Π Π°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² SF-1 ΠΈ Srebp Π½Π° ΠΠΠ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎ-ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Π°
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠ»Ρ ΡΠ°ΠΉΡΠΎΠ² SF-1, ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ SiteGA, SITECON, SiteGA+PWM, ΠΏΠ΅ΡΠ΅ΠΊΡΡΠ²Π°ΡΡΡΡ Π»ΠΈΡΡ ΡΠ°ΡΡΠΈΡΠ½ΠΎ. ΠΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ΄ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ² ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ Π‘Π‘Π’Π€, ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΡ ΠΊΠ°ΠΆΠ΄ΡΠΌ ΠΈΠ· ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ², Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΠΏΡΠ΅Π΄ΡΠΊΠ°Π·Π°Π½ΠΈΠΉΠ½ΠΎΠ²ΡΡ ΡΠ°ΠΉΡΠΎΠ², ΡΡΠΎ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ°ΡΡΠΈΡΡΠ΅Ρ Π½Π°ΡΠΈ Π·Π½Π°Π½ΠΈΡ ΠΎ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ°Π½Π΅Π΅ Π½Π΅ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ Π³Π΅Π½ΠΎΠ²-ΠΌΠΈΡΠ΅Π½Π΅ΠΉ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- ΠΠΠΠΠ I. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. ΠΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΠΎΠΈΡΠΊΠ° ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π² ΡΡΠΊΠ°ΡΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π³Π΅Π½Π°Ρ
ΠΈ ΠΈΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΠΏΡΠΎΠ²Π΅ΡΠΊΠ°
- 1. 1. Π Π°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΠΈΠΌΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΠ΅ Π²ΡΠ±ΠΎΡΠΊΠΈ
- 1. 1. 1. ΠΡΡΠΎΡΠ½ΠΈΠΊΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ Π²ΡΠ±ΠΎΡΠΎΠΊ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ²
- 1. 1. 2. ΠΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΡ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° ΠΎΠ±ΡΡΠ΅Π½ΠΈΠΈ
- 1. 1. 2. 1. ΠΠ΅ΡΠΎΠ΄Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΡΠ° ΠΈ Π²Π΅ΡΠΎΠ²ΡΡ ΠΌΠ°ΡΡΠΈΡ
- 1. 1. 2. 2. ΠΠΎΠ΄Ρ ΠΎΠ΄Ρ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° Π²ΡΡΠ²Π»Π΅Π½ΠΈΠΈ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΈ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΠΠ. ΠΠ΅ΡΠΎΠ΄ SITECON
- 1. 1. 2. 3. ΠΠΎΠ΄Ρ ΠΎΠ΄Ρ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° ΠΌΠ΅ΡΠΎΠ΄Π°Ρ Π΄ΠΈΡΠΊΡΠΈΠΌΠΈΠ½Π°ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°. ΠΠ΅ΡΠΎΠ΄ SiteGA
- 1. 1. 3. ΠΡΠ΅Π½ΠΊΠ° ΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΡ
- 1. 2. Π Π°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² de novo
- 1. 2. 1. ΠΠ΅ΡΠΎΠ΄Ρ ΠΏΠΎΠΈΡΠΊΠ° ΡΠ²Π΅ΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ ΠΌΠΎΡΠΈΠ²ΠΎΠ²
- 1. 2. 2. Π€ΠΈΠ»ΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠΏΡΠΈΠ½ΡΠΈΠ½Π³
- 1. 1. Π Π°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΠΈΠΌΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΠ΅ Π²ΡΠ±ΠΎΡΠΊΠΈ
- 1. ΠΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΠΎΠΈΡΠΊΠ° ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π² ΡΡΠΊΠ°ΡΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π³Π΅Π½Π°Ρ
ΠΈ ΠΈΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΠΏΡΠΎΠ²Π΅ΡΠΊΠ°
- 2. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΡΠΎΠ²Π΅ΡΠΊΠΈ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΠΏΡΠ΅Π΄ΡΠΊΠ°Π·Π°Π½Π½ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ²
- 3. Π’ΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠΉ ΡΠ°ΠΊΡΠΎΡ SF
- 3. 1. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ SF
- 3. 2. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ SF-1 ΠΈ Π΅Π³ΠΎ Π³Π΅Π½Ρ-ΠΌΠΈΡΠ΅Π½ΠΈ
- 4. Π’ΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ SREBP
- 4. 1. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ SREBPs
- 4. 2. ΠΡΠΎΡΠ΅ΡΡΠΈΠ½Π³ SREBP
- 4. 3. Π‘Π°ΠΉΡΡ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ SREBP Π±Π΅Π»ΠΊΠΎΠ²
- 4. 4. ΠΠ·ΠΎΡΠΎΡΠΌΡ SREBP
- 4. 5. ΠΠ΅Π½Ρ — ΠΌΠΈΡΠ΅Π½ΠΈ SREBP
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΡΡΡΠ³ΠΈΠ½Π° Π’.Π., ΠΠ³Π½Π°ΡΡΠ΅Π²Π° Π. Π., ΠΡΠ°Π΄ΡΡΠΊ A.B. ΠΠΎΠ½ΡΠ΅Π½ΡΡΡ ΡΠ°ΠΉΡΠ° ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° SF-1 ΠΈ Π΅Π³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΠ°ΠΉΡΡ Π² 5'-ΡΠ»Π°Π½ΠΊΠΈΡΡΡΡΠΈΡ ΡΠ°ΠΉΠΎΠ½Π°Ρ Π³Π΅Π½ΠΎΠ² ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² ΡΡΠ΅ΡΠΎΠΈΠ΄ΠΎΠ³Π΅Π½Π΅Π·Π° 3bHSDI ΠΈ Π‘ΡΡ 17 ΠΌΡΡΠΈ // ΠΠΈΠΎΡ ΠΈΠΌΠΈΡ, 2003, Π’. 68, Π‘. 467−476.
