Гибель лимфоидных клеток при воздействии окислительного стресса и генотоксических агентов
Диссертация
Основные закономерности клеточной гибели в результате развития окислительного стресса до настоящего времени изучены явно недостаточно, хотя они представляют большой интерес для самых различных специалистов в области молекулярной и клеточной биологии, биохимии, биофизики, медицины, так как составляют фундамент для понимания различных физиологических и патологических процессов, протекающих… Читать ещё >
Содержание
- Гл. 1. Обзор литературы И
- 1. 1. Основные механизмы гибели клеток под действием различных химических и физических факторов
- 1. 2. Активные формы кислорода и их роль в развитии апоптоза
- 1. 3. Особенности клеточной гибели лимфоидных клеток
- 1. 4. Методы регистрации клеточной гибели 34 Гл. 2. Материалы и методы 40 Гл. 3. Результаты и обсуждение
- 3. 1. ДНК-кометы как маркер клеточной гибели
- 3. 2. Гибель мышиных лимфобластных клеток Р388 под действием окислительного стресса, вызываемого менадионом
- 3. 3. Гибель мышиных лимфобластных клеток Р388 под действием оксида азота, индуцируемого нитропруссидом натрия
- 3. 4. Гибель мышиных лимфобластных клеток Р388 под действием фото динамической терапии
- 3. 5. Механизмы радиационной гибели лимфоцитов периферической крови человека
- 3. 6. Клеточная гибель лимфоцитов периферической крови человека под действием этопозида
Список литературы
- Программированная клеточная гибель / Под ред. проф. B.C. Новикова. СПб., Наука, 1996, 276 стр.
- Buttke Т., Sandstrom P. Oxidative stress as a mediator of apoptosis // Immunol. Today, 1994, 15 (1), 7−10.
- Линг Н.Г. Стимуляция лимфоцитов / M., Медицина, 1971, 288 стр.
- Cell death in biology and pathology / Eds I.D.Bowen, R.A.Lockshin. London, 1981.
- Majno G., Joris I. Apoptosis, oncosis and necrosis. An overview of cell death //Amer. J. Pathol., 1995, 146 (1), 3−15.
- Уманский С.P. Апоптоз: молекулярные и клеточные механизмы // Молекулярная биология, 1996, 30 (3), 487−502.
- Kuerbitz S.J., Plunkett B.S., Walsh W.V., Kastan M.B. Wild-type p53 is a cell cycle check point determinant following irradiation // Proc. Nat. Acad. Sci. USA, 1992, 89 (16), 7491−7495.
- Zhen W., Denault C.M., Loviscek K., GengL., Vaughan A.T. The relative radiosensitivity of TK-6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status // Mutat. Res., 1995, 346 (2), 85−92.
- Henderson S., Huen D., Rowe M., Dawson C., Johnson G., Rickinson A. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human В cells from programmed cell death // Proc. Nat. Acad. Sci. USA, 1993, 90 (18), 8479−8483.
- Kozopas K.M., Yang T., Buchan H.L., Zhou P., Craig R.W. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2 // Proc. Nat. Acad. Sci. USA, 1993, 90 (8), 3516−3520.
- Boise L.H., Gonzales-Garcia M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nunez G., Thompson C.B. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death // Cell, 1993, 74 (4), 597−608.
- Oltvay Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death //Cell, 1993, 74 (4), 609−619.
- Kiefer M.C., Brauer M.J., Powers V.C., Wu J.J., Umansky S.R., Tomei L.D., Barr P.J. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak // Nature, 1995, 374 (6524), 736−739.
- Zhivotovsky B. Caspases: their intracellular localization and translocation during apoptosis // Cell Death Differ., 1999, 6 (7), 644−651.
- Gaziev A.I., Kutsyi M.P. Gamma-irradiated DNA activates histone Hl-specific proteinase of rat liver nuclei // Int. J. Radiat. Biol., 1992, 61 (2), 169−174.
- Kutsyi M.P., Gaziev A. I Gamma-irradiation or hydrocortisone treatment of rats increases the proteinase activity associated with histones of thymus nuclei // Radiat Res., 1994,140 (2), 221−229.
- Davie J.R. The nonhistone chromosomal protein, H2A-specific protease, is selectively associated with nucleosomes containing histone HI // J. Biol. Chem., 1986, 261 (22), 10 410−10 416.
- Weaver V.M., Carson C.E., Walker P.R., Chaly N., Lach B., Raymond Y., Brown D.L., Sikorska M. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes // J. Cell Sci., 1996, 109 (1), 45−56.
- Збарский И.Б. Организация клеточного ядра / М., Наука, 1988, 368 стр.
- Filipski J., Leblane J., Youndale Т., Sikorska M., Walker P.R. Periodicity of DNA folding in higher order chromatin // EMBO J., 1990, 9 (4), 13 191 327.
- Amin C., Wagner A.G., Hay N. Sequence specific transcriptional activation by Мус and repression by Max // Mol. Cell. Biol., 1993, 13 (1), 383−390.
- Kokileva L. Multistep chromatin degradation in apoptosis: DNA breakdown in apoptosis // Intern. Arch. Allergy Immunol., 1994,105 (4), 339−343.
- Iovcheva C., Mladenova I., Dessev G. Removal of histone HI exposes linker DNA in chromatin to DNAse I // Mol. Biol. Rep., 1984, 10 (1), 9−12.
