Значение кинетических параметров опухолевого роста в чувствительности лейкемической популяции к химиотерапии при острых лейкозах у детей
Доказательством зависимости чувствительности лейкемнческнх клеток к цнготоксическому действию ХП от нх кинетических параметров служат результаты проведенных нами исследований корреляционных связей между чувствительностью лсйкемических клеток к ХП и кинетическими параметрами опухолевого роета. Так при ОЛЛ у детей группа с высокой чулствнгелыюсгыо лсйхемичсскнх клеток К в&КУПду характеризовалась… Читать ещё >
Содержание
- ГЛАВА 1. Обюр литературы 13 I I Понятие о пролифсратнмгоЛ активности н особенностях шегачккнх параметров лейкемичоеких клеток
- 1. 2. Программа ашмггаэа и механизмы ее реализации
- 1. 3. Биологические основы механизма действия противоопухолевых
- ГЛАВА II. Материалы к методы
- Глав* III. Клиническое значение кннстнческнх параметров опухолевого роста при острых лейкозах
- ГЛАВА IV. Клиническое значение узловых механизмов шоптотнчсского каскада лейксчических клеток при острых лейкоых у детей
- ГЛАВА V. Сравнение кинетического статуса, уиюиых механизмов апоптотического каскада н чувствительности лсйкемнчсскнх клеток к глюкокортиконлным гормонам при острых лей коих у да ей
ГЛАВА VI, Клиническое значение чуткткитслынктм лсйкелнрюских клегок к хммионрепаратам при остром. шмфобласпюм лейкозе у детей по результатам МТГ тес га ГЛлвл VII. Клиническое значение чувствительности лейкемнческнх клеток к хиннонренаратам ггрн остром чыслпбластноч лейкозе у детей, но результатам МТТ теста (7 J
Глава Vil L
Заключение 1%
ВЫВОДЫ 2(Ю
П ФАКТИЧЕСКИ ЕРЕ КОМ ЕНДЛЦИИ
Список литературы
- Астрслина Т.А. Механизм действия анлелейкемнчеекнх премратов при лечении острых нелнмфобластных лейкозов // Гематология и транефузиололм.-М-, 2000, — Jfe 2.' с .34−38,
- Байдун Л 0 Современная диагностика и классификация острой лнмфобластной.тейкемнн. // Гематология и трансфузиология • М, 1997 -т, 42, Jfe3.-e.37−4 2,
- Барышников А.Ю., Шишкин Ю. В. Экспресеня и проявление функциональной активности Fas.'Apo-l/CD-95 антигена, опосредующего апоитоз. при гемобласпвах человека. ЛТематологня н граксфузяология.- М., 1995. -т.40, jVbd -cJ5−38.
- Барышников ЮЛ. Полосухина Е. Р., Шишкин Ю. В. н др. Новый прогностический маркер octpoj’o лимфобласпюго лейкоза антиген CD95 (FAS/APO-1), //Гематология и трансфузиологня- М. 1998. — Ns2 — q.S.
- Барышников Ю А, Шишкин Ю. В. FAS/APO-b'CD95 антиген молекула, опосредующая апоптоз. // Гематолотмя н трянсфузиологня.- М., 1996. — № 6 -с35−38.
- Владимирская Е, Б, Биологические основы противоопухолевой терапии ОчсркнУ/ М, Агат-Мед, 2001.- б-с.3−8.
- Владимирская Б, Б" Кошель ИВ. Курмашов ВЛЖ1ро6д. гсмат, пер, кровн, М., 1971−12-е.6−10.
- Владимирская 1. Е"., Румянцев А. Г. Роль ростовых факторов в регуляции кроветворения Л Гематология и трвнефузкологня. М., 2000. -т.45, Лв 6.- с.4−9.
- Добренькое К В., Тимаков A.M. Ворфоломеева С Р, Урмаева М. М, Lpiiiia Т А. Проблемы лечения лейкозов у детей.// Русский Медицине кий Журнал.-М-Л998,-т.бн№ 23, — с, 14"9−1495
- Карачунский АЛ., Румянцев АГ, Хснпе Г- Основные принципы лечения острой димфобластиой лейкемии у детей н предварительные результаты собственных исследований.'/ Педиатрия -М, 1995 № 4.-с, Ш,
- Карачунекий А, И-, Румянцев АГ., Самочатова Е. В. и др. Результаты лечения острых лейкозов у детей с использованием программ интенсивной терапии. ' Гематология н трансфуэнологня.- М., 1994.-х, 39, Nt2.- с. 18−21,
- Кисляи Н.С., Ленская Р.В, Клетки кропи у детей в норме и патологии. И М., Медицина, 1978, — с. 256.
- Кисляе н.С., Лене кал Р.в. Шведова Е. к). к др. Ретроспективная оценки иммунологических показателей крови у детей в разные сроки ремиссии острого лимфобластного лейкоза. // Гематология и трансфузнологня- М&bdquo- 996 № 2,-с.7−10.
- Ковалева Л.Г. Острые лейкозы. // М, 1990. с. 272,
- Майкова С А. Лечение и прогноз острого лимфоблвстного лейкоза у детей ¦'¦' Лвтореф. дисс. д-ра мед. наук М., 1086.
- Новиков ВС Iпрограммированная клеточная гное ль? i С-Пб., Наука, 1996.- с. 276.
- Погорелое В.М., Козинец Г. И. Морфология апоптоэа при нормальном н патологическом гемопоэдо И Гематология и трансфузнологня- М-, 1995 № 5.- с. 17−24.
- Поддубная ИВ Лекарственная терапия злокачественных опухолей (современное состояние и перспективы).// Русский Медицинский Журнал.-М, J998.-T-6. Л? lQ.-c.62l-62 В.
- Попа А.В. Критерии прогноза н лечение острого неднмфобластного лейкоза у детей j1!1 Авторсф, дисс. канд. мед. наук- М-, 1 996 209
- Румянцев А. Г, Самочатова Е. В, Хамдам Т. Лечение острого лимфобластиого лейкоза у детей jV Псдиатрия-М. 1991- № 1 I.-C.58−63.
- Савицкий В-П. Буглова С. Е., Алейникова О. В. Методы проточной цнтомегрнн в медицинских н биологических исследованиях. //Минск, 2004.- с. 99−104.31 .Савченко В. Г., Паровнчннкова ЕЛ. Лечение острых лейкозов. // М, 2004.-е. 220.
- Сергеев П.В.ДИнмановскнй ПЛ., Петров В H Рецепторы физилогическн активных веществ7/ Монография, М-В, 1999.
- Скобни B.BjVTемдго.тогия н трансфузнология M. I999 NH4 — с.34−37.
- Утешсв Д.Б., Сергееев A.B., Утешев Б.С, Апоптоз: фармакологические аспекты.-1/ Экспериментальны и клиническая фармакология 199S.-t.61, № 4,-0.-57−65.
- ФлейИ1Маи Е-В Сокова ОЛ. Попа A.B. и соавт. Клиническое значение хромосомного анализа при остром мнелондмом лейкозе у детей /I Вопросы гсматолоппп’онкологни и иммунопатологии в педиатрии 2002. — т. 1, X" 1. с. 28.34.
- Adebodura F. Role of intracellular free Ca1* und Zn1* in dcxamcthasonc-induced apopiosis and dcxameihosonc resistance in human leukemic CEM cell lines. // J, Cell. Physiol.- 1995 Vol. 163, № I. P 80−86
- Jg.Adida C-. Recher C., Raffoux E, et.al. Expression and prognostic significance of survivin in de novo acute myeloid leukemia. // Brit J. Haematol.- 2000 Vol. Ill- i* 196−203.
- Akbar A.N., Salmon M-, Janossy C. Role of bcJ-2 and apopiosis in viral infections, // Intcm. Arch. Allergy Immunol 1994 — Vol. 105, № 4 — P. 359−362.
- Akiyama T., Shimizu.e.aj'/Anticancer Drugs 1999, — Vol. 10. -P.67−78.