- ΠΠ΅Π²ΠΈΡΠΊΠΈΠΉ Π.Π., ΠΠ³Π½Π°ΡΡΠ΅Π²Π° Π. Π., ΠΠ½Π°Π½ΡΠΊΠΎ Π. Π., ΠΠ΅ΡΠΊΡΠ»ΠΎΠ²Π° Π’. Π., ΠΠΎΠ»ΡΠ°Π½ΠΎΠ² H.A., Π₯ΠΎΠ΄ΠΆΠΌΠ°Π½ Π’. Π‘. ΠΠ΅ΡΠΎΠ΄ SiteGA Π΄Π»Ρ ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΡ ΡΠ°ΠΉΡΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² // ΠΠΈΠΎΡΠΈΠ·ΠΈΠΊΠ°, 2006, Π’.51, Π‘. 633−639.
- ΠΠ°Π½ΠΈΠ°ΡΠΈΡ Π’., Π€ΡΠΈΡ Π., Π‘ΡΠΌΠ±ΡΡΠΊ Π. ΠΠ΅ΡΠΎΠ΄Ρ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ΅ ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ // Π.: ΠΠΈΡ, 1984. Π‘. 480.
- Π‘ΠΌΠΈΡΠ½ΠΎΠ² Π.Π. Π―Π΄Π΅ΡΠ½ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ: Π½ΠΎΠΌΠ΅Π½ΠΊΠ»Π°ΡΡΡΠ°, Π»ΠΈΠ³Π°Π½Π΄Ρ, ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² // ΠΠΈΠΎΡ ΠΈΠΌΠΈΡ, 2002, Π’. 67(9), Π‘. 1157−1181.
- Alberts Π. Essential Cell Biology: An Introduction to the Molecular Biology of the Cell // New York: Garland Pub, 1998.
- Ananko E.A., Kondrakhin Y.V., Merkulova Π’. I., Kolchanov N.A. Recognition of interferon-inducible sites, promoters, and enhancers // BMC Bioinformatics, 2007, Vol. 8, P. 56.
- Anderson T.W. An introduction to multivariate statistical analysis // John Wiley & Sons Inc., N.Y., 1958.
- Arauzo-Bravo M.J., Sarai A. Knowledge-based prediction of DNA atomic structure from nucleic sequence // Genome Inform., 2005, Vol. 16, P. 12−21.
- Badve S., Deshpande C., Hua Z., Logdberg L. Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus // J Histochem. Cytochem., 2002, Vol. 50(4), P.473−482.
- Bailey T.L. and Elkan C. The value of prior knowledge in discovering motifs with MEM // Proc. Int. Conf. Intell. Syst. Mol. Biol., 1995, Vol. 3, P. 21−29.
- Baldi P., Brunak S., Chauvin Y., Andersen C.A., Nielsen H. Assessing the accuracy of prediction algorithms for classification: an overview //Bioinformatics, 2000, Vol. 16(5), P. 412−424.
- Bank A. Regulation of human fetal hemoglobin: new players, new complexities // Blood, 2006, Vol. 107(2), P. 435−443.
- Beckmann H., Su L.K., Kadesch T. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif // Genes. Dev., 1990, Vol. 4(2), P. 167−179.
- Berezikov E., Guryev V., Cuppen E. Exploring conservation of transcription factor binding sites with CONREAL // Nucleic Acids Res., 2005, Vol. 33, P. 447−450.
- Benecke A. Genomic plasticity and information processing by transcription coregulators // Com. Plex. Us., 2003, Vol. 1, P. 65−76.
- Benecke A. Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs // Eur. Phys. J. E., 2006, Vol. 19, P. 379−84.
- Bennett M.K., Toth J.I., Osborne T.F. Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo // J. Biol. Chem., 2004, Vol. 279(36), P. 37 360−37 367.
- Berg O.G., von Hippel P.H. Selection of DNA binding sites by regulatory proteins. Statistical-mechanical theory and application to operators and promoters // J. Mol. Biol., 1987, Vol. 193(4), P. 723−50.
- Boffelli D., McAuliffe J., Ovcharenko D., Lewis K.D., Ovcharenko I., Pachter L., and Rubin E.M. Phylogenetic shadowing of primate sequences to find functional regions of the human genome // Science, 2003, Vol. 299, P.1391−1394.
- Boffelli D., Weer C.V., Weng L., Lewis K.D., Shoukry M.I., Pachter L., Keys D.N. and Rubin E.M. Intraspecies sequence comparisons for annotating genomes. Genome Res., 2004, Vol. 14, P. 2406—2411.
- Bourdeau V., Deschenes J., Laperriere D., Aid M., White J.H., Mader S. Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells // Nucleic Acids Res., 2008, Vol. 36(1), P. 76−93.
- Brooks D.E. Influence of androgens on the weights of the male accessory reproductive organs and on the activities of mitochondrial enzymes in the epididymis of the rat // J. Endocrinol., 1979, Vol. 82, P. 293−303.
- Bulger M., Groudine M. Enhancers: the abundance and function of regulatory sequences beyond promoters // Dev. Biol., 2010, Vol. 339(2), P. 250−257.
- Bulyk, M., Johnson, P. and Church, G. Nucleotides of transcription factor binding sites exert inter-dependent effects on the binding affinities of transcription factors // Nucleic Acids Res., 2002, Vol. 30, P. 1255−1261.
- Bucher P. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences // J. Mol. Biol. 1990. — Vol. 212. — P. 563−578.
- Bucher P. Regulatory elements and expression profiles // Curr. Opin. Struct. Biol., 1999, Vol. 9(3), P. 400−407.
- Cardinaux J. R., Notis J. C., Zhang Q., Vo N., Craig J. C., Fass D. M., Brennan R. G., Goodman R. H. Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation // Mol. Cell. Biol., 2000, Vol. 20, P. 1546−1552.
- Chang L.W., Nagarajan R., Magee J.A., Milbrandt J., Stormo G.D. A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles // Genome Res., 2006, Vol. 16, P. 405−413.
- Chatterjee S., Szustakowski J.D., Nanguneri N.R., Mickanin C., Labow M.A., Nohturfft A., Dev K.K., Sivasankaran R. Identification of novel genes and pathways regulating SREBP transcriptional activity // PLoS One., 2009, Vol. 4(4), P. e5197.