- Газиев А.И., Куцый М. П. Протеиназа, специфичная к гистону HI, ассоциирована с ядерным матриксом и активируется ДНК, содержащей разрывы или денатурированные участки. Докл. АН СССР, 1988, 299 (1), 240−242.
- Нага S., Halicka H.D., Bruno S., Gong J., Traganos F., Darzynkiewicz Z. Effect of protease inhibitors on early events of apoptosis // Exp. Cell Res., 1996, 223 (2), 372−384.
- Szumiel I. Ionizing radiation-induced cell death // Int. J. Radiat. Biol., 1994, 66(4), 329−41.
- Gaido M.L., Cidlowsky J.A. Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B // J. Biol. Chem., 1991, 266(28), 18 580−18 585.
- Nikonova L.V., Nelipovich P.A., Umansky S.R. The involvement of nuclear nucleases in rat thymocyte DNA degradation after gamma-irradiation // Biochim. Biophys. Acta, 1982,699 (3), 281−289.
- Mannherz H.G., Peitsch M.C., Zanotti S., Paddenberg R., Polzar B. A new function for an old enzyme: the role of DNase I in apoptosis // Curr. Top. Microbiol. Immunol., 1995, 198,161−174.
- Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD // Nature, 1998,391 (6662), 43−50.
- Cohen G.M. Caspases: the executioners of apoptosis // Biochem J., 326 (1), 1−16.
- Nunez G., Benedict M.A., Hu Y., Inohara N. Caspases: the protease of the pathway // Oncogene, 1998, 17 (25), 3237−3245.
- Friesen C., Herr I., Krammer P.H., Debatin K.M. Involvement of the CD95 (APO-l/Fas) receptor/ligand system in drug-indused apoptosis in leukemia cells //Nat. Med., 1996,2 (5), 574−577.
- Thompson C.B. Apoptosis in the pathogenesis and treatment of disease // Science, 1995, 267 (5203), 1456−1462.
- Marchetti P., Susin S.A., Decaudin D., Garnen S., Castedo M., Hirsch T., Zamzami N., Naval J., Senik A., Kroemer G. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA // Cancer Res., 1996, 56 (9), 2033−2038.
- Zamzami N., Susin S.A., Marchetti P., Gomez-Monterrey I, CastedoM., Kroemer G. Mitochondrial control of nuclear apoptosis // J. Exp. Med., 1996, 183 (4), 1533−1544.
- Susin S.A., Zamzami N., Castedo M., Hirsch T., Marchetti P., Macho A., Daugas E., Geuskens M., Kroemer G. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease // J. Exp. Med., 184 (4), 1331−1341.
- ICroemer G., Zamzami N., Susin S.A. Mitochondrial control of apoptosis // Immunol. Today, 1997, 18, 44−52.
- Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones
- D.P., Wang X. Prevention of apoptosis by bcl-2: release of cytochrome C from mitochondria blocked // Science, 1997, 275 (5303), 1129−1132.
- Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome C from mitohondria: a primary site for bcl-2regulation of apoptosis // Science, 1997,275 (5303), 1132−1136.
- Nicholson D.W. Identification and inhibition of the ICE/CED-3protease necessary for mammalian apoptosis // Nature, 1995, 376 (6535), 37−43.
- Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans ced-4, participates in cytochrome C-dependent activation of caspase-3 // Cell, 1997,90 (3), 405−413.
- Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri
- E.S., Wang X. Cytochrome C and dATP-dependent formation of Apaf-l/caspase-9 complex initiates an apoptotic protease cascade // Cell, 1997, 91 (4), 479−489.
- Chinnaiyan A.M., CTRourke K., Lane B.R., Dixit V.M. Interaction of ced-4 with ced-3 ced-9: a molecular framework for cell death // Science, 1997, 275 (5303), 1122−1126.
- Wu D., Wallen H.D., Nunez G. Interaction and regulation of subcellular localization of ced-4 by ced-9 // Science, 1997, 275 (5303), 1126−1129.
- Leist M., Single В., Castoldi A.F., Kuhnle S., Nicotera P. Intracellular adenosine triphosphate (ATP) copncentration: a switch in the decision У between apoptosis and necrosis // J. Exp. Med., 1997, 185 (8), 1484−1486.
- Eguchi Y., Shimuzu S., Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis // Cancer Res., 1997, 57 (10), 18 351 840.
- Lieberthal W., Menza S.A., Levine J.S. Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells // Am. J. Physiol, 1998, 274 (2 Pt 2), F315-F327.
- Липская Л.А. Зависимая от ионов кальция и магния эндонуклеаза 37 кДа активируется при индуцированном колхицином апоптозе в клетках HL-60// Цитология, 1994, 36 (3), 303−309.
- Adebodun F. Role of intracellular free Ca and Zn in dexametazone-induced apoptosis and dexametazone resistance in human leukemic СЕМ cell lines // J. Cell. Physiol., 1995, 163 (1), 80−86.
- Franclin J.L. Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation // J. Neurosci., 1995,15 (2), 643−664.
- Takei N., Endo Y. Ca ionophore-induced apoptosis on cultured embryonic rat cortical neurons // Brain Res., 1994, 652 (1), 65−70.
- Zhivotovsky В., Cedervall В., Jiang S., Nicotera P. Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis //Biochem. Biophys. Res. Communs., 1994, 202 (1), 120−127.
- Болдырев A.A. Карнозин / M., Изд-во МГУ, 1998, 320 стр.
