Закономерности изменений уровня неоптерина и некоторых показателей иммунитета у пациентов со злокачественными опухолями
Диссертация
В настоящее время уже не вызывает сомнений, что биологические особенности малигнизированной ткани во многом определяют гетерогенность иммунологического ответа организма на опухолевые антигены. Клеточный иммунитет играет одну из ведущих ролей в защите организма от вирусных, инфекционных, паразитарных, аутоиммунных заболеваний, в механизмах отторжении трансплантата, а также в противоопухолевых… Читать ещё >
Содержание
- Список сокращений
- ГЛАВА. !
- Биологическая роль нептерина и его участие в клеточном иммунитете
- 1. 1. Неоптерин, его биологические функции
- 1. 1. 1. Метаболизм неоптерина
- 1. 1. 2. Возможные источники неоптерина. ^
- 1. 1. 3. Факторы, влияющие на продукцию неоптерина
- 1. 1. 4. Влияние птеринов на собственную продукцию
- 1. 1. 5. Известные биологические функции неоптерина и его восстановленных форм
- 1. 2. Существующие методы анализа неоптерина. Обзор хроматогра-фического анализа ВЭЖХ неоптерина в биологических жидкостях
- 1. 3. Роль а-ФНО и у-ИФ в продукции неоптерина
- 1. 4. Раково-эмбриональный антиген как индикатор опухолевого процесса
- 1. 5. Некоторые сдвиги комплементарного статуса онкологических больных
- 1. 1. Неоптерин, его биологические функции
- ГЛАВА II.
- Материалы и методы
- 2. 1. Клиническая характеристика обследованных групп
- 2. 2. ВЭЖХ анализ неоптерина в сыворотке с УФ и флюориметрической детекцией
- 2. 3. Методы определения а-ФНО, у-ИФ и раково-эмбрионального антигена
- 2. 4. Методы изучения комплементарного статуса
- 2. 4. 1. Определение активности комплемента в классическом варианте её инициации
- 2. 4. 2. Методы определения компонентов комплемента: С1-ингибитора, СЗа, С5а и фактора Н
- 2. 5. Методика определения молекул средней массы в сыворотке крови
- 2. 6. Оборудование и аппаратура
- 2. 7. Методы статистической обработки результатов
- ГЛАВА III.
- Разработка и оптимизация ВЭЖХ метода определения неоптерина
- ГЛАВА IV.
- Величины неоптерина и некоторых иммунологических параметров у раковых больных
4.1 Закономерности изменений уровня неоптерина и содержания цитокинов у пациентов со злокачественными новообразованиями. 62 4.2. Закономерности изменения комплементарного статуса, содержания раково-эмбрионального антигена и молекул средней массы у пациентов со злокачественными опухолями.
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