- Chen H., Lee J.M., Zong Y., Borowitz M., Ng M.H., Ambinder R.F., Hayward S.D. Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors // J. Virology, 2001, Vol. 75, P. 2929−2937.
- Slater G., Smith J., Spooner W., Stabenau A., Stalker J., Stupka E., Ureta-Vidal A., Vastrik I., Birney E. Ensembl 2002: accommodating comparative genomics //Nucleic. Acids. Res., 2003, Vol. 31, P. 38−42.
- Clarke S.D., Armstrong M.K. Cellular lipid binding proteins: expression, function, and nutritional regulation // FASEB J., 1989, Vol. 3, P. 24 802 487.
- Crawford P.A., Polish J.A., Ganpule G. and Sadovsky Y. The activation function-2 hexamer of steroidogenic factor-1 is required, but not sufficient for potentiation by SRC-1 // Mol. Endocrinol., 1997, Vol. 11, P. 1626−35.
- Desclozeaux M., Krylova I.N., Horn F., Fletterick R.J., Ingraham H.A. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1 // Mol. Cell. Biol., 2002, Vol. 22, P. 7193−7203.
- Down T.A. and Hubbard T.J. NestedMICA: Sensitive inference of over-represented motifs in nucleic acid sequence // Nucleic Acids Res., 2005, Vol. 33, P. 1445−1453.
- Durbin R., Eddy S.R., Krogh A., Mitchson G. Biological sequence analysis // Cambridge University Press., U.K., 1998.
- Ecker J., Langmann T., Moehle C., Schmitz G. Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1 c dependent mechanism // Biochem. Biophys. Res. Commun., 2007, Vol. 352(3), P. 805−11.
- Eddy S.R. Profile hidden Markov models // Bioinformatics, 1998, Vol. 14(9), P. 755−63.
- Efron B., Gong G. A leisure look at the bootstrap, the jackknife and cross-validation // Am. Star., 1983, Vol. 37, P. 36−48.
- Elkon R., Linhart C., Sharan R., Shamir R., Shiloh Y. Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells // Genome Re., s 2003, Vol. 13, P. 773−780.
- Elnitski L., Jin V.X., Farnham P.J., Jones S.J. Locating mammalian transcription factor binding sites: a survey of computational and experimental techniques // Genome Res., 2006, Vol. 16(12), P. 1455−64.
- Ericsson J., Jackson S.M., Lee B.C., Edwards P.A. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene // Proc. Natl. Acad. Sci. USA., 1996, Vol. 93, P. 945−950.
- Euskirchen G., Royce T.E., Bertone P., Martone R., Rinn J.L., Nelson F.K., Sayward F., Luscombe N.M., Miller P., Gerstein M., Weissman S., Snyder M. CREB binds to multiple loci on human chromosome 22 // Mol. Cell. Biol., 2004, Vol. 24, P. 3804−3814.
- Fayard E., Auwerx J., Schoonjans K. LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis // Trends in Cell Biol., 2004, Vol. 14, P. 250−260.
- Ferrara N., LeCouter J., Lin R., Peale F. EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors. // Biochim. Biophys. Acta., 2004, Vol. 1654(1), P. 69−78.
- Ferre-D'Amare A.R. and Burley S.K. DNA recognition by helixloop- helix proteins // Nucleic Acids Mol. Biol., 1995, Vol. 9, P. 285−298.
- Ferre-D'Amare A.R., Prendergast G.C., Ziff E.B. & Burley, S.K. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain //Nature, 1993, Vol. 363, P. 38−45.
- Fijak M., Iosub R., Schneider E., Linder M., Respondek K., Klug J., Meinhardt A. Identification of immunodominant autoantigens in rat autoimmune orchitis // J. Pathol.,. 2005, Vol. 207(2), P. 127−38.
- Fregonese L., Stolk J. Hereditary alpha-1-antitrypsin deficiency and its clinical consequences // Orphanet. J. Rare Dis., 2008, Vol. 3, P. 16.
- Fouchecourt S., Metayer S., Locatelli A., Dacheux F., Dacheux J.L. Stallion epididymal fluid proteome: qualitative and quantitative characterization- secretion and dynamic changes of major proteins // Biol. Reprod., 2000, Vol. 62, P. 1790−1803.
- Fredriksson R., Lagerstrom M.C., Hoglund P.J., Schioth H.B. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions // FEBS Lett., 2002, Vol. 531, P. 407−414.
- Frith M.C., Fu Y., Yu L., Chen J.F., Hansen U., and Weng Z. Detection of functional DNA motifs via statistical over-representation // Nucleic Acids Res., 2004, Vol. 32, P. 1372−1381
- Frith M.C., Ponjavic J., Fredman D., Kai C., Kawai J., Carninci P., Hayshizaki Y., Sandelin A. Evolutionary turnover of mammalian transcription start sites // Genome Res., 2006, Vol. 16(6), P. 713−722.
- Fusi F.M., Lorenzetti L, Mangili F., Herr J.C., Freemerman A.J., Gailit J., Bronson R.A. Vitronectin is a intrinsic protein in human spermatozoa releasing during the acrosome reaction // Mol. Reprod. Dev., 1994, Vol. 39, P. 337−343.
- Gadiraju S., Vyhlidal C.A., Leeder J.S. and Rogan P.K. Genome-wide prediction, display and refinement of binding sites with information theory-based models // BMC Bioinformatics, 2003, Vol. 4, P. 38.
- Galas D.J. and Schmitz A. DNase footprinting: A simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res. 1978, Vol. 5, P. 3157−3170.
- Gelfand M.S. Prediction of function in DNA sequence analysis // J. Comput. Biol., 1995, Vol. 2(1), P. 87−115.
- Gershenzon N.I., Stormo G.D., Ioshikhes I.P. Computational technique for improvement of the position-weight matrices for the DNA/protein binding sites // Nucleic Acids Res., 2005, Vol. 33(7), P. 2290−2301.
- Ghosh D. Object-oriented transcription factors database (ooTFD) // Nucleic Acids Res, 2000, Vol. 28, P. 308−310.
- Gibbs R. A, Weinstock G. M, Metzker M.L., Muzny D. M, Sodergren E.J., Scherer S, Scott G, Steffen D, Worley K. C, Burch P.E. Genome sequence of the Brown Norway rat yields insights into mammalian evolution // Nature, 2004, Vol. 428, P. 493−521.