- AJarcon PA, Trigg ME, OillCr RH el al. Bone marrow transplantation improves survival for acutc lymphoblastic leukemia in relapse: a preliminary report V l ive American Journal of Pediatric Hematology. Oncology. 1990, — Vol 12.-P.468−471.
- Aldcrson L. M-, Castlebcrg R.L., Harsh O. R, ct al, Human gliomas with wild-type p53 express bcl-2, // Cancer Res.- 1995, — Vol. 55, №. 5, — P, 999−1001
- Allen R. G" Ballin K. Oxidative influence on development and differentiation: an overview of free radical theory of development, t! Free Radic. Biol. Med.- 1989 Vol. 6, — P 631−661.
- AHsopp T.E., Wyatt S" Paierson H.V., Davies A.M. The proto-oncogcn bcl-2 can selectively rescue neutrophil- factor-dependent neurons from apopiosis. // Ccll -1993-Vol.73.-P. 295−307.
- Alncmry F"S-, Femandes TJ, Haldar S, ct, al. Involvement of bcI-2 in glucocorticoid induced apoplosis in human prc-B leukemia*. U Cancer Res 1992- Vol. 52.- P. 491 495.
- Alncmry F. S-. Litwack G. Activation of? niernucleosomal DNA clcvage in human CEM lymphocytes by glucocorticoid and novobiocin. // J. Biol, Chcm- 1990, — Vol, 256 -P 317−323,
- Allien D. The molecular basis and potential role of survivin in cancer diagnosis and therapy. // Trends in Molecular Medicine.- 2001.- Vol. 7.- P. 542−547
- Amnti B, Land H. Myc-Max-Mad: a transcnplion factor network controlling cell cycle progression, differentiation and death. // Curt. Opin. Genet Dev.- 1994 Vol. 4.JM.-P. 102−108.
- Ameisen J.S. Programmed cell death (apoptosis) and AIDS pathogenesis U AIDS Res, Hum Retroviruses.' 194, — Vol.10.-Suppl.I, P, 3−5,
- Amcisen J.S. Programmed cell death (apoplosis) and cell survia. regulation relevance to AIDS and cancer, // AIDS, — 1994.-, Vol.8, Ns 9.- P. 1197−1213.
- Andcrer G-, Schrappe M, Brechlin A.M., ct al, Polymorphisms within glutathione S-transfcrase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia, Pharmacogenetics.- 2000, — Vol. 10.-P. 715−726.
- Apoptosis FACS Laboratory Review It Igaku Shorn Lid. USA.- 1997.-P. 60.
- Apoptosis. Applied reagents and technologies.// Pharmingcn* Edition, 1998. 98 P
- Archimbaud E., Fenaux P-, e.a. Gronulocytc-mttcrophagc colony-stimulating factor in association to timed-sequential chemotherapy with initoxanuooc, cioposidc. and cytarabine for rcfnKtory acute myelogenous leukemiaJ/Lcukeima.-1993.- Vol 7.-P372−377.
- Arcnds M J. Morris R.G.* Wyllie A.H. Apoptosis, The role of the endonuclease ft Amcr, J Pathol ¦ 1990.- Vol. 13″.- P.593−598.
- Arends M.J., Wyllie A. H, Apoptosis, Mcchanism and role in pathology Intern, Rev, Exp Pathol.- 1991, — Vol, 32-P.223−254.
- Ausserlechner MJ. Obexcr P, Bock G, Geley S and R Kofler Cyclin D3 and c-MYC control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells // Cell Death and Differentiation.-2004, — Vol. II.- 165−174.
- Azuma Y. r Kusaki H. Molecular mechanisms of apoptosis in the immune system. ' Nippon. Rinsho.- 1995, — Vol. 53, Si 3, — P, 753−760.
- Haer R. Bcl-2 breathes life into embriogencsis. H Amer. J. Pathol.- 1994 Vol- 145, «1, — P. 7−10,
- Iiaggiotini M., Dahingcn C A CC Chemokines in allergic inflammation it Immun Today 1994.- Vol.15- P.127−131.
- Bailey S» Hall A" Pearson A., Redfem C. Tlic role of AP-l in glucocorticoid resistance in leukemia. // Leukemia, 2001, — Vol. 15.- P, 391−398,
- Bailey S., Hall A. G" Pearson A. D" Redfem C.P. The role of AP-l in glucocorticoid resistance in leukaemia, // Leukemia, 2001Vol 15, — 391−397.
- Baradas K" Sizcnsky YA., Faulk WP, Transferrin conjugates of adriamycin are cytotoxic without intercalating nuclear DNA. ft J. Biol. Chem-1992- Vol, 267-P.9437−9442,
- BcUetheim P. Valcnt P, AndrccirM., eA//Blood -1991.- Vol. 77.- P, 700−7 U.
- Black M M. Speer F.D. Effects of cancer chcmotherapcutic agent" on dehydrogenase activity of human cancer tissue En vitro// Am i. Clin Phathol -1953, — Vol. 23.-P.2I8−227.
- Boise L.H., Ciottcbalk A.R., Quintans J. Thompson C B. Bcl-2 and bcl-2-relatcd proteins in apoptosis reflation. // Curr. Top. Microbiol. Immunol.- E995-- Vol. 200-P. 107−121,
- Borgmann A., Stackelberg A- Hcnzc (.?. el at. Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in second remission: a matched pair analysis. H Blood • 2003, — Vol I0l.>ft.0.-P, 3835−9.
- Brcslin M.B., Gcng C.D., Vedeckis W V. Multiple promoters exist in the human gr gene, one of which is activated byglucocortieoids. // Mol Endocrinol 2001, — Vol 1S.-P. 1381−1395,
- Broom J D- Evidence that the 1-as.paraginase of guinea pig scrum is responsible for its antilympoma effects and properties of the 1-as.paraginasc of guinea pig scrum in relation to of the amilymphoma substancc.//J.Exp.Mcd,-1963, — Vol. 1I8.-P.99−120,
- Buchner TV/Acute Leukemia IV: Prognostic Factors and Treatment Strategics,-1993.-Berlin
- Boechner S.A., Wernlt M., Harr T~ Regression of basal cell carcinoma by intmlesion itilerferon-alpha treatment is mediated by CD95 (Apo-l/Fai)-CD95 ligand-indueed suicide. !i i Clin Invest- 1997 Vol, 100, №. II.- P. 2691−2696
- Buhrer C., Hanman R. Fcngler R,. ct al Superior prognosis in combined compared to isolated bone marrow relapses in salvage therapy of childhood acute lymphoblastic leukemia. // Med Ped Oncol- 1993.-Vol. 21J67.-P. 470−6,
- Burke TO., Sartoreifi AC. Tritton TR Selectivity of the antracydines for negativeiy charged model membranes: role of the aminogroup. //Cancer Chemother, Pharmacol 1998 -Vol.21 -P.274−280,
- S7 BtOTCh W Kleme L., Tenniswood M. The biochemistry of cell death by apoptosis .' 'Biochem Cell. Biol.- 1990 Vol. 68 — P. 1071−1083.
- Cairns J.S. Mainwaming M.S. Cacehione ILN, et a! Regulation of apoptosis in thymocytes ttThymus 1993, — Vol.2 .,№ 3- P. 177−193.
- Ciiraiwi.csiic L.M. CfrDowsskl J A. Evaluation of the role of protein synthesis inhibition in apoptosis in glucocorticoid sensitive and glucocorticoid resistant S42 cells., it Endocrinol. J.- 1994 Vol. 2.- P- 47−52.
- Casale F., Addeo R., D’Angelo V., et al. Determination of the in vivo effects of prednisone on Bct-2 family protein expression in childhood acute lymphoblastic leukemia.//Int J Oncol -2003 -Vol 22.-?. 123−128.
- Chabncr B.A., Myers C-E Clinical pharmacology of cancer chemotherapy, /dancer: principles and practice of oncology.- 1989 P.349−395
- Chnmiandari E. Kino T. and ChiWiSOS G, P. Glucocorticoids and Their Actions. If Ann NV Acad Set.- 2004, — Vol. 1024.-P. 1−8 .