- Mello Filho A.C., Hoffmann M.E., Meneghini R. Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron // Biochem. J., 1984,218(1), 273−275.
- Lennon S.V., Martin S.J., Cotter T.G. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli // Cell Prolif, 1991, 24 (2), 203−214.
- Duvall E., Wyllie A.H., Morris R.G. // Macrophage recognition of cells undergoing programmed cell death (apoptosis) // Immunology, 1985, 56 (2), 351−358.
- Albina J.E., Cui S., Mateo R. B., Reichner J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages // J. Immunol., 1993, 150(11), 5080−5085.
- Benchekroun M.N., Pourquier P., Schott B., Robert J. Doxorubicin-induced lipid peroxidation and glutathioneperoxidase activity in tumor cell lines selected for resistance to doxorubicin // Eur. J. Biochem., 1993, 211 (1−2), 141−146.
- Wagner B.A., Buettner G.R., Burns C.P. Increased generation of lipid-derived and ascorbate free radicals by L1210 cells exposed to the ether lipid edelfosine//Cancer Res., 1993, 53 (4), 711−713.
- Muller I., Jenner A., Bruchelt G., Niethammer D., Halliwell B. Effect of concentration on the cytotoxic mechanism of doxorubicin-appoptosis and oxidative DNA damage // Biochem. Biophys. Res. Commun., 1977, 230 (2), 254−257.
- Zhong L.T., Sarafian T., Kane DJ., Charles A.C., Mah S.P., Edwards R.H., Bredesen D.E. Bcl-2 inhibits death of central neural cells induced by multiple agents //Proc. Nat Acad. Sci. USA, 1993,90 (10), 4533−4537.
- Brune В., Hartzell P., Nicotera P., Orrenius S. Spermine prevents endonuclease activation and apoptosis in thymocytes // Exp. Cell Res., 1991, 195 (2), 323−329.
- Galli G. Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by L-acetylcarnitine // Exp. Cell Res., 1993, 204 (1), 5460.
- Bray T.M., Bettger W.J. The physiological role of zinc as an antioxidant // Free Rad. Biol. Med., 1990, 8 (3), 281−291.
- Sandstrom P.A., Mannie M.D., Buttke T.M. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J. Leukocyte Biol., 1994, 55 (2), 221−226.
- Кулинский В.И. Активные формы кислорода и оксидативная модификация макромолекул: польза, вред и защита // Соросовский Образовательный Журнал, 1999, 1, 2−7.
- Saran М., Bors W. Radical reaction in vivo an overview // Radiat. Environ. Biophys., 1990, 29 (4), 249−262.
- Владимиров Ю.А., Арчаков А. И. Перекисное окисление липидов в биологических мембранах / М., Наука, 1972,208 стр.
- Schwartzman R.A., Cidlowki J.A. Apoptosis: the biochemistry and molecular biology of programmed cell death // Endocrine Rev., 1993, 14 (2), 133−151.
- Maltzman W., Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells // Mol. Cell. Biol., 1984, 4 (9), 1689−1694.
- Halliwell В., Gutteridge J.M.C. Role of free radicals and catalytic metal ions in human disease: an overview // Methods Enzymol., 1990,186, 1−85.
- Halliwell B. Drug antioxidant effects. A basis for drug selection? // Drugs, 1991,42(4), 569−605.
- Christ M., Luu B., Mejia J.E., Moosbrugger I., Bischoff P. Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes. // Immunology, 1993, 78 (3), 455−460.
- Sandstrom P.A., Tebbey P.W., Van Cleave S., Buttke T.M. Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency // J. Biol. Chem., 1994, 269 (2), 798−801.
- Larrick J.W., Wright S.C. Cytotoxic mechanism of tumor necrosis factor-alpha // FASEB J., 1990, 4(14), 3215−3223.
- Mattews N., Neale M., Jackson S.K., Stark J.M. Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism // Immunology, 1987, 62(1), 153−155.
- Chang D.J., Ringold G.M., Heller R.A. Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid // Biochem. Biophys. Res. Commun., 1992, 188 (2), 538−546.
- Renard D.C., Seitz M.B., Thomas A.P. Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes // Biochem J., 1992,284 (Pt 2), 507−512.
- Sandstrom P.A., Roberts B., Folks T.M., Buttke T.M. HIV gene expression enhances T cell susceptibility to hydrogen peroxide-induced apoptosis // AIDS Res.Hum. Retroviruses, 1993, 9(11), 1107−13.
- Akbar A.N. A possible role for bcl-2 in regulating T-cell memory- a 'balancing act' between cell death and survival // Immunol. Today, 1993, 14 (11), 526−532.
- Hockenbery D.M., Oltvay Z.N., Milliman C.L., Kotmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis // Cell, 1993, 75 (2), 241−251.
- Allsopp T.E. Wyatt S., Paterson H.F., Davies A.M. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis // Cell, 1993, 73 (2), 295−307.
- Sato N., Iwata S., Nahamura K., Hori T., Mori K., Yodoi J. Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutatione on T cell apoptosis // J. Immunol., 1995, 154 (7), 3194−3203.
- Mayer H., Noble M. N-Acetyl-L-cysteine is a pluropotent protector against cell death and enhancer of trophic factor mediated cell survival in vitro // Proc. Nat. Acad. Sci. USA, 1994, 91 (16), 7496−7500.
- Ferrari G., Yan C.Y., Green L.A. N-Acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells // J. Neurosci., 1995, 15 (4), 2857−2866.
