Влияние дистантного прекондиционирования и ингибитора аргиназы L-норвалина на ишемические и реперфузионные повреждения печени (экспериментальное исследование)
Диссертация
В опубликованных работах, выполненных в соавторстве, автором лично проведена разработка дизайна и протокола исследования, определены ключевые критерии оценки морфофункциональных нарушений при моделировании исследуемой патологии и оценки эффективности вводимых тестируемых препаратов. При непосредственном участии автора проводилось выведение животных из эксперимента с регистрацией физиологических… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Ишемическое и реперфузионное повреждение тканей печени
- 1. 2. Механизмы протекторного действия ишемического прекондиционирования при ишемических и реперфузионных 16 поражениях печени
- 1. 3. Фармакологическое моделирование защитных эффектов ишемического прекондиционирования
- 1. 4. Аргиназы как возможная фармакологическая мишень при моделировании защитного действия второго окна ишемического 28 прекондиционирования
- ГЛАВА 2. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- ГЛАВА 3. РЕЗУЛЬТАТЫ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ
- 3. 1. Исследование ишемического и реперфузионного повреждения печени
- 3. 2. Исследование влияния прямого ишемического прекондиционирования при ишемии/реперфузии печени
- 3. 3. Исследование влияния дистантного ишемического прекондиционирования при ишемии/реперфузии печени
- 3. 4. Исследование влияния Ь-норвалина в дозах 10 и 100 мг/кг и адеметионина в дозе 400 мг/кг при ишемии реперфузии печени
- 3. 5. Исследование влияния сочетанного применения дистантного ишемического прекондиционирования и Ь-норвалина в дозе 100 75 мг/кг
- ГЛАВА4. ОБСУЖДЕНИЕ РЕЗУЛЬТАТОВ СОБСТВЕННЫХ ИССЛЕДОВАНИИ
- ВЫВОДЫ
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