- Consoli U., Von N.T. Neamati N., Mactiadevia R., Bcran M" lhao S and AndelTM Cellular pharmacology of mitoxantrone in P-glicoproicin-positive and «negative human myeloid leukemic cell lines. //Leukemia, -1997. -Vol. II. -P.2066−2076,
- Cortes J, Katarjian H. Acuie leukemia comprehensive review with emphasize on biology and therapy .//Cancer.-1995.- Vol. 76.- P. 2393−2417
- Cortes J. Katarjian H. Acute lymphoblastic leukemia. A comprehensive review with emphasis on biology and therapy. /.Cancer.- 1995.- Vol. 76.-P. 2393−2417.
- Costtow M E, Рш C.H. Nuclear translocation of lymphobiast giucoeorticoid receptor in childhood leukemia does not predict steroid responsiveness, Hi. Steroid. Biochem -1987, — Vol. 26.- P. 15−18.
- Cotman C.W., Anderson AJ, A potential rote for apoptosis in neurodegeneration and Alzheimer diseases If Mol, Neurobiol- 1995.- Vol.10.- P. 19−23.
- Crans If, Sakamoto К Transcription factors and translocations in lymphoid and myeloid leukemia, // Leukemia 2001, — Vol. 15.- P. 313−332.
- Cronkite E P. Analytical review of structure and regulation of hemopoiesis U Blood Cells 1988,-J (j, 14 -P. 313−328.
- Daniel PT. Detecting ihc pathways to death.// Leukemia 2000.- Vol 14,-P, 2035−2044.
- Dchatin K.M., Suss D., Kramer P. H, Differential expression of APO-I on human thymocytes: implication for negative selection. K Eur. J. Immunol- 1994, — Vol. 24 P. 753−758.
- PeGregori J., c. a7/Ge"cs Dev.-1995.- Vol 9.-P 2873−2887
- Deigin V. l» Povcrenny A. M-, Scmina O. V, ct al, Reciprocal efTecl of optical isomerism of EW-dipeptides on immune response // Immun, Letters t999- Vol.67.-P.4I-46.
- Den Boer M.L., Pieters R, Kazemier K.M. eL al. Different expression of glutathione S-transferase alplut, mu and pi in childhood acute lymphoblastic and myeloid leukaemia. // Br J Haematol .- 1999, — Vol. 104 ,-P. 321−327.
- Detection of apoptotic cells using the fluorescent lcchnique. I-ACS lab. // Promega Notes Magazine.- 1996 № 57.- P. 10−43.
- Distelhorst C.W. Benutto B M. Griffith R/C. A «ingle common clectrophoreUc abnormality of glucocorticoid receptors in human leukemia cellsBlood 1985.-Vol. 66.-P, 679−685.
- Dive C-, Hickman J.A. Drug-target interactions: only (he first step in the commitment to a programmed cell death. H Brit J. Cancer.-1991.- Vol. 64, — P 192 196
- Dong J. Nfikihiko Naito and Tacashi Tsuruo, C- Myc plays a role in cellular susceptibility to death receptor- mediated and chemotherapy indticcd apoptosis in human monocitie leukemia U 937 cell, //Oncogene. — 1997 -Vol. l5"Nt6 -P. 639−647
- Donna M. Bnidshaw and Robert J. Arceci Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance, v J.Clin.Oncology 1998. • Vol.16. -P.3674−3690.
- Dordeimann M., Reiter A. Borkhardt A., et al. Prednisone response is the strongest predictor of treatmcnl outcome in infant acute lymphoblastic leukemia ' Blood 1999-Vol 94.-P, 1209−1217,
- Downward J. Mechanisms and consequences of activation of protein kinase B/Act U Curr. Opin. Ceil Biol -1998 Vol.10.- P.262−267
- Dyson Ny/Genes Dev.-1998 Vol 12 -P24 5−2262,
- Effcrth T» Fabri U and Osieka R. Apoptosis and resistance to daunorubicin in human leukemic cell, //Leukemia, 1997, -Vol,. I. -P.I 180−1186.
- Enari M, Mug H" Nagata S. Involvement of an ICE-ltkc protease in FAS-mcdiatcd apoptosis. //Nature,-1995, — Vol, 375, X"6526.- P. 78−81 136, Ernst PjVDan.Med.Bull,-1976,-Vol. I9-P271−284
- Escrida PV., Ferrcs-Moticl AV. Ferragut JA,. Conwtfcs-Ros JM- Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cell: implications in dntg-resistancc phenomena. //Biochemistry. 1990. -Vol, 29. -P, 7275−7282,
- Fan S, P 53 gene mutations are assosiatcd with decreased sensitivity of human lymphoma cells to DNA damaging agents II Cancer Res.- 1994, — Vol.54, № 22 -P.5824−5830.
- T-'anidi A., Harrington E.A., Evan G. J, Cooperative interaction between c-myc and bcl-2 proto-oncogcnes, //Nature.- 1992- Vol.359,Ne.6359.- P.554−556.
- Feng J., Zheng J-, Bennett W.P., el al. Five missense variants tn the amino-tcrminal domain of the glucocorticoid receptor- no association with puerperal psychosis or schizophrenia. // Am J Med Genct.-20QQ.- Vol. 96.-P. 412−417.
- Fesus L.P., Davies J.A., Piacentini M. Apoplosis: Molecular mechanisms in programmed cell death. // Eur, J, Cell. Biol.-1991.- Vol. 56.- P 170−177.
- Firpo E" KoiT A.//Molecular and Ctllutar Biol-1994 Vol. !4.-P.488"MS9l
- Ftsher D. Apoptosis in cancer therapy: crossing theshoid. 7 Cell.- 1994 -Vol, 78 Jft.4, — P.539−542,
- Franceschi C, Cell proliferation, cell death and aging. // Aging Milano.- I989--Vol.lj&.l.- P.3−15.
- Franklin R.A., Mc Cuhrey JA. Kinases: positive and negative regulators of apoptosis,// l, cukemia,-2000.- Vol. I4.-P. 2019−2034,
- Franklin RA, Mc Cubrey JA, Kinases: positive and negative regulators of apoptosis.// Leukemia, — 2000, — Vol. R-P.2019−2034.
- Ganido S., Coopcr J, Appelbaum F. el al. Blasts from eldcrty acule mycloid leukemia patienls ore eharuclcnzed by low leveis of culture- and drug-induccd upoptosis // Utik Res.- 2001.- Vol. 25.- P. 23−32.
- Gsssori J.C., Ryden T. r Bourgeois S. Role of de novo DNA melhylaticm in (he glucocorticoid resistunce of a T-Iymplloid cell lincj'/Nature.- 1983 -Vol. 302 P.62I-623.
- Geiger K. D" Gurushamhaitt D, Howes B.L. et al. Cytokine- mediaicd survival froin leihal herpes simples virus mfeeiioii role of programmed cell neuroaal deaih, .'V Proc Nal. Acad Sci. USA.- 1995 VoL92, Jfr, 8- P.3411−3415
- Gerdes K. Beger C" Lauien M. el al. Quaniifieation of the glucocorlieoid receptor and its splice variant gamma in cbildhood acule lymphoblastic leukemia usmg real-lime PCR. H Btood 2001.- Vol 98 -P. 113a (Abslr-J.
- Gershenson L.E., Rotetlo R.J. Apoptosis: A differenl type of cell death. ff FASEB J.- 1992- Vol. 6.- P. 2450−2457.
- S. Goriick R., Goker. E-, Trippetl T. et al Jntrrnsic and acifuircd rcsistancc (o methotrexate in acute leukemia., VN Engl i Med 1996, — Vol. 33514 -P 1041−8
- Greenstein S., GhiasK. f KreltN.L. and Rosen ST. Mcchonisms ofglucocorticoid-medialcd apopiosis in hematological malignancies clinical cancer research. -2002.-Vol 8-P. 1681−1694.
