Синтез и изучение свойств конъюгатов порфиринов с углеводами
Диссертация
Строение продуктов было подтверждено данными ПМР-спектроскопии и масс-спектрометрии. В спектрах ПМР (5а), (6а) и (9а) (табл. 2) наблюдается исчезновение сигналов в области 6.2 и 7.9 м. д., характерных для винильной группы, и появляются мультиплет в области 5.9−6.05 м.д. и дублет в области 2.1 м.д., характерные для протонов СНз-СН-О-группы. Сигналы л/езо-протонов 5-Н, расположенных наиболее близко… Читать ещё >
Содержание
- ИСПОЛЬЗОВАННЫЕ СОКРАЩЕНИЯ л
- I. ВВЕДЕНИЕ
- II. ЛИТЕРАТУРНЫЙ ОБЗОР «Конъюгаты порфиринов с биомолекулами»
- 1. Гликоконъюгаты порфиринов
- 1. 1. Методы синтеза гликопорфиринов
- 1. 2. Свойства гликопорфиринов. Влияние структуры на характеристики соединений как потенциальных агентов для ФДТ
- 2. Синтез и свойства порфирин-нуклеозидов
- 3. Синтез и свойства липопорфиринов
- 4. Конъюгаты порфиринов с аминокислотами и пептидами
- Заключение
- III. ОБСУЖДЕНИЕ РЕЗУЛЬТАТОВ
- 1. Синтез производных феофорбида, а и пирофеофорбида а, связанных с моносахаридными остатками простой эфирной связью
- 2. Синтез производных пирофеофорбида а, связанных с углеводными фрагментами О-гликозидной связью
- 3. Синтез S-гликозилированных производных пирофеофорбида а
- 4. Синтез производных пирофеофорбида а, связанных с аномерным центром углевода через спейсерные участки
- 5. Синтез производных пирофеофорбида а, связанных с углеводом амидной связью
- 6. Изучение физико-химических характеристик полученных гликоконъюгатов
- 6. 1. Поведение в водных растворах
- ИСПОЛЬЗОВАННЫЕ СОКРАЩЕНИЯ ТФП — тетрафенилпорфирин ФС — фотосенсибилизатор ФДТ — фотодинамическая терапия ДДХ — 2,3-дихлор-5,6-дицианбензохинон ЭСП — электронные спектры поглощения ЦЦ — цикло декстрин
- ЛПНП — липопротеины низкой плотности I II — гематопорфирин ПГО — производное гематопорфирина ДЦК — дициклогексилкарбодиимид ДМАП — 4-диметиламинопиридин
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