- Gimpl G, Burger K, Fahrenholz F. A closer look at the cholesterol sensor //Trends. Biochem. Sci, 2002, Vol. 27(12), P. 596−9.
- Gold L., Brown D, He Y.-Y, Shtatland T., Singer B.S., Wu Y. From oligonucleotide shapes to genomic SELEX: Novel biological regulatory loops // Biochemistry, 1997, Vol. 94, P. 59−64.
- Goldstein J. L, Rawson R. B, Brown M.S. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis // Arch. Biochem. Biophys, 2002, Vol. 397(2), P. 139−148.
- Gondret F, Ferre P., Dugail I. ADD-l/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species // J. Lipid. Res, 2001, Vol. 42(1), P. 106−13.
- Goodman R. H, Smolik S. CBP/p300 in cell growth, transformation, and development. // Genes. Dev., 2000, Vol. 14(13), P. 1553−77.
- Goodridge A.G. Dietary regulation of gene expression: enzymes involved in carbohydrate and lipid metabolism // Annu. Rev. Nutr., 1987, Vol. 7, P. 157−185.
- Gorin A.A., Zhurkin V.B., Olson W.K. B-DNA twisting correlates with base-pair morphology // J. Mol. Biol, 1995, Vol. 247, P. 34−48.
- Gorski K., Carneiro M., Schibler U. Tissue-specific in vitro transcription from the mouse albumin promoter // Cell, 1986, Vol. 47, P. 767−776.
- Grapin-Botton A. Ductal cells of the pancreas. // Int. J. Biochem. Cell. Biol, 2005, Vol. 37(3), P. 504−510.
- Grundy W. N, Bailey T. L, Elkan C. P, Baker M.E. Meta-MEME: motifbased hidden Markov models of protein families // Comput. Appl. Biosci, 1997, Vol. 13, P. 397−406.
- Guan G, Dai P. H, Osborne T. F, Kim J. B, Shechter I. Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene //J. Biol. Chem, 1997, Vol. 272(15), P. 10 295−302.
- Guan G, Jiang G, Koch R.L. and Shechter I. Molecular cloning and functional analysis of the promoter of the human squalene synthase gene //β’ J. Biol. Chem, 1995, Vol, 270, P. 21 958−21 965.
- Gunewardena S., Jeavons P., Zhang Z. Enhancing the prediction of transcription factor binding sites by incorporating structural properties and nucleotide covariations // J. Comput. Biol., 2006, Vol. 13, P. 929−945.
- Hall P.A., Reis-Filho J.S., Tomlinson I., Roulsom R. An introduction to genes, genomes and disease // J. Pathol., 2010, Vol: 220, P. 109−113.
- Hallikas O., Palin K., Sinjushina N., Rautiainen R., Partanen J., Ukkonen E. and Taipale J. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity // Cell, 2006, Vol. 124, P. β’ 47−59.
- Hammer G.D. and Ingraham H.A. Steroidogenic factor-1: its role in endocrine organ development and differentiation // Front. Neuroendocrinol., 1999, Vol. 20, P. 199−223.
- Hayashizaki Y. The Riken mouse genome encyclopedia project // C. R. Biol., 2003, Vol. 326(10−11), P. 923−9.
- Hedger M.P., Meinhardt A. Cytokines and the immune-testicular axis // J. Reprod. Immunol., 2003, Vol. 58, P. 1−26.
- Hertz G.Z., Stormo G.D. Identifying DNA and protein patterns with statistically significant alignments of multiple sequences // Bioinformatics, 1999, Vol. 15, P. 563−77.
- Hinshelwood M.M., Shelton J.M., Richardson J.A., Mendelson C.R. Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development // Dev. Dyn., 2005, Vol. 234(1), P. 159−68.
- Holloway D.T., Kon M., DeLisi C. Integrating genomic data to predict transcription factor binding // Genome Inform., 2005, Vol. 16(1), P. 83−94.
- Holthuis J.C., van Riel M.C., Martens G.J. Translocon-associated protein TRAP delta and a novel TRAPlike protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary // Biochim. J., 1995, Vol. 312, P. 205−213.
- Hoivik E.A., Lewis A.E., Aumo L., Bakke M. Molecular aspects of steroidogenic factor 1 (SF-1) // Mol. Cell. Endocrinol., 2010, Vol. 315(1−2), P. 27−39.
- Horton J.D., Goldstein J.L., Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver // J. Clin. Invest., 2002, Vol. 109(9), P. 1125−31.
- Ho Sui S.J., Mortimer J.R., Arenillas D.J., Brumm J., Walsh C.J., Kennedy B.P., Wasserman W.W. oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes // Nucleic Acids Res., 2005, Vol.33, P. 3154−3164.
- Hu J., Banerjee A., Goss D.J. Assembly of b/HLH/z proteins c-Myc, Max, and Madl with cognate DNA: importance of protein-protein and proteinDNA interactions // Biochemistry, 2005, Vol. 44(35), P. 11 855−63.
- Ikeda Y., Lala D.S., Luo X., Kim E., Moisan M.P., Parker K.L. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression // Mol. Endocrinol., 1993, Vol. 7, P. 852−860.
- Ito M., Yu R., Jameson J.L. DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenital//Mol. Cell. Biol., 1997, Vol. 17(3), P. 1476−83.
- Ito M., Yu R.N. and Jameson J.L. Steroidogenic factor-1 contains a carboxy-terminal transcriptional activation domain that interacts with steroid receptor coactivator-1 //Mol. Endocrinol., 1998, Vol. 12, P.290−301.
- Jacob A.L., Lund J., Martinez P., Hedin L. Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5 // J. Biol. Chem., 2001, Vol. 276(40), P. 37 659−64.
- Jiang C., Xuan Z., Zhao F., Zhang M.Q. TRED: a transcriptional regulatory element database, new entries and other development // Nucl. Acids. Res., 2007, Vol.35, P. D137−140.
