Исследование локализации гена предрасположенности к каталепсии у мышей с помощью полиморфных микросателлитных маркеров
Диссертация
Большая часть поведенческих признаков являются количественными, контролируются полигенно и значительно зависят от факторов внешней среды (Мазер, Джинкс, 1985; Васильева, 1999; Crusio, 1999), но при этом можно выделить главные гены с большим вкладом в изменчивость признака, чем остальные гены (Мазер, Джинкс, 1985). Для изучения генетической структуры количественных признаков был разработан… Читать ещё >
Содержание
- ff ВВЕДЕНИЕ
- ГЛАВА 1. Обзор литературы. Использование полиморфных микросателлитов для ф Генетического анализа и картирования поведенческих признаков
- 1. 1. Микросателлиты и теория их использования.1G
- 1. 1. 1. Микросателлитные повторы, их локализация в геноме, полиморфизм, функции
- 1. 1. 2. Микросателлитные повторы как генетические маркеры
- 1. 1. 3. Сравнение микросателлитов с другими генетическими молекулярными маркерами
- 1. 2. Методы генетического анализа признаков поведения, использующие микросателлиты
- 1. 2. 1. Особенности генетической структуры признаков поведения
- 1. 2. 2. QTL анализ, его принципы, преимущества и недостатки. ф 1.2.3. Метод генов-кандидатов и принцип позиционного клонирования мутаций
- 1. 2. 4. Генетический анализ реакции замирания. Применение QTL анализа для ф картирования галоперидоловой каталепсии
- 1. 1. Микросателлиты и теория их использования.1G
- 1. 1. Экспериментальные животные
- 1. 1. 1. Условия содержания
- 1. 1. 2. Гибридологический эксперимент
- 1. 1. 3. Селекционный эксперимент
- 1. 2. Измерение каталепсии
- 1. 3. Выделение ДНК
- 1. 6. Тестирование функциональной активности 5HTia рецепторов
- 1. 7. Статистическая обработка результатов
- 1. 7. 1. Оценивание выраженности каталепсии
- 1. 7. 2. Проверка гипотезы о сцеплении альтернативнго признака с неполной пенетрантностью
- 1. 1. Доля каталептиков у мышей линий СВА, AKR и их гибридов Fi и бэккроссов
- 1. 2. Локализация гена предрасположенности к каталепсии методом одномаркерного анализа. 1.3. Локализация гена предрасположенности к каталепсии методом интервального оценивания
- 1. 3. 1. Картирование гена каталепсии по методу Brodkin et al. (2002)
- 1. 3. 2. Картирование гена каталепсии методом максимального правдоподобия и минимума %
- 1. 4. Динамика выраженности каталепсии в ходе селекции на данный признак
- 1. 5. Изменение концентрации генотипов и соответствующих аллелей СВА и AKR у мышей в ходе селекции на каталепсию
- 1. 5. 1. Бэккроссы
- 1. 5. 2. Мыши поколения селекции Si и S
- 1. 5. 3. Мыши поколения SgH S
- 1. 6. Изучение функциональной активности 5HTia рецепторов у мышей линий
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