Диагностическая значимость цитокинового профиля конденсата выдыхаемого воздуха у пациентов с бронхиальной астмой
Диссертация
Основные положения диссертационной работы доложены и всесторонне обсуждены на выездной сессии ФГУ «НИИ пульмонологии» ФМБА России (Рязань, 2007) — 17-м и 19-м национальных конгрессах по болезням органов дыхания (Казань, 2007; Москва, 2009) — 3-ей международной научной конференции «Традиционная медицина, перспективы развития» (Улан-Удэ, 2008) — 18-м ежегодном конгрессе Европейского респираторного… Читать ещё >
Содержание
- Список принятых сокращений
- Общая характеристика работы
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Введение
- 1. 2. Механизм действия цитокинов
- 1. 3. Классификация цитокинов
- 1. 4. Характеристика цитокинов
- 1. 5. КВВ и методологические вопросы
- 1. 6. Цитокины в КВВ при бронхиальной астме
- 1. 7. Цитокины в КВВ при других заболеваниях органов дыхания
- Глава 2. МАТЕРИАЛ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Характеристика обследованных групп
- 2. 2. Методы исследования
- 2. 2. 1. Клинико-инструментальные методы
- 2. 2. 2. Исследование функции внешнего дыхания
- 2. 2. 3. Сбор КВВ
- 2. 2. 4. Определение рН КВВ
- 2. 2. 5. Определение цитокинов в КВВ
- 2. 3. Статистическая обработка результатов
- Глава 3. РЕЗУЛЬТАТЫ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ И ИХ ОБСУЖДЕНИЕ
- 3. 1. Клиническая характеристика групп
- 3. 2. Уровень рН и объем КВВ
- 3. 3. Концентрация цитокинов в КВВ и сыворотке крови
- 3. 4. Корреляционный анализ
- 3. 5. Клинические примеры
- ВЫВОДЫ 87 ПРАКТИЧЕСКИЕ РЕКОМЕНДАЦИИ
- СПИСОК ЛИТЕРАТУРЫ
- СПИСОК ПРИНЯТЫХ СОКРАЩЕНИЙ БА — бронхиальная астма
- БАЛ — бронхоальвеолярный лаваж
- ПС — глюкокортикоиды
- ГМ-КСФ — колониестимулирующий фактор гранулоцитов и моноцитов
- ДН — дыхательная недостаточность
- ИКЧ — индекс курящего человека
- ИЛ-4 — интерлейкин
- ИЛ-6 — интерлейкин
- ИЛ-8 — интерлейкин
- ИЛ-13 — интерлейкин
- ИМТ — индекс массы тела
- ИФН-у — интерферон-гамма
- КВВ — конденсат выдыхаемого воздуха
- ЛТ — лейкотриены
- ОФВ1 — объем форсированного выдоха за первую секунду
- ОРВИ — острая респираторная вирусная инфекция
- ПГ — простагландины
- ПСВ — пиковая скорость выдоха
- ПЦР — полимеразная цепная реакция
- СДЛА — среднее давление в легочной артерии
- ФВД — функция внешнего дыхания
- ФЖЕЛ — форсированная жизненная ёмкость легких
- ФНО-а — фактор некроза опухолей-а
- ХОБЛ — хроническая обструктивная болезнь лёгких
- ЧД — частота дыхания
- ЧСС — частота сердечных сокращений
- ATS — Американское торакальное общество
- ERS — Европейское респираторное общество
- GINA — Глобальная стратегия по бронхиальной астме
- I. gE — иммуноглобулин класса Е
- PDGF — фактор роста тромбоцитов
- TGF-J3 — трансформирующий фактор роста-(
- TSLP — тимус-стромальный лимфопоэтин
- V. CAM-1 — молекула адгезии сосудистого эндотелия 1 типа
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