Нейрохимические механизмы церебральных патологий: нитрергическая и протеолитическая системы
Диссертация
Продолжительные и эмоционально-болевые формы стресса связаны со структурно-функциональными изменениями в ЦНС. Например, хронический стресс индуцирует атрофию дендритов пирамидальных нейронов поля САЗ гиппокампа (Magarinos and McEwen, 1995), подавляет нейрогенез в зубчатой фасции (Fuchs and Flugge, 1998; Gould and Tanapat, 1999) и приводит к уменьшению объема гиппокампа (Czeh et al., 2001; van der… Читать ещё >
Содержание
- Список сокращений
- Глава 1. ОБЗОР ДАННЫХ ЛИТЕРАТУРЫ НИТРЕРГИЧЕСКАЯ СИСТЕМА И ЕЕ РОЛЬ В ЦНС
- 1. 1. Изоформы Ж)-синтазы
- 1. 2. Структура Ж)-синтаз
- 1. 3. Локализация изоформ КОС
- 1. 4. Реакции N0 с биологичекими молекулами
- 1. 5. Физиологические функции N0 в ЦНС
- ПРОТЕОЛИТИЧЕСКАЯ СИСТЕМА И ЕЕ РОЛЬ В ЦНС
- 1. 6. Каспазы, структура и функции
- 1. 7. Регуляция активности каспаз
- 1. 8. Пути активации каспаз при апоптозе
- 1. 9. Физиологические функции каспазы-3 в мозге
- 1. 10. Калпаин, структура и локализация в ЦНС
- 1. 11. Регуляция активности калпаина
- 1. 12. Физиологические функции калпаина в ЦНС
- 1. 13. Участие калпаина в патологических процессах в ЦНС
- 1. 14. Катепсины, структура и регуляция активности
- 1. 15. Физиологические функции катепсинов в ЦНС
- 1. 16. Участие катепсина В в патологических процессах в ЦНС
- ВЗАИМОДЕЙСТВИЕ НИТРЕРГИЧЕСКОЙ И ПРОТЕОЛИТИЧЕСКОЙ СИСТЕМ В
- МЕХАНИЗМАХ ГИБЕЛИ КЛЕТОК
- 1. 17. Некротическая гибель клеток
- 1. 18. Апоптотическая гибель клеток
- 1. 19. Окслительный/нитрозативный стресс в гибели клеток
- 1. 20. Изменение проницаемости лизосом в механизмах гибели клеток
- 1. 21. N0 как ингибитор клеточной гибели
- НИТРЕРГИЧЕСКАЯ И ПРОТЕОЛИТИЧЕСКАЯ СИСТЕМЫ ПРИ
- ЦЕРЕБРАЛЬНЫХ ПАТОЛОГИЯХ
- 1. 22. Ишемия мозга
- 1. 23. Болезнь Альцгеймера
- 1. 24. Эпилепсия
- 1. 25. Гибернация
- 1. 26. Стресс
- Глава 2. МАТЕРИАЛЫ И МЕТОДЫ
- 2. 1. Клинический материал и сопутствующие методы
- 2. 2. Работа с различными видами культур клеток и ткани мозга
- 2. 3. Работа с лабораторными животными
- 2. 3. 1. Моделирование ишемического воздействия
- 2. 3. 2. Моделирование нейродегенерации
- 2. 3. 3. Модель судорожной активности
- 2. 3. 4. Гибернационный цикл
- 2. 3. 5. Модели стрессорных воздействий
- 2. 4. Получение гомогенатов ткани мозга
- 2. 5. Биохимические и молекулярно-биологические методы исследования
- 2. 6. Гистологические методы исследования
- 2. 7. Статистическая обработка данных
- Глава 3. РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЙ И ИХ ОБСУЖДЕНИЕ
- 3. 1. Нитрергическая система, модуляция цистеиновых протеаз и иммунный ответ в СМЖ больных после инсульта
- 3. 2. Нитрергическая система, иммунный ответ и активность нейропротеаз после фокальной ишемии мозга у крыс
- 3. 3. Продукция оксида азота и гибель клеток при моделировании ишемии на нейроглиальных и органотипических культурах
- 3. 4. Активность КОС и интенсивность окислительного стресса в мозге крыс после ГИМ, введения АР64А и фрагмента (25−35) Р-амилоидного пептида
- 3. 5. Исследование соотношения активности Ж) С и каспазы-3 при эпилепсии
- 3. 6. Влияние различных типов стресса на состояние нитрергической и протеолитической систем мозга
- 3. 7. Исследование активности Ж) С и каспазы-3 на разных стадиях гибернационного цикла
Список литературы
- Айрапетянц М.Г. Участие церебральной гипоксии в патогенезе неврозов. Новая концепция // ЖВНД 1997. Т. 47. № 2. С. 412−417.
- Гуляева Н.В. Неапоптотические функции каспазы-3 нервной ткани // Биохимия. 2003. № 68. С. 1459 1470
- Корпачев В.Г., Лысенков С. П., Тель Л. З. Моделирование клинической смерти и постреанимационной болезни у крыс // Патол. Физиол. Эксперим. Терапия. 1982. № 3. С. 78−90.
- Лысенков С.П., Корпачев В. Г., Тель Л. З. Балльная оценка общего состояния крыс, перенесших клиническую смерть // Клиника, патогенез и лечение неотложных состояний. Новосибирск, 1982. С. 8−13.
- Родина В.И., Крупина Н. А., Крыжановский Г. Н., Окнина Н. Б. Многопараметровый метод комплексной оценки тревожно-фобических состояний у крыс // Журн. высш. нерв. деят. 1993. Т. 43. № 5. С. 1006−1017.
- Хаспеков Л.Г., Онуфриев М. В., Лыжин А. А., Викторов И. В., Гуляева Н. В. Динамика протеолитической активности, связанной с каспазой-3, при ишемическом воздействии на культивируемые клетки-зерна мозжечка крыс // Нейрохимия. 2002. Т. 19. С. 37−40.
- Abu Soud Н.М., Loftus M., and Stuehr D J. Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function // Biochemistry. 1995. V. 34. P. Ill67— 11 175.
- Abu-Soud H.M., Yoho L.L., Stuehr D.J. Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer//J. Biol. Chem. 1994. V. 269. № 51. P. 32 047−32 050.
- Adams J. M. and Cory S. The Bcl-2 apoptotic switch in cancer development and therapy // Oncogene. 2007. V. 26. P. 1324−1337.
- Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M. NAD (P)H oxidases in rat basilar arterial endothelial cells // Stroke. 2005. V. 36. P. 1040−1046.
- Agullor L. and Garcira A. Characterization of noradrenaline-stimulated cyclic GMP formation in brain astrocytes in culture // Biochem. J. 1992a. V. 288. 619 624.
- Agullor L. and Garcira A. Different receptors mediate stimulation of nitric oxide-dependent cyclic GMP formation in neurons and astrocytes in culture // Biochem. Biophys. Res. Commun. 1992b. V. 182. P. 1362−1368.
- Akama K.T., Albanese C., Pestell R.G., Van Eldik L.J. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism // Proc. Natl. Acad. Sci. USA. 1998. V. 95. P. 5795−5800.
- Aktan F. iNOS-mediated nitric oxide production and its regulation // Life sci. 2004. V. 75. P. 639−653.
- Alderton WK, Cooper CE, and Knowles RG Nitric oxide synthases: structure, function and inhibition // Biochem. J. 2001. V. 357. P. 593−615.
- Almeida A., Almeida J., Bolanos J.P. and Moncada S., Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection // Proc. Natl. Acad. Sci. 2001. V. 98. P. 15 294−15 299.
- Alonso G. Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain // Glia. 2000. V. 31. P. 219−231.
- Amitai Y. Physiologic role for «inducible» nitric oxide synthase: a new form of astrocytic-neuronal interface // Glia. 2010. V. 58. P. 1775−1781.
- Andreeva N., Khodorov B., Stelmashook E., Cragoe E. Jr., Victorov I. Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures // Brain Res. 1991. V. 548. P. 322−325.
- Ankarcrona M, Dypbukt JM, Bonfoco E et al. Glutamate induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function // Neuron. 1995. V. 15. P. 961−973.
- Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I, Bernasconi L, Bernard A, Mermod JJ, Mazzei G, Maundrell K, Gambale F, Sadoul R, Martinou JC. Inhibition of bax channel-forming activity by bcl-2 // Science. 1997. V. 277. P. 370−372.
- Arai A, Vanderklish P, Kessler M, Lee K, Lynch G. A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices // Brain Research. 1991. V. 555. P. 276−280.
- Araujo IM, Carvalho CM. Role of nitric oxide and calpain activation in neuronal death and survival // Curr Drug Targets CNS Neurol Disord. 2005. V. 4. № 4. P. 319−324.
- Arbel I, Kadar T, Silbermann M, Levy A. The effects of long-term corticosterone administration on hippocampal morphology and cognitive performance of middle-aged rats // Brain Res. 1994. V. 657. № 1−2. P. 227−235.
- Arbuzova A, Schmitz AA, Vergeres G. Cross-talk unfolded: MARCKS proteins // Biochem J. 2002. V. 362. P. 1−12.
- Artal-Sanz M. and Tavernarakis N. Proteolytic mechanisms in necrotic cell death and neurodegeneration // FEBS Lett. 2005. V. 579. P. 3287−3296.
- Arthur JS, Elce JS, Hegadorn C, Williams K, Greer PA Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division // Mol Cell Biol. 2000. V. 20. P. 4474−4481.
- Ascenzi P, Salvati L, Bolognesi M, Colasanti M, Polticelli F, Venturini G. Inhibition of cysteine protease activity by NO-donors // Curr Protein Pept Sci. 2001. V. 2. P. 137−153.
- Averna M, Stifanese R, De Tullio R, Beccaria F, Salamino F, Pontremoli S, Melloni E. Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells. J Neurochem // 2009. V. 110. P. 412−421.
- Averna M, Stifanese R, De Tullio R, Salamino F, Bertuccio M, Pontremoli S, Melloni E. Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 // FEBS J. 2007. V. 274. P. 61 166 127.
- Aygul R., Demircan B., Erdem F., Ulvi H., Yildirim A., Demirbas F. Plasma values of oxidants and antioxidants in acute brain hemorrhage: role of free radicals in the development of brain injury // Biol. Trace Elem. Res. 2005. V. 108. P. 4352.
- Back T., Hoehn M., Mies G., Busch E., Schmitz B., Kohno K., Hossmann K. Penumbral tissue alkalosis in focal cerebral ischemia: relationship to energy metabolism, blood flow, and steady potential. // Ann Neurol. 2000. V. 47. P. 485 492.
- Bachis A, Cruz MI, Nosheny RL, Mocchetti I. Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex // Neurosci Lett. 2008. V. 442. P. 104−108.
- Bal-Price A. and Brown G.C., Nitric oxide induced necrosis and apoptosis in PC12 cells mediated by mitochondria // J. Neurochem. 2000. V. 75.P. 1455−1464.
- Bano D., Munarriz E., Chen H., Ziviani E., Lippi G., Young K., Nicotera P. The plasma membrane Na+/Ca2+ exchanger is cleaved by distinct protease families in neuronal cell death // Ann N Y Acad Sci. 2007. V. 1099. P. 451−455.
- Bano D., Munarriz E., Chen H., Ziviani E., Lippi G., Young K., Nicotera P. The plasma membrane Na+/Ca2+ exchanger is cleaved by distinct protease families in neuronal cell death // Ann N Y Acad Sci. 2007. V. 1099. P. 451−455.
- Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P // Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell. 2005 Jan 28−120(2):275−85.
- Bano D. and Nicotera P. Ca2+ signals and neuronal death in brain ischemia // Stroke. 2007. V. 38. P. 674−676.
- Becker K., McCarron R., Ruetzler C., Laban O., Sternberg E., Flanders K., Hallenbeck J. Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia // Proc Natl Acad Sci USA. 1997. V. 94. P. 10 873−10 878.
- Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly // Am J Physiol 1996. V. 271. P. C1424-C1437.
- Bednarski E, Lauterborn JC, Gall CM, Lynch G. Lysosomal dysfunction reduces brain-derived neurotrophic factor expression // Exp Neurol. 1998. V. 150. P. 128−135.
- Bednarski E, Ribak CE, Lynch G. Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus // J Neurosci. 1997. V. 17. № 11. P. 4006−4021.
- Bednarski E., Vanderklish P., Gall C., Saido T.C., Bahr B.A., Lynch G. Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices // Brain. Res. 1995. V. 694. P. 147−157
- Bellamy T., Garthwaite J. «cAMP-specific» phosphodiesterase contributes to cGMP degradation in cerebellar cells exposed to nitric oxide // Mol Pharmacol. 2001. V. 59. № 1. P. 54−61.
