Экспрессия ранних генов вирусов папиллом человека в опухолях шейки матки
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Диссертация
Исследование механизмов, приводящих к длительной инфекции, нарушению жизненного цикла вируса и злокачественной трансформации, поиск клеточных генов, изменение экспрессии или структуры которых позволяло бы отличить инфицированную клетку от трансформированной клетки, являются важными задачами. Эти исследования необходимы для определения групп риска развития рака среди инфицированных больных… Читать ещё >
Содержание
- Список сокращений
- Глава 1. Обзор литературы
- Ранние гены вирусов папиллом человека
- 1. 1. Общая характеристика HR-HPV
- 1. 2. Регуляторная область генома
- 1. 3. Характеристика гена Еб
- 1. 4. Характеристика гена Е
- 1. 5. Индукция нестабильности генома онкогенами Е6 и Е
- 1. 6. Характеристика гена Е
- 1. 7. Характеристика гена Е
- 1. 7. 1. Е2 — регулятор репликации
- 1. 7. 2. Е2 — регулятор транскрипции вирусного генома
- 1. 7. 3. Е2 — регулятор транскрипции клеточного генома
- 1. 7. 4. Роль Е2 в сегрегации вирусного генома в митозе
- 1. 7. 5. Прямое взаимодействие Е2 с вирусными и клеточными белками
- 1. 8. Репликативные факторы Е1 и Е2 и нестабильность клеточного генома
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