Клинико-морфологическая дифференциальная диагностика первичных лимфом кожи, псевдолимфом кожи и парапсориазов
На основе изучения клинико-морфологических и молекулярно-биологических признаков и многолетних катамнестических наблюдений установлено, что спектр лимфопролиферативных заболеваний кожи у пациентов в когортном исследовании (357 больных) является неоднородным и включает злокачественные лимфомы кожи, доброкачественные псевдолимфомы кожи и «клональные» псевдолимфомы с неопределенным злокачественным… Читать ещё >
Содержание
- СПИСОК УСЛОВНЫХ СОКРАЩЕНИЙ
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Исторические аспекты и современное развитие концепции псевдолимфом кожи
- 1. 2. Очерк развития представлений о парапсориазах и их связи с грибовидным микозом
- 1. 3. Эволюция гистологических классификаций и современные представления о гистогенезе лимфом кожи
- Глава 2. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Методы клинического обследования больных лимфомами кожи, псевдолимфомами и парапсориазами
- 2. 2. Гистологические методы исследования биопсийного материала
- 2. 3. Методика иммуногистохимического исследования биопсийного материала
- 2. 4. Методика молекулярно-биологического исследования биопсийного материала
- 2. 4. 1. Выделение ДНК
- 2. 4. 2. Анализ реарранжировки гена Т-клеточного рецептора
- 2. 4. 3. Анализ реарранжировки гена тяжелых цепей иммуноглобулина
- 2. 4. 4. Обнаружение ДНК Borrelia burgdorferi методом ПЦР
- 2. 4. 5. Обнаружение ДНК вируса простого герпеса 1 и 2 типа методом ПЦР
- 2. 4. 6. Обнаружение транслокаций t (l4- 18) и t (l 1- 18) методом флюоресцентной in situ гибридизации
- 2. 5. Методы математической обработки результатов исследования
- Глава 3. ОБЩАЯ КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА ОБСЛЕДОВАННОЙ ГРУППЫ ПАЦИЕНТОВ С ЛИМФОМАМИ КОЖИ, ПСЕВДОЛИМФОМАМИ КОЖИ И ПАРАПСОРИАЗАМИ
- Глава 4. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА ЛИМФОПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ КОЖИ, СОПРОВОЖДАЮЩИХСЯ «ПСЕВДОЛИМФОМАТОИДНЫМ ФОЛЛИКУЛИТОМ»
- 4. 1. Клиническая, гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы псевдолимфом, сопровождающихся «псевдолимфоматоидным трихофолликулитом»
- 4. 2. Клиническая, гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы лимфом, сопровождающихся «псевдолимфоматоидным трихофолликулитом»
4.3. Оптимизация дифференциальной диагностики лимфопролиферативных заболеваний кожи, сопровождающихся псевдолимфоматоидным фолликулитом", с помощью гистологических, иммуногистохимических и молекулярно-биологических критериев.
Глава 5. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА В-КЛЕТОЧНЫХ ЛИМФОМ КОЖИ И ПСЕВДОЛИМФОМ С ФОЛЛИКУЛЯРНЫМ ТИПОМ РОСТА ДЕРМАЛЬНОГО ИНФИЛЬТРАТА.
5.1. Общая клиническая характеристика больных.
5.2. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы первичных лимфом кожи маргинальной зоны.
5.3. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы первичных лимфом кожи из клеток фолликулярного центра.
5.4. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы лимфоцитом кожи.
5.5. Оптимизация дифференциальной диагностики В-клеточных лимфом кожи и псевдолимфом с фолликулярным типом роста дермального инфильтрата с помощью гистологических, иммуногистохимических и молекулярно-биологических критериев
Глава 6. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА КОЖНЫХ ЛИМФОПРО ЛИФ К РАТИВНЫХ ПРОЦЕССОВ ОБЛАСТИ КОЖИ СОСКА И АРЕОЛЫ МОЛОЧНОЙ ЖЕЛЕЗЫ И КОЖИ МОШОНКИ.
6.1. Клиническая, гистологическая, иммуногистохимическая и молеку-лярно-биологическая характеристика группы кожных лимфоидных гиперплазий кожи ареолы и/или соска молочной железы.
6.1.1. Общая клиническая характеристика больных.
6.1.2. Гистологическая и иммуногистохимическая характеристика группы кожных лимфоидных гиперплазий области соска и ареолы молочной железы.
6.1.3. Молекулярно-биологическая характеристика кожных лимфоидных гиперплазий области соска и ареолы молочной железы.
6.1.4. Ассоциация кожной лимфоидной гиперплазии с инфицированием Borrelia burgdorferi
6.2. Клиническая, гистологическая и молекулярно-биологическая характеристика других доброкачественных лимфоидных инфильтратов кожи ареолы и/или соска молочной железы
6.3. Клиническая, гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика пациентки с периферической Т-клеточной лимфомой, неуточненной.
6.4. Клиническая, гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы кожных лимфоидных гиперплазий кожи мошонки
6.5. Оптимизация дифференциальной диагностики кожных лимфопроли-феративных процессов области кожи соска и/или ареолы молочной железы и кожи мошонки с помощью гистологических, иммуногисто-химических и молекулярно-биологических критериев.
Глава 7. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА И ВЗАИМОСВЯЗЬ МЕЖДУ ЗАБОЛЕВАНИЯМИ ГРУППЫ ПАРА! 1С ОРИ АЗОВ И ПЯТНИСТОЙ СТАДИЕЙ ГРИБОВИДНОГО МИКОЗА.
7.1. Общая клиническая характеристика больных.
7.2. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы парапсориазов и пятнистой стадии грибовидного микоза.
7.3. Оптимизация дифференциальной диагностики ранних стадий грибовидного микоза и парапсориазов на основе анализа клинико-морфологических и молекулярно-генетических признаков.
7.4. Взаимосвязь между заболеваниями группы парапсориазов и грибовидным микозом.
Глава 8. ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА ПЕРВИЧНЫХ КРУПНОКЛЕТОЧНЫХ ЛИМФОМ КОЖИ.
8.1. Дифференциальная диагностика первичных Т-клеточных крупноклеточных лимфопролиферативных заболеваний кожи.
8.1.1. Общая клиническая характеристика больных.
8.1.2. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика патологического процесса в коже у группы пациентов с лимфоматоидным папулезом
8.1.3. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика группы пациентов с первичной анапластической крупноклеточной лимфомой кожи.
8.1.4. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика патологического процесса у группы пациентов с трансформацией грибовидного микоза в крупноклеточную лимфому.
8.2. Дифференциальная диагностика первичных В-клеточных крупноклеточных лимфопролиферативных заболеваний кожи.
8.2.1. Общая клиническая характеристика больных.
8.2.2. Гистологическая, иммуногистохимическая и молекулярно-биологическая характеристика патологического процесса у пациентов с первичными кожными крупноклеточными В-клеточными лимфомами.
8.3. Оптимизация клинических, гистологических, иммуногистохимиче-ских и молекулярно-биологических критериев для дифференциальной диагностики первичных крупноклеточных лимфом кожи.
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