ΠΠ΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΡΠ½ΠΊΡΠΈΠΉ Π³Π΅Π½Π° HSM2 Π² ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΠΠ Ρ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ Saccharomyces cerevisiae
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠ²ΡΠ·Π°Π½Π° ΡΠ°ΠΊΠΆΠ΅ Ρ ΡΠ΅ΠΌ, ΡΡΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌ ΠΈΠΌΠ΅Π΅Ρ Π²Π΅ΡΡΠΌΠ° Π²ΡΡΠΎΠΊΠΎΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅. ΠΠ΅ΡΠ²Π°Ρ Π³ΡΡΠΏΠΏΠ° ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ Π·Π°Π΄Π°Ρ, ΡΠ΅ΡΠ°Π΅ΠΌΡΡ ΠΏΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΠΈΡΡΠ΅ΠΌ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ, ΡΠ²ΡΠ·Π°Π½Π° Ρ ΠΈΡ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ Π² Π·Π°ΡΠΈΡΠ΅ ΠΠΠ ΠΎΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΡΡΠ°Π³Π΅Π½ΠΎΠ², ΠΊΠΎΡΠΎΡΠΎΠΌΡ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎ ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π°Π΅ΡΡΡ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΠΏΡΠΈΠ½ΡΠΈΠΏΠ°Ρ ΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°Ρ … Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ 1. Π‘ΠΠ‘Π’ΠΠΠ« ΠΠΠΠΠ ΠΠΠΠΠ― Π‘Π’ΠΠΠΠΠ¬ΠΠΠ‘Π’Π ΠΠΠΠΠ’ΠΠ§ΠΠ‘ΠΠΠΠ ΠΠΠ’ΠΠ ΠΠΠΠ Π£ ΠΠ ΠΠΠΠΠ SACCHAROMYCE CEREVISIAE (ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«)
- 1. 1. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠΈΠΏΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΠΠ ΠΈ ΠΏΡΡΠΈ ΠΈΡ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ
- 1. 2. Π’ΠΈΠΏΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ ΡΠ°Π΄ΠΈΠΎΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠΏΠΈΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π³ΡΡΠΏΠΏΡ Π³Π΅Π½ΠΎΠ²
- 1. 3. ΠΠΊΡΡΠΈΠ·ΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄ΠΎΠ² (ΠΠΏΠΈΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³ΡΡΠΏΠΏΠ° ΠΠΡΠ)
- 1. 4. ΠΠΎΡΡΡΠ΅ΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ²Π½Π°Ρ ΡΠ΅ΠΏΠ°Ρ$ΠΈΡ (ΠΠΏΠΈΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³ΡΡΠΏΠΏΠ° RAD6)
- 1. 5. Π Π΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΡ (ΠΠΏΠΈΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³ΡΡΠΏΠΏΠ° RAD52)
- 1. 6. ΠΠΊΡΡΠΈΠ·ΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 1. 7. ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ
ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 1. 7. 1. Π ΠΎΠ»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ. Π£Π½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 1. 7. 2. ΠΡΠΎΡΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ. HIM ΠΈ HSM Π³Π΅Π½Ρ
- 1. 7. 3. Π‘ΠΏΠΎΡΠΎΠ±Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 2. 1. Π‘ΠΏΠΈΡΠΎΠΊ ΡΠΎΠΊΡΠ°ΡΠ΅Π½Π½ΡΡ Π½Π°Π·Π²Π°Π½ΠΈΠΉ Π²Π΅ΡΠ΅ΡΡΠ² ΠΈ Π±ΡΡΠ΅ΡΠ½ΡΡ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ²
- 2. 2. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ ΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΈΡ
ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
- 2. 2. 1. ΠΠ±ΠΎΠ·Π½Π°ΡΠ΅Π½ΠΈΡ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ
- 2. 2. 2. Π¨ΡΠ°ΠΌΠΌΡ
- 2. 2. 3. Π‘ΠΎΡΡΠ°Π² ΠΏΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ ΡΡΠ΅Π΄ ΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°ΠΌΠΌΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅
- 2. 3. ΠΠ΅ΡΠΎΠ΄Ρ
- 2. 3. 1. ΠΡΠ°ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΠΠ ΡΡΠ°Π½ΠΎΠ»ΠΎΠΌ
- 2. 3. 2. ΠΠ½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Ρ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΠΠ Π² Π»ΡΠ½ΠΊΠ°Ρ
- 2. 3. 3. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½Π΅Π±ΠΎΠ»ΡΡΠΈΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ² Π΄Π²ΡΡΠ΅ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ ΠΈΠ· Π. coli ΠΊΠΈΠΏΡΡΠ΅Π½ΠΈΠ΅ΠΌ
