ Π½Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π΅ Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π²Π°Π΄Ρ†Π°Ρ‚ΠΈ ΡˆΠ΅ΡΡ‚ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… сайтов Π² Π΄Π΅Π²ΡΡ‚ΠΈ Π³Π΅Π½Π°Ρ…-супрСссорах ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΡ‹ с Π²Ρ‹ΡΠΎΠΊΠΈΠΌ ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΌ риском развития спорадичСских Ρ„ΠΎΡ€ΠΌ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½. ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π΅ΡΠΊΠ°Ρ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ. ВыявлСниС Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ², ассоциированных с Π²Ρ‹ΡΠΎΠΊΠΈΠΌ риском развития спорадичСских Ρ„ΠΎΡ€ΠΌ Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹, позволяСт ΠΎΡΡƒΡ‰Π΅ΡΡ‚Π²ΠΈΡ‚ΡŒ Ρ€Π°Π½Π½ΡŽΡŽ диагностику прСдрасполоТСнности ΠΊ Π΄Π°Π½Π½ΠΎΠΉ Ρ„ΠΎΡ€ΠΌΠ΅ онкологичСского заболСвания, Π° Π² Π΄Π°Π»ΡŒΠ½Π΅ΠΉΡˆΠ΅ΠΌ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΡ‹Ρ… профилактичСских мСроприятий ΠΏΠΎ ΠΏΡ€Π΅Π΄ΠΎΡ‚Π²Ρ€Π°Ρ‰Π΅Π½ΠΈΡŽ развития Π±ΠΎΠ»Π΅Π·Π½ΠΈ. Π­Ρ‚ΠΎΡ‚ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ Π² ΠΎΡΠ½ΠΎΠ²Ρƒ выявлСния гСнСтичСской прСдрасполоТСнности ΠΊ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡŽ Ρ€Π°Π·Π½Ρ‹Ρ… Ρ‚ΠΈΠΏΠΎΠ² ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ ΡƒΠΌΠ΅Π½ΡŒΡˆΠΈΡ‚ΡŒ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΉ риск.

1. ΠžΠ±Π·ΠΎΡ€ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹.

1. Анализ Π΄Π²Π°Π΄Ρ†Π°Ρ‚ΠΈ ΡˆΠ΅ΡΡ‚ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… сайтов Π² Π³Π΅Π½Π°Ρ… BRCA1,.

BRCA2, Π 53, Π 21, RAD51, NBS1, BARD1, MSH6, XRCC1 ΠΏΠΎΠΊΠ°Π·Π°Π»,.

Ρ‡Ρ‚ΠΎ ΠΏΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ сайтам распрСдСлСниС Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΎΠ².

статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎ Π½Π΅ ΠΎΡ‚личаСтся ΠΎΡ‚ Ρ€Π°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠ³ΠΎ. Π­Ρ‚ΠΎ.

Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½ΠΎ ΠΊΠ°ΠΊ для ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹, Ρ‚Π°ΠΊ ΠΈ Π΄Π»Ρ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ….

Ρ€Π°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹,.

2. Π˜Π΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ ассоциации ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹Ρ… сайтов,.

Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΡƒΡŽΡ‰ΠΈΠ΅ΡΡ высоким ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΌ риском развития Ρ€Π°ΠΊΠ°.

ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ со ΡΡ€Π΅Π΄Π½Π΅ΠΏΠΎΠΏΡƒΠ»ΡΡ†ΠΈΠΎΠ½Π½Ρ‹ΠΌ. Π‘ΡƒΡ‰Π΅ΡΡ‚Π²Π΅Π½Π½ΡƒΡŽ Ρ€ΠΎΠ»ΡŒ Π² ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΈ риска развития Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ.

ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ ΠΈΠ³Ρ€Π°ΡŽΡ‚ Π°Π»Π»Π΅Π»ΡŒΠ½Ρ‹Π΅ состояния сайтов W Π³Π΅Π½Π° MSH6,.

S Π³Π΅Π½Π° BRCA1 ΠΈ J Π³Π΅Π½Π° Π 53. ΠŸΡ€ΠΈ этом Π²Ρ‹Π΄Π΅Π»Π΅Π½Π½Ρ‹Π΅ Π½Π°ΠΌΠΈ ассоциации.

ΠΌΠΎΠ³ΡƒΡ‚ Π»Π΅ΠΆΠ°Ρ‚ΡŒ Π² ΠΎΡΠ½ΠΎΠ²Π΅ Π±ΠΎΠ»Π΅Π΅ 34% спорадичСских случаСв Ρ€Π°ΠΊΠ°.

ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½,.

3, Показано, Ρ‡Ρ‚ΠΎ частоты встрСчаСмости «Ρ€Π΅Π΄ΠΊΠΎΠ³ΠΎ» Π²Π°Ρ€ΠΈΠ°Π½Ρ‚Π°.

ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½ΠΎΠ³ΠΎ сайта G1420T (G) Π³Π΅Π½Π° BRCA2 ΠΈ Π³Π°ΠΏΠ»ΠΎΡ‚ΠΈΠΏΠ°, А А Π’ Π‘ А.

(М N g П Y), Π² ΡΠΎΡΡ‚Π°Π² ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ³ΠΎ Π²Ρ…ΠΎΠ΄ΠΈΡ‚ этот сайт, Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ….

статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎ прСвосходит Ρ‚Π°ΠΊΠΎΠ²Ρ‹Π΅ Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅,.

4, УстановлСно, Ρ‡Ρ‚ΠΎ гСнСтичСская структура Π³Ρ€ΡƒΠΏΠΏΡ‹ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ с.

выявлСнным Ρ€Π°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΠΏΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ Π½Π°ΠΌΠΈ.

ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„Π½Ρ‹ΠΌ сайтам отличаСтся ΠΎΡ‚ Ρ‚Π°ΠΊΠΎΠ²ΠΎΠΉ Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅.

ΠŸΠΎΠΊΠ°Π·Π°Ρ‚ΡŒ вСсь тСкст

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