- Jin Y.Z., Bannai S., Dacheux J.L., Okamura N. Direct evidence for the secretion of lactoferrin and its binding to sperm in the porcine epididymis // Mol. Reprod. Dev., 1997, Vol. 47, P. 490196.
- Jolly E.R., Chin C.S., Herskowitz I., Li H. Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computational genomic analysis // BMC Bioinformatics, 2005, Vol. 18(6), P. 275.
- Jump D.B., Clarke S.D. Regulation of gene expression by dietary fat // Annu. Rev. Nutr., 1999, Vol. 19, P. 63−90.
- Kan H.Y., Pissios P., Chambaz J., Zannis V.I. DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter // Nucleic Acids Res., 1999, Vol. 27(4), P. 1104−17.
- Kel A., Kel-Margoulis O., Babenko V., Wingender E. Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells // J. Mol. Biol., 1999, Vol. 288, P. 353−376.
- Kel A.E., Kel-Margoulis O.V., Farnham P.J., Bartley S.M., Wingender E., Zhang M.Q. Computer-assisted identification of cell cycle-related genes: new targets for E2 °F transcription factors // J. Mol. Biol., 2001, Vol. 309, P. 99−120.
- Kel A.E., Gossling E., Reuter I., Cheremushkin E., Kel-Margoulis O.V., Wingender E. MATCH: A tool for searching transcription factor binding sites in DNA sequences // Nucleic Acids Res., 2003, Vol. 31(13), P. 3576- 3579.
- Kel A.E., Niehof M., Matys V., Zemlin R. and Borlak J. Genome wide prediction of HNF4a functional binding sites by the use of local and global sequence context // Genome Biology, 2008, Vol. 9(2), P. 36.1−36.19
- Khorasanizadeh S., Rastinejad F. Nuclear-receptor interactions on DNA-response elements // Trends Biochem. Sci., 2001, Vol. 26, P. 384−390.
- Kierszenbaum A.L. Epididymal G protein-coupled receptor (GPCR): two hats and a two-piece suit tailored at the GPS motif // Mol. Reprod. Dev., 2003, Vol. 64, P. 1−3.
- Kim J.B., Spotts G.D., Halvorsen Y.D., Shih H.M., Ellenberger T., Towle
- H.C, Spiegelman B.M. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain // Mol. Cell. Biol., 1995, Vol. 15, P. 2582−2588.
- Kim J. W, Zeller K.I., Wang Y, Jegga A. G, Aronow B. J, O’Donnell K. A, Dang C.V. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays // Mol. Cell. Biol, 2004- Vol. 24, P. 5923−5936.
- Kitahashi M, Sato Y, Fujimura L, Ozeki C, Arima M, Sakamoto A, Yamamoto S, Tokuhisa T, Hatano M. Identification of the consensus DNA sequence for Nczf binding // DNA Cell Biol, 2007, Vol. 26(6), P. 395−401.
- Koyama K, Ito K, Hasegawa A. Role of male reproductive tract CD52 (mrt-CD52) in reproduction // Soc. Reprod. Fertil. Suppl, 2007, Vol. 63, P. 103−110.
- Krivan W, Wasserman W.W. A predictive model for regulatoiy sequencesdirecting liver-specific transcription // Genome Res., 2001, Vol. 11, P. 1559−1556.
- Kumarev V. P, Kobzev V. F, Kuznedelov K. D, Sredin Yu.G. Super-rapid synthesis of oligodeoxynucleotides on a micro-scale // Nucleic. Acids. Symp, 1991, Vol. 24, P. 234.
- Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. //Nature, 1970, Vol. 227(5259), P. 680−685.
- Latchman D.S. Eukariotic transcription factors // ELSEVIER Academic Press, 2004, P. 299−330.
- Laudet V, Auwerx J, Gustafsson J, Wahli W. A unified nimenclature system for the nuclear receptor superfamily // Cell, 1999, Vol. 97, P. 161 163.
- LaVoie H.A. The role of GATA in mammalian reproduction // Exp. Biol. Med, 2003, Vol. 228, P. 1282−1290.
- Lawrence C. E, Altschul S. F, Boguski M.S., Liu J. S, Neuwald A. F, and Wootton J.C. Detecting subtle sequence signals: A Gibbs sampling strategy for multiple alignment // Science, 1993, Vol. 262, P. 208−214.
- Lee M.B., Lebedeva L.A., Suzawa M., Wadekar S.A., Desclozeaux M., Ingraham H.A. The DEAD-box protein DP 103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification // Mol. Cell. Biol., 2005, Vol. 25(5), 1879−1890.
- Lemay D.G., Hwang D.H. Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics // J. Lipid. Res., 2006, Vol. 47(7), P. 1583−1587.
- Lesne A., Benecke A. Probability landscapes for integrative genomics // Theor. Biol. Med. Model., 2008, Vol. 5 (9), P. 1−16.
- Levitsky V.G. and Katokhin A.V. Recognition of eukaryotic promoters using a genetic algorithm based on iterative discriminant analysis // In Silico Biol., 2003, Vol. 3, P. 81−87.
- Li M., Xue K., Ling J., Diao F.Y., Cui Y.G., Liu J.Y. The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells // Mol. Cell. Endocrinol., 2010, Vol. 319(1−2), P. 39−46.
- Li S., Liang Z.G., Wang G.Y., Yavetz B., Kim E.D., Goldberg E. Molecular cloning and characterization of functional domains of a human testis-specific isoform of calpastatin // Biol. Reprod., 2000, Vol. 63, P. 172−178.
- Li Y., Choi M., Suino K., Kovach A., Daugherty J., Kliewer S.A., Xu H.E. Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. // Proc. Natl.
- Acad. Sci., 2005, Vol. 102(27), P. 9505−9510.
- Li X., Zhong S., Wong W.H. Reliable prediction of transcription factor binding sites by phylogenetic verification // Proc. Natl. Acad. Sci., 2005, Vol. 102, P. 16 945−16 950.
- Liu R., Blackwell T.W., States D.J. Conformational model for binding site recognition by the E. coli MetJ transcription factor // Bioinformatics, 2001, Vol. 17(7), P. 622−633.