- 2. 3. 4. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π±ΠΎΠ»ΡΡΠΈΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ² Π΄Π²ΡΡΠ΅ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ ΠΈΠ· Π. coli ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π»ΠΎΡΠ½ΠΎΠ³ΠΎ Π»ΠΈΠ·ΠΈΡΠ°
- 2. 3. 5. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΠΠ ΠΈΠ· Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ΅ ΡΠ΅Π»Π½ΠΎΡΠ½ΡΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ Π² Π. col
- 2. 3. 6. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠ΄Π½ΠΎΡΠ΅ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 3. 7. ΠΠ°ΡΠ°Π±ΠΎΡΠΊΠ° Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³Π°-ΠΏΠΎΠΌΠΎΡΠ½ΠΈΠΊΠ° Π13Π Π² Π±ΠΎΠ»ΡΡΠΈΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π°Ρ
- 2. 3. 8. Π‘Π΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ
- 2. 3. 9. Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ Π. col
- 2. 3. 10. Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ S. cerevisiae
- 2. 3. 11. ΠΠΈΠΊΡΠΎΠΌΠ°Π½ΠΈΠΏΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠ΅ΡΡΠ°Π΄Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·
- 2. 3. 12. Π£ΡΠ΅Ρ ΡΠ°ΡΡΠΎΡΡ ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΡΡ ΠΌΡΡΠ°ΡΠΈΠΉ ΠΊΠ°Π½Π°Π²Π°Π½ΠΈΠ½ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ
- 2. 3. 13. Π£Π€-ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ
- 2. 3. 14. Π£ΡΠ΅Ρ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΡΠΈ Π£Π€-ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠΈ
- 2. 3. 15. Π£ΡΠ΅Ρ ΡΠ°ΡΡΠΎΡΡ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΡΡΠ°Π½ΡΠΎΠ² ΠΏΡΠΈ Π£Π€-ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠΈ ΠΊΡΠ»ΡΡΡΡΡ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ
- 2. 3. 16. ΠΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΠΌΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΏΠΎ ΡΠ°ΡΡΠΎΡΠ΅ ΠΏΡΡΠΌΡΡ ΠΌΡΡΠ°ΡΠΈΠΉ ΠΊΠ°Π½Π°Π²Π°Π½ΠΈΠ½ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ
- 2. 3. 17. ΠΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊ ΠΌΠ΅ΡΠΈΠ»ΠΌΠ΅ΡΠ°Π½ΡΡΠ»ΡΡΠΎΠ½Π°ΡΡ
- 2. 3. 18. Π‘ΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 3. 19. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- 3. 1. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ Ρ ΠΎΠ΄Π½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΠΌΠΈ Π·Π°ΠΌΠ΅Π½Π°ΠΌΠΈ Π² Π³Π΅Π½Π΅ ΠΠΠ
- 3. 2. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΠ΅ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΡ
- 4. 1. Π₯ΡΠΎΠΌΠΎΡΠΎΠΌΠ½Π°Ρ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΡ Π³Π΅Π½Π° ΠΠΠ
- 4. 2. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½Π° Π¨Π2 ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΏΠ»Π΅ΡΠ° Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ IV
- 5. 1. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ 11Π·Ρ2 Π½Π° ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ
Π³Π΅ΡΠ΅ΡΠΎΠ΄ΡΠΏΠ»Π΅ΠΊΡΠΎΠ² ΠΈ ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΡΠΉ ΠΌΡΡΠ°Π³Π΅Π½Π΅Π·
- 5. 1. 1. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ Π³Π΅ΡΠ΅ΡΠΎΠ΄ΡΠΏΠ»Π΅ΠΊΡΠΎΠ² Π² ΡΡΠ°ΠΌΠΌΠ΅ Π΄ΠΈΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
- 5. 1. 2. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ 1Ρ8Π³ΠΏ2 Π½Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ Π³Π΅ΡΠ΅ΡΠΎΠ΄ΡΠΏΠ»Π΅ΠΊΡΠΎΠ²
- 5. 1. 3. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ hsm2 Π½Π° ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ Π³Π΅ΡΠ΅ΡΠΎΠ΄ΡΠΏΠ»Π΅ΠΊΡΠΎΠ²