- Beltran B., Mathur A., Duchen M., Erusalimsky J., Moncada S. The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death // Proc Natl Acad Sci USA. 2000. V. 97. № 26. P. 14 602−14 607.
- Benchoua A., Braudeau J., Reis A., Couriaud C., Onteniente B. Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia // J. Cereb. Blood. Flow. Metab. 2004. V. 24. P. 1272−1279.
- Bender A., Demady D., Osawa Y. Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo // J. Biol. Chem. 2000. V. 275. P. 17 407−17 411.
- Bender A., Beavo J. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use // Pharmacol Rev. 2006. V. 58. № 3. P. 488−520.
- Berlett B., Stadtman E. Protein oxidation in aging, disease, and oxidative stress // J. Biol. Chem. 1997 V. 272. № 33. P. 20 313−20 316.
- Bernardi P. and Forte M., The mitochondrial permeability transition pore // Novartis Found Symp. 2007. V. 287. P. 157−164.
- Beridze M., Sanikidze T., Shakarishvili R., Intskirveli N., Bornstein N. Selected acute phase CSF factors in ischemic stroke: findings and prognostic value // BMC Neurol. 201 l.V. 11. P. 41−47.
- Bevers M., Neumar R. Mechanistic role of calpains in postischemic neurodegeneration // J. Cereb. Blood. Flow Metab. 2008. V. 28. P. 655−673.
- Bhardwaj A., Northington F.J., Koehler R.C., Stiefel T., Hanley D.F., Traystman R.J. Adenosine modulates N-methyl-D-aspartatestimulated hippocampal nitric oxide production in vivo // Stroke. 1995. V. 26. P. 1627−1633.
- Bi X, Pinkstaff J, Nguyen K, Gall CM, Lynch G. Experimentally induced lysosomal dysfunction disrupts processing of hypothalamic releasing factors // J Comp Neurol. 1998. V. 401. № 3. P. 382−394.
- Bi X, Zhou J, Lynch G. Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer’s disease // Exp. Neurol. 1999. V. 158. P. 312−327.
- Blomgren K, Kawashima S, Saido TC, Karlsson JO, Elmered A, Hagberg H. Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia // Brain Res. 1995. V. 684. № 2. P. 143−149.
- Blomgren K, Zhu C, Wang X, Karlsson JO, Leverin AL, Bahr BA, Mallard C, Hagberg H. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of «pathological apoptosis»? // J. Biol. Chem. 2001. V. 276. P.10 191−10 198.
- Boatright, K. M. and Salvesen, G. S. Caspase activation // Biochem. Soc. Symp. 2003. V. 70. P. 233−242.
- Boatright K.M., Renatus M., Scott F.L., Sperandio S., Shin H., Pedersen I.M., Ricci J.E., Edris W.A., Sutherlin D.P., Green D.R., Salvesen G.S. A unified model for apical caspase activation // Mol. Cell. 2003. V. 11. P. 529−541.
- Bobba A., Atlante A., Moro L., Calissano P., Marra E. Nitric oxide has dual opposite roles during early and late phases of apoptosis in cerebellar granule neurons //Apoptosis. 2007. V. 12. № 9. P. 1597−1610.
- Bolanos J., Almeida A. Roles of nitric oxide in brain hypoxia-ischemia // Biochim. Biophys. Acta 1999. V. 1411. P. 415−436.
- Bolotina V.M., Najibi S., Palacino J.J., Pagano P.J., Cohen R.A. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle //Nature. 1994. V. 368. P. 850−853.
- Bon C. L. and Garthwaite J. On the role of nitric oxide in hippocampal long-term potentiation // J. Neurosci. 2003. V. 23. P. 1941−1948.
- Bonthius D., Luong T., Bonthius N., Hostager B., Karacay B. Nitric oxide utilizes NF-kappaB to signal its neuroprotective effect against alcohol toxicity // Neuropharmacology. 2009. V. 56. № 3. P. 716−731.
- Boran MS, Garcia A. The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes // J. Neurochem. 2007. V. 102. № 1. P. 216−230.
- Borutaite V., Morkuniene R., Brown G.C., Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms // FEBS Lett. 2000. V. 467. P. 155−159.
- Borutaite V. and Brown G.C. Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion // Free Rad. Biol. Med. 2003. V. 35. P. 1457−1468.
- Borutaite V. and Brown G.C., S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production // Biochim. Biophys. Acta. 2006. V. 1757. P. 562−566.
- Boulton C.L., Southam E., Garthwaite J. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase // Neuroscience. 1995. V. 69. P. 699−703.
- Boya P., Andreau K., Poncet D., Zamzami N., Perfettini J.L., Metivier D., Ojcius D.M., Jaattela M., Kroemer G. Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion // J Exp Med. 2003. V. 197. P. 1323−1334.
- Brahmachari S., Fung Y.K., Pahan K. Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide // J Neurosci. 2006. V. 26. № 18. P. 49 304 939.
- Brandish P., Buechler W., Marietta M. Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: acceleration by thiols and oxyhemoglobin//Biochemistry. 1998. V. 37. P. 16 898−16 907.
- Braughler J.M., Hall E.D. Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation // Free Radic Biol Med. 1989. V. 6. № 3. P. 289−301.
- Bredesen D.E. Programmed cell death mechanisms in neurological disease // CurrMol Med. 2008. V. 8. P.173−186.
- Bredt D.S., Hwang P.M., Snyder S.H. Localization of nitric oxide synthase indicating a neural role for nitric oxide // Nature. 1990. V. 347. P. 768−770.
- Bredt D.S., Glatt C., Hwang P.M., Fotuhi M., Dawson T.M., Snyder S.H. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase // Neuron. 1991. V. 7. P. 615−624.
- Brown G.C. Reversible binding and inhibition of catalase by nitric oxide // Eur. J. Biochem. 1995. V. 232. P. 188−191.
- Brown G.C.and Borutaite V. Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species // Biochem. Soc. Trans. 2006. V. 34. P. 953−956.
- Brown G.C. Nitric oxide and neuronal death // Nitric Oxide. 2010. V. 23. № 3. P. 153−165.
- Brune B., von Knethen A., Sandau K.B. Nitric oxide and its role in apoptosis // Eur J Pharmacol. 1998. V. 351. № 3. P. 261−272.
- Brunk U., Svensson I. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak // Redox Rep. 1999. V. 4. P. 3−11.
- Buck M.R., Karustis D.G., Day N.A., Honn K.V., Sloane B.F. Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues // Biochem J. 1992. V. 282. P. 273−278.