- Halicka H D. Sciler K. Feldman Ei, Fragonos I", Mitteiman A. Ahmed T. and Dar/yitkiwic/. Cell cycle specificity of apoptosis during treatment of leukemics. II Apoptosis. -1997.-Vol-2. -P25−39.
- Hannum Y. Apoptosis and «he dilemma of cancer chemotherapy. tt Blood ¦ 1997-vol. 89, № 6 -P 1845−1853.
- Harbour J.W. Dean D. C, The Rb/E2 °F pathway expanding roles and emerging paradigms, //Genes and Dcvclopmen-2000.- Vot. l4.-P.2393−2409.
- Harbous D, V. Chantmbon P. Thompson E.B. Steroid mediated lysis of Ivmphoblast requires the DNA binding region of the steroid hormone receptor. // J Steroid. Biochcm -1990 Vol 35-P.3316−3324.
- Mnrtmann B.L., Geley S. Loftier M, et al. Bcl-2 interferes with the execution phase, but not upstream events, in glucocorticoid-induced leukemia apoptosis. Oncogene A 999 -Vol 18-P 713−719.
- Haskell C. L-asparaginase resistance in human leukemia asparaginase-synthetase //Biochem. Pharmacol. -1969-- Vol 18.-P. 2578.
- J 68. HaUa Y. Yarnada Y., Tomoriaga M., KocfSei H. Extensive analysis of retinoblastoma gene in adult T-cel! leukemiai’lymphoma // Leukemia.-1997.- Vol. I1.-P.984-Wl,
- Haupt Y. Rowan S- Oren M. P-53 mediated apoptosis in Hela cells can be overcome by express pRb //Oncogene.- 1995 -Vol. 10, № 10- P 1563−1571
- Hengartner M. The biochemistry of apoptosis. // Naiure.- 2000.- Vol. 407 P 770 776.
- Henze O, Fcngler R, Hartmann R. ct al. Six-year experience with a comprehensive approach to the treatment of recurrent hildhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM groupjV Blood -1991 -Vol. 78,/fe5--P- 1166−72.
- Herman JCivm C., Issa JV/Cancer Rcs-1997.- Vol. 57.-P.837−841.
- Herold R., Stackelberg A. Hartmann R. et aJ. Acute lymphoblastic leukemia relapse study of the Berlin-Frankfurt-Munsier group (ALL-REZ-BFM) experience carly treatment intensity makes the difference. // J Clin Oncol.- 2004.- Vol. 99.- P. 570−1,
- Hillmann A. Ci, Ramdas J., Multonen K, et al. Glucocorticoid receptor gene mutations in leukemic cells acquired in viUo and in vivo. // Cancer Res 2000.- Vol 60.-P. 2056−2062.
- Mraroa T» Akashi M., Koeffler HJ! EHA, Educatio"aJ book -2000. -P. 146−151
- Minima T., Koefller HV/Btood.-1995, — Vol. 86.-84 I -854.
- Hiromatsu K., Aoki M., Makino Y et. al. Increased FAS antigen expression in murine retrovjius-induced immunodeficiency syndrom. MAIDS. // Eur. J. Immunol -1994.-Vol. 24, — P. 2446−2451.
- Holbrook NJ. Bloomficld C.D., Munck A Analysis of activated and non-activated cytoplasmic glucocofiicoid-reeeptor complex from human leukemia cclls fay rapid DNA-diclhylaminoethyl minicolumn chromatography, it Cancer Res -1983 Vol. 43.-P.4478−4482.
- Hongo T, Fujii Y, Igarashi Y An in vitro chcmosensitivity test for the screening of anti-cancer drugs in childhood leukemia^ Cancer.- 1990.- Vol. 65.-P.1263−1272,
- Hongo T. Fujii Y. In vitro ehemoscnsiiivily of lymphoblast at relapse in childhood leukemia using the MTT assay, it lntJ Hcmatol -1991 Vol 54 -P 219−230.
- Hongo T. Yajima S, Sakurai M et af. la vitro drug sensitivity testing can predict induction failure and early relapse of childhood acule lymphoblastic leukemia. //Blood.- 1997.- Vol, 89,-P, 2959−2965.
- Hongo T., Fujii Y, Mizuno Y. Et at. Anticancer drugs sensitivity test using the short-term microplate culture and MTT dye reduction assayJt Jpn J. Cancer Chemother.-1987, — Vol, N-P.472−478.
- Hongo T. Watanabc C, Okada S, Inoue N, Yajima S, Fujii Y, Ohzeki T, Analysis of the circumstances at the end of life in children with cancer symptoms, suffering and acceptance- WPcdiatr tnL- 2003.- Vol, 45, Ntl.-P 60−4
- Howie SAL. Harrison D.J. Wyllie Л. Н- Lymphocyte apoptosis mecharuMiis and implications гл disease. H Immunol. Rev.- 1905.- Vol. 142.- P. МЫ 56.
- Hsu H." Xiong J. Goeddel D.V. The TNF receptor-1 associated protein TRADD signals cell death and NF-kB activation. И CdL- 1995, — Vol. 81- P 495−504,
- Ни X., Zuckerman Ki/Lcukctnia and Еугор1штз-2000.- Vol. 38.-P.23 5−246.
- Jacobson M.D. Reactive oxygen species and programmed cell death, tt Trends Biochem, Sci,-1996--№ 2L- P. S3−94.
- Jamal R .Gale K., l~homas N.e.a. The retinoblastoma gene in acute myeloid leukemia: analysis of gene rcarrengments, protein expression and companson of disease outcomc, I/ BrJ. Haematology .-1996, — Vol. 94,-P, 342−348.
- Janka-Schaub G.E. Harms D O., den Boer M. L" Veerman A, J, Picters R. In vitro drug resislance as independent prognostic factor in the srudy COAI. L-05−92
- Treatment of childhood acute lymphoblastic leukemia- two-tiered classification of treatments based on accepted risk criteria and drug sensitivity profiles in study COALL-06−97, / Klin Padtatr.- 1999 Vol 211 .-P. 233−238,
- Jatella M-, Benedict M, Tewan M. et. al. BcJ-x nd Bcl-2 inhibit TNF and FAS-induced apoptosis and activation of phospholipasc A2 in breast carcinoma cell. Oncogene.- 1995, — Vol. I0J612.- P. 2297−2305.
- Jean-Philippe Viat, Francis Lacombe, Michel R. Boissean. Josy Rafters. and Philippe Bernard. Study of the apoptosis induced in vitro by antitumor at drug a leukemic cell. .VLeukemia Research. 1997. — Vol.21, Jfe2 -P. 163−172.
- John S, Macdonald MD. Drug-induced liver disease. //Clinics in liver disease. -1998. -Vol. 2Jfe3
- Kagi D. I:., Vtgnaux B, l. cdermann K eL al. Fas and perforin pathways as major mechanisms of Tccll-mediated cytotoxicity. // Science 1994 — Vol. 265.- P. 528−530
- Karl M., Lamberts S.W. Koper J.W. el al. Cushing’s disease preceded by generalized glucocorticoid resistance: clinical conscqucnces of a novel, dominantnegative glucocorticoid receptor mutation. H Proe Assoc Am Phys- 1996, — Vol. 108,-P. 296−307.
- Karl M. Lamberts S. WJ, Delera-Wadleigh S.D. ct al, Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene //J Clin Rndocrinol Metab -1993, — Vol, 76.-P 683−689.
- Karovokyros I and Pclilheos F Effect of antineoplastic agents on non proliferating yeast cell a possible membrane effect of doxorubicin. //Anticancer Research -1997, -Vol.17 -P.1079−1Q&9.
