Роль клеток реципиента и нарушения структуры тканевого матрикса в механизме кальцификации трансплантатов сосудов и клапанов сердца
Диссертация
Ранее в Лаборатории тканевой инженерии ИТЭБ РАН была сформулирована и экспериментально подтверждена гипотеза о том, что инициация кальциноза в трансплантатах клапанов сердца и сосудов обусловлена накоплением кальция и фосфатов в митохондриях погибающих клеток. На основании данной гипотезы был разработан и внедрен в медицинскую практику способ антикальцинозной девитализации позволивший радикально… Читать ещё >
Содержание
- 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Морфология, анатомия и гистология клапанов сердца
- 1. 1. 1. Анатомическое строение клапанов сердца
- 1. 1. 1. 1. Строение аортального клапана
- 1. 1. 1. 2. Строение митрального клапана
- 1. 1. 1. 3. Строение клапана легочной артерии
- 1. 1. 1. 4. Строение трикуспидального клапана
- 1. 1. 2. Архитектоника внеклеточного матрикса клапанов сердца 20 1.1.2.1 Состав внеклеточного матрикса клапанов сердца
- 1. 1. 2. 1. 1 Эластин и белки микрофибрилл эластических волокон
- 1. 1. 2. 1. 2 Сосудистый коллаген и лизилоксидазы
- 1. 1. 2. 1. 3 Протеогликаны
- 1. 1. 1. Анатомическое строение клапанов сердца
- 1. 1. Морфология, анатомия и гистология клапанов сердца
- 1. 2. Тканевая инженерия трансплантатов клапанов сердца и сосудов
- 1. 2. 1. Становление тканевой инженерии трансплантатов клапанов сердца и сосудов
- 1. 2. 2. Основные направления тканевой инженерии трансплантатов клапанов сердца и сосудов
- 1. 2. 2. 1. Тканевая инженерия клапанов сердца и сосудов на основе девитализированных и децеллуларизированных биологических матриц
- 1. 2. 2. 2. Техники репопуляции трансплантатов клапанов сердца и сосудов
- 1. 3. 1. Кальциноз собственных сосудов человека, минерализация биопротезов и их связь с и минерализацией трансплантатов сосудов и клапанов сердца
- 1. 3. 1. 1. Митохондриальная гипотеза кальцификации трансплантатов клапанов сердца и сосудов
- 1. 3. 1. 2. Липидная гипотеза кальцификации биопротезов клапанов сердца и сосудов
- 1. 3. 1. 3. Клеточная гипотеза кальцификации клапанов сердца и сосудов
- 1. 3. 2. Ингибиторы и активаторы гетеротопической кальцификации сосудистой ткани
- 1. 3. 3. Эластокальциноз
- 2. 1. Материалы
- 2. 1. 1. Флуоресцентный экспресс-метод оценки жизнеспособности, митотической активности и формы клеточной гибели in vitro и ex vivo
- 2. 2. Обработка материала
- 2. 2. 1. Девитализация/децеллуларизация ткани
- 2. 3. Культура клеток
- 2. 3. 1. Использование постоянной клеточной линии
- 2. 3. 2. Получение первичной культуры гладкомышечных клеток
- 2. 4. Изучение биосовместимости девитализированных/децеллуларизированных тканей in vitro
- 2. 5. Модель подкожной имплантации биоматериалов крысам
- 2. 5. 1. Техника подкожной имплантации биоматриалов крысам
- 2. 5. 2. Лабораторные животные
- 2. 6. Проведение гистологического и гистохимического анализа
- 2. 6. 1. Получение криосрсзов
- 2. 6. 2. Гистологический анализ
- 2. 6. 3. Гистохимический анализ
- 2. 6. 4. Флуоресцентная микроскопия
- 2. 8. Количественное определение минерализованного кальция
- 2. 9. Статистический анализ
- 3. 1. Влияние разрушения клеток донора на степень дегенерации и кальцификации трансплантатов сосудов и клапанов сердца
- 3. 2. Изучение роли клеток реципиента в кальцификации трансплантатов сосудов и клапанов сердца
- 3. 3. Выяснение роли липидов в кальцификации трансплантатов сосудов и клапанов сердца
- 3. 4. Роль повреждений внеклеточного матрикса в кальцификации трансплантатов сосудов и клапанов сердца
- 3. 5. Разработка способа предотвращения кальциноза и повышения биосовместимости трансплантатов сосудов и клапанов сердца на основе полученных результатов
- 3. 6. Разработка способа ускорения репопуляции трансплантатов сосудов и клапанов сердца
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