- Budd S.L., Tenneti L., Lishnak T., Lipton S.A. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons // Proc Natl Acad Sci USA 2000. V. 97. P. 6161−6166.
- Buisson A., Lakhmeche N., Verrecchia C., Plotkine M., Boulu R.G. Nitric oxide: an endogenous anticonvulsant substance // Neuroreport. 1993. V. 4. P. 444 446.
- Burlet S., Leger L., Cespuglio R. Nitric oxide and sleep in the rat: a puzzling relationship //Neuroscience. 1999. V. 92. P. 627−639.
- Burner U., Furtmuller P., Kettle A., Koppenol W., Obinger C. Mechanism of reaction of myeloperoxidase with nitrite // J. Biol. Chem. 2000. V. 275. P. 2 059 720 601.
- Buskila Y, Farkash S, Hershfinkel M, Amitai Y. Rapid and reactive nitric oxide production by astrocytes in mouse neocortical slices // Glia. 2005. V. 52. P. 169−176.
- Volbracht C., Fava E., Leist M., Nicotera P. Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis //Neuroreport. 2001. V. 12. P. 3645−3648.
- Callus B.A., Vaux D.L. Caspase inhibitors: viral, cellular and chemical // Cell Death Differ. 2007. V. 14. P. 73−78.
- Cande C., Cecconi F., Dessen P., Kroemer G. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? // J Cell Sci. 2002. V. 115. P. 4727−4734.
- Canu N., Tufi R., Serafino A.L., Amadoro G., Ciotti M.T., Calissano P. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells // J Neurochem. 2005. V. 92. P. 1228−1242.
- Cao G., Xing J., Liou A., Yin X.-M., Clark R., Graham S.H., Chen J. Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury // J Neurosci. 2007. V. 27. P. 9278−9293
- Cao J., Viholainen J.I., Dart C., Warwick H.K., Leyland M.L., Courtney M.J. The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death // J Cell Biol. 2005. V. 168. P. 117−126.
- Casiano C.A., Ochs R.L., Tan E.M. Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes // Cell Death Differ. 1998. V. 5. P. 183−190.
- Casteel D., Zhuang S., Gudi T., Tang J., Vuica M., Desiderio S., Pilz R. cGMP-dependent protein kinase 1 beta physically and functionally interacts with the transcriptional regulator TFII-I // J biol Chem. 2002. V. 277. P. 32 003−32 014.
- Cauli B., Tong X., Rancillac A., Serluca N., Lambolez B., Rossier J., Hamel E. Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways // J Neurosci. 2004. V. 24. P. 8940−8949.
- Cavas M. and Navarro J. Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat // Prog. Neuropsychopharmacol. Biol. Psychiatry. 2006. V. 30. P. 56−67.
- Chabrier P.E., Demerle-Pallardy C., Auguet M. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases // Cell Mol. Life Sci. 1999. V. 55. P. 1029−1035.
- Chaitanya GV, Babu PP. Activation of calpain, cathepsin-b and caspase-3 during transient focal cerebral ischemia in rat model // Neurochem Res. 2008. V. 33. P. 2178−2186.
- Chan S.H., Wang L.L., Wang S.H., Chan J.Y. Differential cardiovascular responses to blockade of nNOS or iNOS in rostral ventrolateral medulla of the rat // Br J Pharmacol. 2001. V. 133. P. 606−614.
- Chauhan A., Sharma U., Jagannathan N.R., Reeta K.H., Gupta Y.K. Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats // Behav. Brain Res. 2011 V. 225. P. 603−609.
- Chen M., Sun H.Y.,. Li S. J,. Das M, Kong J.M. and. Gao T. M, Nitric Oxide as an Upstream Signal of p38 Mediates Hypoxia/Reoxygenation-Induced Neuronal Death //Neurosignals. 2009. V. 17. P. 162−168.
- Chernaya V. I., Pedan L. F., Zozulya G. I. Structural/functional changes in the brain lysosomal-vacuolar apparatus related to chronic emotional stress // Neurophysiology. 1999. V. 31. № 4. P. 292−293.
- Chesler M. The regulation and modulation of pH in the nervous system. Prog Neurobiol. // 1990. V. 34. P. 401−427.
- Chiavegatto S, Dawson VL, Mamounas LA, Koliatsos VE, Dawson TM, Nelson RJ. Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase // Proc Natl Acad Sci USA. 2001. V. 98. № 3.P. 1277−1281.
- Chien W.L., Liang K.C., Teng C.M., Kuo S.C., Lee F.Y., Fu W.M. Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-l-benzylindazole // Mol. Pharmacol. 2003. V. 63. P. 1322−1328.
- Choi D.W. Excitotoxic cell death // J. Neurobiol. 1992. V. 23. P. 1261−1276.
- Choi Y., Tenneti L., Le D., Ortiz J., Bai G., Chen H., Lipton S. Molecular basis of NMD A receptor-coupled ion channel modulation by S-nitrosylation // Nat. Neurosci. 2000. V. 3. P. 15−21.
- Choi, B.M., Рае, H.O., Jang, S.I., Kim, Y.M., Chung, H. Nitric oxide as an apoptotic as well as anti-apoptotic modulator // J. Biochem. Mol. Boil. 2002. V. 35. P. 116−126.
- Chopp M., Zhang Z.G. Anti-adhesion molecule and nitric oxide protection strategies in ischemic stroke // Curr Opin Neurol. 1996. V. 9. P. 68−72.
- Chrobak J.J., Hanin I., Schmechel D.E., Walsh, T.J. AF64A induced working memory impairment: behavioral, neurochemical and histological correlates // Brain Res. 1988. V. 463. P. 107−117.
- Chrobak JJ, Hanin I, Schmechel DE, Walsh TJ. AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates // Brain Res. 1988. V. 463. P. 107−117.
- Chua B.T., Guo K., Li P. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases // J Biol Chem. 2000. V. 275. P. 5131— 5135.
- Chung H.T., Рае H.O., Choi B.M., Billiar T.R. and Kim Y.M. Nitric oxide as a bioregulator of apoptosis // Biochem. Biophys. Res. Commun. 2001. V. 282. P. 1075−1079.
- Chung K., Thomas В., Li X., Pletnikova O., Troncoso J., Marsh L., Dawson V., Dawson T. S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function// Science. 2004. V. 304. P. 1328−1331.
- Ciani E., Virgili M, Contestabile A. Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones // J Neurochem. 2002a. V. 81. P. 218−228.
