Потенциалоуправляемые кальциевые каналы: взаимозависимость ингибирования и инактивации

Список литературы

1. Ходжкин, А (1965) «Нервный импульс», «Мир», Москва.
2. Ходоров Б. И. (1983) «Физиология возбудимых тканей» в Серии «Руководство по физиологии». Наука. Ленинград.
3. Acharya K.R., Lloyd M.D. (2005) The advantages and limitations of protein crystal structures. Trends Pharmacol Sci 26(1): 10−14.
4. Aczel S., Kurka В., Hering, S. (1998). Mechanism of voltage- and use-dependent block of class A Ca2+ channels by mibefradil. Br. J. Pharmacol 125: 447−454.
5. Adams В., Tanabe T. (1997). Structural regions of the cardiac Ca channel a-subunit involved in Са-dependent inactivation. J. Gen Physiol 110: 379−389.
6. Ankkath J., Campbell K.P. (2003) Auxiliary subumts: essential components of the voltage-gated calcium channel complex. Curr. Opm Neurobiol 13(3): 298−307.
7. Armstrong C.M. (1966) Time course of TEA(+)-induced anomalous rectification in squid giant axons. J Gen. Physiol 50(2): 491−503.
8. Armstrong C.M. (1969) Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons. J. Gen. Physiol 54(5): 553−575.
9. Auld V.J., Goldin A L., Krafte D.S., Marshall J., Dunn J.M., Catterall WA, Lester H A., Davidson N., Dunn R.J. (1988) A rat brain Na+ channel a-subumt with novel gating properties. Neuron 1(6): 449−461.
10. Barnard E.A., Miledi R., Sumikawa K. (1982) Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes. Proc. R Soc Lond В Biol Sci 215:241−246.
11. Bean B.P. (1984) Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci USA 81: 6388−6392.
12. BenatarM.G. (1999) Calcium channelopathies QJM 92(3): 133−141.
13. Berjukow S., Doring F., Froschmayr M., Grabner M., Glossmann H., Hering S. (1996) Endogenous calcium channels in human embryonic kidney (HEK293) cells. Br J Pharmacol 118:748−754.
14. Berjukow S, Hering S. (2001) Voltage-dependent acceleration of Ca (v)1 2 channel current decay by (+) — and (-)-isradipine. Br. J Pharmacol 133: 959−966.
15. Berjukow S., Marksteiner R., Gapp F., Sinnegger M.J., Hering S (2000). Molecular mechanism of calcium channel block by isradipine: Role of a drug-induced inactivated channel conformation. J Biol Chem 275:22 114−22 120.
16. Berjukow S., Marksteiner R., Sokolov S., Weiss R.G., Margreiter E., Hering S. (2001) Amino acids in segment IVS6 and p-subumt interaction support distinct conformational changes during Cav2.1 inactivation. J Biol Chem 276: 1 707 617 082.
17. Bernatchez G., Talwar D., Parent, L. (1998). Mutations in the EF-hand motif impair the inactivation of barium currents of the cardiac a1C channel. Biophys J 75: 1727−1739.
18. Berridge M.J. (1997). Elementary and global aspects of calcium signaling. J Physiol (London) 499: 291−306.
19. Bezanilla F. (2003) Voltage sensor movements. J. Gen. Physiol 120(4) — 465−473.
20. Bezanilla F., Armstrong, C.M. (1977). Inactivation of sodium channel. II. Gating current experiments. J Gen Physiol 70: 567−590.
21. Bezprozvanny I., Scheller R.H., Tsien R.W. (1995). Functional impact of syntaxin on gating of N-type and Q-type calcium channel. Nature 378:623−626.
22. Bezprozvanny I., Tsien R.W. (1999 95?) Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40−5967). Mol Pharmacol 48(3): 540−549.
23. Billups S.J., Carter B.L. (1998) Mibefradil: a new class of calcium-channel antagonists. Ann Pharmacother. 32(6): 659−671.
24. Birnbaumer L., Campbell K P., Catterall W.A., Harpold M.M., Hofmann F., Home W.A., Mori Y., Schwartz A., Snutch T.P., Tanabe T., Tsien R.W. (1994). The naming of voltage-gated calcium channels. Neuron, 13: 505−506.
25. Black J.L. 3rd. (2003) The voltage-gated calcium channel gamma subunits: a review of the literature. J. Bioenerg Biomembr. 35(6): 649−660.
