Коррекция ишемических и реперфузионных повреждений миокарда с использованием липосомальных препаратов
Диссертация
Липосомы, введенные в ишемизированный миокард при температурах 4 °C, 14 °C и 37 °C, включаются в миокардиальную ткань, распределяясь в различных соотношениях между фракциями грубых цитоплазматических мембран, митохондриальной и микросомальной. Интенсивность включения липосом в миокардиоциты и распределение их по субклеточным фракциям в значительной степени зависят от концентрации, липидного… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗУЕМЫХ СОКРАЩЕНИЙ
- ГЛАВА 1. ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ЛИПОСОМАЛЬНЫХ ПРЕПАРАТОВ КАК СПОСОБА ПРЕДУПРЕЖДЕНИЯ И КОРРЕКЦИИ ИШЕМИЧЕСКИХ И РЕПЕРФУЗИОННЫХ ПОВРЕЖДЕНИЙ МИОКАРДА (ОБЗОР ЛИТЕРАТУРЫ)
- 1. 1. Липосомы. Получение и свойства липосом
- 1. 2. Применение липосом в биологии и медицине
- 1. 3. Формирование патогенетической цепи ишемического повреждения миокарда
- 1. 4. Механизмы и роль нарушений энергетического обмена клеток миокарда при острой ишемии и реперфузии
- 1. 5. Активация процессов липопероксидации в период ишемии
- 1. 6. Активация процессов липопероксидации в период реперфузии
- ГЛАВА 2. МЕТАБОЛИЧЕСКИЕ ИЗМЕНЕНИЯ В МИОКАРДЕ ПОСЛЕ ИШЕМИИ И ПОСЛЕДУЮЩЕЙ РЕПЕРФУЗИИ В УСЛОВИЯХ НОРМО- И ГИПОТЕРМИИ
- 2. 1. Структурные повреждения мембран и метаболические изменения в клетках при нормотермической ишемии миокарда
- 2. 2. Структурные повреждения мембран и метаболические изменения в миокарде при ишемии и реперфузии в условиях гипотермии
- ГЛАВА 3. СВОЙСТВА, ТЕХНОЛОГИЯ ПОЛУЧЕНИЯ И СТАНДАРТИЗАЦИИ ЛИПОСОМАЛЬНЫХ ПРЕПАРАТОВ 68 3.1. Получение липосом методом ультразвуковой сонификации
- 3. 1. 1. Получение мультиламеллярных везикул
- 3. 1. 2. Получение малых однослойных липосом методом ультразвуковой сонификации
- 3. 2. Включение и субклеточное распределение липосом в миокарде 71 3.2.1. Метод определения радиоактивности
- 3. 3. Получение малых однослойных липосом методом экструзии
- 3. 4. Влияние способа получения липосом на интралипосомальные биологически активные вещества
- 3. 5. Сравнительная оценка интенсивности процессов свободнорадикального окисления в липосомах, полученных различными методами
- ГЛАВА 4. ПРЕДУПРЕЖДЕНИЕ ИШЕМИЧЕСКИХ И РЕПЕРФУЗИОННЫХ ПОВРЕЖДЕНИЙ МИОКАРДА С ИСПОЛЬЗОВАНИЕМ ЛИПОСОМАЛЬНЫХ ПРЕПАРАТОВ
- 4. 1. Эффекты предварительного системного введения липосомальных препаратов при нормотермической ишемии и реперфузии
- 4. 2. Эффекты интракоронарного введения липосомальных препаратов при нормотермической ишемии и реперфузии
- 4. 3. Эффекты интракоронарного введения липосомальных препаратов в условиях гипотермичекой ишемии
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