- Cohen G.M. Caspases: the executioners of apoptosis // Biochem J. 1997.V. 326. P. 1−16.
- Colasanti M, Persichini T, Fabrizi C, Cavalieri E, Venturini G, Ascenzi P, Lauro GM, Suzuki H. Expression of a NOS-III-like protein in human astroglial cell culture // Biochem Biophys Res Commun. 1998. V. 252. № 3. P. 552−555.
- Concha N., Abdel-Meguid S. Controlling apoptosis by inhibition of caspases // Curr Med Chem. 2002 V. 9. P. 713−726.
- Cook S.C., Wellman C.L. Chronic stress alters dendritic morphology in rat medial prefrontal cortex // J. Neurobiol. 2004. V. 60. P. 236−248.
- Corda M.G., Orlandi M, Lecca D, Giorgi O. Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: antagonism by MK-801 // J Pharmacol Exp Ther. 1992. V. 262. P. 792−800.
- Craven K.B., Zagotta W.N. CNG and HCN channels: two peas, one pod // Annu Rev Physiol. 2006. V. 68. P. 375−401.
- Datta, S., Patterson, E. H. & Siwek, D. F. Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep // Synapse. 1997. V. 27. 69−78.
- Dave K., Prado R., Raval A., Drew K., Perez-Pinzon M. The arctic ground squirrel brain is resistant to injury from cardiac arrest during euthermia // Stroke. 2006. V. 37. P. 1261−1265.
- Dawson V.L., Dawson T.M. Nitric oxide actions in neurochemistry // Neurochem Int. 1996. V. 29. P. 97−110.
- Dawson T. M., Snyder S.H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain // J. Neurosci. 1994. V. 14. P. 5147−5159.
- De Alba J., Cardenas A., Moro M., Leza J., Lorenzo P., Bosca L., Lizasoain I. Down-regulation of neuronal nitric oxide synthase by nitric oxide after oxygen-glucose deprivation in rat forebrain slices // J Neurochem. 1999 Jan-72(l):248−54.
- De Giorgio R., Parodi J., Brecha N., Brunicardi F., Becker J., Go V., Sternini C. Nitric oxide producing neurons in the monkey and human digestive system // J. Comp. Neurol. V. 342. P. 619−627.
- Decaudin D, Marzo I, Brenner C, Kroemer G. Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy // Int J Oncol. 1998. V. 12. P. 141−52.
- Dedio J, Konig P, Wohlfart P, Schroeder C, Kummer W, Muller-Esterl W: NOSIP, a novel modulator of endothelial nitric oxide synthase activity // FASEB J 2001. V. 15. P. 79−89.
- Demarchi F, Bertoli C, Copetti T, Tanida I, Brancolini C, Eskelinen EL, Schneider C. Calpain is required for macroautophagy in mammalian cells // J Cell Biol. 2006. V. 175. P. 595−605.
- Dingman A., Lee S.Y., Derugin N., Wendland M.F., Vexler Z.S. Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia // J. Neurochem. 2006. V. 96. P. 1467−1479.
- Dirnagl U., Klehmet J., Braun J., Harms H., Meisel C., Ziemssen T., Prass K., Meisel A. Stroke-induced immunodepression: experimental evidence and clinical relevance // Stroke. 2007. V. 38. P. 770−773.
- Doyle H., Mamula M. Posttranslational protein modifications: new flavors in the menu of autoantigens // Curr. Opin. Rheumatol. 2002. V. 14. P. 244−249.
- Drapier J., Hibbs J. Aconitases: a class of metalloproteins highly sensitive to nitric oxide synthesis // Methods Enzymol. 1996. V. 269. P. 26−36.
- Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c dependent caspase activation by eliminating IAP inhibition // Cell. 2000. V. 102. P. 3312.
- Dunbar AY, Kamada Y, Jenkins GJ, Lowe ER, Billecke SS, Osawa Y. Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis // Mol Pharmacol. 2004. V. 66. P. 964−969.
- Dunn A.J. Brain catecholaminergic and tryptophan responses to restraint are attenuated by nitric oxide synthase inhibition // Neurochem Int. 1998. V. 33. P. 551−557.
- During M., Symes C., Lawlor P., Lin J., Dunning J., Fitzsimons H., Poulsen D., Leone P., Xu R., Dicker B., Lipski J., Young D. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy // Science. 2000. V. 287. P. 1453−1460.
- Durmaz R., Ozden H, Kanbak G, Aral E, Arslan O., Kartkaya K., Uzuner K. The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia // Neurochem Res. 2008. V. 33. P. 1683−1691.
- Dutt P., Croall D., Arthur S., De Veyra T., Williams K., Elce J., Greer P. m-Calpain is required for preimplantation embryonic development in mice // BMC Dev Biol. 2006. V. 6.P.3.
- Eckelman B.P., Salvesen G.S., Scott F.L. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family // EMBO Rep. 2006. V. 7. P. 988−994.
- Eliasson M., Huang Z., Ferrante R., Sasamata M., Molliver M., Snyder S., Moskowitz M. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage // J. Neurosci. 1999. V. 19. V.5910−5918.
- Elmore S. Apoptosis: a review of programmed cell death // Toxicol Pathol. 2007. V. 35. P. 495−516.
- Endoh M., Maiese K., Wagner J.A. Expression of the neural form of nitric oxide synthase by CA1 hippocampal neurons and other central nervous system neurons //Neuroscience. 1994. V. 63. P. 679−689.
- Espey M., Miranda K., Feelisch M., Fukuto J, Grisham M., Vitek M., Wink D. Mechanisms of cell death governed by the balance between nitrosative and oxidative stress // Ann. NY Acad. Sci. 2000. V. 899. P. 209−221.
- Estevez AG, Spear N, Manuel SM, Barbeito L, Radi R, Beckman JS. Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture // Prog Brain Res. 1998. V. 118. P. 269−280.
- Faherty CJ, Xanthoudakis S, Smeyne RJ. Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment // Brain Res Mol Brain Res. 1999. V. 70. P. 159−163.
- Fang M., Jaffrey S.R., Sawa A., Ye K., Luo X., Snyder S.H. Dexrasl: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON // Neuron. 2000. V. 28. P. 183−193.
- Faraci FM, Breese KR. Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain // Circ Res. 1993. V. 72. P. 476−480.
- Faraci F.M., Brian J.E. 7-Nitroindazole inhibits brain nitric oxide synthase and cerebral vasodilatation in response to N-methyl-D-aspartate // Stroke. 1995. V. v26. P. 2172−2175.