26. Bourinet E., Soong T.W., Sutton K., Slaymaker S., Mathews E., Monteil A., Zamponi G.W., Nargeot J., Snutch T.P. (1999). Splicing of a1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci 5:407−415.
27. Bouron A., Soldatov N. M., Reuter H. (1995). The Pi-subunit is essential for modulation by protein kinase C of an human and a non-human L-type Ca2+ channel. FEBS Lett 377:159−162.
28. Brehm P., Eckert R. (1978). Calcium entry leads to inactivation of calcium channel in Paramecium. Science 202:1203−1206.
29. Catterall W.A. (1995) Structure and function of voltage-gated ion channels. Annu. Rev.Biochem. 64:493−531.
30. Catterall WA. (1998) Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium. 24: 307−323.
31. Catterall W.A. (1999). Interactions of presynaptic Ca2+ channel and snare proteins in neurotransmitter release. Ann NY Acad Sci 868:144−159.
32. Catterall W.A. (2000) Structure and regulation of voltage-gated Ca2+ channels Annu Rev Cell Dev Biol 16:521−555.
33. Catterall W.A., Striessnig J. (1992) Receptor sites for Ca2+ channel antagonists. Trends. Pharmacol Sci 3(6): 256−262.
34. Cens T., Restituito S., Galas S, Charnet P. (1999). Voltage and calcium use the same molecular determinants to inactivate calcium channels. J Biol Chem 274: 5483−5490.
35. Chandy KG., Gutman G.A. (1993) Nomenclature for mammalian potassium channel genes. Trends. Pharmacol Sci 14(12): 434.
36. Chien A J., Carr K.M., Shirokov R.E., Rios E., Hosey M.M. (1996). Identification of palmitoylation sites within the L-type calcium channel p2a subunit and effects on channel function. J Biol Chem 271:26 465−26 468.
37. Cole K.S. (1949) Dynamic electrical characteristics of the squid axon membrane. Arch Sci Physiol. 3: 253−258.
38. Courtney K R. (1975) Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. J. Pharmacol Exp Ther. 195: 225−236.
39. Curtis B.M., Catterall W.A. (1984) Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules. Biochemistry 23(10): 2113−2118.
40. Dascal N. (1987). The use of Xenopus oocytes for the study of ion channels. CRC. Crit Rev. Biochem 22: 317−387.
41. Degtiar V.E., Scheller R.H., Tsien, R.W. (2000). Syntaxln modulation of slow inactivation of N-type calcium channels. J. Neurosci 20:4355−4367.
42. De Leon M., Wang Y., Jones L., Perez-Reyes E., Wei X., Soong T.W., Snutch T.P., Yue D.T. (1995). Essential Ca2±binding motif for Ca2±sensitive inactivation of L-type Ca2+ channels. Science 270:1502−1506.
43. De Waard M., Liu H., Walker D., Scott V.E., Gurnett C.A., Campbell, K P. (1997). Direct binding of G-protein p-y complex to voltage-dependent calcium channels. Nature 385: 446−450.
44. De Waard M., Campbell, P.P. (1995). Subunit regulation of the neuronal aiA Ca2+ channel expressed in Xenopus oocytes. J. Physiol 485: 619−634.
45. Doering F., Degtiar V. E., Grabner M., Striessnig J., Hering S., Glossmann H. (1996). Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of aiA (Bl). J Biol Chem 271:11 745−11 749.
46. Dolphin AC. (1998). Mechanisms of modulation of voltage-dependent calcium channels by G proteins. J. Physiol. 506: 3−11.
47. Dolphin A.C., Wyatt C.N., Richards J., Beattie R.E., Craig P., Lee J. H, Cribbs L.L., Volsen S.G., Perez-Reyes E. (1999). The effect of a2−5 and other accessory subunits on expression and properties of the calcium channel a1G. J Physiol. 519: 35−45.
48. Doyle D A., Morais Cabral J., Pfuetzner RA, Kuo A., Gulbis J.M., Cohen S.L., Chait B.T., MacKinnon R. (1998). The structure of the potassium channel molecular basis of KC conduction and selectivity. Science 280. 69−77.
49. Eller P., Berjukov S., Wanner S., Huber I., Hering S., Knaus H.G., Toth G., Kimball S.D., Striessnig J. (2000) High affinity interaction of mibefradil with voltage-gated calcium and sodium channels. Br. J Pharmacol. 130(3): 669−677.