- Troy C.M., Shelanski M.L. Down-regulation of cooper/zink superoxide dismutase causes apoptotic death in PC 12 neuronal cells // Proc. Nat. Acad. Sci. USA, 1994, 91 (14), 6384−6387.
- Greenlund L.J., Deckwerth T.L., Johnson T.V. Jr. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death//Neuron, 1995,14 (2), 303−315.
- Nathan C. Nitric oxide as a secretory product of mammalian cells // FASEB J., 1992,6(12), 3051−3064.
- Mayer В., Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells // Trends Biochem. Sci., 1997, 22 (12), 477−481.
- Knowles R.G., Moncada S. Nitric oxide synthases in mammals // Biochem. J., 1994, 298 (Pt2), 249−258.
- Nathan C., Xie Q.-W. Regulation of biosynthesis of nitric oxide // J. Biol. Chem., 1994, 269 (19), 13 725−13 728.
- Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology // Pharmacol Rev., 1991, 43 (2), 109 142.
- Gross S.S., Wolin M.S. Nitric oxide: pathophysiological mechanisms // Annu. Rev. Physiol., 1995, 57, 737−769.
- Xie Q.-W., Nathan C. The high-output nitric oxide path-way: role and regulation // J. Leukocyte Biol., 1994, 56 (5), 576−582.
- Kronke K.-D., Fehsel K., Kolb-Bachofen V. Nitric oxide: cytotoxicity versus cytoprotection, how, why, when and where? // Nitric Oxide, 1997, 1 (2), 107−120.
- Murphy M.E., Noack E. Nitric oxide assay using hemoglobin method // Methods Enzymol., 1994, 233,240−250.
- Ванин А.Ф. К вопросу о стабильности динитрозильного комплекса железа с цистеином как кандидата на роль эндотелиального фактора релаксации кровеносных сосудов // Биохимия, 1995, 60 (2), 308−314.
- Boese М., Mordvintcev P.I., Vanin A.F., Busse R., Mulsch A. S-nitrosation of serum albumin by dinitrosyl-iron complex // J. Biol. Chem., 1995, 270 (49), 29 244−29 249.
- Stamler J.S. Redox signalling: nitrosylation and related target interactions of nitric oxide // Cell, 1994, 78 (6), 931−936.
- Schmidt H.H.H.W., Walter U. NO at work // Cell, 1994, 78 (6), 919- 925.
- Kerwin J.F., Lancaster J.R., Feldman P.L. Nitric oxide: a new paradigm for second messengers // J. Med. Chem., 1995, 38 (22), 4343−4362.
- Butler A.R., Flitney F.W., Williams D.L.H. NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron nitrosyls inbiology: a chemist’s perspective//TrendsPharmacol. Sci., 1995, 16(1), 18−22.
- Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad and the ugly // Am. J. Physiol., 1996, 271 (5Ptl), CI424-C1437.
- Hausladen A., Fridovich I. Superoxide and peroxynitrite inactivate aconitases, nitric oxide does not // J. Biol. Chem., 1994, 269 (47), 2 940 529 408.
- Jia L., Bonaventura C., Bonaventura J., Stamler J.S. S-Nitrosohaemoglobin: a dynamic activity of blood involved invascular control//Nature, 1996, 380 (6571), 221−226.
- Stamler J.S., Jaraki O., Osborne J., Simon D.J., Keaney J., Vita J., Singel D. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin // Proc. Natl. Acad. Sci. USA, 1992, 89 (16), 76 747 677.
- Wink D.A., Miranda K.M., Espey M.G. Effects of oxidative and nitrosative stress in cytotoxity // Semin. Perinatol., 2000, 24 (1), 20−23.
- Liu X., Gillespie J.S., Martin W. Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols // Br. J. Pharmacol., 1994, 111 (4), 1287−1295.
- Stamler J.S., Singel D.J., Loscalzo J. Biochemistry of nitric oxide and its redox activated forms // Science, 1992, 258 (5090), 1898−1902.
- Stamler J.S., Hausladen A. Oxidative modifications in nitrosative stress // Nature Struct. Biol., 1998, 5 (4), 247−249.
- Meyer M., Schreck R., Baeuerle P.A. H202 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor // EMBO J., 1993, 12 (5), 20 052 015.
- Tabuchi A., Sano K., Oh E., Tsuchiya T., Tsuda M. Modulation of AP-1 activity by nitric oxide in vitro // FEBS Lett., 1994, 351 (1), 123−127.
- Lander H.M., Sehajpal P.K., Novogrodsyk A. Nitric oxide signalling: a possible role for G-proteins // J. Immunol, 1993,151 (12), 7182−7187.
- Fukuto J.M., Wink D.A. Nitric oxide (NO): formation and biological roles in mammalian systems // Met. Ions Biol. Syst., 1999, 36, 547−595.
- Lander H.M., Ogiste J.S., Pearce S.F., Levi R., Novogrodsky A. Nitric oxide signalling: a possible role for G-proteins // J. Biol. Chem., 1995, 270 (13), 7017−7020.
- Gopalakrishna R., Chen Z.H., Gundimeda U. Nitric oxide and nitric oxide generating agents induce a reversible inactivation of protein kinase C // J. Biol. Chem., 1993, 268 (36), 27 180−27 185.
- Murphy M.P., Paker M.A., Scarlett J.L., Martin S.W. Peroxynitrite: a biologically significant oxidant // Gen. Pharmacol., 1998, 31 (2), 179−186.