- Fariello R.G., Ghilardi O., Peschechera A. et al. Regional distribution of ubiquinones and tocopherols in the mouse brain // Neuropharmacology. 1988. V.27. P. 1077−1080.
- Felbor U, Kessler B, Mothes W, Goebel HH, Ploegh HL, Bronson RT, Olsen BR. Neuronal loss and brain atrophy in mice lacking cathepsins B and L // Proc Natl Acad Sci USA. 2002. V. 99. P. 7883−7888.
- Feldman S., Weidenfeld J. Involvement of endogeneous glutamate in the stimulatory effect of norepinephrine and serotonin on the hypothalamo-pituitary-adrenocortical axis //Neuroendocrinology. 2004. V. 79. P. 43−53.
- Feldstein A., Werneburg N., Canbay A., Guicciardi M., Bronk S., Rydzewski R, Burgart LJ, Gores GJ. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway // Hepatology. 2004. V. 40. P. 185−194.
- Feldstein A., Werneburg N., Canbay A., Guicciardi M., Bronk S., Rydzewski R., Burgart L., Gores G. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway // Hepatology. 2004. V. 40. № l.p. 185−194.
- Felger J., Abe T., Kaunzner U., Gottfried-Blackmore A., Gal-Toth J., McEwen B., Iadecola C., Bulloch K. Brain dendritic cells in ischemic stroke: time course, activation state, and origin // Brain Behav Immun. 2010. V. 24. P. 724−737.
- Feron O, Beihassen L, Kobzik L, Smith TW, Kelly RA, Michel T: Endothelial nitric oxide synthase targeting to caveolae: specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells // J Biol Chem. 1996. V. 271. P. 22 810−22 814.
- Ferreira VM, Valenzuela CF, Morato GS. Role of nitric oxide-dependent pathways in ethanol-induced anxiolytic effects in rats // Alcohol Clin Exp Res. 1999. V. 23. P. 1898−1904.
- Ferrer I., Friguls B., Dalfo E, Justicia C, Planas A. Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat // Neuropathol Appl Neurobiol. 2003. V. 29. P. 472−481.
- Ferrer I, Lopez E, Blanco R, Rivera R, Krupinski J, Marti E. Differential c-Fos and caspase expression following kainic acid excitotoxicity // Acta Neuropathol. 2000. V. 99. P. 245−256.
- Ferrer I., Planas AM. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra // J Neuropathol Exp Neurol. 2003. V. 62. P. 329−339.
- Figueiredo C., Pais T.F., Gomes J.R., Chatterjee S. Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK½ // Journal of Neurochemistry. 2008. V. 107. P. 73−85.
- Floeter M., Greenough W. Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys // Science. 1979. V. 206. P. 227 229.
- Foghsgaard L., Wissing D., Mauch D., Lademann U., Bastholm L., Boes M., Elling F., Jaattela M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor // J Cell Biol. 2001. V. 153. P. 999−1010.
- Forrester M., Foster M., Stamler J. Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress // J. Biol. Chem. 2007. V. 282. P. 13 977−13 983.
- Foster M., Stamler J. New insights into protein S-nitrosylation. Mitochondria as a model system // J. Biol. Chem. 2004. V. 279. P. 25 891−25 897.
- Foxton RH, Land JM, Heales SJ. Tetrahydrobiopterin availability in Parkinson’s and Alzheimer’s disease- potential pathogenic mechanisms // Neurochem Res. 2007. V. 32. P. 751−756.
- Frerichs K.U., Kennedy C., Sokoloff L., Hallenbeck J.M. Local cerebral blood flow during hibernation, a model of natural tolerance to «cerebral ischemia» // J Cereb Blood Flow Metab. 1994. V. 14. P. 193−205.
- Friebe A, Koesling D. The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse models //Nitric Oxide. 2009. V. 21. P. 149−156.
- Fuchs E, Fliigge G. Stress, glucocorticoids and structural plasticity of the hippocampus //Neurosci Biobehav Rev. 1998. V. 23. P. 295−300.
- Fukuto J., Dutton A., Houk K. The chemistry and biology of nitroxyl (HNO): a chemically unique species with novel and important biological activity // Chembiochem. 2005. V. 6. P. 612−619.
- Furchgott R., Zawadzki J. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine // Nature. 1980. V. 288. P. 373−376.
- Gahwiler B., Capogna M., Debanne D., McKinney R., Thompson S. Organotypic slice cultures: a technique has come of age // Trends Neurosci. 1997. V. 20. P. 471−477.
- Galea E., Feinstein D., Reis D. Induction of calciumin-dependent nitric oxide synthase activity in primary rat glial cultures // Proc. Natl Acad. Sci. USA. 1992. V. 89. P. 10 945−10 949.
- Gao G. and Dou Q. N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death // J Cell Biochem. 2000. V. 80. P. 53−72.
- Garcia M., Bondada V., Geddes J. Mitochondrial localization of mu-calpain // Biochem Biophys Res Commun. 2005. V. 338. P. 1241−1247.
- Garthwaite J, Boulton C. Nitric oxide signaling in the central nervous system // Annu Rev Physiol. 1995. V. 57. P. 683−706.
- Garthwaite J. Concepts of neural nitric oxide-mediated transmission // Eur J Neurosci. 2008. V. 27. P. 2783−2802.
- Garthwaite J. and Boulton C. L. Nitric oxide signaling in the central nervous system // Annu. Rev. Physiol. 1995. V. 57. P. 683−706.
- Garthwaite J. Dynamics of cellular NO-cGMP signaling // Front Biosci. 2005. V. 10. P. 1868−1880.
- Garthwaite J., Charles S., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain // Nature. 1988. V. 336. P. 385−388.
- Gelderblom M., Leypoldt F., Steinbach K., Behrens D., Choe C., Siler D., Arumugam T., Orthey E., Gerloff C., Tolosa E., Magnus T. Temporal and spatial dynamics of cerebral immune cell accumulation in stroke // Stroke. 2009. V. 40. P. 1849−1857.
- Gendelman H. Neural immunity: Friend or foe? // J Neurovirol. 2002 V. 8. P. 474−479.
- Germain M., Affar E., D’Amours D., Dixit V., Salvesen G., Poirier G. Cleavage of automodified poly (ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. // J Biol Chem. 1999. V. 274. P. 2 837 928 384.