50. Ellinor P.T., Yang J., Sather W.A., Zhang J.F., Tsien R.W. (1995). Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron 15: 11 211 132.
51. Ernst M.E., Kelly M.W. (1998) Mibefradil, a pharmacologically distinct calcium antagonist. Pharmacotherapy 18(3):463−485.
52. Ertel E A, Campbell K.P., Harpold M.M., Hofmann F., Mori Y., Perez-Reyes E., Schwartz A., Snutch T.P., Tanabe T., Birnbaumer L., Tsien R.W., Catterall W.A. (2000) Nomenclature of voltage-gated calcium channels. Neuron 25(3): 533−535.
53. Fatt P., Ginsbourg B.L. (1958) The ionic requirements for the production of action potential in crustsean muscle fibres. J Physiol (Lond) 142: 516−543.
54. Felix R. (2000) Channelopathies: ion channel defects linked to heritable clinical disorders .J Med Genet 37(10):729−740.
55. Fleckenstein A. (1983a). History of calcium antagonists Circ Res 52:13−16.
56. Fleckenstein A. (1983b). Calcium antagonism in heart and smooth muscle. New York, John Wiley & Sons
57. Fletcher C.F., Lutz C.M., O’Sullivan T.N., Shaughnessy J D. Jr, Hawkes R., Frankel W.N., Copeland N.G., Jenkins N.A. (1996) Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell 87: 607−617.
58. Forsythe I.D., Tsujimoto T., Barnes-Davies M., Cuttle M.F., Takahashi T. (1998) Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse. Neuron 20: 797−807.
59. Ganitkevich V.Ya., Shuba M.F., Smirnov S.V. (1987) Calcium-dependent inactivation of potential-dependent calcium inward current in an isolated guinea-pig smooth muscle cell. J Physiol 392:431−449.
60. Glossmann H., Ferry D.R. (1985) Assay for calcium channels. Methods Enzymol 109:513−550.
61. Glossmann H, Ferry D.R., Striessnig J., Goll A., Moosburger K. (1987) Trends Pharmacol Sei. 8:95−100.
62. Glossmann H., Striessnig J. (1990). Molecular properties of calcium channels. Rev Physiol Biochem. Pharmacol. 114:1−105.
63. Grabner M., Wang Z., Hering S., Striessnig J., Glossmann H. (1996). Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (Bl) calcium channels. Neuron. 16: 207−218.
64. Gundersen C.B., Miledi R., Parker I. (1984) Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes. Nature 308: 421−424.
65. Gurdon J.B., Lane C.D., Woodland H.R., Marbaix G. (1971) Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells. Nature 233. 177−182.
66. Hagiwara S., Saito N. (1959) Voltage-current relations in nerve cell membrane of Onchidium verruculatum. J. Physiol (Lond) 148:161−179.
67. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cellfree membrane patches. PflugersArch 391(2): 85−100.
68. Handrock R., Rao-Schymanski R., Klugbauer N., Hofmann F., Herzig S. (1999) Dihydropyridine enantiomers block recombinant L-type Ca2+ channels by two different mechanisms. J. Physiol 521(1): 31−42.
69. Hanlon M.R., Wallace B.A. (2002) Structure and function of voltage-dependent ion channel regulatory p-subunits. Biochemistry. 41(9): 2886−2894.
70. He M., Bodi I., Mikala G., Schwartz A. (1997) Motif III S5 of L-type calcium channels is involved in the dihydropyridine binding site. A combined radioligand binding and electrophysiological study. J Biol Chem 272(5): 2629−2633.
71. Heady T.N., Gomora J.C., Macdonald T.L., Perez-Reyes E. (2001) Molecular pharmacology of T-type Ca2+ channels. Jpn. J. Pharmacol. 85(4): 339−350.
72. Hering S. (2002) p-Subunits: fine tuning of Ca2+ channel block. Trends Pharmacol Sci 23(11): 509−513.
73. Hering S., Aczel S., Kraus R.L., Berjukow S., Striessnig J., Timin, E.N. (1997). Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation. Proc Natl Acad Sci. USA 94: 1 332 313 328.
74. Hering S., Berjukow S., Aczel S., Timin, E.N. (1998). Calcium channel block and inactivation: common molecular determinants. Trends Pharmacol Sci 19: 439 443.