- Maria S.S., Lee J., Groves J.T. Peroxynitrite rapidly permeates phospholipid bilayers // Proc. Natl. Acad. Sci. USA, 1997, 94 (26), 1 424 314 248.
- Liu X., Miller M.J.S., Joshi M.S., Thomas D.D., Lancaster J.R. Jr. Accelerated reaction of nitric oxide with oxygen within the hydrophobic interior of biological membranes // Proc. Natl. Acad. Sci. USA, 1998, 95 (5), 2175−2179.
- Wink D.A., Mitchell J.B. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytopropective mechanisms of nitric oxide //Free Radic. Biol. Med., 1998, 25 (4−5), 434−456.
- Ioannidis I., de Groot H. Cytotoxicity of nitric oxide in FU5 hepatoma cells: evidence for cooperative action with hydrogen peroxide // Biochem. J., 1993, 296 (Pt2), 341−345.
- Wolosker H., Panizzutti R., Engelender S. Inhibition of creatine kinase by S-nitrosoglutathione // FEBS Lett., 1996, 392 (3), 274−276.
- Konorev E.A., Kalyanaraman B. Rapid and irreversible inhibition of creatine kinase by peroxynitrite // FEBS Lett., 1998, 427 (2), 171−174.
- Brown G.C., Cooper C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase // FEBS Lett., 1994,356 (2−3), 295−298.
- Richter C., Gogvadze V., Schlapbach R., Schweizer M., Schlegel J. Nitric oxide kills hepatocytes by mobilizing mitochondrial calcium // Biochem. Biophys. Res. Commun., 1994, 205 (2), 1143−1150.
- Schweizer M., Richter C. Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension // Biochem. Biophys. Res. Commun., 1994, 204(1), 169−175.
- Cleeter M.W.J., Cooper J.M., Darley-Usmar V.M., Moncada S., Schapira A.H.V. Reversible inhibition of cytochromec oxidase, the terminal enzyme of mitochondrial respiratorychain, by nitric oxide // FEBS Lett., 1994, 345 (1), 50−54.
- Brown G.C. Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase // FEBS Lett., 1995, 369 (2−3), 136−139.
- Packer M.A., Porteous C.M., Murphy M.P. Mitochondrial superoxide production in the presence of nitric oxide leads to the formation of peroxynitrite // Biochem. Mol. Biol. Int., 1996, 40 (3), 527−534.
- MacMillan-Crow L.A., Crow J.P., Kerby J.D., Beckman J.S., Thompson J.A. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts // Proc. Natl. Acad. Sei. USA, 1996, 93 (21), 11 853−11 858.
- Packer M.A., Scarlett J.L., Martin S.W., Murphy M.P. Induction of the mitochondrial permeability transition by peroxynitrite // Biochem. Soc. Trans., 1997, 25 (3), 831−836.
- Hausladen A., Fridovich I. Superoxide and peroxynitriteinactivate aconitases, nitric oxide does not // J. Biol. Chem., 1994, 269 (47), 2 940 529 408.
- Lizasoain I., Moro M.A., Knowles R.G., Darley-Usmar V., Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose // Biochem. J., 1996, 314 (Pt3), 877−880.
- Cassina A., Radi R. Differential inhibitory action of nitricoxide and peroxynitrite on mitochondrial electron transport // Arch. Biochem. Biophys., 1996, 328 (2), 309−316.
- Radi R., Rodriguez M., Castro L., Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite // Arch. Biochem. Biophys., 1994, 308 (1), 89−95.
- Rubbo H., Denicola A., Radi R. Peroxynitrite inactivatesthiol-containing Trypanosoma cruzi energetic metabolismand inhibits cell respiration // Arch. Biochem. Biophys., 1994, 308 (1), 96−102.
- Szabo C., Salzman A.L. Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages //Biochem. Biophys. Res. Commun., 1995,209 (2), 739−743.
- Gunter T.E., Gunter K.K., Sheu S.-S., Gavin C.E. Mitochondrial calcium transport: physiology and pathological relevance // Am. J. Physiol., 1994, 267 (2Ptl), C313-C339.
- Nicotera P., Ankarcrona M., Bonfoco E., Orrenius S., Lipton S.A. Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress // Adv. Neurol., 1997, 72, 95−101.
- Nicotera P., Orrenius S. Ca2+ and cell death // Ann. NY Acad. Sci., 1992, 648, 17−27.
- Ichas F., Jouaville L.S., Mazat J.-P. Mitochondria are excitable organnelles capable of generating and conveying electrical and calcium signals // Cell, 1997,89(7), 1145−1153.
- Salgo M.G., Stone K., Squadrito G.L., Battista J.R., Pryor W.A. Peroxynitrite causes apoptosis in rat thymocytes // Biochem. Biophys. Res. Commun, 1995, 210 (3), 1025−1030.
- Lautier D., Lagueux J., Thibodeau J., Menard L., Poirier G.G. Molecular and biochemical features of poly (ADP- ribose) metabolism // Mol. Cell. Biochem., 1993,122 (2), 171−193.
- Zhang J., Dawson V.L., Dawson T.M., Snyder S.H. Nitric oxide activation of poly (ADP-ribose) synthase in neurotoxicity // Science, 1994, 263 (5147), 687−689.
- Levine A.J. p53, the cellular gatekeeper for growth and division // Cell, 1997, 88(3), 323−331.
