Естественная рекомбинация у пикорнавирусов

Выводы.

1. Естественная рекомбинация широко распространена у родов Hepatovirus (вирус гепатита А) и Kobuvirus (вирус Айчи) семейства Picornaviridae.

2. Рекомбинация у родов Hepatovirus (вирус гепатита А) и Kobuvirus (вирус Айчи) выявляется во всех участках генома с приблизительно одинаковой частотой, в отличие от других пикорнавирусов.

3. На основании молекулярно-эпидемиологических данных показана репродуктивная изоляция генотипов вируса гепатита А. Каждый генотип вируса гепатита, А удовлетворяет репродуктивному критерию в биологической концепции вида и может представлять самостоятельный таксономический вид.

4. Закономерности рекомбинации у парэховирусов в целом сходны с таковыми у энтеровирусов и большинства других пикорнавирусов. В пределах области генома, кодирующей поверхностные белки капсида, рекомбинация обнаруживается редко, а в кодирующей неструктурные белки часто, чаще всего на границах структурной области генома в областях, кодирующих белки VP0 и 2А.

5. Впервые зафиксирована рекомбинация внутри области генома, кодирующей поверхностные белки капсида парэховирусов, между вирусами, принадлежащими к одному серотипу.

6. Впервые для вирусов с несегментированным геномом показана географическая специфичность варианта фрагмента генома независимо от других участков генома, возможная благодаря частой рекомбинации. Монофилетический вариант фрагмента генома парэховирусов, кодирующий протеазу ЗС, преобладал на протяжении порядка 150 лет у вирусов четырех различных серотипов, циркулировавших на территории Бразилии.

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