75. Hering S., Berjukow S., Sokolov S., Marksteiner R., Weiss R. G, Kraus R., Timin E.N. (2000) Molecular determinants of inactivation in voltage-gated Ca2+ channels. J Physiol 528: 237−249.
76. Hille B. (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen Physiol 69:497−515.
77. Hille, B. (1978) in Biophysical Aspects of cardiac Muscle (Academic Press), 55−73.
78. Hille B. (1992). Ion channels of excitable membranes. 2nd edition, Smauer assciates, Sunderland, Massachusets.
79. Hockerman G.H., Dilmac N., Scheuer T., Catterall W.A. (2000) Molecular determinants of diltiazem block in domains IIIS6 and IVS6 of L-type Ca2+ channels. Mol Pharmacol 58(6): 1264−1270.
80. Hockerman G.H., Johnson B.D., Scheuer T., Catterall WA. (1995) Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels. J. Biol Chem 270(38): 22 119−22 122.
81. Hockerman G.H., Peterson B. Z, Johnson B.D., Catterall W.A. (1997b). Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol 37:361−396.
82. Hodgkin A.L., Huxley A.F. (1952a) Currents curried by sodium and potassium ions through the membrane of the giant axon of Loligo. J. Physiol (Lond) 116: 449 472.
83. Hodgkin A. L, Huxley A F. (1952b) The components of membrane conductance in the giant axon of Loligo. J. Physiol (Lond) 116:473−496.
84. Hodgkin A.L., Huxley A.F. (1952c) The dual effect of membtrane potential on sodium conductance in the giant axon of Loligo. J Physiol (Lond J 116:497−506.
85. Hodgkin A.L., Huxley A.F. (1952d) A quantitative decription of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond) 117: 500−544.
86. Hodgkin A.L., Keyenes R.D. (1955a) Active transport of cations in giant axon from Sepia and Loligo. J Physiol (Lond.) 128: 28−60.
87. Hodgkin A.L., Keyenes R.D. (1955b) Potassium permeability of a giant nerve fibre. J. Physiol (Lond.) 128: 61−88.
88. Hofmann F., Lacinova L. Klugbauer N. (1999) Voltage-dependent calcium channels: from structure to function. Rev Physiol. Biochem Pharmacol 139: 3387.
89. Hondghem L.M., Katzung B.G. (1977) A unifying molecular model for the interaction of antiarrhythmic drugs with cardiac sodium channels: application to quinidine and lidocaine. Biochim. Biophys Acta 472: 373−377.
90. Horton R.M., Hunt H.D., Ho S.N., Pullen J.K., Pease L.R. (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77(1): 61−68.
91. Hoshi T., Zagotta W.N., Aldrich R.W. (1990) Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250: 533−538.
92. Jen J. (1999) Calcium channelopathies in the central nervous system. Curr. Opm Neurobiol 9: 274−280.
93. Jentsch T. J., Steinmeyer K., Schwarz G. (1990). Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348: 510−514.
94. Jimenez C., Bourinet E., Leuranguer V., Richard S., Snutch T.P., Nargeot J. (2000) Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 39:1−10.
95. Julius D., MacDermott AB., Axel R" Jessell T. M. (1988). Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241:558−564.
96. Jiang Y., MacKinnon R. (2000) The barium site in a potassium channel by X-ray crystallography. J Gen Physiol. 115:269−272.
97. Katz B. (1962) The Croonian lecture. The transmission of impulses from nerve to muscle and subcellular unit of synaptic action. Proc R. Soc Lond B. 155: 455 477.
98. Khodorov B.I. (1979) Some aspects of the pharmacology of sodium channels in nerve membrane. Process of inactivation. Biochem Pharmacol 28:1451−1459.
99. Khodorov B.I. (1981) Sodium inactivation and drug-induced immobilization in nerve membrane Prog Biophys Mol Biol 37: 49−89.
100. Kim M.S., Morii T., Sun L.X., Imoto K., Mori Y. (1993). Structural determinants of ion selectivity in brain calcium channel. FEBS Lett 318:145−148.
101. Klugbauer N., Dai S., Specht V., Lacinova L., Marais E., Bohn G, Hofmann F. (2000). A family of y-like calcium channel subunits. FEBS Lett 470:189−197.