- Hale A.J., Smith C.A., Sutherland L.C., Stoneman V.E.A., Longthorne V.L., Culhane A.C., Williams G.T. Apoptosis: molecular regulation of cell death // Eur. J. Biochem., 1996, 236 (1), 1 -26.
- Leist M., Nicotera P. The shape of cell death // Biochem. Biophys. Res. Commun, 1997,236 (1), 1−9.
- Albina J. E, Cui S, Mateo R. B, Reichner J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol, 1993, 150 (11), 5080−5085.
- Messmer U.K., Lapetina E.G., Brune B. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds // Mol. Pharmacol., 1995, 47 (4), 757−765.
- Kaneto H., Fujii J., Seo H.G., Suzuki K., Matsuoka T., Nakamura M., Tatsumi H., Yamasaki Y., Kamada T., Taniguchi N. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells // Diabetes, 1995, 44 (7), 733−738.
- Ankarcrona M., Dypbukt J.M., Brune B., Nicotera P. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5 °F cells//Exp. Cell Res., 1994, 213 (1), 172−177.
- Fehsel K., Kroncke K.-D., Meyer K.L., Huber H., Wahn V., Kolb-Bachofen V. // J. Immunol., 1995,155 (6), 2858−2865.
- Sandau K., Brune B. The dual role of S-nitroglutathione (GSNO) during apoptosis // Cell. Signal., 1996, 8 (3), 173−177.
- Blanco F.J., Ochs R.L., Schwarz H., Lotz M. Chondrocyte apoptosis induced by nitric oxide // Am. J. Pathol., 1995,146 (1), 75−85.
- Muhl H., Nitsch D., Sandau K., Brune B., Varga Z., Pfeilschifter J. Apoptosis is triggered by the cyclic AMP signaling pathway in renal mesangial cells // FEBS Lett., 1996, 382 (3), 271−275.
- Messmer U.K., Ankarcrona M., Nicotera P., Brune B. p53 expression in nitric oxide-induced apoptosis // FEBS Lett., 1994, 355 (1), 23−26.
- Messmer U.K., Reimer D.M., Reed J., Brune B. Nitric oxide induced poly (ADP-ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl-2 // FEBS Lett., 1996, 384 (2), 162−166.
- Beauvais F., Michel L., Dubertret L. The nitric oxide donors, acide and hidroxylamine, inhibit the programmed cell death of cytokine-deprived human eosinophils //FEBS Lett., 1995, 361 (2−3), 229−232.
- Liepe В.A., Stone С., Koistinaho J., Copenhagen D.R. Nitric oxide synthase in Muller cells and neurons of salamander and fish retina // J. Neurosci., 1994,14 (12), 7641−7654.
- Terenzi F., Diaz-Guerra M.S., Casado M. et al. Bacterial lipopeptides induced nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages // J. Biol. Chem., 1995, 270 (11), 6017−6021.
- Kim Y.-M., Bergonia H., Lancaster J.R. Jr. Nitric oxide-induced autoprotection in isolated rat hepatocytes // FEBS Lett., 1995, 374 (2), 228 232.
- Kim Y.-M., deVera M.E., Watkins S.C., Billiar T.R. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-a-induced apoptosis by inducing heat shock protein 70 expression // J. Biol. Chem., 1997, 272 (2), 1402−1411.
- Bellmann K., Jaattela M., Wissing D., Burkart V., Kolb H. Heat shock protein Hsp70 overexpression confers resistance against nitric oxide // FEBS Lett., 1996,391 (1−2), 185−188.
- Хэм А., Кормак Д. Гистология / M., изд. «Мир», 1983, т.2, гл. 13, «Лимфоидная ткань», стр. 191−252.
- Lewin В. Genes / Oxford, NY, Tokyo- Oxford University Press, 1997, 1260 pp.
- Сунгуров А.Ю. Радиобиология клеточной поверхности / М., изд. ВИНИТИ, 1988, 180 стр.
- Методы исследований в иммунологии / Лефковитс И., Пернис Б. (ред.), М., изд. «Мир», 1981, 488 стр.
- Пальцев М.А., Иванов А. А. Межклеточные взаимодействия / М., Медицина, 1995,224 стр.
- Lu L., Lejtenyi D., Osmond D.G. Regulation of cell survival during B lympophopoiesis: suppressed apoptosis of pro-B cells in p53-deficient mouse bone marrow // Eur. J. Immunology, 1999, 29 (8), 2484−2490.
- Haks M.C. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells // Immunity, 1999,11(1), 91−101.
- Ling Y.H., el-Naggar A.K., Priebe W., Perez-Soler R. Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells // Mol. Pharmacology, 1996, 49 (5), 832−841.
- Hong M., Lai M.D., Lin Y.S., Lai M.Z. Antagonism of p53-dependent apoptosis by mitogen signals // Cancer Res., 1999, 59 (12), 2847−2852.
- Cherbonnel-Lasserre C., Dosanjh M.K. Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage // Biochimie, 1997, 79 (9−10), 613−617.
- Matter A. Microcinematographic and electron micrographic analysis of target cell lysis induced by cytotoxic T-lymphocytes // Immunology, 1979, 36 (2), 179−190.
- Russel S.W., Rosenau W., Lee J.C. Cytolysis induced by human lymphotoxin. Carcinographic and electron microscopic observation // Amer. J. Pathol., 1972, 69 (1), 103−118.