- Liu R., McEachin R.C., States D.J. Computationally identified novel NF-kB regulated immune genes in the human genome // Genome Res., 2003, Vol. 13, P. 654−661.
- Liu W., Liu M., Fan W., Nawata H., Yanase T. The Glyl46Ala variation in human SF-1 gene: its association with insulin resistance and type 2 diabetes in Chinese // Diabetes. Res. Clin. Pract., 2006, Vol. 73(3), P. 322−8.
- Lo S.H., Lo T.B. Cten, a COOH-terminal tensinlikeprotein with prostate restricted expression, is downregulated in prostate cancer // Cancer Res., 2002, Vol. 62, P. 4217−4221.
- Lopez J. M., Bennett M.K., Sanchez H.B., Rosenfeld J.M. and Osborne T.E. Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid // Proc. Natl. Acad. Sci. USA., 1996, Vol. 93, P. 1049−1053.
- Luo X., Ikeda Y. and Parker K.L. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation // Cell, 1994, Vol. 77, P. 481−90.
- Luo X., Ikeda Y., Schlosser D.A., Parker K.L. Steroidogenic factor 1 is the essential transcript of the mouse Ftz-Fl gene // Mol. Endocrinol., 1995, Vol. 9(9), P. 1233−1239.
- Magana M.M. and Osborne T.F. Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter // J. Biol. Chem., 1996, Vol. 271, P. 3 268 932 694.
- Man T.K., Stormo G.D. Non-independence of Mnt repressor-operator interaction determined by a new quantitative multiple fluorescence relative affinity (QuMFRA) assay // Nucleic Acids Res., 2001, Vol. 29, P. 24 712 478.
- Mangelsdorf DJ., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. The nuclear receptor superfamily: the second decade // Cell, 1995, Vol. 83, P. 835−839.
- Mater M.K., Thelen A.P., Pan D.A. and Jump D. B. Sterol response element binding protein lc (SREBPlc) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription // J. Biol. Chem., 1999, Vol. 274, P. 32 725−32 732.
- Meierhans D., Sieber M. and Allemann R.K. High affinity binding of MEF-2C correlates with DNA bending // Nucleic Acids Res., 1997, Vol. 25, P. 4537−4544.
- Mizuguchi G., Vassilev A., Tsukiyama T., Nakatani Y., Wu C. ATP-dependent nucleosome remodeling and histone hyperacetylation synergistically facilitate transcription of chromatin // J. Biol. Chem., 2001, Vol. 276(18), P. 14 773−83.
- Moe M., Meuwissen T., Lien S., Bendixen C., Wang X., Conley L.N., Berget I., Tajet H., Grindflek E. Gene expression profiles in testis of pigs with extreme high and low levels of androstenone // BMC Genomics, 2007, Vol. 8, P. 405.
- Moon Y.A., Lee J.J., Park S.W., Ahn Y.H., Kim K.S. The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter // J. Biol. Chem., 2000, Vol. 275(39), P. 3 028 030 286.
- Morales A., Vilchis F., Chavez B., Chan C., Robles-Diaz G., Diaz-Sanchez V. Expression of steroidogenic factors 1 and 2 in normal human pancreas // J. Steroid. Biochem. Mol. Biol., 2006, Vol. 98(4−5), P. 254−258.
- Morohashi K., Honda S., Inomata Y., Handa H., Omura T. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s // J. Biol. Chem., 1992, Vol. 267, P. 17 913−17 919.
- Mulligan M.E., Hawley D. K, Entriken R., McClure W.R. Escherichia Coli promoter sequences predict in vitro RNA polymerase selectivity // Nucleic Acids Res, 1984, Vol. 12, P. 789 800.
- Nagoshi E. and Yoneda Y. Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin P // Mol. Cell. Biol, 2001, Vol. 8, P. 2779−2789.
- Nikula H, Koskimies P, El-Hefnawy T, Huhtaniemi I. Functional characterization of the basal promoter of the murine LH receptor gene in immortalized mouse Leydig tumor cells // J. Mol. Endocrinol, 2001, Vol. 26(1), P. 21−29.
- Ninomiya Y, Okada M, Kotomura N, Suzuki K, Tsukiyama T, Niwa O, Genomic organization and isoforms of the mouse ELP gene. J. Biochem, 1995, Vol. 118, P. 380−389.
- Nohturfffc A, Yabe D, Goldstein J. L, Brown M.S., Espenshade P.J. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes // Cell, 2000, Vol. 102(3), P. 315−23.
- Nuclear Receptors Nomenclature Committee. A unified nomenclature system for the nuclear receptor superfamily // Cell, 1999, Vol. 97(2), P. 161−163.
- Nuovo G. J, Preissner K. T, Bronson R.A. PCRamplified vitronectin RNA localizes in situ to permatocytes and round spermatides in the human testes // Hum. Reprod, 1995, Vol. 10, P. 2187−2191.
- O’Brien C. A, Manolagas S.C. Isolation and characterization of the human gpl30 promoter // J. Biol. Chem, 1997, Vol. 272, P. 15 003−15 010.
- Okuno M, Arimoto E, Ikenobu Y, Nishihara T, Imagawa M. Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha // Biochem. J, 2001, Vol. 353, P. 193−198.
- Oliner J. D, Andresen J. M, Hansen S. K, Zhou S. and Tjian R. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein // Genes. Dev., 1996, Vol. 10, P. 2903−2911.
- O’Lone R, Frith M. C, Karlsson E. K, Hansen U. Genomic targets of nuclear estrogen receptors // Mol. Endocrinol, 2004, Vol. 18, P. 1859−1875.
- Omura T, Morohashi K.J. Gene regulation of steroidogenesis // Steroid Biochem. Mol. Biol, 1995, Vol. 53, P. 19−25.
- Paillard G., Deremble C., Lavery R. Looking into DNA recognition: zinc finger binding specificity // Nucleic Acids Res., 2004, Vol. 32(22), P. 6673−6682.
- Parker K.L., Schimmer B.P. Steroidogenic factor 1: a key determinant of endocrine development and function // Endocr. Rev., 1997, Vol. 18, P. 361— 377.