- Kaspcrs GJ. Veermatt A J.P., Pieters R, Van-Zantwyfc I. Kt al. Drug combination testing in acute Lymphoblastic leukemia using the M’rf'-assay.//Leuk-Res.-l995.-Voll9.m-P!75-«l
- Kaspers GJJ, Pieters R, Van Zantwijk C. Y et al. Prednisolone resistance in childhood acute lymphoblastic leukemia: viiro-vivo correlations and cross-resistance to other drugs. // Blood.- 1998, — Vol. 92^sl P.259−266,
- Kaspers GJJ*., Vcerman AJ.P., Pieters R. ct al. In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia. IIBlood -1997.-Vol, 907, — P.2723−2729.
- Kaspcrs GJ, Crcutzig U. Pediatric acute myeloid leukemia: international progress and future directionsJl Leukemia. -2005.- Vol. 19rNsl2.-P025−9.
- Kaufmann S.H., Dcsnoycrs S,. Ottiviano Y et. al Specific proleolitic cleavage of poly (ADP-ribosc) polymerase. An early marker of chcmothcrapy-mduced apoptosis U Canccr Res l993--№ 53 — P- 3976−3985
- Keams PR-, Pieters R., Rattier M.M., ct al. Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocy tic leukemia // Blood.- 2001- Vol. 97 -P. 393−398
- Keizer HG-, Pinedo HM., Schuurhies CJ., Joenje H. Doxorubicin (adriamvein): a critical review of free radical-dcpcndcnt mechanism of cvtotoxity. /V Pharmacol. Ther. 1990,-Vol, 47- -P.219−231.
- Ken- J F. Sehrikagc Necrosis: A distinct mode of cellular death // J. Pathol,-1971-Vol.105.- P.13−18.
- Kerr JJ, Wyllie A.M., Curtie A.R. e (al. Apoptosis: a basic biological phenomenon with wide-tanging implications in tissue kinetics. // Brit. J. Cancer -1972, — Vol.26, Xs 4.- P.239−257.
- Kersey J, Fifty years of stidtes of the biology1 and therapy of ehilhood leukemia // Blood.- 1997, — Vol. 90, — P 4243−4251.
- Kitajiama J. Kawahara K,. Nakajtma T. et. al, Nitric oxide-mediated apoptosis in murine mastocytoma, tt Biochem. Biophis. Res. Communs.- 1994.- Vol. 204, Np I.- P. 244−251.
- Komblau S,.Chcn N-.del Giglio A., e, a, Retinoblastoma protein expression in CLL. U Cancer Res -1994.- Vol 54-P.242−250.
- Korsmeyer SJ» Shutter J R., Vies D. et al Bcl-2/Bax: a rheostat that regulates an antioxidant pathway and cell death expression of lymphocyte death. H Immun. Today. 1992 Vol. 13, — Semin. Cancer Biol.- 1995, — Vol, 4, №, 6, — P, 327−332.
- Kotani T, Aratake Y., Kondo S. Et al, Expression of functional Fas ajitigcn on adull T-cell leukemia. //Lcuk-Res 1994,-VoI, 18.-P.305−310.
- Kravtsov D, Greer JP, Whitlock J A ct al. Use of the microcullure kinetic assay of apoptosis to determine chemoscnsitivjty of Icukemiasi1' Blood.- 1998.- Vol. 92.-P, 968−980.
- Kroemer G Mitochondrial implication in apopcosis, // Cell Death And Diffcrcn.-1997.* Vol. 1- P- 450−456.
- Laeronique V., Mignon M, Fahre В. et iL Bcl-2 protect from Irthal hepatic apoptosis induced by en onfi-Fas antibody' in mice. // Nature Med.- 1996, — Vol, 2, — P 80−86.
- L-fli J. Prcudhomme C., Zandccki M Et al Myelodysplasie syndromes and acute myeloid leukemia with 17p deletion, An entity characterized by specific dysgranulopoiesis and a high incidence of P53 mutations-''/ Leukemia.-1995 -VoL9 -P.370−81.
- Lajtha L7/Blood cells,-1981 Vol 7.-P.45−63.
- Lauten M. Carlo G, Asgcdom G" et al. Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia-// llaematologica’jounial of hematology 2003,-Vol, 88-P, 1253−1258.
- Laytragoon-Lewin N" Rossmann E-. Castro J. Significance of phosphotyrosine proteins, BCL-2 and P53 for apopcosis in resting B-chronic lymphocytic leukemia (CLL)ceHs, 11 Inf J, Cancer 2Ш- Vol. 97 — P. 344*348
- Lennon S., Martin S,. Gottcr T Dose-dependent induction of apoptosis in human tumor cell Lines. //Cell, Prolif- 1991Vol. 24,^ P, 203−214
- Li X. Traganos F-, Melamed M.R. eLal. Single step procedure for labelling DNA slrand breaks with fluorescein- or BODIPY-eonjugated deoxynucleotidcs Detection of apoptosis and bromdeoxyuriduie incorporation. // Cytometry.- 1995.- Vol. 20, — P. 172−180.
- Liies W.C. DbJc D C «.Kfebanofl» S. J, Glucocorticoids inhibit apoptosis of human neutrophils. //Blood.-1995, — Vol 86.№",-P.318.-3l88.
- Linda A. ilogarth and Andrew G. Hall Increased BAX Expression Is Associated With an Increased Risk of Relapse in Childhood Acute Lymphocytic Leukemia /•'Blood.* 1999,-Vol 93, № 8.-P. 2671−2678,
- List A.F. Role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia. IILeukemia, -1996, -Vol,.0Jfs6. -P.937−942.
- Lloyd RV., e. a .// Am J Pathol,-1999, — Vol 154.-P 313−323.
- Lfiiilcr M" Aus-wriechner M.J., Tonka M. et, «1 c-Mye does not prevent glucocorticoid- induced apoptosis of human leukemic Jymphoblasts. //Oncogene.-1999 -Vol. 18,-P 4626−4631.
- Longui CAH Vottcro A. Adamson PC., et at, Low glucocorticoid receptor alpha/beta ratio m T-cell lymplroblastic leukemia /llorm Mctab Res -2000 Vol 32-P. 401−406.
- Marchctti P. Natoli V., Kartellen F.O. etal Glucocorticoid receptor studies in human leukemia.//J. Steroid. Biochem, J981.- Vol, I5.-P.261−26B
- Marks D, Kur?. BL, Line M. High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis. II Blood.- 1996.-Vol.87.-P. 1155−61
- Martin SJ. et. al. ApoAlett anncsin V apoptosis kiL // J, Exp. Med, 1995.- Vol, 182.- P. 1545−1566
- Marlin S J. Brien G Л, Nishtoka W, cl, a!- Prutcilysis of fodrin during apoptosis. Hi. Biol. Chem 1995 — Vol 270Л12-- P. 6435−6428,26S МнШпВ LT» Wrtston i.C. Tumor inhibitory effect from E. coliJ/ Л rch Biohem Uiophys -1964, — Vol, 105 -P 450−452.
- Musson E. Relting M.Synold T. ct al. Accumulation оГ methotrexate polyghnainatcs in lymphobuists ¡-я a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate. // J, Clin.lnvcst.-1996.-Vol.97--P.?3−80
- Matsuoka S. c a//Gcnes Dcv.-1995.- Vol. 9 -P 650−662
- Mauer ЛЛСшгРгоЫ. Cancer.-1977-- Vol. 2 -P. 1−46.
- Mauer A M /Haematologica -1975, — Vol 60.-P.394−399
- Bcl-2 regulated caspase activation,/'" Mo J Cell BodocrinoL- I99″.- Vol, 139.-P 229−238.
- McConkey D.J. Orrenius S. Signal transduction pathways to apopiosis. // Trends Celt Biol.- 1994.- Xi 4 P. 370−276.
- Mechanisms of cell death II. The third annual conference of the international cell death society, ff Annals of the New-York Acad Sci-2000.- Vol. 926.-P.238,
- Metcalf D. The colony stimulating factors, discovery, development, and clinical applications // Cancer 1990, — Vol.65.- P.2185−2195.
- Mizel S.B. The inlerleukines. U FASEB J.- 1989-- Vol.13.- P.2779−2388.