- Bursch W.C., Paff B., Putz G., Schulte-Hermann R. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats // Carcinogenesis, 1990,11 (5), 847−853.
- Akagi Y., Ito K., Sawada S. Radiation-induced apoptosis and necrosis in MOLT-4 cells: a study of dose-response relationships and their modification // Int. J. Radiat. Biol., 1993, 64 (1), 47−56.
- Sun A.-M., Cohen G.M. Mg+2-dependent cleavage of DNA into kilobase pair fragmentsis reasonable for the initial degradation of DNA in apoptosis // J. Biol. Chem., 1994, 269 (21), 14 857−14 860.
- Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry // Cytometry, 1992, 13 (8), 795−808.
- Dive C., Gregory C.D., Phipps D.J., Evans D.L., Milner A.E., Wyllie A.H. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry // Biochim. Biophys. Acta, 1992, 1133 (3), 275−285.
- Swat W., Ignatowicz L., Kisielow P. Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry // J. Immunol. Methods, 1991, 137 (1), 79−87.
- Hara S., Halicka H.D., Bruno S., Gong J., Traganos F., Darzynkiewicz Z. Effects of protease inhibitors on early events of apoptosis // Exp. Cell Res., 1996, 223 (2), 372−384.
- Fairbairn D.W., Olive P.L., O’Neill K.L. The comet assay: a comprehensive review // Mutation Res., 1995, 339 (1), 37−51.
- Тронов В.А., Пелевина И. И. Метод ДНК-комет для индивидуальных клеток. Обоснование и применение метода // Цитология, 1996, 38 (4−5), 427−439.
- Ostling O., Johanson K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells // Biochem. Biophys. Res. Commun., 1984, 123 (1), 291−298.
- Singh N.P., Stephens R.E. Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching//Mutation Res., 1997, 383 (2), 167 175.
- Olive P.L., Banath J.P. Induction and rejoining of radiation-induced DNA single-strand breaks: «tail moment» as a function of position in the cell cycle // Mutation Res., 1993,294 (3), 275−283.
- Olive P.L., Wlodek D., Durand R.E., Banath J.P. Factors influencing DNA migration from individual cells subjected to gel electrophoresis // Exp. Cell Res., 1992, 198 (2), 259−67.
- Ostling O., Johanson K.J., Blomquist E., Hagelquist E. DNA damage in clinical radiation therapy studied by microelectrophoresis in single tumor cells // Acta Oncologics 1987,26 (1), 45−48.
- Carson D.A., Ribeiro J. Apoptosis and desease // Lancet, 1993, 341 (8855), 1251−1254.
- Eastman A. Apoptosis: a product of programmed and unprogrammed cell death//Toxicol. Appl. Pharmacol., 1993,121 (1), 160−164.
- Humphrey C.D., Pittman F.E. A simple methylene blue azure II — basic fuchsin stain for epoxy embedded tissue sections // Stain Technol., 1974, 49 (1), 9−14.
- Kerr J.F.R, Winterford C.M., Harmon B.V. Apoptosis: its significance in cancer and cancer therapy // Cancer, 1994, 73 (8), 2013−2026.
- McConkey D. J, Zhivotovsky B, Orrenius S. Apoptosis molecular mechanisms and biomedical implications // Molec. Aspects Med, 1996, 171., i-iio.
- Ormerod M.G. Apoptosis, flow cytometric studies // Microsc. & Anal, 1993, 22 (1), 27−29.
- Sarraf C. E, Bowen I.D. Kinetic studies on a murine sarcoma and analysis of apoptosis // Br. J. Cancer, 1986, 54 (6), 989−998.
- Schwartz L. M, Osborne B.A. Programmed cell death, apoptosis and killer genes //Immunol. Today, 1993,14 (12), 582−590.
- Willie A.H. Cell death // Int. Rev. Cytol, 1987, 17, 755−785.
- Willie A.H. Apoptosis //Atlas of Sci.: Immunol, 1988, 1 (3−4), 192−196.
- Hermann M, Lorenz H.-M, Voll R, Grunke M, Woith W, Kalden J.R. A rapid and simple method for isolation of apoptotic DNA fragments // Nucl. Acids Res, 1994, 22, 5506−5507.
- Olive P. L, Wlodek D, Banath J.P. DNA double-strand breaks measured in individual cell subjected to gel electrophoresis // Cancer Res, 1991, 51, 4671−4676.
- Урбах В.JI. Биометрические методы / М, Наука, 1964, 416 стр.
- Elmen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus // J. Immunol, 1994, 152 (7), 3685−3692.
- Лисицына T. A, Тронов B. A, Коноплянников M. A, Дурнев А. Д, Иванова M.M. Исследование поврежденности ДНК мононуклеарных клеток крови больных системной красной волчанкой методом ДНК-комет // Бюлл. Эксп. Биол. и Мед, 1998, 125 (1), 75−78.
- Halliwell B.H., Gutteridge J.M.C. Free Radicals in Biology and Medicine / Oxford University Press, Oxford, 1989.
- Sun Y.L., Zhao Y., Hong X., Zhai Z.H. Cytochrome C release and caspase activation during menadione-induced apoptosis in plants // FEBS Lett., 1999, 462(3), 317−321.
- Castilho R.F., Ward M.W., Nicholls D.G. Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells//J. Neurochem., 1999, 72 (4), 1394−1401.