- Getting S., Segieth J., Ahmad S., Biggs, C., Whitton P. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo // Brain Res. 1996. V. 717. P. 196−199.
- Ghatan S., Larner S., Kinoshita Y., Hetman M., Patel L., Xia Z., Youle R., Morrison R. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosisin neurons // J Cell Biol. 2000. V. 150. P. 335−347.
- Ghosh D., Stuehr D. Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction // Biochemistry. 1995. V. 34. P. 801−807.
- Giasson B., Duda J., Murray I., Chen Q., Souza J., Hurtig H., Ischiropoulos H., Trojanowski J., Lee V. Oxidative damage linked to neurodegeneration byselective alpha-synuclein nitration in synucleinopathy lesions // Science. 2000. V. 290. P. 985−989.
- Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D. Antioxidant therapy in acute central nervous system injury: current state // Pharmacol Rev. 2002. V. 54. P.271−284.
- Gillardon F, Bottiger B, Schmitz B, Zimmermann M, Hossmann K. Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy // Brain Res Mol Brain Res. 1997. V. 50. P. 16−22.
- Gilman C., Mattson M. Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? // Neuromolecular Med. 2002. V. 2. P. 197 214.
- Giraldez R., Panda A., Xia Y., Sanders S., Zweier J. Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart // J Biol Chem. 1997. V. 272. P. 21 420−21 426.
- Gobeil S, Boucher CC, Nadeau D, Poirier G. Characterization of the necrotic cleavage of poly (ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases // Cell Death Differ. 2001. V. 8. P. 588−594.
- Goll D. Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin? // Bioessays. 1992. V. 14. P. 549−556.
- Golstein P, Kroemer G. Cell death by necrosis: towards a molecular definition // Trends Biochem Sci. 2007. V. 32. P. 37−43.
- Gonfalves D, Karl J, Leite M, Rotta L, Salbego C, Rocha E, Wofchuk S, Gonfalves CA. High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes //Neuroreport. 2002. V. 13. P. 1533−1535.
- Good P., Werner P., Hsu A., Olanow C., Perl D. Evidence of neuronal oxidative damage in Alzheimer’s disease // Am J Pathol. 1996. V. 149. P. 21−28.
- Goodwin J., Kehrli M., Uemura Jr. E. Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide // Brain Res. 1997. V. 768. P. 279−286.
- Gould E, Tanapat P. Stress and hippocampal neurogenesis // Biol Psychiatry. 1999. V. 46. P. 1472−1479.
- Govers R., de Bree P, Rabelink T. Involvement of the proteasome in activation of endothelial nitric oxide synthase // Life Sci. 2003. V. 73. P. 22 252 236.
- Gow A., Duran D., Malcolm S., Ischiropoulos H. Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation // FEBS Lett. 1996. V. 385. P. 63−66.
- Graber S, Maiti S, Halpain S. Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines // Neuropharmacology. 2004. V. 47. P. 706−713.
- Graber S., Maiti S., Halpain S. Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines // Neuropharmacology. 2004. V. 47. P. 706−713.
- Graber S, Maiti S, Halpain S. Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines // Neuropharmacology. 2004. V. 47. P. 706−713.
- Grammer M, Kuchay S, Chishti A, Baudry M. Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice // Neurobiol Learn Mem. 2005. V. 84. P. 222−227.
- Grandati M., Verrecchia C., Revaud M., Allix M., Boulu R., Plotkine M. Calcium-independent NO-synthase activity and nitrites/nitrates production intransient focal cerebral ischaemia in mice // Br J Pharmacol. 1997. V. 122. P. 625 630.
- Green D., Kroemer G. The pathophysiology of mitochondrial cell death // Science. 2004. V. 305. P. 626−629.
- Gruener N., Gross B., Gozlan O., Barak M. Increase in superoxide dismutase after cerebrovascular accident // Life Sci. 1994. V. 54. P. 711−713.
- Gu Z., Kaul M., Yan B., Kridel S., Cui J., Strongin A., Smith J., Liddington R., Lipton S. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death // Science 2002. V. 297. P. 1186−1190.
- Gudi T., Casteel D., Vinson C., Boss G., Pilz R. NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation // Oncogene. 2000. V. 19. P. 6324−6333.
- Guicciardi M., Bronk S., Werneburg N., Gores G. cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis // Am J Physiol-Gastroint Liver Physiol. 2007. V. 292. P. G1337-G1346.
- Guikema B., Lu Q., Jourd’heuil D. Chemical considerations and biological selectivity of protein nitrosation: implications for NO-mediated signal transduction //Antioxid. Redox. Signal. 2005. V. 7. P. 593−606.
- Guix F., Uribesalgo I., Coma M., Munoz F. The physiology and pathophysiology of nitric oxide in the brain // Prog. Neurobiol. 2005. V. 76. P. 126−152.
- Gulyaeva N.V., Kudryashov I.E., Kudryashova I.V. Caspase activity is essential for long-term potentiation // J Neurosci Res. 2003. V. 73. P. 853−864.
- Guner Y.S., Ochoa C.J., Wang J., Zhang X., Steinhauser S., Stephenson L., Grishin A., Upperman J.S. Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes // Biochem. Biophys. Res. Commun. 2009. V. 384. P. 221−225.
- Guttmann R., Baker D., Seifert K., Cohen A., Coulter D., Lynch D. Specific proteolysis of the NR2 subunit at multiple sites by calpain // J Neurochem. 2001. V. 78. P. 1083−1093.
- Guttmann R., Sokol S., Baker D., Simpkins K., Dong Y., Lynch D. Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ // J Pharmacol,: Exp Ther. 2002. V. 302. P. 1023−1030.
- Ha K., Kim K., Kwon Y., Bai S., Nam W., Yoo Y., Kim P., Chung H., Billiar T., Kim Y. Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC 12 cells through cGMP-dependent PI3 kinase/Akt activation // FASEB J. 2003. V. 17. P. 1036−1047.
- Hajimohammadreza I., Raser K., Nath R., Nadimpalli R, Scott M, Wang K. Neuronal nitric oxide synthase and calmodulin-dependent protein kinase Ilalphai (i
- Hall F., Huang S., Fong G., Pert A., Linnoila M. Effects of isolation-rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats // Psychopharmacology (Berl). 1998. V. 139. P. 203−209.
- Hama H., Hara C, Yamaguchi K. Miyawaki A. PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes //Neuron. 2004. V. 41. P. 405−415.
- Han D., Yamada K, Senzaki K, Xiong H. Nawa H., Nabeshima T. Involvement of nitric oxide in pentylenetetrazole-induced kindling in rats // J Neurochem. 2000. V. 74. P. 792−798.
