Патоморфология хронических сочетанных вирусных гепатитов у детей
Научно-практнческая значимость. Результаты работы направлены на изменение подходов врачей-гепатологов к оценке прогноза сочетанных вирусных гепатитов у детей, к диагностике и лечению этой патологии, призваны повысить внимание к тяжелым осложнениям и прогнозу в целом при переходе пациентов во «взрослую» медицину. Охарактеризованы морфологические особенности вирусных гепатитов у детей, диагностика… Читать ещё >
Содержание
- Список сокращений
- Введение.,
- Глава 1. Обзор литературы
- 1. 1. Современные представления о патогенезе и патоморфологии вирусных гепатитов и их особенностях в детском возрасте
- 1. 2. Вирусные гепатиты и героиновая наркомания
- 1. 3. Фиброз печени.'. ¦
- 1. 4. Оценка скорости фиброзирования печени. Факторы, влияющие на скорость фиброзирования у человека
- 1. 5. Лекарственный патоморфоз вирусных гепатитов
- Глава2. Материалы и методы исследования
- Глава 3. Результаты собственных исследований и их обсуждение
- 3. 1. Сравнительная характеристика хронических гепатитов у детей без противовирусного лечения).&bdquo-.79″
- 3. 1. 1. Морфологические проявления вирусных гепатитов у детей.'
- 3. 1. 2. Сравнительная характеристика моногепатитов и сочетанных гепатитов у детей
- 3. 1. 3. Морфологическая активность гепатитов у детей
- 3. 1. 4. Корреляции между перипортальными и лобулярными некрозами гепатоцитов и другими параметрами активности гепатита
- 3. 1. 5. Зависимость морфологической активности гепатитов от репликативного статуса."
- 3. 1. 6. Репликативный статус детей с ХГВС в сравнении с ХГВ и хгс.-.Л
- 3. 1. 7. Динамика репликативного статуса ХГВС при увеличении продолжительности инфекции
- 3. 1. 8. Дельта-гепатит у детей. Л
- 3. 1. 9. Особенности вирусного гепатита с аутоиммунным компонентом у детей
- 3. 1. 10. Взаимосвязь уровня АЛТ и параметров гистологической активности при вирусных гепатитах у детей
- 3. 1. 11. Сравнительная характеристика различных систем полуколичественной оценки тяжести гепатита и стадии фиброза
- 3. 1. Сравнительная характеристика хронических гепатитов у детей без противовирусного лечения).&bdquo-.79″
- 3. 2. Спонтанный и индуцированный интерфероном патоморфоз вирусных гепатитов у детей
- 3. 3. Влияние героиновой наркомании на морфологию печени детей с хроническими вирусными гепатитами
3.4 Связь иммунологических параметров и морфологической активности у детей с гепатитами.:. 3.4.1 Фактор некроза опухолей-альфа и фиброзирование печени у детей с хроническими вирусными гепатитами В, С и В+С при лечении интерфероном-альфа.
Обсуждение.'.
3.4.2 Взаимосвязь иммунного статуса с параметрами морфологической активности у детей с хроническими вирусными гепатитами.1.
Обсуждение.
Основные положения и
выводы раздела 3.4.
3.5. Фиброз печени при вирусных гепатитах у детей.
3.5.1 Морфогенез фиброза печени у детей.
3.5.2 Полуколичественная оценка фиброза.
3.5.3 Скорость прогрессии фиброза.
3.5.4 Факторы риска фиброза.-.
3.5.5 Оценка накопленной вероятности фиброза.
3.5.6 Группы больных по скорости фиброзирования. 3.5.7 Проспективный анализ.
Обсуждение.:.
Основные положения и
выводы раздела 3.5.
3.6. Экспериментальный фиброз печени и его связь с иммунным статусом у животных разных возрастных групп.
3.6.1 Уровень фиброзирования печени и иммунный статус мышей разного возраста после воздействия героина и длительного периода абстиненции.
3.6.2 Влияние интерферона-альфа на ССЦ-индуцированный фиброз печени и иммунный статус у мышей разного возраста.
Обсуждение.
Основные положения и
выводы раздела 3.6.
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