- Parekh H., Chavan S., Chitnis M. Modulation of thiol pools by vitamin K3 and its effect on survival of sensitive and resistant murine tumor cells // Anticancer Drugs, 1991, 2 (2), 159−168.
- Ross D., Thor H., Threadgill M.D., Sandy M.S., Smith M.T., Moldeus P., Orrenius S. The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes // Arch. Biochem. Biophys., 1986, 248 (2), 460−466.
- Caricchio R., Kovalenko D., Kaufmann W.K., Cohen P.L. Apoptosis provoked by the oxidative stress inducer menadione (Vitamin K (3)) is mediated by the Fas/Fas ligand system // Clin. Immunol., 1999, 93 (1), 65−74.
- Franke W. Molecular biological methods motors of progress in cancer research / In: «Deusches Krebsforschungszentrum. Current cancer research, 1986», Springer, NY, 1986, pp. 26−28.
- Takeda Y., Tashima M., Takahashi A., Uchiyama T., Okazaki T. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3 // J. Biol. Chem., 1999, 274(15), 10 654−10 660.
- Wang H., Keiser J.A. Molecular characterization of rabbit CPP32 and its function in vascular smooth muscle cell apoptosis // Am. J. Physiol., 1998, 274 (4 Pt 2), HI 132−1140.
- Vincent A.M., Maiese K. Nitric oxide induction of neuronal endonuclease activity in programmed cell death // Exp. Cell Res., 1999, 246 (2), 290−300.
- Agarwal M.L., Clay M.E., Harvey E.J., Evans H.H., Antunez A.R., Oleinick N.L. Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouselymphoma cells // Cancer Res., 1991, 51 (21), 5993−5996.
- He X.-Y., Sikes R., Thomsen S., Chung L.W.K. and Jacques S.L. Photodynamictherapy with photofrin II induces programmed cell death in carcinoma cell lines // Photochem. Photobiol., 1994, 59 (4), 468−473.
- Luo Y., Chang C.K. and Kessel D. Rapid initiation of apoptosis by Western blots for cytochrome с and photodynamic therapy // Photochem. Photobiol., 1996, 63 (4), 528−534.
- Granville D.J., Levy J.G. and Hunt D.W.C. Photodynamic therapy induces caspase-3 activation in HL-60 cells // Cell Death Differ., 1997, 4, 623−628.
- He J., Whitacre C.M., Xue L.Y., Berger N.A., Oleinick N.L. Proteaseactivation and cleavage of poly (ADP-ribose) polymerase: an integral part of apoptosis response to photodynamic therapy // Cancer Res., 1998, 58 (5), 940−946.
- Luo Y., Kessel D. Initiation of apoptosis vs. necrosis by photodynamictherapy with chloroaluminum phthalocyanine // Photochem. Photobiol., 1997, 66 (4), 479−483.
- Kessel D., Luo Y. Mitochondrial photodamage and PDT-induced apoptosis // J. Photochem. Photobiol., B: Biology, 1998,42 (1), 89−95.
- Тронов В.А., Гринько E.B., Кончаловский M.B., Данилова Н. Б., Терещенко Д. Г., Филиппович И. В. Остаточные повреждения ДНК впериферических лимфоцитах после тотального облучения человека // Медицинская радиология. 1993, 39 (2), 38−41.
- Payne С.М., Bjore C.G., Scultz D.A. Change of the frequency of apoptosis after low- and high-dose X-irradiation of human lymphocytes // J. Leukoc. Biol., 1992, 52 (4), 433−440.
- Johnstone A.P. Rejoining of DNA strand breaks is an early nuclear event during the stimulation of quiescent lymphocytes // Eur. J. Biochem., 1984, 140, 401−406.
- Walker P.R., Weaver V.M., Lach В., Leblanch J., Sikorska M. Endonucleas activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis // Exp. Cell Res., 1994, 213,100−106.
- Etoposide (VP-16), current status and new developments / Eds. Issel B.F., Muggia F.M., Carter S.K. Academic Press, New York, 1984, 346 pp.
- Fournel S., Genestier L., Rouault J.P., Lizard G., Flacher M., Assossou O., Revillard J.P. Apoptosis without decrease of cell DNA content // FEBS Lett., 1995,367(2), 188−192.
- Lagarkova M.A., Iarovaia O.V., Razin S.V. Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers // J. Biol. Chem., 1995, 270 (35), 20 239−20 241.
- Long B.H., Musial S.T., Brattain M.G. DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide // Cancer Res., 1986,46 (8), 3809−3816.
- Wang J.C. DNA topoisomerases // Annu. Rev. Biochem., 1985, 54, 665 697.
- Heck M.M., Earnshaw W.C. Topoisomerase II: A specific marker for cell proliferation // J. Cell Biol., 1986,103 (6 Pt 2), 2569−2581.
- Jaxel C., Taudou G., Portemer C., Mirambeau G., Panijel J., Duguet M. Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes // Biochemistry, 1988, 27 (1), 95−99.
- Hsiang Y.H., Liu L.F. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin // Cancer Res., 1988,48 (7), 1722−1726.
- Oshita F., Saijo N. Rapid polymerase chain reaction assay to detect variation in the extent of gene-specific damage between cisplatin- or VP-16-resistant and sensitive lung cancer cell lines // Jpn. J. Cancer Res., 1994, 85 (7), 669−673.
- Sun X.M., Cohen G.M. Mg (2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis // J. Biol. Chem, 1994, 269 (21), 14 857−14 860.138