Разработка биокаталитических систем для энантиоселективного восстановления карбонилсодержащих соединений
Диссертация
Практическая значимость. Разработаны высокостереоселективные биокатализаторы на основе штаммов Pichia sp. 80−11 и Metschnikowia sp. 8413, осуществляющих энантиоселективное восстановление этилацетоацетата в Sи R-энантиомеры этил-3-оксибутирата высокой оптической чистоты. Созданы препаративные методы синтеза высокочистых (S) — и ® — этил-3-оксибутирата (не менее 98%ее). Полученный оптически чистый… Читать ещё >
Содержание
- 1. ЛИТЕРАТУРНЫЙ ОБЗОР Микробиологическое энантиоселек-тивное восстановление карбонилсодержащих соединений
- 1. 1. Введение. Применение оптически активных продуктов асимметрического восстановления карбонилсодержащих соединений
- 1. 2. Ферменты, ответственные за реакции восстановления карбонилсодержащих соединений
- 1. 2. 1. Восстановление кетосодержащих соединений при помощи выделенных ферментов
- 1. 3. Коферменты, участвующие в реакциях восстановления и способы их регенерации 15 1.4 Восстановление карбонилсодержащих соединений целыми клетками микроорганизмов ¦
- 1. 4. 1. Восстановление кетосодержащих соединений клетками пекарских дрожжей
- 1. 4. 2. Восстановление кетосодержащих соединений другими дрожжевыми штаммами
- 1. 4. 3. Восстановление кетосодержащих соединений бактериальными штаммами
- 1. 5. Повышение стереоселективности реакций биовосстановления
- 1. 6. В осстановление труднорастворимых кетосодержащих соединений
- 2. ОБЕКТЫ, МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Объекты исследования
- 2. 2. Материалы исследования
- 2. 2. 1. Синтез ® — или (S)-30B
- 2. 2. 2. Синтез (S) — 3,3-Диметил-2-гидроксибутиролактона
- 2. 3. Методы исследования
- 2. 3. 1. Культивирование микроорганизмов
- 2. 3. 2. Получение накопительных культур
- 2. 3. 3. Выделение чистых культур микроорганизмов 46 2.3.4 Идентификация микроорганизмов
- 2. 3. 5. Иммобилизация микроорганизмов в полиакриламид- 46 ный гель
- 2. 3. 6. Трансформация кетосодержащих соединений 47 покоящимися клетками микроорганизмов
- 2. 3. 7. Определение оптической чистоты продуктов биотрансформации
- 2. 3. 8. Наработка оптически чистого (S)-30B иммобилизованными клетками Pichia sp
- 3. 1. Скрининг микроорганизмов с энантиоселективной карбо-нилредуктазной активностью
- 3. 1. 1. Исследование карбонилредуктазной активности пекарских дрожжей
- 3. 1. 2. Селекция штаммов с ЭАА-активностью
- 3. 1. 3. Исследование продуктов трансформации ЭАА микроорганизмами
- 3. 2. Идентификация и исследование патогенных свойств перспективных штаммов
- 3. 3. Исследование восстановление ряда карбонилсодержащих соединений
- 3. 4. Поиск методов подавления побочных реакций биовосстановления ЭАА
- 3. 4. 1. Влияние химических ингибиторов
- 3. 4. 2. Температурная предобработка биомассы штамма Pichia sp
- 3. 5. Поиск оптимальных условий восстановления этилацетоацетата исследуемыми микроорганизмами
- 3. 5. 1. Зависимость от температуры
- 3. 5. 2. Зависимость от рН
- 3. 5. 3. Влияние концентрации субстрата
- 3. 5. 4. Зависимость от концентрации биомассы
- 3. 5. 5. Исследование зависимости трансформации ЭАА от вида атмосферы
- 3. 5. 6. Исследование кинетики аэробной трансформации
- 3. 6. Влияние условий выращивания на трансформацию ЭАА
- 3. 6. 1. Зависимость восстановления ЭАА от возраста биомассы
- 3. 6. 2. Трансформация ЭАА биомассой Pichia sp. 80−11, выращенной в анаэробных условиях
- 3. 6. 3. Восстановление ЭАА биомассой Pichia sp.80−11, выращенной на этаноле
- 3. 7. Исследование возможности повторного использования биомассы для восстановления ЭАА
- 3. 8. Поиск экзогенных восстановителей для регенерации отработанной биомассы
- 3. 9. Разработка иммобилизованного биокатализатора на основе клеток Pichia sp
- 3. 10. Разработка препаративных методов получения S- и R-энантиомеров ЭОБ
- 3. 11. Использование S-энантиомера ЭОБ в синтезе феромонов насекомых
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