Тромбозы стентов с антипролиферативным лекарственным покрытием в отдаленном периоде
В 2004 году появились первые сообщения о поздних тромбозах стентов с антипролиферативным покрытием, редкие случаи возникновения которых, ассоциировались с отменой дезагрегантной терапии. В течение двух последующих лет в результатах более поздних исследований пациентов, перенесших имплантацию стентов с лекарственным покрытием, но уже по «расширенным» (off-label) показаниям, в сложных анатомических… Читать ещё >
Содержание
- Список сокращений
- Цель и задачи исследования
- Глава 1. Обзор литературы
- 1. 1. Определение тромбоза стента
- 1. 2. Клинические проявления и последствия тромбоза стента
- 1. 3. Частота встречаемости позднего и очень позднего тромбозов стентов
- 1. 4. Механизмы, способствующие развитию тромбоза стента
- 1. 5. Факторы риска тромбоза стента в отдаленном периоде
- 1. 6. Реакция сосудистой стенки на стенты с лекарственным покрытием
- 1. 7. Профилактические подходы и перспективы
- Глава 2. Материалы и методы исследования
- 2. 1. Клиническая характеристика пациентов
- 2. 2. Методы исследования и лечения
- 2. 3. Лабораторные методы исследования
- 2. 4. Электрокардиографическое и эхокардиографическое исследования
- 2. 5. Методика проведения велоэргометрического исследования
- 2. 6. Методика проведения стресс-эхокардиографического исследования
- 2. 7. Методика выполнения селективной коронарографии и левой вентрикулографии, анализ данных коронарографии
- 2. 8. Методика определения симптомсвязанной артерии
2.9. Методика выполнения коронарной ангиопластики, критерии оценки результатов рентгеноэндоваскулярных вмешательств .54 2.10. Дезагрегантная и антикоагулянтная терапия при ангиопластике коронарных артерий.
2.11. Статистический анализ.
Глава 3. Результаты первичного стентирования группы больных с поздними и очень поздними тромбозами стентов.
3.1. Непосредственные результаты первичного стентирования группы больных с поздними и очень поздними тромбозами стентов.
3.2. Отдаленные результаты первичного стентирования группы больных с поздними и очень поздними тромбозами стентов.
Глава 4. Лечение и профилактика поздних и очень поздних тромбозов стентов.
4.1. Непосредственные результаты лечения пациентов с поздними и очень поздними тромбозами стентов.
4.2. Непосредственные результаты эндоваскулярных вмешательств в связи с поздними и очень поздними тромбозами стентов.
4.3 Отдаленные результаты лечения пациентов с поздними и очень поздними тромбозами стентов.
4.4. Факторы риска развития тромбозов стентов в отдаленном периоде.
4.5. Меры профилактики развития тромбозов стентов в отдаленном периоде.
4.6. Примеры клинических наблюдений.
Глава 5. Обсуждение результатов
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