Π ΠΎΠ»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΠΠ (MMR) Π² ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ΅ Π³Π΅Π½ΠΎ-ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΠΈΠ»Π½ΠΈΡΡΠΎΠ·ΠΎΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ Π² ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
![ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ: Π ΠΎΠ»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΠΠ (MMR) Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ΅ Π³Π΅Π½ΠΎ-ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΠΈΠ»Π½ΠΈΡΡΠΎΠ·ΠΎΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ Π² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°](https://westud.ru/work/2531472/cover.png)
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ Π² ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² 30% ΡΠ»ΡΡΠ°Π΅Π² Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠΏΠΎΡΠ°Π΄ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π Π’Π Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΡΠ°ΠΊΠΆΠ΅ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΠ‘Π Π³Π΅Π½ΠΎΠΌΠ°. ΠΠ΄Π½Π°ΠΊΠΎ, Π² ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΎΡ ΡΠ΅ΠΌΠ΅ΠΉΠ½ΠΎΠΉ ΡΠΎΡΠΌΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π·Π΄Π΅ΡΡ ΠΠ‘Π ΡΠ°ΡΠ΅ Π²ΡΠ΅Π³ΠΎ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π° Π½Π΅ Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ Π² Π³Π΅Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΡ MMR, Π° Ρ Π³ΠΈΠΏΠ΅ΡΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠΎΠ² ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ². Π‘ΡΠ΄Π° ΠΆΠ΅ ΠΌΠΎΠΆΠ½ΠΎ ΠΎΡΠ½Π΅ΡΡΠΈ ΠΈ ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΡ Π³ΡΡΠΏΠΏΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΡΠΎΡΠΌΠΈΡΡΡΡΠΈΡ ΡΠ°ΠΊ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΠΎ ΡΠ΅ΠΌΠ΅
- 2. 1. ΠΠΠ₯ΠΠΠΠΠΠ« ΠΠΠ‘Π¦ΠΠΠΠΠΠΠΠ Π ΠΠΠΠ ΠΠ¦ΠΠ ΠΠΠ Π ΠΠΠΠ’ΠΠ
- 2. 1. 1. ΠΠΎΡΠ΅ΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ²Π½Π°Ρ ΡΠΊΡΡΠΈΠ·ΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΡ
- 2. 1. 2. ΠΠΎΡΡΡΠ΅ΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ²Π½Π°Ρ ΡΠΊΡΡΠΈΠ·ΠΈΠΎΠ½Π½Π°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΡ
- 2. 2. 06-MeG ΠΠΠΠ£ΠΠ’ΠΠ MMR Π ΠΠΠΠΠ’ΠΠΠ
- 2. 3. Π ΠΠ Π’ΠΠΠ‘Π’ΠΠΠ ΠΠΠ¨ΠΠ§ΠΠΠΠ: ΠΠΠ€ΠΠ¦ΠΠ’ MMR, ΠΠ¦ΠΠΠΠ Π ΠΠ‘ΠΠ Π ΠΠΠΠΠ’ΠΠ― ΠΠΠΠΠΠΠΠΠΠΠ― Π‘ΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 3. 1. ΠΠΠ’ΠΠ ΠΠΠΠ« Π ΠΠΠ’ΠΠΠ«
- 3. 1. 1. ΠΠ»Π΅ΡΠΊΠΈ
- 3. 1. 2. ΠΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ
- 3. 1. 3. ΠΡΠ΅Π½ΠΊΠ° ΠΆΠΈΠ·Π½Π΅ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΠ’Π’-ΡΠ΅ΡΡΠ°
- 3. 1. 4. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΆΠΈΠ·Π½Π΅ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΏΠΎ Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΈΠ½Π΄Π΅ΠΊΡΡ
- 3. 1. 5. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π΄Π²ΡΠ½ΠΈΡΠ΅Π²ΡΡ ΡΠ°Π·ΡΡΠ²ΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠΠ-ΠΊΠΎΠΌΠ΅Ρ
- 3. 1. 6. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ Π² Π³Π΅Π½Π°Ρ MLH1 ΠΈ MSH2 Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Colo320HSR
- 3. 2. Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π«
- 3. 2. 1. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΠΠ Π½Π° ΠΊΠ»Π΅ΡΠΊΠΈ HeLa ΠΈ ΠΠ‘Π’
- 3. 2. 2. ΠΠ΅Π½ΠΎ- ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡΡ ΠΠΠ Π½Π° ΠΊΠ»Π΅ΡΠΊΠ°Ρ Colo320HSR
- 3. 2. 3. ΠΡΡΠ°ΡΠΈΠΈ Π² Π³Π΅Π½Π°Ρ MLH1 ΠΈ MSH2 Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Colo320HSR
- 3. 3. ΠΠΠ‘Π£ΠΠΠΠΠΠ Π ΠΠΠ£ΠΠ¬Π’ΠΠ’ΠΠ ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ―
- 2. 1. ΠΠΠ₯ΠΠΠΠΠΠ« ΠΠΠ‘Π¦ΠΠΠΠΠΠΠΠ Π ΠΠΠΠ ΠΠ¦ΠΠ ΠΠΠ Π ΠΠΠΠ’ΠΠ
- ΠΡΠ²ΠΎΠ΄Ρ
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