Клеточные модели оценки уровня и характера апоптоза клеток крови человека
Клетки крови и кроветворных органов являются легко доступным объектом для изучения как в норме, так и при различных патологических процессах в организме человека (23). Любые соматические клетки, в том числе и клетки крови, несут в себе исчерпывающую информацию о геномике данного субъекта и связанных с этим особенностях его метаболизмамежклеточных и межорганных связях, характерных для каждой… Читать ещё >
Содержание
- ГЛАВА I. Обзор литературы
- 1. 1. Определение апоптоза и механизмы реализации апоптотической программы
- 1. 2. Роль апоптоза в опухолевом росте и реализации противоопухолевого эффекта химиотерапии
- 1. 3. Способы оценки индуцированного и спонтанного апоптоза в клеточных популяциях
- ГЛАВА II. Материалы и методы
- ГЛАВА III. МТТ-анализ в оценке чувствительности клеток к индуцированному апоптозу
- III. 1 Методика оценки полученных данных
- 111. 2. Результаты использования модели индуцированного апоптоза для тестирования эффективности химиотерапии и оценки биологических характеристик клеток опухоли
- 111. 3. МТТ-анализ в тестировании модулирующей апоптоз активности новых лекарственных соединений
- III. 1 Методика оценки полученных данных
- IV. 1 Сравнительная оценка различных методов цитофлюориметрического анализа уровня и характера апоптоза клеток крови
- IV. 2 Апоптоз клеток крови в оценке отсроченного миелосупрессивного эффекта полихимиотерапии
- IV. 3 Спонтанный апоптоз лейкемических клеток в прогнозе эффективности индукционной терапии OJIJI
- IV. 4 Влияние новых лекарственных соединений (синтнтических тимических пептидов) на апоптоз клеток крови
- V. 1 Оригинальный метод оценки кинетики апоптоза клеток крови
V.2 Кинетика апоптоза лейкоцитов периферической крови у здоровых людей и в длительной ремиссии OJTJT. 104 V.3 Кинетика апоптоза лейкемических клеток в прогнозе их чувствительности к химиопрепаратам и эффективности терапии.
ГЛАВА VI. Фармакоэкономический расчет использования апоптотических клеточных моделей. 113-
ГЛАВА VII. Перспективы и ограничения в использовании апоптотических клеточных моделей для оценки состояния кроветворения и биологических свойств клеток.118−123.
ВЫВОДЫ. 129
ПРАКТИЧЕСКИЕ РКОМЕНДАЦИИ.
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