Генетическое разнообразие и фармакодинамическое обоснование прогноза резистентности к антимикробным препаратам нозокомиальных штаммов Acinetobacter spp. в различных регионах России и Беларуси
Диссертация
Смоленск, 2009 г.), совместном заседании сотрудников кафедр госпитальной педиатрии с курсом неонатологии ФПК и 1JLL1C, клинической фармакологии, микробиологии, поликлинической педиатрии, терапии педиатрического и стоматологического факультета, терапии ФПК и ППС, общественного здоровья и здравоохранения, травматологии и ортопедии, урологии, факультетской терапии, сотрудников НИИ антимикробной… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗОВАННЫХ СОКРАЩЕНИЙ
- ЧАСТЬ 1. ОБЗОР ЛИТЕРАТУРЫ
- ГЛАВА 1. A CINETOBACTER SPP
- 1. 1. Общие представления о микроорганизме
- 1. 2. Клиническое значение Acinetobacter spp
- 1. 3. Методы идентификации acinetobacter spp
- ГЛАВА 2. РЕЗИСТЕНТНОСТЬ К АНТИМИКРОБНЫМ ПРЕПАРАТАМ
- 2. 1. Механизмы антибиотикорезистентности ^с/л^гшлсгяя spp
- 2. 2. Активность основных антимикробных препаратов в отношении нозокомиальных штаммов Acinetobacter spp
- ЧАСТЬ 2. СОБСТВЕННЫЕ ИССЛЕДОВАНИЯ
- ГЛАВА 3. МАТЕРИАЛ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 3. 1. клинический материал
- 3. 2. Фенотипическое исследование микроорганизмов
- 3. 3. Контроль качества при определении чувствительности
- 3. 4. Обработка данных и статистический анализ
- 3. 5. Генотипическое изучение микроорганизмов
- ГЛАВА 4. РЕЗУЛЬТАТЫ И ИХ ОБСУЖДЕНИЕ
- 4. 1. Значимость Acinetobacter spp. как возбудителя нозокомиальных инфекций в России
- 4. 1. 1. Сроки проведения и география исследования
- 4. 1. 2. Структура грамотрицательных возбудителей нозокомиальных инфекций в России и положение рода Acinetobacter
- 4. 2. Резистентность нозокомиальных штаммов Acinetobacter spp. к используемым антимикробным препаратам и оценка перспективных антибиотиков
- 4. 2. 1. Динамика резистентности к используемым антибиотикам и различия в зависимости от профиля отделения
- 4. 2. 2. Оценка резистентности нозокомиальных Acinetobacter spp. к используемым антимикробным препаратам в 2006—2008 гг.
- 4. 2. 3. Оценка активности перспективных антимикробных препаратов
- 4. 2. 4. Перекрёстная резистентность к карбапенемам
- 4. 3. Выявление продукции приобретённых карбапенемаз нозокомиальными штаммами Acinetobacter spp
- 4. 3. 1. Выявление продукции приобретённых металло-бета-лактамаз
- 4. 3. 2. Разработка метода мультиплекс-ПЦР для детекции генов приобретённых ОХА-карбапенемаз у Acinetobacter spp
- 4. 3. 3. Выявление генов приобретённых ОХА-карбапенемаз у карбапенеморезистентных штаммов Acinetobacter spp
- 4. 3. 4. Выявление «молчащих» генов приобретённых ОХА-карбапенемаз у карбапенемочувствительных штаммов acinetobacter spp
- 4. 4. мультилокусное секвенирование-типирование штаммов Acinetobacter ва umanni
- 4. 4. 1. Оптимизация протокола MJICT штаммов а. ва umanni
- 4. 4. 2. Изучение генетического разнообразия штаммов a. baumannii, циркулирующих на территории России и Беларуси
- 4. 1. Значимость Acinetobacter spp. как возбудителя нозокомиальных инфекций в России
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