- Parraga A., Bellsolell L., Ferre-D'Amare A.R., Burley S.K. Co-crystal structure of sterol regulatory element binding protein la at 2.3 A resolution // Structure, 1998, Vol. 6(5), P. 661−672.
- Pasini B., Stratakis C.A. SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes //J. Intern. Med., 2009, Vol. 266(1), P. 19−42.
- Patel M.V., McKay I.A., Burrin J.M. Transcriptional regulators of steroidogenesis, DAX-1 and SF-1, are expressed in human skin // J. Invest. Dermatol., 2001, Vol. 117, P. 1559−1565.
- Pawlu C., Bausch B., Neumann H.P. Mutations of the SDHB and SDHD genes // Fam. Cancer, 2005, Vol. 4(1), P. 49−54.
- Pavesi G., Mereghetti P., Mauri G., and Pesole G. Weeder Web: Discovery of transcription factor binding sites in a set of sequences from co-regulated genes // Nucleic Acids Res., 2004, Vol. 32, P. W199-W203.
- Pavesi G., Zambelli F., Pesole G. WeederH: an algorithm for finding conserved regulatory motifs and regions in homologous sequences // BMC Bioinformatics, 2007, Vol. 8, P.46.
- Perissi V., Rosenfeld M.G. Controlling nuclear receptors: the circular logic of cofactor cycles // Nat. Rev. Mol. Cell. Biol., 2005, Vol. 6, P. 542−554.
- Perier R.C., Praz V., Junier T., Bonnard C., Bucher P. The eukaryotic promoter database (EPD) // Nucleic Acids Res., 2000, Vol. 28(1), P. 302−303.
- Phuc Le P., Friedman J.R., Schug J., Brestelli J.E., Parker J.B., Bochkis I.M., Kaestner K.H. Glucocorticoid receptor-dependent gene regulatory networks // PLoS Genet., 2005, Vol. 1(2), P. el6.
- Reddy T.E., Pauli F., Sprouse R.O., Neff N.F., Newberry K.M., Garabedian M.J., Myers R.M. Genomic determination of the glucocorticoid responsejreveals unexpected mechanisms of gene regulation. // Genome Res., 2009, Vol. 19(12), P. 2163−2171.
- Rice D.A., Mouw A.R., Bogerd A.M. and Parker K.L. A shared promoter element regulates the expression of three steroidogenic enzymes // Mol. Endocrinol., 1991, Vol. 5, P. 1552−1561'.
- Roulet E., Fisch I., Junier T., Bucher P.', Mermod N. Evaluation of computer tools for the prediction of transcription factor binding sites on genomic DNA // In Silico Biol., 1998, Vol. 1(1), P. 21−28.
- Roulet E., Bucher P., Schneider R., Wingender E., Dusserre Y., Werner T., Mermod N. Experimental analysis and computer prediction of CTF/NFI transcription factor DNA binding sites // J. Mol. Biol., 2000, Vol. 297(4), P. 833−848.
- Sablin E.P., Blind R.D., Krylova I.N., Ingraham J.G., Cai F., Williams J.D., Fletterick R. JI, Ingraham H.A. Structure of SF-1 bound, by different phospholipids: evidence for regulatory ligands // Mol. Endocrinol., 2009, Vol. 23(1), P. 25−34.
- Sandelin A., Wasserman W.W. Prediction of nuclear hormone receptor response elements //Mol. Endocrinol., 2005, Vol. 19(3), P. 595−606.
- Sanchez H.B., Yieh L. and Osborne T.F. Cooperation by sterol regulatory element binding protein and Spl in sterol regulation of low density lipoprotein receptor gene // J. Biol. Chem., 1995, Vol. 270, P. 1161−1169.
- Sato R., Inoue J., Kawabe Y., Kodama T., Takano T., Maeda M. Sterol-dependent transcriptional regulation of sterol regulatory element binding protein-2 // J. Biol. Chem., 1996, Vol. 271, P. 26 461−26 464.
- Schneider T.D. Evolution of biological information. // Nucleic Acids Res., 2000, Vol. 28(14), P. 2794−2799.
- Schoonjans K., Gelman L., Haby C., Briggs M., Auwerx J. Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes // J. Mol. Biol., 2000, Vol. 304(3), P. 323−334.
- Shapiro D. J, Sharp P. A, Wahli W. W, Keller M.J. A high-efficiency HeLa cell nuclear transcription extract//DNA, 1988, Vol. 7, P. 47−55.
- Shih H. M, Liu Z. and Towle H.C. Two CACGTG motifs with proper β’ spacing dictate the carbohydrate regulation of hepatic gene transcription // J. Biol. Chem, 1995, Vol. 270, P. 21 991−21 997.
- Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes // Prog. Lipid. Res, 2001, Vol. 40(6), P. 439−52.
- Shimano H. SREBPs: physiology and pathophysiology of the SREBP family // FEBS J, 2009, Vol. 276(3), P. 616−21.
- Sipila P, Jalkanen J, Huhtaniemi I. T, Poutanen M. Novel epididymal proteins as targets for the development of post-testicular male contraception //Reproduction, 2009, Vol. 137(3), P. 379−389.
- Starr D.B., Hoopes B.C. and Hawley D.K. DNA bending is an important component of site-specific recognition by the TATA binding protein // J. Mol. Biol, 1995, Vol. 250, P. 434 -446.
- Stoeckert C.J. Jr., Salas F., Brunk B., Overton G.C. EpoDB: a prototype database for the analysis of genes expressed during vertebrate erythropoiesis //Nucleic Acids Res., 1999, Vol. 27, P. 200−203.
- Stoesser G., Tuli M.A., Lopez R., Sterk P. The EMBL Nucleotide Sequence Database//Nucleic Acids Res., 1999, Vol. 27(1), P. 18−24.
- Stormo G.D., Schneider T.D., Gold L. Quantitative analysis of the relationship between nucleotide sequence and functional activity // Nucleic Acids Res., 1986, Vol. 14, P. 6661−6679.
- Sun H., Palaniswamy S.K., Pohar T.T., Jin V.X., Huang T.H., Davuluri R.V. MPromDb: an integrated resource for annotation and visualization of mammalian gene promoters and ChlP-chip experimental data // Nucleic Acids Res., 2006, Vol. 34, P. D98−103.