102. Kobilka B.K., Kobilka T.S., Daniel K., Regan J.W., Caron M.G., Lefkowitz R.J. (1988) Chimeric a2-p2 adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science. 240:1310−1316.
103. Kraus R.L., Hering S., Grabner M., Ostler D., Striessnig J. (1998) Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J. Biol Chem. 273: 27 205−27 215.
104. Kraus R.L., Sinnegger M.J., Glossmann H., Hering S., Striessnig, J. (1998). Familial hemiplegic migraine mutations change a1A Ca2+ channel kinetics. J. Biol Chem 273: 5586−55 890.
105. MacKinnon R. (2003) Potassium channels. FEBS Lett. 555: 62−65.
106. Marmont G. (1949) Studies on the axon membrane. I. A new method. J. Cell Comp Physiol 34:351−382.
107. McDonald T.F., Pelzer D., Trautwein W. (1984) Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock. J Physiol 352: 217 241.
108. Mikala G., Bahinski A., Yatani A., Tang S., Schwartz A. (1993). Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore. FEBS Lett 35: 265−269.
109. Miledi R., Parker I., Sumikawa K. (1982) Properties of acetylcholine receptors translated by cat muscle mRNA in Xenopus oocytes. EMBO J 1:1307−1312.
110. Miljanich G.P., Ramachandran J. (1995) Antagonists of neuronal calcium channels: structure, function, and therapeutic implications. Annu Rev Pharmacol Toxicol 35: 707−734.
111. Moorman J. R., Kirsch G. E., VanDongen A. M., Joho R. H., Brown A. M. (1990). Fast and slow gating of sodium channels encoded by a single mRNA. Neuron 4: 243−252.
112. Motoike H.K., Bodi I., Nakayama H., Schwartz A., Varadi, G. (1999). A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzodiazepines. J Biol Chem 274: 9409−9420.
113. Muth J.N., Bodi I., Lewis W., Varadi G., Schwartz A. (2001a) A Ca2±dependent transgenic model of cardiac hypertrophy: A role for protein kinase C-a. Circulation. 103(1): 140−147.
114. Muth J.N., Varadi G., Schwartz A. (2001b) Use of transgenic mice to study voltage-dependent Ca2+channels. Trends Pharmacol Sci 22(10): 526−532.
115. Nakamura Y., Nakajima S., Grunfest H. (1965) Analysis of spike electrogenesys and depolarizing K inactivation in electroplaques of Electrophorus electricus, L. J Gen Physiol 49: 321−349.
116. Narahashi T.J., Moore W., Scott W.R. (1964) Tetrodotoxin blocade of sodium conductance increase in lobster giant axon. J Gen Physiol 47:965−974.
117. Nawrath H., Wegener J.W. (1997) Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels. Naunyn Schmiedebergs Arch Pharmacol 355: 79−86.
118. Neher E., Sakmann B. (1976) Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 260: 799−802.
119. Ophoff R A., Terwindt G.M., Vergouwe M.N., van Eijk R., Oefner P.J., Hoffman S M., Lamerdin J.E., Mohrenweiser H.W., Bulman D.E., Ferrari M., Haan J., Lindhout D., van Ommen G.J., Hofker M.H., Ferrari M.D., Frants R.R. (1996)
120. Familial hemiplegie migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87(3): 543−552.
121. Parent L., Gopalakrishnan M., Lacerda A.E., Wie X., Perez-Reyes E. (1995). Voltage-dependent inactivation in a cardiac-skeletal chimeric calcium channel. FEBSLett 360:144−150.
122. Patil P.G., Brody D.L., Yue, D.T. (1998). Preferential closed-state inactivation of neuronal calcium channels. Neuron 20:1027−1038.
123. Perez-Reyes E., Lee J.H., Cribbs L-L. (1999). Molecular characterization of two members of the T-type calcium channel family. Ann N Y. Acad Sci. 868:131−143.
124. Peterson B Z., DeMaria C.D., Yue D.T. (1999). Calmodulin is the Ca2+ sensor for Ca2±dependet inactivation of L-type calcium channels. Neuron 22: 549−558.
125. Peterson B Z, Johnson B.D., Hockerman G.H., Acheson M, Scheuer T., Catterall WA (1997) Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis. J. Biol Chem. 272(30): 18 752−18 758.