- MoalU PA. Pitlay S,. Krett N.L., Rosen S-T. Alternatively spliced glucocorticoid receptor messenger RN. Ys in glucoco/ticoid-restftan! human multiple myeloma cells. // Cancer Res -1993 , — Vol. 53, — P, 3S77−3S79,
- Morgan D. WAnnu Rev Cell Dev. Biol -1997 Vol. 13 .-P 261−299.
- Mosmann T. Rapid calorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, ff i. Immunol Methods. -1983.-Vol, 65.-P.55−63
- Mu/io M., Chmnaiyan AM, Kbehkcl F. C, et al. FLICE, a novel FADD-homologous ICE/CED-3-like proteasc to the CD 95 (FAS/APO-I) dealh-inducing signaung complcx. // Cell.- 1996 № 85 — P 817−826.
- Nac&niura. S-, Takeshitna, M. Nacumuxa, E. r Ontake. S,. and Maisuda, N. tnduclioo of apopiosis in HL 60 leukenuc cell by anticancef drugs in combination walh anti-Fas monoclonal antibody. //Anticaflcer Research 1997. -VoI.I7,NbIA. -P. 173−179.
- Nagata S. Apopiosis by dealh factor, //Cell 1997.- Vol-88 — P.35J-365.
- Nagalu S. Apopiosis regulated by a dcath factor and itt reeeptor FAS ligand and FAS.!/ Phil Trans R. Soc Laad. Biol 19M — № 345 — P 281−294
- Nakayama K. Vamada Y .Koji T.e.a. Eixprcsion and phosphonlation status of relinoblaxtonia protein in adull T-cett Icukcmia’lyiJiphonia // Leukemia Research .2000, — Vol. 24.-P299−305.
- Nailtiin C.E., Xic Q. Nitric oxide synthases, roles, lools and control. H Cell-1994.- Vol. 78.- P- 915−918.
- Neta N. Oppenheint JJ, Cytokines in therapy of radiation injury. // Blood.-1988, — Vol, 723.- P, 1093−1098.
- Nicholson D.W. From bench to clinic with apoptosis-bosed therapeutic agents. Nature.- 2000, — Vol. 407.- P. 810−816.
- Nicota N A Hematopoietic cell growth factors and their receptors U Annu. Rev Bwcbem 1989, — Vol.58.- P.45−47.
- N icoletty 1." Migl iorati G, Pagliaeei M-C. et al. Cel lular enginiring. //J. 1 mmunol. Methods 1991.- Vol. 139-P 271−279.
- Norgaord J.M., Skovgaanl Paulsen H. Glucocorticoid reccptors in human malignancies: A review.// Ann Oncol,-1991, — Vol. 2.-P.54I-557.
- Nosaka T. et al. Dcfcctivc lymphoid development in mice lacking JAK3. II Science.- 1995, — Vol .270.- P.800−806,
- Nrump BF, Beeersky I K- the role of cytosolic Ca in cell injury, necrosis and apoptosis. // Curt. Opto, Cell, Biol -1992.- Vol. 290, № 2.- P 527−538
- O Gorman DM, Cotter TG. Molecular signals in anti-apoptotic survival pathways Jt Leukemia.- 2001.- Vol. I5.-PJ1−34.
- Ormcrod MG, Orr RM. Peacock JH. The role of apoptosis in cell killing by cisplaiin: a (low cytometry study.// BrJ. Cancer-1993.- Vol. 69.-P 104−110.
- Palombella VJ., Rando OJ., Goldberg A.L. The uboquiun-proteasome pathway is retired for processing the NF-kBI precursor protein and the activation of NF-kB. H Cell, — 1994, — Vol, 78 Jfs 5, — P 773−785.
- Paul JT, Henton ES, Mai S, Mushinski FJ, Chcang M, Gibson SB, Johnston JB, Cyclin D expression in chronic lymphocytic leukemia/'Leuk Lymphoma, — 2005,-Vol. 469.-P, 1275−85,
- Pieters R. Kaspcrs GJL, Van Wering ER ct. al Cellular drug resistance profiles that might the prognostic value of immunophenotipe and age in childhood acute lymphoblastic leukemia. //Leukemia 1993, — Vol. 3.-P.392.
- Pieters R. Raspers GJL, Van Wering ER ct. al In vitro drug resistance in childhood acute lymphoblastic leukemia in relation to age and iminunophenotypc-//Haemotof Blood Transf.-1992.-Vof. 34.-P3Q9−320.
- Pieters R, Huismans DR, l, ooncn AH ct al. Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukemia/' Lancet.-1991, — Vol. 338.-P 399−403.
- Prefers R. Ifursmaits f>.R, Leyva A" Vcemurrt AJP Adaptation of (fie rapid automated tctrazolium dye bases MTT- assay for chemosensitivity testing in childhood leukemia // Cancer Lctt-1988.- Vol. 41 ,-PJ23−332.
- Pieters R. Kaspcrs G.J. Klumpcr E, Vcerman A.J. Clinical relevance of in vitro drug resistance testing in childhood acute lymphoblastic leukemia: the stale of the art-// Med-Pediatr-Oncol. -1994, -Vol, 22Jfi5. -P.299−308.
- ЗМ Pike В., Robinson W, Human bone marrow colony growth in agar-gel // J. Ceil Physiol.- 1970.- Vol.76,№ I.- P. 77−84
- Piters R, Klumper E, Kaspers GJL, Veerman AJP. Everything you always wanted to know about cellular drag resistance in childhood acute lymphoblastic leukemia. Л review. //Critical Reviews in Hematology/ Oncology, — 1997 Vol. 25,-PI 1−26,
- Pitman, S.M., Strickland, D., and Ireland, C, M, Polymerization of tubulin in apoptic cell is not cell cycle dependent. VExp. Cell Research 1994. -Vol.2! 5Jfi2. -P 263−272.
- Qin J, Tao D, Chen X. Feng Y, Hu J. Reed E, Li QQ. Gong J Down-regulation of cyclrn E expression by call erne promotes cancer cell entry into the S* phase of the cell eyelet Anticancer Res 2004 — Vol. 24Jfi-5A -P 2991−5,
- Qin JC, Chen XX, Tao DD, Feng YD, Hu JB, Gong JP. Promotive effect of decreased cyelin E threshold on cell proliferation.// Ai Zheng ¦ 2004, — Vol. 23hN?1 I -P-1244−8,
- Qucsncl B., e. aJ/B.ood,-l998 Vol. 91.-P.2985−2990.
- Radosevic N, Delmcr A. Tang R. Marie JP, Ajchcnbaum-Cymbalista F. Cell cycle regulatory protein expression in fresh acute myeloid leukemia cells and after drug exposures Leukemia. -2001.- Vol, .5,№ 4.-P: 559−66.
- RaiTaelc Addeo, Michclc Caraglia, Alfonso Baldi et. al Prognostic Rote of bcl-xL and p53 in Childhood Acute Lymphoblastic Leukemia (ALL) //Cancer Biology & Therapy, — 2004.- Vol. 4.- Issue P. 132−138.
- Ramachadran G" You W, and Krishan F. Bcl-2 and mdr-t gene expression during doxorubicin-induced apoptosis in murine leukemic cell. /JAnticancer Research -1997 -Vol.17. -P.3369−3376.
- Rapi S., Gardini A. Panel I i A. et al. Flow cytometric measurement of DNA content in human fotlid tumor // Cytometry (Comunicontimus in Clinical Cytometry) 1996.- VoL26.- P 192−197
- Ray D.W., Davis J.R.E., White A., Clark AJ. L, Glucocorticoid receptor vtrocture and function in glucocorticoid-resistant small cell lung carcinoma celts. D Cancer Res 1996 — Vol 56,-P 3276- 3280.
- Reichardt KM., Kaestncr KM., Tuckermann J. DNA binding of the glucocorticoid receptor is not essential for survival.// Cell, — 1998.- Vol. 93.-P. 531−541.