- 5. 1. 4. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ hsm.2 ΠΈ ΠΌΡΡΠ°ΡΠΈΠΈ pmsl ΠΏΡΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 5. 1. 5. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ hsm2 Π½Π° ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΡΠΉ ΠΌΡΡΠ°Π³Π΅Π½Π΅Π·. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ hsm2 ΠΈ ΠΌΡΡΠ°ΡΠΈΠΈ pmsl ΠΏΡΠΈ ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΠΎΠΌ ΠΌΡΡΠ°Π³Π΅Π½Π΅Π·Π΅
- 5. 2. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ hsm2 Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ Π² Π³Π΅Π½Π°Ρ
Π΄ΡΡΠ³ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΠΠ ΠΏΡΠΈ Π£Π€-ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠΈ ΠΈ ΠΏΡΠΈ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ΅ ΠΌΠ΅ΡΠΈΠ»ΠΌΠ΅ΡΠ°Π½ΡΡΠ»ΡΡΠΎΠ½Π°ΡΠΎΠΌ
- 5. 2. 1. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ hsm2 Π½Π° ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΊ Π£Π€-ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ ΠΈ ΠΠΠ‘ ΠΈ Π½Π° ΠΈ Π£Π€-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΌΡΡΠ°Π³Π΅Π½Π΅Π·
- 5. 2. 2. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ hsm2 ΠΈ rad
- 5. 2. 3. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ hsm2 ΠΈ rev
- 5. 2. 4. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ hsm2 ΠΈ rad
- 5. 2. 5. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ hsm2 ΠΈ pmsl
- 5. 2. 6. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ hsm2 ΠΈ hsm
- 6. 1. Π‘ΠΈΡΡΠ΅ΠΌΠ° ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 6. 2. ΠΠΎΠ²ΡΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ Ρ S. cerevisiae
- 6. 3. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΈ hsm2 Π½Π° ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π°Ρ . Π ΠΎΠ»Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π³Π΅Π½Π° HSM2 Π² ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ ΡΠΏΠ°ΡΠ΅Π½Π½ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΉ
- 6. 4. Π£ΡΠ°ΡΡΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π³Π΅Π½Π° HSM2 Π² ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΡ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠ°Π±ΠΎΡΡ «ΡΠΊΠ»ΠΎΠ½Π½ΠΎΠΉ ΠΊ ΠΎΡΠΈΠ±ΠΊΠ°ΠΌ» ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ"
- 6. 5. ΠΠΈΠΏΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡ Π΅ΠΌΠ° ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΡ ΠΏΡΠΈ ΠΎΠ±Ρ ΠΎΠ΄Π΅ Π½Π΅ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΠΠ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π³Π΅Π½Π° HSM
- 6. 6. Π£ΡΠ°ΡΡΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π³Π΅Π½Π° PMS1 Π² ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΏΡΠΈ Π£Π€-ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠΈ
- 6. 7. Π‘ΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ΅ ΡΡΠ°ΡΡΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π³Π΅Π½ΠΎΠ² HSM2 ΠΈ HSM Π² ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ
- 6. 8. Π Π΅ΠΏΠ°ΡΠ°ΡΠΈΡ ΠΏΡΠ΅Π΄ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π³Π΅Π½Π° HSM2 ΠΊΠ°ΠΊ Π½ΠΎΠ²ΡΠΉ ΠΏΡΠΈΠΌΠ΅Ρ ΡΡΠ°ΡΡΠΈΡ ΠΠΠ‘Π Π² ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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- ΠΡΡΠ°ΠΆΠ°Ρ Π³Π»ΡΠ±ΠΎΠΊΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ ΡΠ²ΠΎΠ΅ΠΌΡ Π½Π°ΡΡΠ½ΠΎΠΌΡ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ ΠΠ»Π°Π΄ΠΈΠΌΠΈΡΡ ΠΠ΅Π½Π½Π°Π΄ΡΠ΅Π²ΠΈΡΡ ΠΠΎΡΠΎΠ»Π΅Π²Ρ Π·Π° Π²ΡΡΠ°Π±ΠΎΡΠΊΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ² ΠΊ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ, Π½Π΅ΠΎΡΠ΅Π½ΠΈΠΌΡΡ ΠΏΠΎΠΌΠΎΡΡ ΠΏΡΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², ΠΈ Π·Π° ΠΏΠΎΡΡΠΎΡΠ½Π½ΡΡ Π·Π°Π±ΠΎΡΡ ΠΈ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅.