126. Peterson B. Z, Lee J.S., Mulle J.G., Wang Y., DeLeon M., Yue D.T. (2000) Critical determinants of Ca2±dependent inactivation within an EF-hand motif of L-type Ca2+ channels. Biophys J. 78:1906−1920.
127. Peterson B.Z., Tanada T.N., Catterall W.A. (1996) Molecular determinants of high affinity dihydropyridine binding in L-type calcium channels J. Biol. Chem 271(10): 5293−5296.
128. Pichler M., Cassidy T.N., Reimer D., Haase H., Kraus R., Ostler D., Striessnig J. (1997) p-subunit heterogeneity in neuronal L-type Ca2+ channels. J. Biol Chem 272:13 877−13 882.
129. Pietrobon D, Striessnig J. (2003) Neurobiology of migraine. Nat Rev Neurosci 4(5): 386−98.
130. Platzer J., Engel J., Schrott-Fischer A, Stephan K., Bova S., Chen H., Zheng H., Striessnig J. (2000) Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca"2* channels. Cell. 102(1): 89−97.
131. Plomp J.J., Vergouwe M.N., Van den Maagdenberg AM., Ferrari M.D., Frants R.R., Molenaar P.C. (2000) Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering
132. Pragnell M., DeWaard M., Mori Y., Tanabe T., Snutch T P., Campbell, K.P. (1994) Calcium channel p-subunit binds to a conserved motif in the l-ll cytoplasmic linker of the a1-subunit. Nature 368: 67−70.
133. Qin N., Olcese R., Bransby M., Lin T., Birnbaumer L. (1999). Ca2±induced inhibition of the cardiac Ca2+ channel depends on calmodulin. Proc Natl Acad Sci USA 96: 2435−2438.
134. Ritchie J.M., Rogart R.B., Strichartz G.R. (1976) A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves. J. Physiol. 261(2): 477−494.
135. Rettig J., Sheng Z.H., Kim D.K., Hodson C.D., Snutch T.P., Catterall W.A. (1996). Isoform-specific interaction of the a1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25. Proc. Natl Acad Sci USA 3: 73 637 368.
136. Sanger F., Nicklen S., Coulson A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad Sci U S A 74(12): 5463−5467.
137. Sanguinetti M.C., Kass R. S (1984) Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists Circ Res. 55:336−348.
138. Sather W.A., McCleskey E.W. (2003) Permition and selectivity in calcium channels. Annu Rev. Physiol. 65:133−159.
139. Sather W.A., Tanabe T., Zhang J F., Mori Y., Adams M. E, Tsien R.W. (1993) Distinctive biophysical and pharmacological properties of class A (Bl) calcium channel a1 subunits. Neuron 11: 291−303.
140. Schmid A., Romey G., Barhanin J., Lazdunski M. (1989) SR33557, an indolizinsulfone blocker of Ca2+ channels: identification of receptor sites and analysis of its mode of action. Mol Pharmacol 35(6): 766−773.
141. Schuster A., Lacinova L., Klugbauer N. Ito H., Birnbaumer L., Hofmann F. (1996) The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. EMBOJ 15(10): 2365−2370.
142. Serysheva I.I., Ludtke S.J., Baker M.R., Chiu W., Hamilton S.L. (2002) Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc. Natl. Acad Sci USA 99(16): 10 370−10 375.
143. Sokolov S., Timin E., Hering S. (2001) On the role of Ca2± and voltage-dependent inactivation in Cav1.2 sensitivity for the phenylalkylamine (-)gallopamil. Ore Res 89: 700−708.
144. Sokolov S., Weiss R.G., Kurka B., Gapp F., Hering, S. (1999) Inactivation determinant in the l-ll loop of the Ca2+ channel a1-subunit and p-subunit interaction affect sensitivity for the phenylalkylamine (-)-gallopamil J Physiol 519: 315−322.
145. Sokolov S., Weiss R.G., Timin E.N., Hering S. (2000). Modulation of slow inactivation in class A Ca2+ channels by p-subunits. J. Physiol. 527:445−454.
146. Starmer C.F., Grant A.O. (1985) Phasic ion channel blockade. A kinetic model and parameter estimation procedure. Mol Pharm 28:348−356.
147. Spaetgens R.L., Zamponi G.W. (1999) Multiple structural domains contribute to voltage-dependent inactivation of rat brain a1E calcium channels. J Biol Chem 274: 22 428−22 436.
