Молекулярное моделирование строения и функционирования метаботропных глутаматных рецепторов и компьютерный дизайн их потенциальных лигандов
Диссертация
Автор признателен профессорам Роберто Пелличари и Габриэле Костантино (университет г. Перуджа, Италия) за ряд ценных критических замечаний и обсуждений, проводимых на разных этапах работы, а также за возможность выполнения части работы в Университете г. Перуджа (Италия). Осуществлено построение пространственных моделей трансмембранных доменов mGlu рецепторов, содержащих сайт связывания… Читать ещё >
Содержание
- Глава 1. Литературный обзор
- 1. 1. Сигнальная система
- 1. 2. G-Белок сопряженные рецепторы
- 1. 3. Классификация глутаматных рецепторов
- 1. 4. Семейство метаботропных глутаматных рецепторов
- 1. 5. Пространственное строение mGlu рецепторов
- 1. 6. Лиганды mGlu рецепторов
- 1. 6. 1. Агонисты I группы mGlu рецепторов
- 1. 6. 2. Агонисты II группы mGlu рецепторов
- 1. 6. 3. Агонисты III группы mGlu рецепторов
- 1. 6. 4. Антагонисты mGlu рецепторов
- 1. 6. 5. Неконкурентные антагонисты и аллостерические модуляторы
- 1. 7. Модели активации и функционирования mGlu рецепторов
- 1. 8. Распознавание и связывание лигандов mGlu рецепторами
- 1. 9. Агонист-независимая активность mGlu рецепторов
- 1. 10. Модуляция mGlu рецепторов катионами кальция
- 1. 11. Димеризация и гликозилирование mGlu рецепторов и их роль в активации mGlu рецепторов
- 1. 12. Передача сигналов mGlu рецепторами
- 1. 12. 1. Области, участвующие в сопряжении с G-белками и их активации
- 1. 12. 2. Влияние сплайсинг-варианта СКД на передачу сигнала
- 1. 12. 3. Передача сигнала mGlu рецепторами не через G-белки
- 1. 12. 4. Взаимодействие mGlu рецепторов с Homer- и RGS-белками
- 1. 12. 5. Фосфорилирование и его влияние на функционирование mGlu рецепторов, участие РКС в процессе десенситизации mGlu рецепторов
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