NMDA-ергические механизмы опиатной анальгезии на модели хронической боли
Диссертация
Длительная активация ноцицепторов или повреждение афферентного нерва, которые приводят к центральной сенситизации ноцицептивной системы, лежат в основе многих формхронических болевых синдромов (Herrero et al., 2000). Предполагаемый механизм этой сенситизации (явление «взвинчивания» или «wind-up») обладает всеми* свойствами, присущими процессам нейрональной пластичности, и зависит от активации… Читать ещё >
Содержание
- ГЛАВА 1. РОЛЬ NMDA-РЕЦЕПТОРНОГО КОМПЛЕКСА В ПАТОГЕНЕЗЕ ХРОНИЧЕСКИХ БОЛЕВЫХ СИНДРОМОВ И ОПИАТНОЙ ТОЛЕРАНТНОСТИ Хронические болевые синдромы и опиатная терапия
- Определение боли
- Проведение болевой информации
- Механизмы хронических болевых синдромов
- Методы моделирования ХБС
- Механизмы опиатной аналгезии
- Опиоидные рецепторы
- Опиатные аналгетики и их побочные эффекты
- Толерантность к опиатной аналгезии
- Хроническая толерантность
- Острая толерантность
- Резистентность хронических болевых симптомов к опиатной терапии
- Возможные пути совершенствования опиатной терапии
- Роль NMDA-рецепторов в опиатной аналгезии и толерантности
- NMDA-рецепторный комплекс
- Возможности терапевтического использования антагонистов NMDA-рецепторов
- Взаимодействие опиоидпых и NMDA-рецепторов в контроле болевого реагирования
- МуШАергические механизмы ХБС
- Спинальный уровень взаимодействия глутаматной и опиоидной систем
- Супраспинальный уровень взаимодействия глутаматной и опиоидной систем 42 Системный уровень взаимодействия глутаматной и опиоидной систем 44'
- Влияние антагонистов NMDA-рецепторов на развитие и проявление опиатной толерантности
- ГЛАВА 2. МАТЕРИАЛЫ И МЕТОДЫ Экспериментальные животные и условия их содержания
- Вещества
- Формалиновая" модель хронической боли
- Плантарный тест (тест Харгривса)
- Тест «вращающийся стержень"*
- Электрофизиологические эксперименты*
- Периферический компонент опиатной алгезии
- Развитие острой толерантности к аналгетическому эффекту опиатных агонистов
- Развитие острой толерантности к морфину
- Развитие острой толерантности к л операми ду
- Методы статистического анализа результатов
- ГЛАВА 3. РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЙ И ОБСУЖДЕНИЕ Модель тонической боли
- Эффекты морфина
- Эффекты антагонистов NMDA-рецепторов 69 Эффекты сочетанного введения морфина и канальных блокаторов NMDAрецепторов
- Эффекты лоперамида
- Эффекты сочетанного введения лоперамида и антагонистов NMDA-рецепторов
- Острая толерантность к эффектам морфина
- Острая толерантность к эффектам лоперамида
- Перекрестная толерантность между морфином и лоперамидом
- Модель острой боли (тест Харгривса)
- Тест «вращающийся стержень»
- Электрофизиологические данные
- Обсуждение результатов
- Антиноцицептивные эффекты агонистов опиоидных рецепторов центрального и периферического действия
- Влияние антагонистов разных классов NMDA-рецепторного комплекса на аналитический эффект опиатов
- Влияние антагонистов NMDA-рецепторного комплекса на развитие острой толерантности к эффектам морфина и лоперамида
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