КАрдиометаболические нарушения при инверсии цикла «день/ночь»: особенности формирования и методы коррекции
Диссертация
Мы живем в обществе с 24-часовой световой ориентацией, которое уже не имеет строгой синхронизации с сезонными изменениями в продолжительности светового дня и температуре. Круглогодичный «летний день» является результатом искусственного освещения, хотя и недостаточной интенсивности для стабильной стимуляции. Слишком мало известно о последствиях нерегулярности действия света на чувствительную… Читать ещё >
Содержание
- Глава 1. Литературный обзор
- 1. 1. Используемая терминология
- 1. 2. Кардиометаболические нарушения: история проблемы
- 1. 3. Кардиометаболические нарушения: эпидемиология
- 1. 4. Кардиометаболические нарушения: клинические особенности
- 1. 5. Факторы риска развития метаболических нарушений
- 1. 6. Кардиометаболические нарушения: влияние циркадианной системы
- 1. 7. Гормон эпифиза мелатонин как регулятор циркаднных ритмов
- 1. 7. 1. История вопроса
- 1. 7. 2. Эмбриогенез эпифиза
- 1. 7. 3. Строение эпифиза
- 1. 7. 4. Синтез и метаболизм мелатонина
- 1. 7. 5. Регуляция синтеза мелатонина
- 1. 8. Роль мелатонина в развитии метаболического синдрома
- 1. 8. 1. Влияние мелатонина на секрецию инсулина и чувствительность инсулиновых рецепторов
- 1. 8. 2. Влияние мелатонина на синтез лептина и роль последнего в развитии инсулиновой резистентности
- 1. 8. 3. Влияние мелатонина на уровень магния и роль последнего в развитии инсулиновой резистентности
- 1. 8. 4. Влияние мелатонина на синтез тестостерона и роль последнего в развитии инсулиновой резистентности
- 1. 8. 5. Влияние мелатонина на оксидативный стресс и роль последнего в развитии инсулиновой резистентности
- 1. 9. Влияние мелатонина на деятельность сердечно-сосудистой системы
- 1. 9. 1. Регулирующее влияние мелатонина на артериальное давление
- 1. 9. 2. Экспериментальная гипертония
- 1. 9. 3. Секреция мелатонина у пациентов с артериальной гипертензией и без таковой
- 1. 9. 4. Механизмы воздействия мелатоиина на артериальное давление
- 1. 9. 5. Влияние мелатонина на процессы ремоделирования сердца и сосудов
- 1. 10. Регулирующее влияние мелатонина на плазменный уровень глюкозы
- 1. 11. Регулирующее влияние мелатонина на жировую ткань и вес тела
- 1. 12. Мелатонин и контроль настроения и поведения
- 1. 13. Применение препаратов экзогенного мелатонина
- Глава 2. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Дизайн исследования
- 2. 2. Материал исследования
- 2. 3. Методы исследования
- 2. 3. 1. Клинические методы обследования
- 2. 3. 2. Лабораторные методы исследования. Получение биологического материала
- 2. 3. 3. Инструментальные методы исследования
- 2. 3. 4. Статистическая обработка результатов исследования
- 3. 1. Частота встречаемости кардиометаболических нарушений среди организованного работающего населения города Ростова-на-Дону
- 3. 2. Сменная работа как фактор риска развития метаболического синдрома
- 3. 3. Сравнительный анализ концентрации метаболита мелатонина при нормальном и инвертированном цикле «день/ночь»
- 3. 4. Взаимосвязи между нарушенной секрецией мелатонина и патогенетическими механизмами развития инсулиновой резистентности при инверсии цикла «день/ночь»
- 3. 4. 1. Концентрация 6-СОМТ в моче и степень выраженности инсулиновой резистентности
- 3. 4. 2. Концентрация 6-СОМТ и содержание других веществ, оказывающих действие на развитие инсулиновой резистентности и имеющих циркадный характер регуляции
- 3. 4. 3. Концентрация 6-СОМТ и параметры окислительного стресса
- 3. 5. Связь изменения секреции мелатонина с клиническими проявлениями метаболического синдрома
- 3. 5. 1. Концентрация 6-СОМТ в моче и суточная динамика АД и ЧСС
- 3. 5. 2. Связь концентрации 6-СОМТ в моче с показателями углеводного и жирового обменов
- 3. 6. Соотношение концентрации 6-СОМТ в моче и психоэмоционального статуса
- 3. 7. Коррекция препаратом экзогенного мелатонина артериальной гипертензии и других проявлений метаболического синдрома
- 3. 8. Изменение психоэмоционального состояния на фоне лечения экзогенным мелатонином
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