Модифицированные олигонуклеотиды, содержащие химически активные группы в 2'-положении углеводного фрагмента, и получение конъюгатов на их основе
Диссертация
Гидроксильные группы соединения 2.8 были блокированы защитой Маркевича. На второй стадии проводили реакцию с 2-нитрофенолом, что позволяло необходимое для того, чтобы предотвратить последующее алкилирование по А^-атому, аналогично описанному в работе. (92'-Атом соединения 2.10 алкилировали аллилметилкарбонатом в присутствии палладиевого катализатора. Следующей стадией синтеза было получение… Читать ещё >
Содержание
- 1. УСЛОВНЫЕ СОКРАЩЕНИЯ
- 2. ВВЕДЕНИЕ
- 3. НУКЛЕОЗИДЫ И ОЛИГОНУКЛЕОТИДЫ С ХИМИЧЕСКИ АКТИВНЫМИ 9 ГРУППАМИ ПРИ С2-АТОМЕ: СИНТЕЗ И ПРИМЕНЕНИЕ Литературный обзор)
- 3. 1. Введение
- 3. 2. Синтез модифицированных нуклеозидов, содержащих 11 реакционноспособные группы в 2'-положении углеводного фрагмента
- 3. 2. 1. Синтез нуклеозидов, содержащих нуклеофильные группы в
- 3. 2. 1. 1. Синтез 2'-амино-2'-дезоксинуклеозидов
- 3. 2. 1. 2. Синтез 2'-0-аминоалкилнуклеозидов
- 3. 2. 1. 3. Синтез нуклеозидов, содержащих аминооксигруппу
- 3. 2. 1. 4. Синтез нуклеозидов, содержащих тиольную группу
- 3. 2. 2. Синтез нуклеозидов, содержащих электрофильные группы в 31 2'-положении углеводного фрагмента
- 3. 2. 2. 1. Синтез 2'-оксонуклеозидов
- 3. 2. 2. 2. Синтез нуклеозидов, содержащих альдегидную группу или 33 диальдегидную группировку
- 3. 2. 2. 3. Синтез нуклеозидов, содержащих карбоксильную группу
- 3. 2. 2. 4. Синтез нуклеозидов, содержащих другие электрофильные группы
- 3. 3. Синтез 2'-конъюгатов нуклеозидов и олигонуклеотидов
- 3. 3. 1. Синтез конъюгатов нуклеозидов с различными соединениями
- 3. 3. 2. Синтез 2'-конъюгатов олигонуклеотидов твердофазным методом
- 3. 3. 3. Синтез 2'-конъюгатов олигонуклеотидов в растворе
- 3. 4. Применение нуклеозидов, нуклеотидов и олигонуклеотидов, содержащих 72 реакционноспособные группы в 2'-положении углеводного фрагмента, и конъюгатов на их основе
- 3. 4. 1. Применение нуклеозидов и нуклеотидов
- 3. 4. 2. Применение 2'-модифицированных олигонуклеотидов
- 3. 4. 2. 1. Антисмысловая и антигенная биотехнология
- 3. 4. 2. 2. Изучение ДНК-белковых взаимодействий
- 3. 4. 2. 3. Изучение структуры нуклеиновых кислот
- 3. 4. 2. 4. Рибозимы 87
- 4. 1. Синтез модифицированных олигонуклеотидов, содержащих альдегидную 92 группу при 02'-атоме, и получение конъюгатов на их основе в растворе
- 4. 2. Синтез модифицированных олигонуклеотидов, содержащих альдегидную 109 группу при (32'-атоме, и получение конъюгатов на их основе твердофазным методом
- 4. 3. Синтез и свойства олигонуклеотидов, содержащих другие химически 117 активные группы в 2'-положении углеводного фрагмента
- 4. 3. 1. Синтез олигонуклеотидов, содержащих остаток 117 2' -0-(2-гидразиноэтил)ури дина
- 4. 3. 2. Синтез олигонуклеотидов, содержащих (3-дикетогруппировку в 122 2'-положении углеводного фрагмента
- 4. 3. 3. Синтез олигонуклеотидов, содержащих остаток 2'-0- 126 (карбоксиметил)уридина
- 4. 3. 4. Синтез олигонуклеотидов, содержащих остаток 128 2'-0-(2,3-диаминопропил)уридина
- 4. 3. 5. Синтез олигонуклеотидов, содержащих остаток 2'-О- 133 {2,3-ди-[МА^-бис (этоксикарбонилметил)амино]пропил}уридина
- 4. 4. Синтез ^/-модифицированных пептидов и получение олигонуклеотидо- 135 пептидных конъюгатов
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