Распространенность, клинико-аллергологическая характеристика аллергических заболеваний у детей г.Томска и Томской области
Наше понимание патофизиологии астмы значительно трансформировалось, признав основополагающей роль хронического воспаления дыхательных путей. Воспаление развивается как в относительно крупных и средних бронхах, так и в периферических дыхательных путях (<2 мм в диаметре). В настоящее время одним из методов оценки воспаления респираторного тракта признано определение маркеров окислительного… Читать ещё >
Содержание
- Глава 1. Эпидемиология аллергических заболеваний у детей и факторы, определяющие эволюцию патологии на современном этапе (обзор литературы)
- 1. 1. Распространенность аллергических заболеваний в популяции и методология эпидемиологических исследований
- 1. 1. 1. Основные эпидемиологические характеристики A3 в мире по протоколам программы «ISAAC»
- 1. 1. 2. Основные эпидемиологические характеристики A3 в мире по протоколам программы «ISAAC» I и III этапов
- 1. 2. Основные биологические маркеры и факторы риска формирования аллергических заболеваний
- 1. 2. 1. Атопия и её вклад в развитие аллергических болезней
- 1. 2. 2. Роль интра- и перинатальных факторов в формировании аллергических болезней
- 1. 2. 3. Хрипы и астма
- 1. 3. Участие оксида азота в развитии и течении аллергических заболеваний
- 1. 3. 1. Механизмы действия и эффекты оксида азота
- 1. 3. 2. Роль оксида азота в развитии бронхиальной астмы
- 1. 3. 3. Значение NO в диагностике астмы
- 1. 4. Основные иммунологические теории развития атопических болезней
- 1. 4. 1. Гигиеническая гипотеза
- 1. 4. 2. Гипотеза иммунотолерантности
- 1. 4. 3. Роль бытовых аллергенов в развитии аллергических болезней
- 1. 4. 4. Роль гельминтов в развитии аллергических болезней
- 1. 1. Распространенность аллергических заболеваний в популяции и методология эпидемиологических исследований
- 2. 1. Скрининговый этап
- 2. 2. Клинический этап
- 2. 2. 1. Формирование выборки для изучения распространенности маркеров сенсибилизации
- 2. 2. 2. Формирование выборки для исследования концентрации выдыхаемого оксида азота в популяции здоровых и детей, имеющих аллергические заболевания
2.2.3 Формирование выборки для исследования содержания ИЛ-4, полиморфизмов гена IL-4 (С589Т, G/C 3 'UTR) и его рецептора IL4RA (Q551R и 150V) в популяции здоровых и детей, имеющих аллергические заболевания у детей города и сельской местности
2.2.4 Стандартные процедуры клинического этапа.
2.3 Статистическая обработка данных.
Глава 3. Распространенность аллергических болезней в популяции школьников г. Томска и Томской области по результатам, полученным с помощью вопросника ISAAC.
3.1 Распространенность АД по результатам, полученным с использованием вопросника ISAAC.
3.1.1 Распространенность симптомов атопического дерматита у школьников города.
3.1.2 Распространенность симптомов АД у школьников сельской местности Томской области.
3.1.3 Распространенность атопического дерматита в городе и в сельской местности.
3.2 Распрострненность симптомов бронхиальной астмы.
3.2.1 Распространенность симптомов бронхиальной астмы у всех обследованных детей.
3.2.2 Распространенность симптомов бронхиальной астмы у детей, проживающих в городе.
3.2.3 Распространенность симптомов бронхиальной астмы в сельских районах Томской области.
3.2.4 Распространенность симптомов бронхиальной астмы у школьников, проживающих в городской и сельской местности.
3.3 Распространенность симптомов аллергического ринита у всех обследованных школьников.
3.3.1 Распространенность симптомов аллергического ринита у школьников города Томска.
3.3.2 Распространенность симптомов аллергического ринита в сельской местности Томской области.
3.3.3 Распространенность симптомов аллергического ринита у школьников, проживающих в городской и сельской местности.
3.3.4 Распространенность симптомов сезонного и круглогодичного аллергического ринита.
Глава 4. Распространенность сенсибилизации в популяции школьников г. Томска и Томской области.
4.1 Результаты аллерготестирования школьников Томска (города) и Томской области (сельской местности).
4.2 Распространенность сенсибилизации, выявляемой методом кожных аллергопроб, у детей с симптомами аллергических болезней.
4.2.1. Распространенность сенсибилизации у детей с симптомами бронхиальной астмы.
4.2.2 Распространенность сенсибилизации у детей с симптомами аллергического ринита.
4.2.3 Распространенность сенсибилизации у детей с симптомами аллергического риноконъюнктивита.
4.2.4 Распространенность сенсибилизации у детей с симптомами атопического дерматита.
4.2.5 Распространенность сенсибилизации при различных симптомах аллергических заболеваний.
4.3 Распространенность сенсибилизации, выявляемой методом определения IgE (общего и специфического).
4.3.1 Распространенность IgE общего у детей.
4.3.2 Распространенность IgE специфического у детей.
4.3.3 РаспространенностьЕб у детей с симптомами бронхиальной астмы.
4.3.4 РаспространенностьЕб у детей с симптомами аллергического ринита.
4.3.5 РаспространенностьЕб у детей с симптомами аллергического риноконъюнктивита.
4.3.6 РаспространенностьЕб у детей с симптомами атопического дерматита.
4.3.7 Распространенность маркеров сенсибилизации у детей с симптомами аллергических болезней в городе и сельской местности.
Глава 5. Уровень оксида азота в выдыхаемом воздухе в популяционном исследовании распространенности аллергических болезней у детей школьного возраста.
5.1 Анкетный опрос и формирование выборки для статистического исследования
5.2 Чувствительность и специфичность.
Глава 6. Сравнительный анализ факторов риска формирования аллергических болезней при реализации гигиенической гипотезы
6.1 Характеристика популяции.
6.2 Анализ уровня ИЛ-4 у детей с аллергическими болезнями в городе и сельской местности.
6.3 Ассоциация полиморфизмов гена ІЬ4(С589Т, в/С З ТІТЯ) и его рецептора 1Ь4КА (С>551Ы и 150У) с аллергическими болезнями и их патогенетическими признаками у детей города и сельской местности
Глава 7. Обсуждение.
ВЫВОДЫ.
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