- Suomela S., Cao L., Bowcock A., Saarialho-Kere U. Interferon alpha-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers // J. Invest. Dermatol., 2004, Vol. 122(3), P. 717−21.
- Suzuki Y., Yamashita R., Sugano S., Nakai K. DBTSS, DataBase of transcriptional Start Sites: progress report // Nucleic. Acids. Res., 2004, Vol. 32, P. D78-D81.
- Swinnen J.V., Alen P., Heyns W. and Verhoeven G. Identification of diazepam-binding Inhibitor/Acyl-CoA-binding protein as a sterol regulatory element binding protein-responsive gene // J. Biol. Chem., 1998, Vol. 273, P.19 938−19 944.
- Tagle D. A, Koop B. F, Goodman M, Slightom J. L, Hess D.L. and Jones R.T. Embryonic e and y globin genes of a prosimian primate (Galago crassicaudatus) // J. Mol. Biol, 1988, Vol. 203, P. 439−455.
- Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta Y, Serizawa M, Ohshima N, Kato N, Yanai K. // J. Recept Signal Transduct. Res, 2010, Vol. 30(2), P. 88−105.
- Thompson W, Rouchka E. C, Lawrence C.E. Gibbs Recursive Sampler: finding transcription factor binding sites // Nucleic Acids Res, 2003, Vol. 31(13), P. 3580−3585.
- Tompa M. Identifying functional elements by comparative DNA sequence analysis // Genome Res, 2005, Vol. 11, P. 1143−1144.
- Toth J. L, Datta S, Athanikar J. N, Freedman L. P, Osborne T.F. Selective coactivator interactions in gene activation by SREBP-la and -lc // Mol. Cell. Biol, 2004, Vol. 24(18), P. 8288−8300.
- Towle H.C. Metabolic regulation of gene transcription in mammals // J. Biol. Chem, 1995, Vol. 270, P. 23 235−23 238.
- Tremblay J. J, Viger R.S. A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4 // J. Biol. Chem, 2003, Vol. 278, P. 4 263 742 642.
- Tronche F., Ringeisen F., Blumenfeld M., Yaniv M., Pontoglio M. Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome // J. Mol. Biol., 1997, Vol. 266, P. 231−245*.
- Tsien R.Y. The green fluorescent protein // Annu. Rev. Biochem., 1998, Vol. 67, P. 509−544.
- Tsukiyama, T., Ueda, H., Hirose, S., Niwa, O. Embryonal long terminal repeatbinding protein is amurine homolog of FTZ-F1, amember of the steroid receptor superfamily // Mol. Cell Biol., 1992, Vol. 12, P. 12 861 291.
- Tuerk C. and Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase // Science, 1990, Vol. 249, P. 505−510.
- Ueda H., Sonoda S., Brown J.L., Scott M.P., Wu C. A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression // Genes Dev., 1990, Vol. 4(4) — P. 624−35.
- Vavouri T. and Elgar G. Prediction of cis-regulatory elements using binding site matrices—the successes, the failures and the reasons for both // Curr. Opin. Genet. Dev., 2005, Vol. 15, P. 395−402.
- Vlieghe D., Sandelin A., De Bleser P.J., Vleminckx K., Wasserman W.W., van Roy F., Lenhard B. A new generation of JASPAR, the open-access repository for transcription factor binding site profiles // Nucleic Acids Res., 2006, Vol. 34, P. D95−97.
- Vyhlidal C.A., Rogan P.K. and Leeder J.S. Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: Insights into PXR-mediated gene regulation // J. Biol. Chem., 2004, Vol. 279, P. 46 779−46 786.
- Wang D. and Sul H.S. Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter // J. Biol. Chem., 1997, Vol. 272, P. 26 367−26 374.
- Wang X., Sato R., Brown M.S., Hua X., Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterolregulated proteolysis // Cell, 1994, Vol.77, P. 53−62.
- Warburg O., Christian W. // Biochemische Z., 1941, V. 310, P. 384−421.
- Wingender E. The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation // Brief. Bioinform, 2008, Vol. 9(4), P. 326−32.
- Winnay J. N, Hammer G.D. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation // Mol. Endocrinol, 2006, Vol. 20(1), P. 147- 166.
- Wright W. E, Binder M, Funk W. Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site // Mol. Cell. Biol, 1991, Vol. 11, P. 4104—4110.
- Xie X, Lu J, Kulbokas E. J, Golub T. R, Mootha V, Lindblad-Toh K, Lander E. S, and Kellis M. Systematic discovery of regulatory motifs in human promoters and 3 UTRs by comparison of several mammals // Nature, 2005, Vol. 434, P. 338−345.
- Yabe D, Brown M.S., Goldstein J.L. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins // Proc. Natl. Acad. Sci, 2002, Vol. 99(20), P. 12 753−8.
- Yang H. M, Do H. J, Kim D. K, Park J. K, Chang W. K, Chung H. M, Choi S. Y, Kim J.H. Transcriptional regulation of human Oct4 by steroidogenic factor-1 // J. Cell. Biochem, 2007, Vol. 101(5), P. 1198−209.
- Yang T, Espenshade P. J, Wright M. E, Yabe D, Gong Y, Aebersold R, Goldstein J. L, Brown M.S. Crucial step in cholesterol homeostasis: sterolspromote binding of SCAP retention of SREBPs in ER // Cell, 2002, Vol. 110(4), P. 489−500.
- Yeung C.H., Perez-Sanchez F., Schroter S., Kirchhoff C., Cooper T.G. Changes of the major sperm maturation- associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation // Mol. Hum. Reprod., 2001, Vol. 7, P. 617−624.
- Yokoyama C., Wang X., Briggs M.R., Admon A., Wu J., Hua X., Goldstein J.L., Brown M.S. SREBP-1, a basic-helixloop-helix-leucine zipper protein that controls transcription of the lowdensity lipoprotein receptor gene // Cell, 1993, Vol. 75, P. 187−197.
- Zhang M. and Marr T. A weight array method for splicing signal analysis // Comput. Appl. Biosci., 1993, Vol. 9, P. 499−509.