Роль микробного фактора в генезе системного воспаления и полиорганной недостаточности после операций с искусственным кровообращением
Диссертация
Тревожной общемировой тенденцией в последние десятилетия является неуклонный рост частоты заболеваний сердечно-сосудистой системы (Бокерия JI.A. с соавт., 1998). Болезни сердца и сосудов выходят на одно из ведущих мест в ряду причин, приводящих к инвалидизации и снижению продолжительности жизни населения, особенно среди лиц трудоспособного возраста. В связи с этим, благополучие общества во многом… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- Актуальность темы исследования
- Цель исследования
- Задачи исследования
- Научная новизна работы
- Практическая значимость
- Внедрение в практику
- Положения диссертации, выносимые на защиту
- Апробация работы
- Публикации
- Структура и объем диссертации
- ГЛАВА 1. СИСТЕМНОЕ ВОСПАЛЕНИЕ ПОСЛЕ ОПЕРАЦИЙ НА ОТКРЫТОМ СЕРДЦЕ (ОБЗОР ЛИТЕРАТУРЫ)
- 1. 1. Общие сведения
- 1. 2. Патогенез ССВР после кардиохирургических операций
- 1. 3. Особенности ССВР в детской кардиохирургии
- 1. 4. Профилактика ССВР в кардиохирургии
- 1. 5. Диагностика ССВР
- 1. 6. Прокальцитонин — специфичный маркер ССВР бактериальной этиологии
- 1. 7. гомеостаз малых молекул микробного происхождения. хромато-масс-спектрометрическое детектирование микробных маркеров
- ГЛАВА 2. КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА БОЛЬНЫХ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Структура исследования
- 2. 2. Клиническая характеристика обследованных больных
- 2. 2. 1. Клиническая характеристика больных на I этапе исследования (группы I и II)
- 2. 2. 2. Клиническая характеристика больных на II этапе исследования (группа III)
- 2. 2. 3. Клиническая характеристика больных на III этапе исследования (группа IV)
- 2. 3. Методы исследования
- 2. 3. 1. Измерение концентрации РСТ в плазме крови
- 2. 3. 2. Определение концентрации микробных маркеров методом
- ГЛАВА 3. РЕЗУЛЬТАТЫ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ
- 3. 1. Частота и структура ССВР в послеоперационном периоде у кардиохирургических больных
- 3. 1. 1. Частота и структура ССВР в послеоперационном периоде у больных в группе
- 3. 1. 2. Частота и структура ССВР в послеоперационном периоде у больных группы II
- 3. 2. Результаты периоперациоиного мониторинга РСТ, его связь с наличием ССВР, тяжестью состояния больных и госпитальной летальностью
- 3. 3. Взаимосвязь длительности ИК и уровня РСТ в первые сутки после операции
- 3. 4. Влияние инотропной терапии на уровень РСТ
- 3. 5. Послеоперационный ССВР и инфекционные осложнения
- 3. 6. Результаты изучения периоперационной динамики концентраций микробных маркеров в крови больных группы I методом ГХ-МС
- 3. 7. Взаимосвязь маркера эндотоксина и уровня прокальцитонина в раннем послеоперационном периоде
- 3. 8. Прокальцитонин- предиктор послеоперационных инфекционных осложнений
- 3. 9. Модуляция послеоперационного системного воспалительного ответа путем заместительной иммунотерапии у детей раннего возраста со сложными ВПС
- 3. 10. Мониторинг клинико-лабораторных показателей и уровня РСТ у больных с СПОН в раннем послеоперационном периоде
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