- Retter A. Schrappe M, Ludwig W.D., et at. Chemotherapy in 998 unselectcd childhood acute lymphoblastic leukemia patients, Results and conclusions of the multicenter trial ALL-BFM 86, //Blood.- 1994, — Vol 84.-P 3122−3133.
- Riehm H4 Gadncr H. Hen" G, Kornhuber B. Lampert F. Niethammer D. Reiter A, Selicllong G- Results and significance of six randomized trials in four consecutive ALL-BFM studies/rtiaematol Blood Transfus. -1990 Vol. 33,-P, 439−50.
- Rivers C-, Levy A., Hancock J., et al. Insertion of an amino acid in the DNA-binding domain of the glucoconicoid receptor as a result of alternative spiking.// J Clin Endocrinol Mctab- 1999 Vol. 84.-P 4283−4286.
- Roberts J. prager M.D., Bacbinsky N. The antitumor activity of E. coli I-asparaginasej'/Cancer.Res.-1966, — Vol, 26.- P. 2213−2217.
- Ron Rose, Marccl Verheij, Adriana Haimovitz-Friedman, et al. Ceramide sinthase mediates daunorudicin induced apoptosis an alternative mechanism for general ing deartt signa). //CcIL-1995- Vol. 82 — P405−414
- Ross M.E. Caligiuri M. Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regylate the innate immune response // Blood • 1997.- Vol, 89, Jfe. 3, — P 6348−6352.
- Ross T.M. Spotlight on apoptosis. // Leukemia, — 2001, — Vol. 15.- P. 332−342.
- Roszak AW, Lcfebvre YA. Howell GM. Codding P.W. Structural requirements for die binding of dexamcihasone to nuclear envelopes and plasma membranes. HI. Steroid Biochem.Mol.Riol.- 1990, — Vol. 37.-P. 201−214
- Rots MG, Kaspers GJL, Noordhuis P et al. In vitro cytotoxity test Tail to determine resistance to methotrexate of childhood leukemia eel Is Jt Abstract 2ni Int. Svmp. Drug resistance in Leukemia and Lymphoma -1996.-P.I6.
- Roy N. Machudeven M.S. McLean M. ct al. The gene for neuronal apoptosis inhibitory protein is portiaJle delected in individuals with spinal muscular alrophy // Cell 1995 -Vol 80, Ksl.- P. 167−178,
- Ru" M. Lind U" Gafvels M, Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary Cortisol resistance. // Clin KndocrinoL- 2001.- Vol. 55.-P. 363−371.
- Sargent JM. Taylor CG. Appraisal of the MTT assay as a rapid test of chcmosensitivity in acute micloid leukemia.// Br J.Cancer.-I989.- Vol. 60.-P.206−2I0.
- Sasano H. Frost AR. Saitoh R- Immunolocali/ation of cyclins D and E and cyelin dependent kinase (cdk) 2 and 4 in human breast carcinoma. // Anticancer Res -199? ¦ Vol. 17JfaSA.-P 3685−90,
- Sato N. Sakamaki K, Terada N. et at. Signal transduction by the high-affinity GM-CSF receptor two distinct cytoplasmic regions of die common fl-subwnit responsible for different signaling. // EMBO J 993.- Vol.12.- P 4181−4189
- Saucrbrey A. Hafer R, Zinll F, Volm M. Analysis of cyclin Dl in de novo and relapsed childhood acute lymphoblastic leukemia^// Anticancer Res. -1999 Vol. l9JfelB.-P645−9.
- Sausville E., e. a//Ann NY Acad. Seu-2000.- Vol, 910.-P.207−221.
- SatHville E, Zacharevitz D, e aJTharmiKol Thcr -1999 Vol «2.-P 285−292.
- Savasan S» Oacgen M., Buck S., Wein W2. liamre M. WetnsiemY Becton D. Ravindranth Y. Heterogeneous effect of free radical scavenging on cytarabine and npoptosis in childhood AML. //Blood. 1998, — Vol, 92, Nt lO. supplement 1,194b. -P 3830,
- Savill J, Apoptosis an d the kidney, ft J, Amer Nephrol1994Vol.5, Jfe I.- P. 1221.
- Schwartz J. H, Reeves J.Y., Broom JD. Two l-asparaginases from E. coli and their action against tumors, //Proejjatl.Acad. Sci. USA, — 1966, — Vol. 56.-P.244−252.
- Schwarlzman R.A. Gidlowski J. A Glucocorticoid induced apoptosis of lymphoid cells. // Intern Arch. Allergy Jmmun- 1994 Vol. 105, №.4 — P347−354.
- Scuderi R, Palucka KA, Pokrovskaja K, Bjorkholm M, Wiman KG, Pisa P- Cyclin -. overcxpression in relapsed adult aculc lymphoblastic (cukcinius of B-ccJI lineage Blood. 1996 Apr l5−87(8):3360−7, '/Erratum in: Blood- 1996 Vol 88.NEtO.-P 4083
- Segercn C. M-, Sonneveld P., de Lange P. et al. Molecular mechanisms of thcrapyrcsistajice in multiple myeloma: the role of the non-functional glucocorticoid receptor delta. M Blood.- 1999.-Vol. 94.-P. 593a (Absir).
- Sendcrowicz A., Sausville EJt J. Natl Cancer lnst--20Q0.- Vol. 92.-P.-376−387.
- Senderowicz A.M. Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. // Leukemia -2001-Vol. I5J&1 -P. 1−9.
- Sencibrey A, Zinll F, Malke H et al Results and experiences with a modified BFM protocol for treatment of recurrences In children with acute lymphoblastrc teukemia in East German areas. // Klin Pcdialr-1993 Vol, 205 -P 28t-287.
- Sengupta S., Wasylvk B. Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors. // Ann NY Acad Set.- 2004, — VoL 1024,-P. 54−71
- Shi J. Shao ZH, Lui H etal. Expression of cell control genes in myelodysplastte syndromes. !i Zhonghua Xue Ye Xue Za Zhi jan 2000 Vol.26jfsl -P. 10−14.
- Shin S. t Sung B. Cho Y.S. et.al. An anti-apoptotic protein human survivin is direct inhibitor of caspase-3 and -7. tl Biochemistry.- 2001.- Vol. 40.- P, 1117−1123
- Sdnffcr C A. Acute myeloid leukemia in adults // Cancer Medicine, 4i! i edn Holland J-F-, Bast R.C. Jr., Morton D.L. et al. (Eds.) Baltimore Williams & Wilkins.-I996. — P. 2617−2649.
- Shiobara M. C-BJ,/Btood.-l994, — Vol, 84.-P.3781−3784
- Siitoncn T. Mantymaa P., Sally M., Savolainen E.R., Koistcn P Apoptosis induced by etoposid in not associated with fa" pathway in acute mycloblasttc leukemia cell, //Blood.-1998. -Vol.92, № IO, supplemcmf. -P I95b- 3832,
- Slovak M, Ho J., Bhardwaj G, at al Localization of a novel multidrug resistant t-assotiated gene m the HT 1080 / DR 4 and H 69 AR Human Tumor cell lines. //Cancer Rcsearsh-1993. -Vol.53. -P.3221−3225.
- Smith B.D. Bambach BJ. Vala M.S., Barber J, P cl al, Inhibited apoptosis and drug resistance in acute myeloid leukemia, ti British Journal Hacmatology. -1998 ¦ Vol 102Jf?4 -P, 1042−1049.
- Solary E., Dram N, Bettaied A. et al. Positive and negative regulation of apoptotic paihways by Citotoxic agents in hematological malignances, .'.leukemia -2000, -Vol. 14 -P 1833−1849.
- Steinman H, M. The Bct-2 oncoprolcin functions as a pro-oxidant. // J. Biol. Chem.-1995, — Vol. 270, № S.-P. 3487−3490.
- Stellate C Post-transcripiional and nongenomic effects of glucocorticoids // Pmc Am Tborac Soc 2004 -Vol. L-P. 255−263.