148. Stotz S.C., Hamid J., Spaetgens R.L., Jarvis S.E., Zamponi, G.W. (2000) Fast inactivation of voltage-dependent calcium channels. A hinged-lid mechanism? J Biol. Chem 275: 24 575−24 582.
149. Straub R. E., Freeh G. C., Joho R. H., Gershengorn M. C. (1990). Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci. U S A 87: 9514−9518.
150. Striessnig J., Grabner M., Mitterdorfer J., Hering S., Sinnegger M.J., Glossmann H. (1998) Structural basis of drug binding to L-type Ca2+ channels. Trends Pharmacol Sci. 19:108−115.
151. Strichartz G.R. (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen Physiol. 62: 37−57.
152. Stuhmer W., Methfessel C., Sakmann B., Noda M., Numa S. (1987). Patch clamp characterization of sodium channels expressed from rat brain cDNA. Eur. Biophys J. 14:131−138.
153. Tanabe T., Takeshima H., Mikami A., Flockerzi V., Takahashi H., Kangawa K., Kojima M., Matsuo H., Hirose T., Numa S. (1987). Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 328: 313−318.
154. Tanaka 0., Sakagami H., Kondo, H. (1995) Localization of mRNAs of voltage-dependent Ca2±channels: four subtypes of a1- and p-subumts in developing and mature rat brain. Brain Res Mol Brain Res 30:10−16.
155. Tang S., Mikala G., Bahinski A, Yatani A., Varadi G., Schwartz A. (1993). Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel. J Biol Chem 268:13 026−13 032.
156. Tang S., Yatani A, Bahinski A., Mori Y., Schwartz A. (1993) Molecular localization of regions in the L-type calcium channel critical for dihydropyridine action. Neuron 11:1013−1021.
157. Tareilus E., Schoch J., Breer H. (1994) Ca2±dependent inactivation of P-type calcium channels in nerve terminals. J. Neurochem. 62: 2283−2291.
158. Timin E.N., Hering S. (1992) A method for estimation of drug affinity constants to the open conformational state of calcium channels. Biophys J 63: 808−814.
159. Walker D., Bichet D., Campbell K.P., De Waard M. (1998) A p4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel alAsubunit. J Biol Chem 273: 2361−2367.
160. Walker D., Bichet D., Geib S., Mori E., Cornet V., Snutch T P., Mori Y., De Waard M. (1999) A new p-subtype-specific interaction in a1A subunit controls P/Q-type Ca2+ channel activation. J. Biol Chem 274:12 383−12 390.
161. Walker D., De Waard M. (1998) Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function. Trends Neurosci 21(4): 148−154.
162. West J., Patton D., Scheuer T. f Wang Y., Goldin A., Catterall W. (1992) A cluster of hydrophobic amino acid residues is required for fast sodium channel inactivation. Proc Natl Acad Sci USA 89:10 910−10 914.
163. Williams M.E., Feldman D.H., McCue A F., Brenner R., Velicelebl G., Ellis S.B., Harpold M.M. (1992) Structure and functional expression of a1, a2, and p subunits of a novel human neuronal calcium channel subtype. Neuron 8: 71−84.
164. Wu L.G., Westenbroek R.E., Borst J.G.G., Catterall W.A., Sakmann B. (1999) Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J. Neurosci 19: 726−736.
165. Yang J., Ellinor P.T., Sather W.A., Zhang J.F., Tsien RW (1993) Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca channels. Nature 366:158−161.
166. Zamponi G.W., Soong T.W., Bourinet E., Snutch T.P. (1996) p-Subunit coexpression and the a1 subunit domain l-ll linker affect piperidine block of neuronal calcium channels. J Neurosci 6:2430−2443.
167. Zhang J.F., Ellinor P.T., Aldrich R.W., Tsien R.W. (1994) Molecular determinants of voltage-dependent inactivation in calcium channels Nature 372: 97−100.
168. Zhong H., Yokoyama C.T., Scheuer T., Catterall W. (1999) Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin. Nat. Neurosci 2:939−941.
169. Zuhlke R.D., Bouron A., Soldatov N.M., Reuter H. (1998) Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human a1C subunit gene. FEBS Lett. 427: 220−224.
170. Zuhlke R.D., Pitt G.S., Deisseroth K., Tsien R.W., Reuter H. (1999) Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 399: 159−162.