- Hardingham N, Fox K. The role of nitric oxide and GluRl in presynaptic and postsynaptic components of neocortical potentiation // J Neurosci. 2006. V. 26. P. 7395−7404.
- Harkin A., Connor T.J., Walsh M., St. John N., Kelly J.P. Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors // Neuropharmacology. 2003. V. 44. P. 616−623.
- Hars B. Endogenous nitric oxide in the rat pons promotes sleep // Brain Res. 1999. V. 816. P. 209−219.
- Hartmann H., Eckert A., Muller W.E. Beta-Amyloid protein amplifies calcium signalling in central neurons from the adult mouse // Biochem. Biophys. Res. Commun. 1993. V.194. P. 1216−1220.
- Hashiguchi A, Yano S, Morioka M, Hamada J, Ushio Y, Takeuchi Y, Fukunaga K. Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the
- CA1 subfield of gerbil hippocampus // J Cereb Blood Flow Metab. 2004. V. 24. P. 271−279.
- He J., Kang H., Yan F. and Chen C. The endoplasmic reticulum-related events in S-nitrosoglutathione-induced neurotoxicity in cerebellar granule cells // Brain Res. 2004. V. 1015. P. 25−33.
- He X., Patel M., Whitney K., Janumpalli S., Tenner A., McNamara J. Glutamate receptor GluR3 antibodies and death of cortical cells // Neuron. 1998. V. 20. P. 153−163.
- Heidbreder CA, Weiss IC, Domeney AM, Pryce C, Homberg J, Hedou G, Feldon J, Moran M., Nelson P. Behavioral, neurochemical and endocrinologicalcharacterization of the early social isolation syndrome // Neuroscience. 2000. V. 100. P. 749−768.
- Heneka M. and Feinstein D. Expression and function of inducible nitric oxide synthase in neurons // J. Neuroimmunol. 2001. V. 114. P. 8−18.
- Hengartner M. The biochemistry of apoptosis // Nature. 2000. V. 407. P. 770−776.
- Henshall D., Schindler C., So N., Lan J., Meiler R., Simon R. Death-associated protein kinase expression in human temporal lobe epilepsy // Ann Neurol. 2004. V. 55. P. 485−494.
- Henshall D., Skradski S., Bonislawski D., Lan J., Simon R. Caspase-2 activation is redundant during seizure-induced neuronal death // J Neurochem. 2001. V. 77. P. 886−895.
- Hernlund E., Kutuk O., Basaga H, Linder S, Panaretakis T., Shoshan M. Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation // Free Radic Biol Med. 2009. V. 46. P. 1607−1613.
- Hess D., Matsumoto A., Kim S., Marshall H., Stamler J. Protein S-nitrosylation: purview and parameters // Nat. Rev. Mol. Cell. Biol. 2005. V. 6. P. 150−166.
- Hirabayashi H., Takizawa S., Fukuyama N., Nakazawa H, ShinoharaY N-methyl-D-aspartate receptor antagonist reduces nitrotyrosine formation in caudate-putamen in rat focal cerebral ischemia-reperfusion // Neurosc. i Lett. 2001. V. 299. P. 159−161.
- Hirabayashi H., Takizawa S., Fukuyama N., Nakazawa H., Shinohara Y. 7-Nitroindazole attenuates nitrotyrosine formation in the early phase of cerebral ischemia-reperfusion in mice // Neurosci Lett. 1999. V. 268. P. 111−113.
- Hirabayashi H., Takizawa S., Fukuyama N., Nakazawa H., Shinohara Y. Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion // Brain Res. 2000. V. 852. P. 319−325.
- Hiramatsu K, Kassell NF, Lee KS. Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor // Stroke. 1993. V. 24. P. 1725−1728.
- Hogg N. The biochemistry and physiology of S-nitrosothiols // Annu. Rev. Pharmacol. Toxicol. 2002. V. 42. P. 585−600.
- Holcik M. The IAP proteins // Trends Gen. 2002. V. 18. P. 537−538.
- Honda S, Marumoto T, Hirota T, Nitta M, Arima Y, Ogawa M, Saya H Activation of m-calpain is required for chromosome alignment on the metaphase plate during mitosis // J Biol Chem. 2004. V. 279. P. 10 615−10 623.
- Hood J., Logan B., Sinai A., Brooks W., Roszman T. Association of the calpain/calpastatin network with subcellular organelles // Biochem Biophys Res Commun. 2003. V. 310. P. 1200−1212.
- Hook VY. Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease // Biol Chem. 2006. V. 387. P. 1429−1439.
- Hortnagl H., Potter P.E., Kindel G., Hanin I. Noradrenaline depletion protects cholinergic neurons in rat hippocampus against AF64A-induced damage // J Neurosci Methods. 1989. V. 27. P. 103−108.
- Hosfield C., Elce J., Davies P., Jia Z. Crystal structure of calpain reveals the structural basis for Ca (2+)-dependent protease activity and a novel mode of enzyme activation // EMBO J. 1999. V. 18. P. 6880−6889.
- Hu J, Akama K., Krafft G., Chromy B., Van Eldik L. Amyloid-beta peptideactivates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release // Brain Res. 1998. V. 785. P. 195−206.
- Huang W., Lin Y., Chen C., Wang C., Chiu W., Lin C. Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia // J Pharmacol Exp Ther. 2009. V. 329. P. 524−531.
- Hulse R., Swenson W., Kunkler P., White D., Kraig R. Monomelic IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha // J Neurosci. 2008. V. 28. P. 12 199−12 211.
- Hum P., Subramanian S., Parker S., Afentoulis M., Kaler L., Vandenbark A., Offner H. T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation // J Cereb Blood Flow Metab. 2007. V. 27. P. 17 981 805.
- Iadecola C., Xu X., Zhang F., el-Fakahany E., Ross M. Marked induction of calcium-independent nitric oxide synthase activity after focal cerebral ischemia // J Cereb Blood Flow Metab. 1995. V. 15. P. 52−59.
- Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer’s disease // Nat Rev Neurosci. 2004. V. 5. P. 347−360.
- Iadecola C., Zhang F., Casey R., Nagayama M., Ross M. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the induciblernitric oxide synthase gene // J Neurosci. 1997. V. 17. P. 9157−9164.
- Iadecola C., Anrather J. The immunology of stroke: from mechanisms to translation // Nat Med. 2011. V. 17. P. 796−808.p