- Thompson S.E. Effects of thymopentin on disease progression and surrogate markers in HIV infection A. one year study, tt Abstr. WS D.484. 6°' Inter. Conf. on Aim, S-Fran 1994.- P.20−24.
- Tissing W.J.E" Meijcrink J.P.P. den Boer M. L-, Pieiexs R. Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia- // Leukemia.- 2003, — Vol. 17.-P.17−25.
- Tonko M, Ausserlechner M. J, Bernhard D. et al- Ciene expression profiles of proliferating vs. Ci 1 /GO arrested human leukemia cells suggest a mechanism for glucocorttcoidinduced apoptosis //FASEB J 2001.- Vol. 5,-P. 643−699.
- Touw Ivo P. Cytokine Receptor Signaling Pcrturbances in Hematopoietic Disordery HISH ¦ EHA, Amsterdam, — 1998, — P.57−59.
- Towatari M-. Adachi K-.Kato H. Saito H. Absence of retinoblastoma gene product in die megakaryoblastic crisis ofCML. // Blood -1991- Vol 78.-P.2178−2191.
- Treiscn. C, Fulda, S. r and Debatin. K- Deficient activation of the CD 95 (APO-|/Fas) system in drug-resistant cell. //Leukemia. -1997. -Vol.1 1. -P. 1833−1841.
- Tnmarchi J.M.Lees J. A Siblings rivalry in the E2 °F family. Nature fcviewcs //Molecular cell biology 2001, — Vol. 31.-P. 11−20,
- Tsujimoto Y Molecular Mechanism of Cell Death ft ISII EHA, Combined Hematology Congress. Amsterdam -1998, — P, 78−81
- Tsujimoto Y" Gorham J., Cossman J, ct al. The 1(14:18) chromosome translocations involved in B-cdl neoplasms result from mistakes in VDJ joining Jf Science,-1985.-Vol299. -P. 1390−1393,
- Tsurusawa. M-. Sack", K. and Fusimobo. T. Differential induction of apoptosis on human lymfoblastic leukemia NALT-6 and MOLT-4 cell by various antitumor drug*. //IntJ.Hatmatology. 1997, -Vol, 66Jisl. -P. 79−88.
- Twcntyman PR. Fox NE, Recs JK, Chemoscnsitivity testing of fresh leukemia cells using the MTT colorimetric assa>vVBrJ-Haonotol.-1989.- Vol- 71 .-P, 19−24
- Twentyman PR. Luscobe M, A study or some variables in a tetra? olium dvc (MIT) bases assay for cell growth and chcmosensitivhy J/Br J. Cancer- 1987 Vol, S6.-P.279−285.
- Ucda K. Kino K. Taguehi Y., et aE. Role of P-gly copra tein in the transport of hormones and peptides. In: Gupta S. Tsuruo T (eds), H Multidrug Resistance in Cancer Cells Jolin Wiley & Sons- Chichester- 1996,-P. 303−319.
- Vaux D. L-, Haccker G., Strasser A. Prevention of prognumcd cell dath in C. Elcgans by human bcl-2.//CdL- 1994, — Vol. 76.- P. 777−785.
- J. Veerman A J., Raspers GJ, Pietcrs R. Cellular drug resistance in childhood leukemia. // Ann llematol, -1994. -Vol.69 (Suppl.l). -P S31-S34
- Veerman AJ. P, Pietcrs R, Drug sensitivity assays in leukemia and lymphoma // Br- HaemotoL- 1990.- Vol, 74.-P. 381−384,
- Veerman AJP, Pieters R Drug sensitivity assay inleukemia and lymfciOftJ/BrJ. Yaemotol -1990.- Vol. 74,-P381−384.
- Vint J.P. Gclloct F. Study of the apoptosis induced in vitro by antitumoral drugs on Icukacmic celts. // Leukemia Res -1996 Vol. I — P. 163−172.
- Vinogradova Yu. E, Zanuilacva 1A, Sclivanova EJ. ct at, Diagnostics of B~ cellular lymphoid leukemia using two-color flow cytofluorometry II Abstracts of VII international Conference on Malignant Lymphoma,. Lugano. Switzerland.- 19 991. P.32I.
- Von Stackelbcrg A., Harms D-. Ktingebiel T. et al. Improved outcome after relapse of childhood ALL results of trial ALL-REZ-BFM 95/96 (abstract). // Med Pediatr 0neo1.-2002.- Vol. 39.-P.23i.
- Voutsadakis I, Apoptosis and the pathogenesis of lymphoma, tt Acta Oncologics ¦ 2000,-Vol. 39 -P, 151−156.
- Waga S, Walsh K ?/Nature.-1994, — Vol 369.-P.574−578,
- Want/in G t Karle H., Killmann S-VRr J Haematol,-1976, — Vol. 32.-P.283−289
- Wcide R, Ticmann MPlluger K .e.a. Altered expression of the retinoblastoma gene product in human high-grade non-Hodgkin's lymphoma. // Leukemia -1994 -Vol SJfel.-P.97-I0L
- Weiscnthal LM. Morsden J. A «Dill P. L^Macaluso C .K, A novel dye exclusion method for testing in vitro chcmoscnsiiivity of human tumor*.'/ Cancer Res.-1983 -Vol. 43-P.749−757.
- Wells RG. Lapldn BC, Woods WG. Acute micloid leukemia in children // From the book: Cancer Medicine. 4, h edition. Edited by Holland IF, Bast RC. Morton DL, Frel Eetal. Williams -fcWitkms.- 1997 -Vol. 2 -P.2961−2973
- White J.L., Eileen F. K, Life, death and the pursuit of apoptosis // Genes And Develop.- l996.-№t0.- P. 1−15.
- Wikstrflm AC. Glucocorticoid action and novel mechanisms of steroid resistance role of glucocorticoid receptor-interacting proteins for glucocorticoid responsiveness // Journal of Endocrinology.- 2QQ3- Vol- 178.-P. 331−337.
- William S. Beck Hematology, ed. London. England.-1991.- P. t-20,
- Woods W.G., Kobrinsky N. Buckley J. D- ct al- Timed-sequential induction chcmoLherapy improves post-remission outcome in acute myeloid leukemia: a report from the children’s cancer group // Blood 1996. Vol. 87 — P 4979^1985.
- Wu SJ. Du X, Chen YX. Jiang WL. Zhong LY, Lin V, Huang ZL. Relationship between cyclins and prognosis of acute leukemia //Ai Zheng.- 2003.- Vol. 22J*fe8,-P.852−5.
- Wylii AH,» J Pathol-1987-Vol. I532.-P, 313−316,
- Wyllie Л. Н, Km G. F" Curric A.R. c← al, Apoptosis: a basic biological phenomenon with wide ranging implication. И Brit- J. Cancer 1972, — Vol. 26, №. 4 -P. 239−257.
- Wyllie A H. Kerr G.F. Curric A. R ct al. The significance of apoptosis // Int. Rev. Cytol-1992.- Vol. 68 P. 251−264.
- Wyllie A. H, Glucocorticoid induced thymocytes apoptosps is assosiatcd with endogenous endonuctcasc activation, //Nature, — 1980.- Vol, 284, — P. 555−556,
- Yamamo К R, Steroid rcccptor regulated transcription of specific genes and gave networks,//Annu Rcv, Gcik*.-I985.- Vol. I9 -P 209−252,
- Ych W, C" Pompn M.E., McCurrsch H-B. ct. at. FADD: essential for embryo development and signalling from some, but not all, inducers of apoptosis, II Scicnce-1998, — Vol. 279, — P. 739−750.427. /hang H. Postigo A., «can D7/Ccll.-1999.- Vol. 97.-P.53−61.
- Zhang L, Li i Expression and role of cycline D3 in childhood acute leukemia. // Zhonghua Xue Yc Xuc Za Zhi juL-2003.- Vol. 20,№ 7,-P, 347−349
- Zina Ben-Ishay, Prindal G"Sharon S//Leuk Res -1991.- Vol, 15 -P 321 -325.