- Π― Π³Π»ΡΠ±ΠΎΠΊΠΎ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»Π΅Π½ Π‘Π²Π΅ΡΠ»Π°Π½Π΅ ΠΠ°ΡΠΈΠ»ΡΠ΅Π²Π½Π΅ ΠΠΎΠ²Π°Π»ΡΡΠΎΠ²ΠΎΠΉ ΠΈ ΠΡΠΈΠ½Π΅ ΠΠ°ΡΠΈΠ»ΡΠ΅Π²Π½Π΅ Π€Π΅Π΄ΠΎΡΠΎΠ²ΠΎΠΉ Π·Π° ΠΏΠΎΠΌΠΎΡΡ Π² ΠΎΠ²Π»Π°Π΄Π΅Π½ΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ. C.B. ΠΠΎΠ²Π°Π»ΡΡΠΎΠ²Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΊΠ°Π·Π°Π»Π° ΠΌΠ½Π΅ ΠΏΠΎΠΌΠΎΡΡ Π² ΠΊΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π³Π΅Π½Π° HSM2, Π·Π° ΡΡΠΎ Ρ Π΅ΠΉ ΠΈΡΠΊΡΠ΅Π½Π½Π΅ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»Π΅Π½.
- ΠΡΡΠ°ΠΆΠ°Ρ ΠΈΡΠΊΡΠ΅Π½Π½ΡΡ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΡΡΠ΅ΡΠ»Π°Π²Ρ Π’ΠΈΠΌΠΎΡΠ΅Π΅Π²ΠΈΡΡ ΠΠ΅ΡΠ΅Ρ ΠΎΠ½ΠΎΠ²Ρ, ΠΎΠ±ΡΡΠΈΠ²ΡΠ΅ΠΌΡ ΠΌΠ΅Π½Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ.
- Π― Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ΅Π½ ΡΠ°ΠΊΠΆΠ΅ Π‘Π΅ΡΠ³Π΅Ρ ΠΠ»Π΅ΠΊΡΠ΅Π΅Π²ΠΈΡΡ ΠΠΎΠΆΠΈΠ½Ρ Π·Π° ΠΏΠ»ΠΎΠ΄ΠΎΡΠ²ΠΎΡΠ½ΠΎΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠ΅Π½Π½ΡΠ΅ ΡΠΎΠ²Π΅ΡΡ ΠΏΠΎ ΠΎΡΠΎΡΠΌΠ»Π΅Π½ΠΈΡ ΡΠ°Π±ΠΎΡΡ.
- ΠΠΎΠ»ΡΡΠΎΠ΅ ΡΠΏΠ°ΡΠΈΠ±ΠΎ Π²ΡΠ΅ΠΌ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΡΡΠΊΠ°ΡΠΈΠΎΡ ΠΠΠ Π ΠΠΠ―Π€ Π·Π° ΠΏΠΎΠΌΠΎΡΡ ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΡ.